Ranibizumab-nuna

Basel, 29 April 2026 – Sandoz (SIX: SDZ/OTCQX: SDZNY), the global leader in affordable medicines, today presents its net-sales performance for the first quarter of 2026. Q1 2026 % Q1 2025 Change USD m Net sales USD m USD % CC %1,2,3 Net sales 2,756 100% 2,480 11% 3% Biosimilars 853 31% 671 27% 18% Generics 1,903 69% 1,809 5% -3% Europe 1,556 57% 1,372 13% 2% International 609 22% 590 3% -2% North America 591 21% 518 14% 12% Performance in line with Company expectations. Overall net sales up by 3% at CC, and by 5% when excluding effect of adverse dynamics in anti-infective B2B business4. Impact of dynamics in year concentrated in first quarter, with remaining effects dissipating thereafter Biosimilar net sales up by 18% at CC, with generics net sales declining by 3% at CC. Underlying generics net sales declined by 1% at CC when excluding aforementioned anti-infective B2B impact North America net sales up by 12% at CC, reflecting exceptional biosimilars performance. Europe net sales up by 2% at CC with biosimilars net sales up by double digit. Excluding anti-infective B2B impact, Europe net sales up by 4% at CC. Exceptional International biosimilar net sales, with region’s generics result impacted by active portfolio rationalisation and phasing of sales, as well as anti-infective B2B effect Announcement of strategic partnership with Samsung Bioepis, covering up to five biosimilar assets Full-year 2026 guidance confirmed Richard Saynor, Chief Executive Officer of Sandoz, commented: “The performance in the first quarter illustrates the underlying strengths of Sandoz. I was delighted by the exceptional growth in North America and International across biosimilars, supported by new launches and excellence in execution. We produced sales growth in line with our expectations, and the fundamentals of the 2026 roadmap are strong. We are happy to confirm our full-year guidance today. “As we look further out, I’m excited by the overwhelming scale of the opportunities ahead. We’ll complete the construction of our biosimilar hub soon; we’re rapidly expanding the biosimilar pipeline; regulatory streamlining is an important tailwind, and a very significant number of losses of exclusivity are approaching. More than 20,000 Sandoz colleagues are ready to capitalise on these opportunities and deliver even more for patients and shareholders.” BUSINESS HIGHLIGHTS In March 2026, Sandoz and Samsung Bioepis entered a strategic partnership covering up to five biosimilar assets, with the first being a proposed vedolizumab biosimilar. The agreement expands the Sandoz biosimilar pipeline to up to 32 assets In the period, the Company focused its biosimilar development, manufacturing and supply activities under newly appointed Armin Metzger. This will drive faster decision making, greater vertical integration and improved launch readiness across the expanding biosimilars pipeline. There are no changes to the Company’s financial-reporting structure The European Medicines Agency (EMA) recently confirmed that, for well‑characterised biological medicines, a robust analytical comparability package, combined with comparative pharmacokinetic data, may be sufficient to demonstrate biosimilarity, and comparative clinical efficacy and safety studies are not necessarily required. The EMA commented, “this tailored clinical approach is expected to be applicable for the majority of biosimilar candidates” In March 2026, the US FDA expanded the label for Enzeevu® (aflibercept) to include macular edema following retinal vein occlusion, diabetic retinopathy and diabetic macular edema, along with the previously approved indication of neovascular (wet) age-related macular degeneration. This significantly broadened the treatable patient population and supports a planned Q4 2026 US launch In the period, the European Commission granted marketing authorisation for Ranluspec® (ranibizumab) across all reference indications, reinforcing the Company’s ophthalmology franchise and paving the way for an expected H2 2026 European launch In April2026, following a Commerce Department investigation, the US government confirmed that generic and biosimilar medicines “should not be subject to section 232 tariffs at this time” During the period, the Company announced the issuance of a CHF 275 million bond with a six-year maturity and a CHF 275 million bond with a 10-year maturity, for the refinancing of maturing debt and other general corporate purposes. Sandoz is on track to extend its average debt maturity to six to seven years FULL-YEAR 2026 GUIDANCEThe Company continues to anticipate strong net-sales growth and further core EBITDA-margin expansion this year. As a result, the Company confirms its guidance for 2026: Net sales to grow at CC by a mid-to-high single-digit percentage Core EBITDA-margin expansion of around 100 basis points No material contribution from any potential launch of generic semaglutide is expected in 2026, while overall pricing is expected to decline by a low-to-mid single-digit percentage. The guidance excludes any impacts of unforeseen events or unconfirmed developments, including the imposition of new tariffs emanating from the US government. CONFERENCE CALL A conference call and webcast for investors and analysts will begin today at 9.30am CET. Details can be found here, with the accompanying presentation here. NOTES The performance shown in this Media Release covers the three-month period ended 31 March 2026 (Q1 2026), compared to the three-month period ended 31 March 2025 (Q1 2025). In this Media Release, ‘Company’ refers to Sandoz Group AG. Over one billion patients were reached by Sandoz in 2025, including an estimated 0.2 billion patients reached through API sales. CALENDARThe Company intends to publish its half-year results on 5 August 2026.DISCLAIMERThis Media Release contains forward-looking statements, which offer no guarantee with regard to future performance. These statements are made on the basis of management’s views and assumptions regarding future events and business performance at the time the statements are made. They are subject to risks and uncertainties including, but not confined to, future global economic conditions, exchange rates, legal provisions, market conditions, activities by competitors and other factors outside of the control of Sandoz. Should one or more of these risks or uncertainties materialise or should underlying assumptions prove incorrect, actual outcomes may vary materially from those forecasted or expected. Each forward-looking statement speaks only as of the date of the particular statement, and Sandoz undertakes no obligation to publicly revise any forward-looking statements, except as required by law. REFERENCES1 Constant currencies. 2 Non-IFRS measures are defined in the Supplementary financial information section of the Integrated Annual Report 2025. 3 For Q1 2026, all growth at constant currencies is the same as the comparable growth rate. Sandoz defines the comparable growth rate (CGR) as the growth rate of net sales at CC excluding the effects of material acquisitions and divestments. In the case of divestments, net sales are excluded for the corresponding period. Similarly, for acquisitions, the relevant net sales are excluded for the corresponding period. Material acquisitions and divestments are transactions in scope of significant transactions in the Company’s consolidated financial statements. Sandoz believes the presentation of CGR is meaningful for management and investors to evaluate the performance of the business over time. 4 As part of its vertically integrated penicillin production, the Company sells certain amounts of active pharmaceutical ingredients (APIs) on a business-to-business (B2B) basis. The imposition of tariffs by the US government in 2025 led to reduced exports from China to the US, prompting Chinese suppliers to significantly lower global prices for key penicillin APIs, including 6 Aminopenicillanic acid (6 APA), the foundational compound for all penicillin. This price decline coincided with an increase in global market supply. Penicillin API represented a significant part of anti-infective B2B net sales in FY 2025. ABOUT SANDOZ Sandoz (SIX: SDZ; OTCQX: SDZNY) is the global leader in affordable medicines, with a growth strategy driven by its Purpose: pioneering access for patients. More than 20,000 colleagues of 100 nationalities work together to ensure over one billion patients are reached by Sandoz, generating substantial global healthcare savings and an even larger social impact. Its leading portfolio of approximately 1,300 medicines addresses diseases from the common cold to cancer. Headquartered in Basel, Switzerland, Sandoz traces its heritage back to 1886. In 2026, Sandoz celebrates 20 years of pioneering biosimilars, 80 years of antibiotics manufacturing and 140 years of heritage. In 2025, Sandoz recorded net sales of USD 11.1 billion. CONTACTS Global Media Relations contacts Investor Relations contacts Global.MediaRelations@sandoz.com Investor.Relations@sandoz.com Alexis Kalomparis +41 79 279 0285 Craig Marks +44 7818 942 383 Chris Lewis +49 174 244 9501 Tamara Hackl +41 79 790 5217 Gregor Rodehueser +49 170 574 3200 Silvia Siegfried +41 79 795 9061 FIRST-QUARTER NET SALES Net sales of USD 2,756 million in the quarter represented growth of 3% at CC. Volumes grew by 7%, partly offset by price erosion of 4%. Net-sales growth was primarily driven by the performance of biosimilars, which continue to benefit from an extensive launch programme. When excluding the impact of adverse dynamics in the anti-infective B2B business, the growth in net sales amounted to 5% at CC. By business Q1 2026 Q1 2026 % Q1 2025 change USD m Net sales USD m USD % CC % CGR % Net sales 2,756 100% 2,480 11% 3% 3% Biosimilars 853 31% 671 27% 18% 18% Generics 1,903 69% 1,809 5% -3% -3% Biosimilars overview Net sales of biosimilars of USD 853 million reflected a strong growth of 18% at CC. Biosimilars represented 31% of total net sales (Q1 2025: 27%). The Europe biosimilars performance benefited from the launch of Afqlir® (aflibercept) and good performances from Hyrimoz® (adalimumab) and Binocrit® (epoetin alfa). Exceptional North America biosimilar net-sales growth reflected the strong launch of Wyost® & Jubbonti® (denosumab), while an exceptional International biosimilar result was driven by the performances of Hyrimoz, Rixathon® (rituximab) and the recent launches of Wyost & Jubbonti. Generics overview Net sales of generics of USD 1,903 million reflected a decline of 3% at CC and, when excluding the impact of adverse dynamics in the anti-infective B2B business, this translated to a decrease of 1% at CC. Generics represented 69% of net sales (Q1 2025: 73%). The decline in net sales was mainly driven by the performance in the International business which was significantly impacted by active portfolio rationalisation and the phasing of sales, as well as the aforementioned anti-infective B2B effect. By region Q1 2026 Q1 2026 % Q1 2025 change USD m Net sales USD m USD % CC % CGR % Net sales 2,756 100% 2,480 11% 3% 3% Europe 1,556 57% 1,372 13% 2% 2% International 609 22% 590 3% -2% -2% North America 591 21% 518 14% 12% 12% Europe overview Net sales in Europe were USD 1,556 million, reflecting growth of 2% at CC, with a double-digit biosimilars performance at CC outweighed by a decline in generics net sales, with the latter impacted by the effect of adverse dynamics in the anti-infective B2B business. This performance was also driven by unfavourable seasonal effects on the sale of antibiotics and over-the-counter cold & cough medicines, alongside the impacts of market dynamics in Germany, price erosion and healthcare-policy changes in France. International overview Net sales in International were USD 609 million, a decline of 2% at CC. Biosimilars delivered an exceptional performance, driven by Hyrimoz, Rixathonand the recent launches of Wyost & Jubbonti. Generics net sales decreased at CC, primarily due to active portfolio rationalisation and the phasing of sales, as well as the impact of adverse dynamics in the anti-infective B2B business. North America overview Net sales in North America were USD 591 million, representing growth of 12% at CC. An exceptional biosimilar result was driven by the strong launches of Wyost & Jubbonti. Generics net-sales growth was driven by recent US launch of lisdexamfetamine and the performance of estradiol. The Company provides the net-sales performance by region by business at each half-year and full-year results. APPENDIX QUARTERLY 2025 NET SALES BY BUSINESS Q1 2025 change Q2 2025 change Q3 2025 change Q4 2025 change USD m USD % CC % USD m USD % CC % USD m USD % CC % USD m USD % CC % Biosimilars 671 8% 11% 825 15% 12% 862 16% 13% 934 21% 16% Generics 1,809 -3% 0% 1,927 5% 2% 1,963 6% 3% 2,095 8% 2% Net sales 2,480 0% 3% 2,752 8% 5% 2,825 9% 6% 3,029 12% 6% BY REGION Q1 2025 change Q2 2025 change Q3 2025 change Q4 2025 change USD m USD % CC % USD m USD % CC % USD m USD % CC % USD m USD % CC % Europe 1,372 3% 7% 1,460 12% 6% 1,530 12% 6% 1,574 15% 6% International 590 -8% -2% 694 11% 11% 659 4% 4% 770 18% 14% North America 518 -1% 1% 598 -4% -3% 636 6% 7% 685 -1% -2% Net sales 2,480 0% 3% 2,752 8% 5% 2,825 9% 6% 3,029 12% 6% Investors Media Patients & Caregivers Partners (B2B) Job seekers Suppliers Contacts Our policies Transparency Careers Sandoz Site Directory Report Adverse Event Medical inquiry SpeakUp Email subscription 1 A Pharma Hexal Lek Investors Media Patients & Caregivers Partners (B2B) Job seekers Suppliers Contacts Our policies Transparency Careers Sandoz Site Directory Report Adverse Event Medical inquiry SpeakUp Email subscription 1 A Pharma Hexal Lek

眼科领域正悄然掀起一场变革，生物类似药进军视网膜疾病治疗领域，有望重新定义临床诊疗的经济学格局。 视网膜药物市场的产业变革从原研药垄断逐步转向“原研药+生物类似药”的多元竞争。作为获批生物制剂的高度相似仿制品，生物类似药为各类常见且治疗成本高昂的致盲性视网膜疾病，提供了全新治疗选择。 就像厨师在厨房里斟酌不同品牌的刀具一样，视网膜专科医生如今在治疗方案的选择上有了更多余地，每一种选择都可能对患者护理、诊疗经济学及更广泛的医疗体系产生影响。 “生物类似药是治疗药物生命周期中不可避免的演进产物，” 美国 NJRetina 视网膜专科医生 Paul Hahn 医学博士解释道，“我认为与参比药物相比，它们在疗效上不太可能展现出显著优势，但潜在的成本节约可能是推动其应用的重要因素。” Part.01 不断变化的市场格局 视网膜疾病治疗领域的生物类似药发展始于2021年，彼时美国 FDA 批准了由韩国仁川三星生物制剂公司研发的 Byooviz（雷珠单抗 - nuna）。此后多款雷珠单抗生物类似药相继上市，其中包括中国齐鲁制药的安卓明®（雷珠单抗眼内注射液），作为国内首款获批的雷珠单抗生物类似药，该药物不仅通过国际多中心 III 期临床试验验证了与原研药的等效性，还成功登陆欧盟市场（商品名：Rimmyrah）；另有瑞士巴塞尔 Sandoz 公司的 Cimerli（雷珠单抗-eqrn），这款药物已获得 FDA 的可互换性认定。 如今，阿柏西普生物类似药正成为焦点。2023年底，齐鲁制药的卓初明®（阿柏西普眼内注射液）获批上市，成为中国首个获批的阿柏西普生物类似药。2025年11月，博安生物研发的博优景®获中国国家药监局批准，用于治疗新生血管性年龄相关性黄斑变性和糖尿病性黄斑水肿，成为中国第二款同类产品。 还需关注的是，印度班加罗尔的 Biocon 生物制剂公司近期与美国纽约的 Regeneron 公司达成和解，为其研发的 Yesafili（阿柏西普-jbvf）——Eylea 的可互换生物类似药 —— 铺平了道路，计划于2026年底前或根据特定条款提前在美国上市。 “此次和解为 Biocon 生物制剂公司成为首批向美国患者和医疗服务提供者提供可靠、高质量阿柏西普生物类似药的企业之一扫清了障碍，”Biocon 公司首席执行官 Shreehas Tambe 在新闻稿中表示。 这是在一个庞大市场中迈出的大胆步伐。Eylea 在2023年的销售额约为94亿美元，预计到2028年市场规模将增长至127.3亿美元，使其成为生物类似药竞争的热门目标[1]。 Part.02 解读生物类似药 与小分子药物的完全拷贝品，仿制药不同，生物类似药是另一类特殊药物。它们是由活细胞培育而成的大型复杂蛋白质，因此无法制造出与原研生物制剂完全一致的复制品。但尽管无法做到完全相同，它们与参比药物在结构、纯度和效价上极为相似，疗效也与参比药物相当。 “根据定义，生物类似药的分子和蛋白质特征必须与参比产品相似，”Bressler 等人在《Survey of Ophthalmology》（眼科学综述）上发表的一篇综述中解释道，“生物制剂本身就具有一定的内在微观异质性。” 也就是说，生产过程中必然存在微小差异。这些差异源于生产药物所用活细胞的自然变异，以及生产过程中的细微变化[2]。 这种内在变异性意味着，即使是同一参比产品的不同批次，也并非绝对一致。正如 Bressler 等人所指出的：“2018年生产的参比药物雷珠单抗（Lucentis）批次，与2022年生产的同产品批次可能并非完全相同[2]。” 要获得 FDA 批准，生物类似药必须经过严格测试以证明其临床等效性，但其研发过程比原研生物制剂更快、成本更低[2]。 “坦率地说，开发生物类似药成本更低，因为无需经历原研药的全新研发流程，” 美国俄亥俄州视网膜中心首席执行官 Suber Huang 博士解释道，“例如，对于安维汀（Avastin），要开发生物类似药就必须经历完整的新流程，因为原研药安维汀（贝伐珠单抗） 最初获批的适应症是恶性肿瘤，并非眼科领域的参比药物。” Part.03 成本考量 推动生物类似药研发的最大动力之一是实实在在的成本节约。首款雷珠单抗生物类似药上市时，价格较参比药物降低了40%，平均销售价格差异约为31.3%。考虑到新生血管性年龄相关性黄斑变性或糖尿病性黄斑水肿等疾病患者，仅在治疗第一年就可能平均接受9次注射，这一成本节约潜力显著[2]。 加拿大的一项估算显示，2023年改用雷珠单抗生物类似药可能节省7000万至2.01亿加元。其他市场情况类似，尤其是随着更多生物类似药进入市场并展开价格竞争，也有望实现大幅成本节约[2]。 当然，成本节约只有在生物类似药得到应用的情况下才能实现，这就涉及到药物的使用率问题。“当有更便宜的选择时…… 如果疗效和安全性相当，患者、保险、社会乃至整个医疗体系通常都会倾向于选择这些药物，”Huang 博士表示。 Part.04 临床应用经验与推广挑战 尽管生物类似药具有降低成本和扩大医疗可及性的潜力，但在眼科领域的推广起步较为缓慢。2023年，其使用率仅为3%，2024年也仅小幅上升至约10%[3]。 那么，犹豫的背后原因是什么？根据 Hahn 医生的说法，并非视网膜专科医生怀疑生物类似药的疗效。“我认为当生物类似药首次成为视网膜治疗方案的考量选项时，人们对此存在诸多犹豫，” 他解释道，“这种犹豫本质上是思维模式的差异：一方面，生物类似药的疗效和原研参比药物相当，并非‘更有效’，其核心优势是成本更低；另一方面，多数眼科医生的职业习惯是聚焦‘为患者选择疗效最优的治疗方案’，这种思维惯性让医生对以成本为核心优势的生物类似药产生了选择上的迟疑[3]。” 但这种思维模式的转变正在缓慢发生，对于那些已经率先采用生物类似药的医生来说，结果令人鼓舞。“我们已将雷珠单抗生物类似药纳入临床治疗，应用于新患者和现有治疗患者，整合过程总体顺利，”Hahn 博士表示，“一旦医生们对其安全性和疗效特征感到放心，患者通常会遵循医生的建议，不会有太多顾虑。” Part.05 阶梯治疗的难题 谈到生物类似药，美国的视网膜专科医生并不担心药物本身，但他们对保险公司可能利用生物类似药推行限制性阶梯治疗方案表示担忧。 “我认为最大的问题之一是强制阶梯治疗，”Huang 博士说，“当保险公司强制规定必须按特定顺序尝试药物时，我认为这与医学实践的本质相悖。” Hahn 医生也表达了同样的担忧。“如今市场上有多种生物类似药，还有一种虽未获批眼科适应症但成本更低的选择，视网膜专科医生现在背负着多重‘阶梯’，必须在每个阶梯的治疗失败后，才能更换为另一种治疗方案，”他解释道。 这些阶梯并非仅存在于理论中。根据凯撒家庭基金会的数据，98%的联邦医疗保险优势计划（Medicare Advantage）目前对B部分药物采用阶梯治疗，影响着超过40%的联邦医疗保险受益人。在实际临床中，这通常意味着首先使用复方贝伐珠单抗进行治疗，只有在该方案“失败”后，才能使用 FDA 批准的原研药[4]。 眼科界并未对此坐视不管。正如 Hahn 医生所指出的，美国视网膜专家学会（ASRS）等组织“积极维护医生在治疗选择中的判断权和选择权”。美国眼科学会（AAO）也对此表示反对，称“药物治疗的选择应由患者和医生在充分讨论每种治疗的风险和益处后共同决定，而非由保险公司决定[5]。” Part.06 患者沟通与接受度 在与患者沟通生物类似药时，视网膜专科医生发现，清晰、简洁的解释往往能达到良好效果。 “患者通常理解仿制药的作用并愿意接受使用。我向他们解释，生物类似药相当于注射类疗法的仿制药，患者通常不会有顾虑，”Hahn 医生说，“对于那些确实有顾虑的患者，我会解释我们有多种选择，如果未达到预期效果，我们随时可以更换其他治疗方案。” 尽管随着生物类似药的普及，患者教育仍然很重要，但目前仍存在一定的知识缺口需要弥补。一份行业报告发现，50%的受访者表示对生物制剂和生物类似药“了解甚少”。不过，在眼科领域，注射治疗由医生实施，患者的认知可能不如医生对产品的信心重要。即便如此，清晰的沟通总归是有益的[6]。 Part.07 视网膜疾病治疗中生物类似药的未来 随着更多生物类似药加入治疗工具箱，以及临床医生对其使用越来越熟悉，视网膜疾病治疗的格局必然会发生变化。但变化会有多大？这取决于你询问的对象。 Hahn 医生并不认为生物类似药是变革者，而更倾向于将其视为有益的补充。“与目前正在研发的视网膜疾病创新治疗方法相比，我认为生物类似药不会从根本上改变我们治疗视网膜疾病的方式，”他说，“治疗工具箱中更多治疗选择的出现总体上是有价值的，尤其是在社会和患者个体层面，治疗成本的重要性日益凸显的情况下。” 与此同时，Huang 博士就药物研发的优先级提出了一个发人深省的问题。“生物医学研究投入的大量时间和资金…… 这些资源最终被用于研发一种实际上并不比我们已有的药物更好的产品，”他指出，“如果永远无法实现改进，那么我们所做工作中非常有价值的一部分。即努力研发更好的产品，就会丢失。” 尽管如此，问题的另一面：“如果生物类似药成本更低，更多人就能负担得起。如果更多人能够获得治疗。而且疗效同样良好。那么你就以另一种但同样有意义的方式改善了医疗服务，” Huang 博士补充道。 Part.08 新工具 在眼科生物类似药的新时代，或许 Huang 博士用一个烹饪比喻说得最为贴切：“如果两把刀由不同制造商生产，它们仍然是刀，用来准备晚餐的效果是一样的。” 换句话说，生物类似药并没有重塑视网膜疾病的治疗方案，但它们为视网膜专科医生提供了更多可用工具。这些工具功能相似，但价格不同。就像切洋葱不一定需要正光（Masamoto Sohonten）刀具一样，有效治疗患者也不一定总是需要原研生物制剂。 关键在于？确保这些额外的选择赋予医生权力，而不是束缚他们的手脚。“作为一个社会，我们必须确保这些额外的治疗方式为医生提供更多选择，而不是限制选择，”Hahn 医生警告说。 通过完善的教育、周密的推广，以及对安全性和疗效的密切关注，生物类似药有望在扩大医疗可及性的同时，减轻视网膜疾病治疗的经济负担。从这个意义上说，它们不仅仅是另一套工具，更是为更多患者创造更好治疗结果的机会。 Part.09 迎接生物类似药时代 对于希望将生物类似药纳入临床诊疗的视网膜专科医生来说，适当的准备有助于实现平稳过渡。以下是一些关键点： 👉 做好功课：深入了解临床试验数据和真实世界证据，扎实掌握每种生物类似药的安全性和疗效。 👉 关注细节：熟悉“可互换性”等监管术语，更重要的是，了解这些标签对你日常临床决策的实际意义（及其局限性）。 👉 准备简洁说明：用清晰、直白的方式向患者解释生物类似药，有助于缓解他们的顾虑。 👉 关注医保动态：随着生物类似药的普及，做好应对保险覆盖政策变化的准备。 👉 跟踪结果：监测患者疗效，以建立自己对这些药物的信心。 归根结底，信任是关键。“患者信任他们的医生，”Hahn 医生提醒道，“如果你对提供给患者的治疗方案感到放心，患者通常也会感到放心。” 参考文献 （上下滑动可查看） [1] Eylea (Aflibercept) Market Research Report 2025: Strategic Partnerships and Biosimilars Enhance Accessibility, Diabetes-Related Retinal Issues and Myopia Surge Boost – Long-term Forecasts to 2033. Research and Markets. February 12, 2025. Available at: https://www.globenewswire.com/news-release/2025/02/12/3024804/28124/en/Eylea-Aflibercept-Market-Research-Report-2025-Strategic-Partnerships-and-Biosimilars-Enhance-Accessibility-Diabetes-Related-Retinal-Issues-and-Myopia-Surge-Boost-Long-term-Forecast.html. Accessed on June 2, 2025. [2] Bressler NM, Kaiser PK, Do DV, et al. Biosimilars of anti-vascular endothelial growth factor for ophthalmic diseases: A review. Surv Ophthalmol. 2024;69(4):521-538. [3] Jeremias S. Retina Specialists’ Evolving View on Biosimilars in AMD Treatment. The Center for Biosimilars. March 16, 2025. Available at: https://www.centerforbiosimilars.com/view/retina-specialists-evolving-view-on-biosimilars-in-amd-treatment. Accessed on June 2, 2025. [4] Freed M, Biniek JF, Damico A, et al. Medicare Advantage in 2024: Enrollment Update and Key Trends. August 8, 2024. Available at: https://www.kff.org/medicare/issue-brief/medicare-advantage-in-2024-enrollment-update-and-key-trends/. Accessed on June 2, 2025. [5] Congress’ Physicians Prep Strong Message Opposing Step Therapy in Medicare. AAO. June 27, 2019. Available at: https://www.aao.org/advocacy/eye-on-advocacy-article/congress-physicians-prep-strong-message-opposing. Accessed on June 2, 2025. [6] National Survey on Innovator Biologics and Biosimilars. Biologics Prescribers Collaborative. August 8, 2023. Available at: https://biologicsprescribers.org/wp-content/uploads/2023/08/BPC_Patient-Choice_National-Survey-Report_August-2023.pdf. Accessed on June 2, 2025. 视网膜研究最新亮点 | 2025年美国视网膜专家学会（ASRS）年会报告精选 30种药物与视网膜脱离相关联：来自FDA不良事件报告系统 ESCRS临床趋势调查：老视 睿盟希国际视觉科学基金，以 For better vision and insight 为愿景，致力于全球范围内挖掘并投资视觉科学领域的创新科技公司 我们专注于细分领域跨境投资、并购、 商务合作和技术转移 长按以下二维码关注