Etidronate Disodium

10 月的广州，就职于示康药业年近七旬的余传林教授正与CRO公司线上、线下交流创新一类药（全球新）的临床前研究事宜，共同解决一个又一个的技术难题。余传林教授专注于新药研发近四十年，这位从鄂东船乡英山那个名叫 “建船” 的少年，到手握 8 项国家一类、二类、四类新药证书、斩获 10 项军队科技进步奖的新药研发领军人，他用五十载光阴，在医药科研的沃土上，书写了一段关于热爱、坚守与担当的壮阔传奇。      1957 年的春天，武汉运输船队的江面上，货轮往来穿梭，江水拍岸的声响中，一个小生命悄然降临。因生于英山船队造船的繁忙年代，父母为他取了饱含时代印记的小名 “建船”，这个带着乡土温度的名字，成为他人生故事的第一个注脚。谁也未曾想，这个在英山县杨柳湾镇白马乡黄泥畈村余家湾的田埂间长大的孩子，未来会在医药领域踏出一条横跨半个世纪的深耕之路，用科研之力为国人健康 “造船护航”。       七岁那年，母亲的离世给年幼的余传林带来了沉重的打击，也让他第一次直面生命的脆弱。这份深埋心底的伤痛，悄然埋下了对 “生命与健康” 的懵懂思考 ——“若有良药，或许就能留住挚爱”。17 岁时，怀揣着对未知的探索欲与一份朴素的担当，他穿上军装，成为一名解放军战士。次年，他有幸投身 162 师卫生员培训，从辨认田间草药、背诵医药基础理论开始，一步步叩开医学的大门。在 485 团卫生队的日子里，他身兼数职：门诊部里，他是耐心倾听、细致问诊的卫生员；住院部里，他是彻夜值守、守护病患的值班员；手术室内，他是默契配合、沉着冷静的手术助手。手术灯的光圈下，他见证过生死离别的悲恸，也亲历过医学技术挽救生命的希望，这些经历让 “以医助人” 的信念在他心中愈发坚定。三年多的时间里，他刻苦钻研业务，热心服务每一位患者，凭借突出的表现，先后被军、师、团评为雷锋式优秀战士，被誉为医疗卫生战线上的 “春苗” 式好战士。这份认可，更让他萌生了进一步深造、精进医术的想法。 命运总会眷顾有准备的人。1978 年，凭借在部队的优异表现与日复一日的不懈努力，余传林通过保送与考试的双重考验，成功踏入中国人民解放军第一军医大学的校园。在这里，他如饥似渴地汲取着医学理论知识，像海绵吸水般填补着专业空白，打下了坚实的药理学基础。后来，为适配新药研发过程中对合规性的严苛要求，他又主动攻读了解放军西安政治学院的法律课程，最终成为兼具医学与法学双学历的综合型人才。这份跨学科的视野与积淀，日后成为他开展新药研发、破解科研合规难题的独特优势，让他在复杂的医药科研领域中始终行稳致远。       毕业后，余传林留校任教，从药理学教研室的科研与教学工作起步，正式开启了与医药研发相伴相生的职业生涯。1991 年，他与药理教研室主任一同调任，牵头组建第一军医大学药物研究所。此后的二十余年里，他的身影始终活跃在实验室、新药研发一线、申报现场与临床研究阵地。2005 年，学校集体转制为南方医科大学，身份的转变并未打乱他的科研节奏，他依旧带领团队攻坚克难。担任所长助理期间，他既要统筹协调各类科研项目的推进，又要躬身投入具体的研发实验，同时还肩负着导师的重任，合作培养出一批又一批抗炎免疫药理学专业的硕士、博士研究生，为医药科研事业输送了新鲜血液。       自上世纪 80 年代中旬投身药物研发以来，余传林与同事们交出了一份份亮眼的成绩单：参与研发的 “三九胃泰”，以确切的疗效成为无数家庭信赖的肠胃 “守护神”；“洁银牙膏” 开创性地将医药理念融入日常护理，开辟了药用牙膏的新方向；李锦记增健口服液中研发的免疫复合多糖成分，为保健品行业的创新发展提供了全新思路。在专业医药领域，他的贡献更是意义深远：作为主要研制者参与研发的钆喷酸葡胺注射液，成功实现核磁共振检查造影剂的进口替代，为国家节约了大量外汇；盐酸洛拉曲克冻干粉针、蛇毒血凝酶冻干粉针等一类新药，为肿瘤治疗、止血急救领域注入了强劲动力；降压药卡维地洛片、骨质疏松药依替膦酸二钠片等，成为临床治疗中不可或缺的重要药物。截至退休前，他参与的新药项目共斩获 8 个国家一类、二类、四类新药证书，4 项军队科技进步奖二等奖、6 项三等奖，3 次荣立个人三等功，发表 70 余篇高质量科研论文，手握多项专利授权，每一项成果都镌刻着他深耕不辍的足迹。       2017 年，退休的钟声并未让余传林停下前行的脚步。南方医科大学向他发出返聘邀请，他毫不犹豫地加入实验室安全巡查专家组，用数十年积累的科研经验为校园科研安全筑牢防线；与此同时，广州示康药业有限公司的橄榄枝如期而至，他再次扛起创新一类药研发的大旗，全力推进创新一类药（全球新）的临床前研究工作，在自己热爱的医药领域继续发光发热。 从鄂东船乡英山的少年，到军队卫生战线上的 “春苗” 战士，再到南方医科大学的正师职教授、新药研发领军人，五十余载医者路，余传林用坚守诠释着对医学事业的赤诚热爱，用一项项实打实的科研成果书写着对行业、对国家、对人民的责任担当。他的故事，不仅是一个人跨越半个世纪的成长史诗，更是中国医药科研人代代传承、砥砺前行的生动缩影 —— 以初心为舵，以坚守为帆，在守护国人健康的航程中，续写着永不停歇的传奇。 图片来自《湖北日报》     余传林教授简介 余传林，1957 年 3 月生于湖北省英山县，中共党员，南方医科大学（原第一军医大学）教授，正师职（正厅职），拥有医学与法律双学历。1974 年 12 月参军入伍，1975 年 2 月参与 162 师卫生员培训，后在 162 师 485 团卫生队历任卫生员、卫生班长，深耕门诊部、住院部、手术室一线诊疗工作。1978 年考入中国人民解放军第一军医大学，毕业后留校任职于药理学教研室，兼顾科研与教学工作。1991 年至 2017 年退休前，任职于第一军医大学药物研究所（2005 年转制为南方医科大学药物研究所），担任所长助理，同时作为抗炎免疫药理学导师组导师，合作培养多名该专业硕士、博士研究生。期间专注新药、保健品等研发，参与军队及国家级科研项目十余项，斩获国家一类、二类、四类新药证书 8 个（含核磁共振造影剂、抗肿瘤药物等关键成果），获军队科技进步奖二等奖 4 项、三等奖6项，在军队荣立个人三等功3次，发表高质量科研论文 70 余篇。

Researchers provide experimental data about how radiation travels through dense plasmas. Their data will improve plasma models, which allow scientists to better understand the evolution of stars and may aid in the realization of controlled nuclear fusion as an alternative energy source. Most people are familiar with solids, liquids, and gases as three states of matter. However, a fourth state of matter, called plasmas, is the most abundant form of matter in the universe, found throughout our solar system in the sun and other planetary bodies. Because dense plasma -- a hot soup of atoms with free-moving electrons and ions -- typically only forms under extreme pressure and temperatures, scientists are still working to comprehend the fundamentals of this state of matter. Understanding how atoms react under extreme pressure conditions -- a field known as high-energy-density physics (HEDP) -- gives scientists valuable insights into the fields of planetary science, astrophysics, and fusion energy. One important question in the field of HEDP is how plasmas emit or absorb radiation. Current models depicting radiation transport in dense plasmas are heavily based on theory rather than experimental evidence. n a new paper published in Nature Communications, researchers at the University of Rochester Laboratory for Laser Energetics (LLE) used LLE's OMEGA laser to study how radiation travels through dense plasma. The research, led by Suxing Hu, a distinguished scientist and group leader of the High-Energy-Density Physics Theory Group at the LLE and an associate professor of mechanical engineering, and Philip Nilson, a senior scientist in the LLE's Laser-Plasma Interaction group, provides first-of-its-kind experimental data about the behavior of atoms at extreme conditions. The data will be used to improve plasma models, which allow scientists to better understand the evolution of stars and may aid in the realization of controlled nuclear fusion as an alternative energy source. "Experiments using laser-driven implosions on OMEGA have created extreme matter at pressures several billion times the atmospheric pressure at Earth's surface for us to probe how atoms and molecules behave at such extreme conditions," Hu says. "These conditions correspond to the conditions inside the so-called envelope of white dwarf stars as well as inertial fusion targets." Using x-ray spectroscopy The researchers used x-ray spectroscopy to measure how radiation is transported through plasmas. X-ray spectroscopy involves aiming a beam of radiation in the form of x-rays at a plasma made of atoms -- in this case, copper atoms -- under extreme pressure and heat. The researchers used the OMEGA laser both to create the plasma and to create the x-rays aimed at the plasma. When the plasma is bombarded with x-rays, the electrons in the atoms "jump" from one energy level to another by either emitting or absorbing photons of light. A detector measures these changes, revealing the physical processes that are occurring inside the plasma, similar to taking an x-ray diagnostic of a broken bone. A break from conventional theory The researchers' experimental measurements indicate that, when radiation travels through a dense plasma, the changes in atomic energy levels do not follow conventional theories currently used in plasma physics models -- so-called "continuum-lowering" models. The researchers instead found that the measurements they observed in their experiments can only be explained using a self-consistent approach based on density-functional theory (DFT). DFT offers a quantum mechanical description of the bonds between atoms and molecules in complex systems. The DFT method was first described in the 1960s and was the subject of the 1998 Nobel Prize in Chemistry. "This work reveals fundamental steps for rewriting current textbook descriptions of how radiation generation and transport occurs in dense plasmas," Hu says. "According to our experiments, using a self-consistent DFT approach more accurately describes the transport of radiation in a dense plasma." Says Nilson, "Our approach could provide a reliable way for simulating radiation generation and transport in dense plasmas encountered in stars and inertial fusion targets. The experimental scheme reported here, based on a laser-driven implosion, can be readily extended to a wide range of materials, opening the way for far-reaching investigations of extreme atomic physics at tremendous pressures." Researchers from Prism Computational Sciences and Sandia National Laboratories and additional researchers from the LLE, including physics graduate students David Bishel and Alex Chin, also contributed to this project.