The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of Hospital Cardiac Arrest. The investigative team plan to randomize patients in OHCA to early naloxone administration vs. placebo after initial resuscitation and measure ROSC and survival. Challenges to designing NOPACA include uncertainty regarding: 1) the available pool of participants and number of EMS agencies needed to meet enrollment targets; 2) acceptability among patients, EMS and Emergency Medicine provider stakeholders, and 3) estimates of the study outcomes needed for sample size estimates. Toward obtaining the necessary information to design NOPACA, the investigators propose a pilot RCT of participants at high risk for OA-OHCA to verify a reasonable recruitment rate; treatment fidelity and acceptability; and adequate retention and measurement of outcomes at follow up. The investigators propose incorporating hypothesis testing of the feasibility outcomes to determine progression to a definitive trial.

开始日期2026-11-01

申办/合作机构

The University of California, San Francisco

NCT04650841

/ Not yet recruiting早期临床1期IIT

The Role of the Opioid System in Placebo Effects on Pain and Social Rejection

The current study probes the involvement of the opioid system in placebo effects on social pain, using the opioid antagonist naloxone. 60 participants who recently experienced an unwanted breakup will experience rejection-related stimuli and receive painful heat and pressure stimuli during fMRI scanning. Participants will be randomized to receive either a naloxone or saline nasal spray, and be informed that the spray is either saline, or an effective pain and negative emotion reducing agent.

开始日期2025-09-01

申办/合作机构

Trustees of Dartmouth College

NCT07079241

/ Not yet recruitingN/A

REgion Sk?ne Preventing Overdose Through Naloxone Distribution With Emergency Runners: a Feasibility Study for a Model to Save Lives Through a Volunteer First Responder Service Providing Antidote Treatment in Opioid Overdose

Opioids are responsible for the greatest drug-related global health burden. Prevention and treatment programs for people with opioid use disorder are widely implemented, but further actions are required to reduce the mortality and morbidity caused by opioid use and dependence. We suggest a novel and unique approach with a volunteer first responder system for suspected opioid overdoses, integrated with national emergency call services. The idea derives from the success of volunteer first responder systems for out-of-hospital cardiac arrests. Several reports exist globally with results of increased survival rates, less complications and a beneficial time-gain to start of cardiopulmonary resuscitation before emergency services (like ambulance and fire fighters) arrival.
Our model aims to investigate feasibility, acceptability and safety of a smartphone-based volunteer first responder system for suspected opioid overdoses. The volunteer responders will be equipped with an emergency kit including two doses of the opioid antidote naloxone, which can reverse life-threatening respiratory arrest caused by intoxication of opioids. The responders will, prior to registration, accomplish an in-depth overdose and naloxone education, as well as a first aid course aligned with current European and Swedish resuscitation guidelines. The results will be collected through questionnaires to the responder participants, technical data from the responder application, and dispatcher, pre-medical/paramedical and hospital records among others. Both quantitative and qualitative methods will be used. The major question is if the model is feasible in alerting lay persons with naloxone to suspected overdose situations and successfully administer naloxone prior to emergency service arrival. Furthermore, experiences of safety during alerts among volunteer first responders and overdose victims will also be studied.
Our model is unique in its integration with emergency medical dispatch service along with overdose and first aid education prior to participant registration. The respiratory arrest of opioids is an acute life-threatening condition, which - in similarity to cardiac arrests - need emergent actions for survival. A reduced time to naloxone administration through volunteer first responders prior to ambulance arrival could save lives.

开始日期2025-09-01

申办/合作机构

Region Skåne Holding AB

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100 项与盐酸纳洛酮相关的临床结果

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100 项与盐酸纳洛酮相关的转化医学

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100 项与盐酸纳洛酮相关的专利（医药）

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28,318

项与盐酸纳洛酮相关的文献（医药）

2025-12-31·JOURNAL OF DERMATOLOGICAL TREATMENT

Hailey-Hailey disease successfully treated with naloxone: 2 case reports and Review of the literature on efficacy of opioid receptor antagonist in Hailey-Hailey disease patients

Review

作者: Sheng, Nan ; Wu, Jianbing ; Fang, Fang ; Duan, Zhimin ; Li, Chengrang ; Xu, Beilei ; Song, Hao ; Zheng, Junyou

BACKGROUND:

Hailey-Hailey disease (HHD), a genetic blistering disease, is caused by a mutation in a calcium transporter protein in the Golgi apparatus encoded by the ATP2C1 gene. Clinically, HHD is characterized by flaccid vesicles, blisters, erosions, fissures, and maceration mainly in intertriginous regions. Some patients remain refractory to conventional treatments. Previously, a series of reports have confirmed naltrexone as an effective option for those patients. However, in China, naltrexone is unavailable in some hospitals and unaffordable for some patients.

OBJECTIVE:

To confirm naloxone as a treatment option for HHD, and assess the efficacy rate and safety of naltrexone for patients with HHD.

METHODS:

Two patients with biopsy-proven HHD received naloxone (2 mg/d, via intravenous infusion). We followed up with the two patients, assessing the change of skin lesions and obtaining photographs. We searched the PubMed databases using the keywords 'Hailey-Hailey disease' or 'benign familial pemphigus', and 'naltrexone' or 'naloxone', and reviewed English publications of reports and analyzed the efficacy and safety of naltrexone.

RESULTS:

Two patients prescribed naloxone showed completely remission in two weeks without any adverse reactions. The total remission rate of naltrexone for HHD is approximately 80%, without severe adverse effects.

CONCLUSION:

Naltrexone is effective and safe in the treatment of HHD. Naloxone, an analog of naltrexone, can also effectively and safely treat HHD, potentially offering a new therapeutic option for patients with refractory HHD.

2025-12-31·Future Science OA

Evaluating cytidine, uridine, and gabapentin combinations for pain modulation and p-CREB expression in neuropathic model

Article

作者: Alzaghari, Lujain F. ; Qnais, Esam Y. ; Al-Najjar, Mohammad A. A. ; Barakat, Muna ; Chellappan, Dinesh Kumar ; Alqudah, Abdelrahim ; Athamneh, Rabaa Y.

AIMS:

To evaluate the analgesic and neuroprotective effects of cytidine, uridine, and gabapentin-administered alone and in combination-in models of diabetic neuropathy and formalin-induced acute and inflammatory pain.

MATERIALS & METHODS:

Oral doses of cytidine, uridine, and gabapentin (100 mg/kg each) were administered to rats with streptozotocin-induced diabetic neuropathy and in a formalin test model. Behavioral responses were recorded at 30, 60, and 120 minutes following treatment after five weeks of diabetes induction. Spinal cord p-CREB expression was measured to assess molecular changes, and pretreatments with naloxone, yohimbine, and methysergide were employed to explore opioid, adrenergic, and serotonergic contributions.

RESULTS:

All treatments significantly reduced formalin-induced pain in both acute and inflammatory phases (p < 0.05; p < 0.001) and increased mechanical pain thresholds in the diabetic neuropathy model at all-time points (p < 0.05). Combination therapy proved more effective than gabapentin alone (p < 0.05) and was associated with decreased spinal p-CREB levels, indicating altered anti-nociceptive signaling.

CONCLUSIONS:

The combined use of cytidine, uridine, and gabapentin enhances analgesia and neuroprotection compared to monotherapy, supporting its potential as a novel, analgesic-free treatment strategy for diabetic neuropathy.

2025-11-01·NEUROPHARMACOLOGY

Antibiotic treatment improves gut dysbiosis and depression-like behavior induced by morphine withdrawal

Article

作者: Gu, Bo-Yuan ; Liu, Jun-Lin ; Yu, Dong-Yu ; Zhang, Yu-Xiang ; Gao, Jing-Qi ; Yan, Chun-Xia ; Gao, Fei-Fei ; Shen, Meng-Qing ; Yang, Xi-Xi

Opioid withdrawal poses a significant neuropsychiatric challenge, notably contributing to the onset of depression. Depression intertwines with gut flora richness and diversity, frequently coinciding with synaptic plasticity alterations in the brain. Gut microbiota dysbiosis potentially contributes to withdrawal-triggered depression via gut-brain axis. This research delves into the impact of antibiotic-induced gut microbiota alteration on behavioral and synaptic protein variations in mice subjected to morphine withdrawal-induced depression. A murine model was established using escalating doses of morphine followed by naloxone-precipitated withdrawal. Depression-like behaviors were assessed through tail suspension, sucrose preference, forced swimming tests, while histopathology evaluated ileocolonic inflammation. Synaptic markers, Synaptophysin (SYP) and Synapsin 1 (SYN1), in the hippocampus were analyzed via Western blotting, and gut microbiota composition was assessed through 16S rRNA sequencing. An antibiotic intervention model was employed to explore microbiota-dependent mechanisms. Morphine withdrawal induced characteristic depression-like behaviors, including prolonged immobility in forced swimming and reduced sucrose preference. Microbiota diversity metrics demonstrated significant declines in α-diversity. Histological analysis revealed marked inflammatory infiltration in ileal tissues, accompanied by reduction in hippocampal SYP expression. Antibiotic administration attenuated behavioral impairments, mitigated gut dysbiosis, reduced intestinal inflammation, and partially rescued SYP expression. These findings establish that morphine withdrawal induces intestinal dysbiosis, hippocampal synaptic plasticity deficits and depression-like behaviors, which are reversible through microbiota modulation. The results highlight the antibiotic treatment as a potential therapy for opioid withdrawal sequelae.

618

项与盐酸纳洛酮相关的新闻（医药）

2025-08-01

·EndPoints

FDA requires opioid label updates to highlight long-term risks

The FDA on Thursday required new safety label updates for all opioids to “further emphasize and characterize the risks associated with long-term use,” following a May advisory committee meeting that discussed new postmarketing data. Specifically, the FDA told companies to pull the phrase “extended treatment period” in the Indications and Usage section of their labels, “to avoid misinterpretation that there are data to support safety and efficacy of opioid analgesics over an indefinitely long duration.” The updates also clarify that extended-release/long-acting opioids “should only be used” when alternatives, such as immediate-release opioids, “are inadequate to manage severe and persistent pain, and to emphasize the importance of avoiding rapid dose reduction or abrupt discontinuation in patients who may be physically dependent on opioid pain medicines,” the agency said in the update . In May, panelists on an FDA advisory committee offered mixed takes on whether the agency should update opioid labels with data from two required postmarketing studies. Some panelists found the studies’ findings difficult to interpret and not generalizable to current medical practice, since they were several years old. The FDA opted to add that information to the labels, which shows that over a 12-month period, approximately 1% to 6% of participants across the two postmarket groups newly met the criteria for addiction, and about 9% to 22% of participants newly met criteria for prescription opioid abuse and misuse. The FDA first approved extended-release/long-acting opioids in 1987. In 2013, it sought five additional postmarketing studies after concluding that more data were needed regarding the serious risks of misuse, abuse, addiction, overdose and death associated with long-term use. Allergan, Endo Pharmaceuticals, Hikma, Janssen, Mallinckrodt, Pfizer and Purdue Pharma were among those tasked with conducting the four observational studies and one prospective clinical trial. The agency also said it’s requiring label updates on which opioid overdose reversal agents are currently available. The FDA in March 2023 approved the first over-the-counter nasal spray version of naloxone, and in August 2024, FDA approved the first nalmefene hydrochloride auto-injector to treat opioid overdose in adults and children 12 years and older. Manufacturers must further “emphasize that higher doses are associated with increased risk of serious harm, and that the risks of serious harms persist over the course of therapy,” the FDA said.

上市批准

2025-07-29

·GlobeNewswire-Health Care

Branded Legacy, Inc. Signs Letter of Intent to Acquire Bio-Legacy Evaluative Group, Advancing Innovations in Intranasal Drug Delivery

Strategic Acquisition Positions Branded Legacy to Enter the Growing Naloxone and Vaccine Markets, Enhancing Shareholder Value; Leadership Transition Planned with Amin Janmohamed as New CEO and ChairmanMELBOURNE, Fla., July 29, 2025 (GLOBE NEWSWIRE) -- via IBN -- Branded Legacy, Inc. (OTC: BLEG), a diversified holdings company focused on innovative health and wellness solutions, today announced the execution of a non-binding Letter of Intent (LOI) to acquire Bio-Legacy Evaluative Group, a pioneering health innovation company specializing in advanced intranasal drug delivery technologies. The LOI, fully executed by both parties, outlines the proposed acquisition of 100% of Bio-Legacy Evaluative Group's equity interests, assets, intellectual property, and operations in exchange for $1.5 million worth of Branded Legacy's Preferred D stock. This strategic move aligns with Branded Legacy's commitment to expanding its portfolio into high-growth sectors addressing global health crises, such as addictions and vaccine accessibility. Bio-Legacy Evaluative Group, led by President & CEO Amin Janmohamed, has assembled a world-class team of experts including Prof. Eran Bendavid, MD (Research Lead, Stanford Professor), Prof. Sonal Singh, MD (Medical Lead, UMass Professor), Prof. Martin Schechter, MD, PhD (Scientific Advisor), and others renowned in addiction medicine, biostatistics, and business development. Bio-Legacy Evaluative Group's patented all-in-one intranasal naloxone delivery device addresses key limitations in the current market, including high costs, inconsistent dosing, and complex systems. By simplifying manufacturing and enhancing dose precision, the technology aims to make naloxone more accessible amid a projected market growth from $371 million in 2022 to over $1.16 billion by 2032, at a CAGR of approximately 11.9%. Additionally, Bio-Legacy Evaluative Group's platform enables nasal administration of compounds previously constrained by physical, chemical, or manufacturing challenges, opening new opportunities in vaccines, cold-chain dependent medications and medications unstable in solution. This could facilitate faster pandemic responses, self-use vaccination, and improved logistics for underserved regions globally. Under the terms of the LOI, the Preferred D stock issued as consideration will be subject to a two-year holding period and convertible only upon Bio-Legacy Evaluative Group achieving a $40 million post-acquisition valuation, as determined by an independent third-party firm. Branded Legacy has also committed to a $1 million research and development budget for Bio-Legacy Evaluative Group's initiatives, effective upon the company's uplisting to the OTCQB market tier and achieving a minimum share price of $0.01 per share. The parties intend to close the transaction within 14 days, subject to due diligence, definitive agreements, and necessary approvals. Upon completion, Bio-Legacy Evaluative Group will become a wholly-owned subsidiary of Branded Legacy, integrating its innovative pipeline—including manufacturing prototyping targeted for Q3 2025, clinical trials in 2026, and market readiness for the naloxone device by Q1 2027—to drive revenue growth. Projected revenues for Bio-Legacy Evaluative Group under average growth scenarios could reach up to $183.3 million by Year 5. Following the closing of the acquisition, Amin Janmohamed will assume the roles of CEO and Chairman of Branded Legacy, Inc., leveraging his experience as a pharmacist, clinical studies investigator, and executive to guide the combined entity's strategic direction. "We are thrilled to announce this LOI with Bio-Legacy Evaluative Group, a company at the forefront of tackling the escalating global addictions crisis through cutting-edge technology," said Robison, CEO of Branded Legacy, Inc. "This acquisition not only bolsters our health innovation capabilities but also positions us to capitalize on expanding markets like naloxone and intranasal vaccines, ultimately creating long-term value for our shareholders." Amin Janmohamed, CEO of Bio-Legacy Evaluative Group, added, "Partnering with Branded Legacy represents a significant milestone in our mission to make life-saving treatments more effective and accessible. Their resources and vision will accelerate our development timeline and help us reach patients worldwide who need these solutions most. I am excited to step into the role of CEO post-acquisition to lead this next phase of growth." The LOI includes standard provisions for exclusivity during negotiations and confidentiality. The transaction is expected to enhance Branded Legacy's competitive edge in the biotech and medical device sectors. For more information about Branded Legacy, Inc., visit www.brandedlegacy.com. About Branded Legacy, Inc. Branded Legacy, Inc. (OTC: BLEG) is a diversified holdings company dedicated to acquiring and growing innovative businesses in the health, wellness, and technology sectors. With a focus on strategic partnerships and shareholder value, Branded Legacy aims to deliver cutting-edge solutions that address real-world challenges. Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements are based on current expectations and beliefs and involve risks and uncertainties that could cause actual results to differ materially. Branded Legacy undertakes no obligation to update these statements except as required by law. Investor Relations: Branded Legacy, Inc. Email: info@brandedlegacy.com Phone: 877-814-4188

并购

2025-07-28

·PRNewswire

Standard drug screening fails to identify some children who have been exposed to substances in unsafe home environments

New findings at ADLM 2025 could remedy this CHICAGO, July 28, 2025 /PRNewswire/ -- According to research presented today at ADLM 2025 (formerly the AACC Annual Scientific Meeting & Clinical Lab Expo), standard drug screening misses low concentrations of targeted substances in around 5% of urine samples taken from patients under age 18, suggesting that children with drugs in their systems are sometimes released from healthcare settings into unsafe home environments. The study highlights an adjustment that clinical labs can make to improve the accuracy of results and to help ensure that substance-exposed children and their families get appropriate support. Researchers have long known that standard urine drug screening (UDS) — which is typically done using a technique known as immunoassay — can sometimes trigger false positives, or erroneous results that indicate the presence of a drug when there isn't one. It's the reason a second confirmatory test with mass spectrometry is typically used to verify results for patients who test positive on immunoassay. However, the opposite issue, where UDS indicates an absence of drugs in patients who have actually taken them (false negatives), has not been well studied. This mistake is more likely to occur in samples taken from infants and young children whose kidneys are still developing or who have incidental exposure to a low level of drugs, resulting in a low drug concentration in their urine that may not reach the cutoff used in standard UDS. One approach for minimizing this possibility is to use mass spectrometry on all pediatric patients, skipping the initial immunoassay. "To our knowledge, St. Louis Children's is the only hospital in the U.S. to adopt this 'direct-to-mass-spectrometry' approach," said Dr. Yanchun Lin, one of the study's authors and a clinical chemistry fellow at Washington University in Saint Louis, Missouri. "So we really want to urge laboratorians to reconsider the approach they adopt for pediatric UDS testing." The researchers used two strategies to compare immunoassay results with mass spectrometry for detecting substances in common drug tests, including amphetamine/methamphetamine, cocaine/benzoylecgonine (the main metabolite of cocaine), THC, opiates, fentanyl, benzodiazepines, and methadone. In the first approach, they studied 125 urine samples over a 5-month period from pediatric patients with weakly positive results on mass spectrometry to check how many of them were missed by immunoassay (forward approach). For the second strategy, they assessed 115 urine samples that tested negative on immunoassay to assess if mass spectrometry could detect any drugs (reverse approach). Among the 125 samples that tested positive on mass spectrometry, 112 (approximately 90%) contained compounds not detected by immunoassay, most commonly methamphetamine and benzoylecgonine. Thirty-eight (33%) of the 115 samples found negative on routine UDS tested positive for at least one substance when re-examined by mass spectrometry. Moreover, mass spectrometry identified substances in six samples (5%) that were targeted but missed by immunoassay. In addition, the researchers identified 32 pediatric urine samples that contained prescription medications not picked up by immunoassay, including lorazepam, ketamine, bupropion, methylphenidate, clonidine, quetiapine, venlafaxine, and naloxone. They also found five samples containing fentanyl, which wasn't on the UDS menu at some study centers from which samples were taken. Taken together, the results indicate that UDS may miss low drug concentrations in approximately 1 in 20 pediatric urine samples. This finding held true using both the forward and reverse schemes, spanning multiple clinical environments and analytic platforms. Using a direct-to-mass spectrometry approach would significantly lessen the risk of false-negative drug screens and largely eliminate false-positive findings as well, the authors conclude. That said, making this change isn't without challenges for labs. "It's actually pretty labor intense," Lin said, "and it's much harder to maintain the assay" using the direct-to-mass spectrometry approach. "You need highly trained personnel and dedicated full-time employees," she added. But labs that can make the shift will benefit from more accurate results that could translate to better care. "If it's possible, it should definitely be adopted, especially for pediatric patients," Lin said. Session information ADLM 2025 registration is free for members of the media. Reporters can register online here: Abstract A-349: False-negative immunoassay drug screens uncovered with a direct to mass spectrometry approach in a pediatric population will be presented during: Student poster competition Monday, July 28 9:30 a.m. – 4 p.m. Room S405 Scientific poster session Tuesday, July 29 9:30 a.m. – 5 p.m. (presenting authors in attendance from 1:30 – 2:30 p.m.) Poster Hall on the Expo show floor Both sessions will take place at McCormick Place, Chicago. About ADLM 2025 ADLM 2025 (formerly the AACC Annual Scientific Meeting & Clinical Lab Expo) offers 5 days packed with opportunities to learn about exciting science from July 27-31 in Chicago. Plenary sessions will explore urgent problems related to clinical artificial intelligence (AI) integration, fake medical news, and the pervasiveness of plastics, as well as tapping into the promise of genomics and microbiome medicine for personalized healthcare. At the ADLM 2025 Clinical Lab Expo, more than 800 exhibitors will fill the show floor of the McCormick Place Convention Center in Chicago, with displays of the latest diagnostic technology, including but not limited to AI, point-of-care, and automation. About the Association for Diagnostics & Laboratory Medicine (ADLM) Dedicated to achieving better health for all through laboratory medicine, ADLM (formerly AACC) unites more than 70,000 clinical laboratory professionals, physicians, research scientists, and business leaders from 110 countries around the world. Our community is at the forefront of laboratory medicine's diverse subdisciplines, including clinical chemistry, molecular diagnostics, mass spectrometry, clinical microbiology, and data science, and is comprised of individuals holding the spectrum of lab-related professional degrees, certifications, and credentials. Since 1948, ADLM has championed the advancement of laboratory medicine by fostering scientific collaboration, knowledge sharing, and the development of innovative solutions that enhance health outcomes. For more information, visit . Christine DeLong ADLM Director, Editorial and Media Relations (p) 202.835.8722 [email protected] Bill Malone ADLM Senior Director, Strategic Communications (p) 202.835.8756 [email protected] SOURCE Association for Diagnostics & Laboratory Medicine (ADLM) WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

临床结果临床研究

100 项与盐酸纳洛酮相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01340	盐酸纳洛酮	A06AH04 V03AB15	DB01183

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
急性淋巴细胞白血病	加拿大	Hikma Pharmaceuticals LLC	2025-02-01
阿片类药物过量	美国	Emergent Devices, Inc.	1971-04-13

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适应症	最高研发状态	国家/地区	公司	日期
阿片滥用	临床前	美国	Consegna Pharma, Inc.	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03751111 (CTgov)	临床1/2期	瘙痒 \| 肛门瘙痒	126	Naloxone (Naloxone)	襯鏇膚淵糧窪艱廠獵糧(壓網觸網壓夢鹹餘壓範) = 範襯鬱製鹹蓋壓蓋窪糧餘襯簾網願繭顧夢構築 (衊壓獵鬱鏇糧齋鬱窪憲, 2.15) 更多	-	2025-04-20
				Placebo (Placebo)	襯鏇膚淵糧窪艱廠獵糧(壓網觸網壓夢鹹餘壓範) = 醖鹹鏇淵築衊簾餘網鏇餘襯簾網願繭顧夢構築 (衊壓獵鬱鏇糧齋鬱窪憲, 1.99) 更多
NCT04473950 (CTgov)	临床1期	阿片相关性障碍 \| 慢性疼痛	10	Placebo+Naloxone Hydrochloride (Pain Group)	簾選艱鬱齋襯廠齋鏇齋(窪鏇夢構鹽蓋餘窪淵夢) = 簾網壓齋顧鹽鑰餘願餘憲積壓簾齋願餘壓衊夢 (糧獵鏇襯網夢廠遞廠糧, 1.17) 更多	-	2025-03-26
				Placebo+Naloxone Hydrochloride (No Pain Group)	簾選艱鬱齋襯廠齋鏇齋(窪鏇夢構鹽蓋餘窪淵夢) = 鑰鑰壓齋鏇構襯窪簾積憲積壓簾齋願餘壓衊夢 (糧獵鏇襯網夢廠遞廠糧, 0.92) 更多
NCT03176316 (FusionIleus, CTgov)	临床4期	肠阻塞	53	Naloxone	製淵窪蓋繭鹽範醖衊餘 = 製構鑰願鹽顧願鹹鹹觸壓夢鏇蓋膚鬱範衊窪築 (餘遞製艱選蓋壓獵蓋構, 網壓選獵選餘觸簾築憲 ~ 遞簾獵鏇積鬱餘淵膚鏇) 更多	-	2024-07-01
NCT03149770 (CTgov)	临床2期	1型糖尿病 \| 低血糖	30	Naloxone (Naloxone)	膚齋憲鏇鹹顧窪鹹窪積(遞醖夢積構顧鬱衊齋製) = 顧築網製餘蓋鹽繭築鹹網襯膚顧獵衊觸窪廠淵 (鹽壓鑰壓選醖夢製齋鹽, 12) 更多	-	2024-04-16
				placebo (Placebo)	膚齋憲鏇鹹顧窪鹹窪積(遞醖夢積構顧鬱衊齋製) = 顧鹹蓋廠鏇製窪鏇繭築網襯膚顧獵衊觸窪廠淵 (鹽壓鑰壓選醖夢製齋鹽, 13) 更多
NCT04764630 (Pubmed \| JAMA Netw Open)	临床1期	阿片类药物过量	21	1 dose at 0, 2.5, 5, and 7.5 minutes	壓衊觸網衊網顧構鏇構(鏇鑰繭蓋鹹壓衊顧網顧) = 壓構選繭糧醖積築夢衊鑰獵憲築鹹願獵繭積淵 (艱壓鹽鏇獵顧鹹獵齋觸 )	-	2024-01-23
				2 doses at 0 and 2.5 minutes	壓衊觸網衊網顧構鏇構(鏇鑰繭蓋鹹壓衊顧網顧) = 獵齋廠衊衊齋鏇鹽獵夢鑰獵憲築鹹願獵繭積淵 (艱壓鹽鏇獵顧鹹獵齋觸 )
NCT03570099 (Pubmed \| BMJ Open)	N/A	阿片类药物过量	-	Take-home naloxone distribution	築繭製膚觸糧糧獵積餘(鬱窪構鹽夢簾艱鹹遞願) = 憲網獵壓艱壓網繭餘遞製淵繭衊醖顧簾願襯襯 (鏇顧膚鬱艱願衊餘遞顧 )	-	2024-01-01
				intranasal naloxone (Control period (2013-2017))	築繭製膚觸糧糧獵積餘(鬱窪構鹽夢簾艱鹹遞願) = 簾願製鬱願積廠顧選膚製淵繭衊醖顧簾願襯襯 (鏇顧膚鬱艱願衊餘遞顧 )
NCT02700048 (CTgov)	临床1/2期	1型糖尿病 \| 低血糖 \| 意识丧失	11	Intra-nasal saline (Placebo)	餘衊製窪繭膚醖蓋鑰鏇(遞醖鏇窪窪醖醖簾遞艱) = 窪襯選選築蓋鹹鹽鏇廠範簾鑰蓋選鏇鬱蓋襯齋 (繭鏇製構遞齋積鏇衊窪, 壓淵鬱範糧窪築顧網鏇 ~ 獵觸廠繭鹹憲鏇範壓構) 更多	-	2023-03-27
				intra-nasal naloxone (Treatment With Intra-nasal Naloxone)	餘衊製窪繭膚醖蓋鑰鏇(遞醖鏇窪窪醖醖簾遞艱) = 艱襯鹹繭遞鹹簾鬱蓋選範簾鑰蓋選鏇鬱蓋襯齋 (繭鏇製構遞齋積鏇衊窪, 窪繭繭壓願獵範夢夢鏇 ~ 糧鏇廠製積鬱襯製製觸) 更多
NCT04713709 (Corporate Publications) 人工标引	临床1期	阿片类药物过量	56	FMXIN001	網獵艱鑰積鏇簾製範顧(艱憲範顧鏇鏇選壓醖鹽) = 鹽製艱淵餘窪簾繭鹹觸顧壓齋艱壓遞壓鏇製繭 (餘選衊鏇衊網觸構築憲 ) 更多	相似	2022-07-28
				NARCAN	網獵艱鑰積鏇簾製範顧(艱憲範顧鏇鏇選壓醖鹽) = 憲夢顧膚鹽糧蓋襯製襯顧壓齋艱壓遞壓鏇製繭 (餘選衊鏇衊網觸構築憲 ) 更多
NCT04764630 (CTgov)	临床1期	-	21	naloxone (A. Four Naloxone Nasal Spray Doses (1 Every 2.5 Min))	鬱製壓願壓積築蓋膚鑰(壓獵遞鏇範選網淵構選) = 選簾觸願窪簾願鑰壓廠廠餘鏇觸醖遞醖鹽壓醖 (繭夢齋鬱遞積鏇積遞廠, 70) 更多	-	2022-07-15
				naloxone (C. Two Naloxone Nasal Spray Doses (1 Every 2.5 Min))	鬱製壓願壓積築蓋膚鑰(壓獵遞鏇範選網淵構選) = 壓艱顧顧艱齋餘鬱憲鹽廠餘鏇觸醖遞醖鹽壓醖 (繭夢齋鬱遞積鏇積遞廠, 159) 更多
NCT02805972 (BEE, CTgov)	临床2期	肥胖	41	Placebo+Naloxone (Placebo, Then Naloxone)	壓鑰鑰願製鏇夢製淵衊(齋齋獵築膚築獵選憲糧) = 製獵網膚鏇遞觸願廠鑰淵繭淵夢鏇廠築鹹獵廠 (觸願夢鏇蓋製餘廠醖壓, 構鏇醖鏇製窪遞築壓艱 ~ 憲鬱廠製獵築餘襯獵鏇) 更多	-	2021-11-03
				Placebo+Naloxone (Naloxone, Then Placebo)	壓鑰鑰願製鏇夢製淵衊(齋齋獵築膚築獵選憲糧) = 糧淵網壓遞願餘鏇艱鏇淵繭淵夢鏇廠築鹹獵廠 (觸願夢鏇蓋製餘廠醖壓, 遞齋衊積鹹艱膚襯鏇鏇 ~ 構襯築鏇夢衊築鏇窪願) 更多