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更新于：2025-12-17
Rizatriptan Benzoate
苯甲酸利扎曲普坦
更新于：2025-12-17
概要
基本信息
非在研机构 |
最高研发阶段批准上市 |
首次获批日期 墨西哥 (1998-01-21), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C22H25N5O2 |
InChIKeyJPRXYLQNJJVCMZ-UHFFFAOYSA-N |
CAS号145202-66-0 |
关联
38
项与 苯甲酸利扎曲普坦 相关的临床试验ChiCTR2500112412
A Chinese real-world study of Rizatriptan Benzoate Capsules for the acute treatment of migraine
开始日期2025-11-10 |
申办/合作机构- |
NCT06473597
A Comparison of Rimegepant Orally Disintegrating Tablet (Nurtec ODT) to Rizatriptan Benzoate Orally Disintegrating Tablet (Maxalt MLT-ODT) in Adult Patients Presenting to the ED With Migraine Headache: Randomized, Double-Blind, Clinical Trial
Rimegepant (Nurtec) is an orally administered small molecule CGRP receptor antagonist with efficacy in the acute treatment of migraine. Rizatriptan benzoate (MAXALT), is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist. Rizatriptan binds with high affinity to human cloned 5-HT1B and 5-HT1D receptors which leads to activation of these receptors results in cranial vessel constriction, inhibition of neuropeptide release and reduced transmission in trigeminal pain pathways with resultant relieve of the headache.
Teh investigators hypothesize that the administration of Rimegepant ODT would provide better analgesic efficacy than Rizatriptan ODT with respect to analgesic efficacy at 60 min and 120 minutes in ED patients with acute headache.
This is a prospective, randomized, double-blind superiority trial evaluating and comparing analgesic efficacy and safety of Rimegepant ODT 75 mg to Rizatriptan ODT 10 mg in adult patients presenting to the Emergency Department of Maimonides Medical Center with acute migraine headache.
Teh investigators hypothesize that the administration of Rimegepant ODT would provide better analgesic efficacy than Rizatriptan ODT with respect to analgesic efficacy at 60 min and 120 minutes in ED patients with acute headache.
This is a prospective, randomized, double-blind superiority trial evaluating and comparing analgesic efficacy and safety of Rimegepant ODT 75 mg to Rizatriptan ODT 10 mg in adult patients presenting to the Emergency Department of Maimonides Medical Center with acute migraine headache.
开始日期2024-09-01 |
申办/合作机构 |
IRCT20230913059428N1
A clinical trial of sublingual Rizatriptan versus oral Betahistin in acute phase treatment of vertigo in patients suffering from vestibular migraine
开始日期2023-10-23 |
100 项与 苯甲酸利扎曲普坦 相关的临床结果
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100 项与 苯甲酸利扎曲普坦 相关的转化医学
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100 项与 苯甲酸利扎曲普坦 相关的专利（医药）
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1,448
项与 苯甲酸利扎曲普坦 相关的文献（医药）2025-12-31·JOURNAL OF MEDICAL ECONOMICS
Lost earnings among triptan non-responders in the general population of Denmark: a measure of disproportionate migraine-attributed burden and of unrecognised and unmet treatment need
Article
作者: Spanggaard, Maria ; Ashina, Messoud ; Hansen, Jakob Møller ; Steiner, Timothy J. ; Hauberg, Daniel Sloth ; Stallknecht, Sandra Benkjer ; Lønberg, Ulla Sofie ; Hansen, Thomas Folkmann ; Olsen, Jens
AIMS:
Migraine leads to substantial healthcare utilization and associated costs. However, much higher costs are attributed to lost productivity. The impact of effective migraine treatment on these costs, at the individual level, has not been well established. Even less known is the impact of treatment failure. The objective of this study was to assess lost earnings as a measure of migraine-attributed burden among triptan non-responders in Denmark.
MATERIALS AND METHODS:
We used data from the Danish National Prescription Register and Danish Income Statistics Register over the 27-year period 1995-2021. We identified 4,979 triptan non-responders (85.9% female) and matched them for sex, age and region of residence with 14,292 continuing users of triptans (triptan responders) and 13,592 individuals from the background population (triptan never-users). We then estimated average annual individual earnings, and compared those among triptan non-responders, from 3 years prior to and 10 years after their last triptan redemption, with those among their matched triptan responders and triptan never-users over the same periods.
RESULTS:
Triptan non-responders earned significantly less than both their matched triptan responders and their matched triptan never-users. The earnings gap was evident even 3 years prior to the last triptan prescription (€4,344 and €4,356 respectively). This gap widened substantially over time, so that average cumulative earnings over the 14-year period of follow-up for each triptan non-responder were €93,684 less than those of responders and €99,485 less than those of never-users.
LIMITATIONS:
There are uncertainties with regard to the reasons for triptan discontinuation (whether non-response or otherwise), and to lack of diagnostic confirmation of migraine.
CONCLUSIONS:
Triptan non-response represents failure of currently available acute treatment options. It is associated with substantial and cumulative lost earnings, highlighting a disproportionate economic burden. These findings underscore the potential economic benefit of recognizing, and rectifying, unmet treatment needs in migraine management.
2025-12-31·NMC case report journal
Pediatric Triptan-induced Reversible Cerebral Vasoconstriction Syndrome with Both Hemorrhagic and Ischemic Stroke: Case Report and Literature Review
Article
作者: KAWASAKI, Takashi ; ONODERA, Hidetaka ; HORI, Satoshi ; OKAZAKI, Yotaro ; TAKAGI, Ryosuke ; YAMAMOTO, Tetsuya ; SAKATA, Katsumi ; OHTAKE, Makoto ; NAKAMURA, Taishi
Reversible cerebral vasoconstriction syndrome is characterized by severe headaches and diffuse, segmental constriction of cerebral arteries. We report a rare pediatric case of triptan-induced reversible cerebral vasoconstriction syndrome, complicated by both subarachnoid hemorrhage and cerebral infarction. A 10-year-old boy presented with persistent severe headaches initially suspected to be migraines, for which he was prescribed rizatriptan. Five days after starting rizatriptan, he developed impaired consciousness (Japan Coma Scale 10) and partial right-sided hemiparesis, prompting emergency hospitalization. A head computed tomography scan revealed subarachnoid hemorrhage in the left frontal cortical region. Cerebral angiography showed stenotic changes in the internal carotid artery, middle cerebral artery, anterior cerebral artery, and posterior cerebral artery. Suspecting triptan-induced reversible cerebral vasoconstriction syndrome, rizatriptan was discontinued, and verapamil treatment was initiated. Subsequent magnetic resonance imaging and magnetic resonance angiography revealed cerebral infarction in the right cerebellum, left middle cerebral artery territory, and right occipital lobe, with persistent stenotic changes from earlier findings. Edaravone was added to the treatment regimen. The patient's condition gradually improved, and follow-up magnetic resonance angiography showed almost complete resolution of the prior stenotic changes. His partial right-sided hemiparesis nearly resolved, and he was discharged home. Triptans should be used with caution, as they may precipitate reversible cerebral vasoconstriction syndrome or exacerbate cerebral vasoconstriction. Careful monitoring and vascular imaging are essential for patients presenting with symptoms following triptan administration.
2025-12-01·REVUE NEUROLOGIQUE
First-bite syndrome following triptan intake: A report of three cases
Letter
作者: Fayolle, V ; Moreau, N ; Demarquay, G ; Redon, S
93
项与 苯甲酸利扎曲普坦 相关的新闻（医药）2025-12-11
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截至12月11日15点59分，近期共有 465 本期刊发布了 966 篇文章，其中糖尿病相关的文章共 356 篇，覆盖 31 个领域的内容。中国专家参与发表的文章有 94 篇。今日，影响因子最高的文章刊登在 The New England Journal of Medicine (IF: 78.500) 期刊上。
今日头条
Headlines
01 Diabetes care IF: 16.600 用水替代人工甜味饮料对2型糖尿病患者血糖和体重指标的影响：一项随机人工甜味饮料研究（SODAS）
Odegaard, Andrew O, Chang, Jenny, Jiang, Luohua, Rashid, Syma, Rydell, Sarah, Mitchell, N Reed, etc.
一项新发布的随机临床试验结果显示，对于糖化血红蛋白控制在一定范围内的2型糖尿病患者，将日常饮用的人工甜味饮料替换为纯净水，在为期24周的观察中，并未带来预期的血糖改善。这项名为“人工甜味饮料研究”（Study of Drinks with Artificial Sweeteners, SODAS）的研究，为临床医生和患者提供了关于饮品选择的直接证据。
该研究旨在回答一个常见的临床与生活建议：对于需要控制血糖的糖尿病患者，用水替代人工甜味饮料是否更好？研究团队设计了一项随机对照试验，将181名年龄在35岁及以上、糖化血红蛋白（HbA1c）介于6.5%至8.5%之间、并且有规律饮用市售人工甜味饮料习惯的2型糖尿病患者纳入研究。参与者被随机分为两组。
在长达24周的干预期内，一组参与者作为对照组，继续每日饮用24盎司（约710 ml）其自选的人工甜味饮料。另一组作为干预组，则被要求每日饮用等量的、其自选的无味瓶装或罐装水（可选择气泡水或静水），以完全替代往常饮用的人工甜味饮料。研究在两家学术健康中心开展，并在基线、第12周和第24周对参与者的各项指标进行了评估。
研究的主要观察终点是反映长期血糖控制水平的HbA1c变化。结果显示，在179名完成24周研究的参与者中，与持续饮用人工甜味饮料的组别相比，改用饮用水的组别，其HbA1c水平的下降幅度更小。具体而言，从基线到第24周，水组的HbA1c变化值平均比人工甜味饮料组高出0.29%，这一差异具有统计学意义。
除了主要指标，研究还分析了包括果糖胺、空腹血糖、空腹胰岛素、体重以及连续血糖监测数据在内的多项次要指标。数据分析表明，在这些次要临床指标上，用水替代人工甜味饮料也未显示出显著的改善效果。所有次要指标的变化趋势均与主要结果的方向一致。
基于上述发现，研究团队得出结论：对于HbA1c低于8.5%且习惯饮用人工甜味饮料的2型糖尿病患者，在24周的时间内，用水完全替代人工甜味饮料的这一行为，并未提供能够改善其血糖相关临床管理指标的证据。
本文由 韩玉莲 编辑
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Diabetes care | Ahead of Print.
10.2337/dc25-1516
02 Diabetes, obesity & metabolism IF: 05.700 2型糖尿病患者有意减重的临床意义：一项真实世界数据库研究
Jain, Akshay, Kristensen, Peter Nørgaard, Wasehuus, Rie Strøbeck, Kruse, Christian, Nørtoft, Emil, etc.
一项最新的大型真实世界研究为肥胖合并2型糖尿病的治疗策略提供了有力的数据支持。该研究证实，通过有意的体重减轻，降低体重指数（BMI），能够显著减少患者未来发生糖尿病相关并发症的风险，并且这一益处与血糖控制的改善相辅相成。
这项研究的数据来源于英国具有代表性的临床实践研究数据链（CPRD Aurum）数据库，时间跨度为2006年至2022年。研究者们从中筛选出超过10万名BMI达到或超过30 kg/m²的肥胖2型糖尿病成年患者，对其医疗记录进行了深入分析。研究重点关注了患者在经历为期四年的有意减重期后微血管和大血管并发症的发生情况。
在研究期间，这10万名平均年龄为53.3岁的患者中，男性占58%。分析显示，他们的BMI平均实现了2.2%的相对降低，而反映长期血糖水平的糖化血红蛋白（HbA1c）平均变化为0.0%。研究者运用严谨的统计模型，量化了体重和血糖变化与并发症风险之间的关系。
结果明确显示，减重带来的BMI下降与血糖指标的改善，均能独立且显著地降低并发症风险。具体而言，BMI每降低1%，患者发生微血管并发症（如视网膜病变、神经病变、慢性肾病）的复合风险就降低1.0%，发生大血管并发症（如心肌梗死、卒中、外周动脉疾病）的复合风险则降低0.4%。更为显著的是，HbA1c每降低1个百分点，上述两类并发症的复合风险均能大幅降低约13%。
研究进一步对不同种类的并发症进行了细分分析。研究发现，BMI和HbA1c的降低，均与视网膜病变、神经病变、慢性肾病以及外周动脉疾病的风险下降显著相关。而对于心肌梗死和卒中这两种严重的心脑血管事件，其风险的降低主要与HbA1c水平的下降有关。
这项研究的结论在所有的患者亚组分析中都保持了一致性，增强了结果的可靠度。它清晰地表明，对于肥胖的2型糖尿病患者而言，积极进行体重管理，有意减轻体重导致BMI和HbA1c的降低，能直接带来降低微血管和大血管并发症风险的临床获益。
本文由 韩玉莲 编辑
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Diabetes, obesity & metabolism | Ahead of Print.
10.1111/dom.70350
03 Health psychology review IF: 09.700 短信传递的健康行为干预对2型糖尿病成人患者HbA1c变化的有效性：一项随机对照试验的系统综述与荟萃分析
Hong, Qiumian, Zhang, Xiaoying, Guo, Mengxi, Wen, Zhaoyang, Tang, Qing, Zhou, Jiali, etc.
一项最新发表的系统综述与荟萃分析研究为2型糖尿病的数字化管理提供了有力的新证据。该研究证实，通过手机短信传递的健康行为干预，能够有效帮助成人2型糖尿病患者降低长期血糖控制的关键指标——糖化血红蛋白（HbA1c）水平。
这项研究由来自多所研究机构的研究人员共同完成，系统回顾并分析了2016年至2025年间发表的37项随机对照试验，共涉及8,971名2型糖尿病患者。分析结果显示，与常规护理或对照组相比，接受短信干预的患者其HbA1c水平出现了具有统计学意义的显著下降（g=-0.32）。
进一步分析发现，干预措施显著改善了健康行为，而这些改善反过来预测了HbA1c水平的显著下降。后续亚组分析显示，持续时间较短（≤6个月）的研究往往能带来更大的血糖改善效果。
更值得关注的是，研究团队识别出了与更佳降糖效果密切相关的几种核心行为改变技术。当短信干预内容中包含了“身体变化”（如提示关注血糖或体重变化）、“习惯形成”、“可靠来源”、“行为结果自我监测”以及“具体的行为执行指导”这五项技术时，患者的HbA1c降低幅度更为明显。这些效果在侧重于体力活动、健康饮食和药物依从性的试验中尤为显著。
综合这些发现，研究者得出结论：基于短信传递的健康行为干预应针对特定目标行为，并纳入这些高影响力的行为改变技术，以全面优化糖尿病管理。
本文由 韩玉莲 编辑
扫描二维码查看源文
Health psychology review | Ahead of Print.
10.1080/17437199.2025.2595126
中国发表（94）
China
Eur J Med Res IF: 03.400Ahead of Print.No.01A study of post-urination external genital cleansing behavior and its impact on improving dapagliflozin adherence in Chinese male heart failure patients一项关于中国男性心力衰竭患者便后外生殖器清洁行为及其对提高达格列净用药依从性影响的研究DOI: 10.1186/s40001-025-03495-2
Eur J Med Res IF: 03.400Ahead of Print.No.02Unveiling the prognostic power of FIB-4 index: a new frontier in heart failure mortality揭示FIB-4指数的预后能力：心力衰竭死亡率预测的新前沿DOI: 10.1186/s40001-025-03616-x
Eur J Med Res IF: 03.400Ahead of Print.No.03A novel scoring system as a predictor for delayed pain disappearance after percutaneous balloon compression for trigeminal neuralgia一种预测三叉神经痛经皮球囊压迫术后延迟性疼痛消失的新型评分系统DOI: 10.1186/s40001-025-03472-9
Communications medicine IF: 06.300Ahead of Print.No.04Productivity-adjusted life year loss among the late middle-aged adults in China中国中老年人群的生产力调整生命年损失DOI: 10.1038/s43856-025-01294-8
Journal of controlled release IF: 11.500Ahead of Print.No.05Redox-responsive chitosan hydrogel releases mitochondria-targeted fullerenol to reprogram M1/M2 macrophage balance for diabetic wound healing氧化还原响应型壳聚糖水凝胶释放靶向线粒体的富勒烯醇以重编程M1/M2巨噬细胞平衡促进糖尿病伤口愈合DOI: 10.1016/j.jconrel.2025.114506
J Am Acad Dermatol IF: 11.800Ahead of Print.No.06Methodological Considerations of GPT-4 Vision in Dermoscopic Image Analysis. Comment on "Comparative Assessment of GPT-4 Vision in Dermoscopic Image Analysis"GPT-4 Vision在皮肤镜图像分析中的方法学考量：评《Comparative Assessment of GPT-4 Vision in Dermoscopic Image Analysis》DOI: 10.1016/j.jaad.2025.09.117
Journal of Advanced Research IF: 13.000Ahead of Print.No.07Discovery of FBP1 as novel therapeutic target and asiatic acid-hydrogen sulfide donors accelerate diabetic wound healingFBP1作为新治疗靶点的发现及积雪草酸-硫化硫供体促进糖尿病伤口愈合DOI: 10.1016/j.jare.2025.12.003
Redox biology IF: 11.900Ahead of Print.No.08The G9a-TRIM21 axis exacerbates diabetic renal ischemia-reperfusion injury by inducing methylation-dependent ubiquitination and degradation of FoxO3a to promote oxidative stress and pyroptosisG9a-TRIM21轴通过诱导甲基化依赖性泛素化和降解FoxO3a促进氧化应激与细胞焦亡，从而加剧糖尿病肾缺血再灌注损伤DOI: 10.1016/j.redox.2025.103964
Mol Genet Metab IF: 03.500Ahead of Print.No.09Underrecognized need for early detection of inborn errors of metabolism in China: A population-based study of 14.31 million residents (2012-2023)中国先天性代谢缺陷早期识别未被充分认知的需求：一项基于1431万居民（2012-2023年）的人口研究DOI: 10.1016/j.ymgme.2025.109702
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.10Cascade catalytic nanoreactor based on electronic regulatory engineering and biomimetic mineralization strategy for effectively combat bacterial infection in diabetic wounds基于电子调控工程与仿生矿化策略的级联催化纳米反应器有效对抗糖尿病伤口细菌感染DOI: 10.1016/j.colsurfb.2025.115345
Colloids Surf B Biointerfaces IF: 05.600Ahead of Print.No.11Preparation of thymol-loaded Pickering emulsion gel film and its application in wound healing百里酚负载Pickering乳液凝胶膜的制备及其在伤口愈合中的应用DOI: 10.1016/j.colsurfb.2025.115342
Communications biology IF: 05.100Ahead of Print.No.12Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis琥珀酸驱动的PKM2琥珀酰化与二聚化加速年龄相关性心脏纤维化DOI: 10.1038/s42003-025-09337-5
J Assist Reprod Genet IF: 02.700Ahead of Print.No.13SETD7 regulates decidual senescence through FOXO1-dependent mechanisms in human endometrial stromal cellsSETD7通过FOXO1依赖性机制调节人子宫内膜基质细胞蜕膜衰老DOI: 10.1007/s10815-025-03771-4
Eur J Med Res IF: 03.400Ahead of Print.No.14Screening and predictive analysis of common regulatory genes in diabetes and rectal cancer: transcriptional and drug modulation mechanisms糖尿病与直肠癌共同调控基因的筛选与预测分析：转录及药物调控机制DOI: 10.1186/s40001-025-03640-x
Population health management IF: 02.100Ahead of Print.No.15Identification and Validation of a Machine Learning Predictive Model for Type 2 Diabetes Mellitus Based on Inflammation-Related Indicators基于炎症相关指标的2型糖尿病机器学习预测模型的识别与验证DOI: 10.1177/19427891251401221
Journal of diabetes IF: 03.700Volume 17, Issue 12No.16Association Between Arterial Stiffness and Bone Microarchitectural Deterioration in Type 2 Diabetes: A Cross-Sectional Study2型糖尿病中动脉僵硬与骨微结构恶化的相关性：一项横断面研究DOI: 10.1111/1753-0407.70181
Renal failure IF: 03.000Volume 47, Issue 1No.17Impact of diabetes on survival and clinical outcomes in elderly patients receiving peritoneal dialysis糖尿病对老年腹膜透析患者生存及临床结局的影响DOI: 10.1080/0886022X.2025.2589586
Int J Biol Macromol IF: 08.500Volume 335, Issue Pt 2No.18Effects of extraction technique on structural characterization, antioxidant and hypoglycemic activities of polysaccharides from Aralia elata (Miq.) seem shoots提取技术对龙牙楤木嫩芽多糖的结构表征、抗氧化及降血糖活性的影响DOI: 10.1016/j.ijbiomac.2025.149405
Scientific reports IF: 03.900Volume 15, Issue 1No.19Quantitative LFQ-DIA proteomics reveals FTH1-MCM5/WNT axis mediated osteoblastic dysfunction via ferroptosis drives diabetic osteoporosis定量LFQ-DIA蛋白质组学揭示FTH1-MCM5/WNT轴通过铁死亡介导成骨细胞功能障碍驱动糖尿病骨质疏松症DOI: 10.1038/s41598-025-27559-9
BMC Complement Med Ther IF: 03.400Ahead of Print.No.20Quantitative assessment of the effects of sumac (Rhus Coriaria) supplementation on cardiovascular disease risk factors: evidence from a meta-analysis of randomized controlled trials定量评估苏木（Rhus Coriaria）补充剂对心血管疾病风险因素的影响：基于随机对照试验荟萃分析的证据DOI: 10.1186/s12906-025-05213-1
BMC psychology IF: 03.000Ahead of Print.No.21The interactive roles between coping tendency and focus on COVID-19 information time in Adolescent Obesity应对倾向与关注COVID-19信息时间在青少年肥胖中的交互作用DOI: 10.1186/s40359-025-03766-x
Systematic reviews IF: 03.900Ahead of Print.No.22Effects of glucagon-like peptide-1 receptor agonists on patients with metabolic dysfunction-associated steatohepatitis: protocol for a systematic review and sequential meta-analysis胰高血糖素样肽-1受体激动剂对代谢相关脂肪性肝炎患者的影响：一项系统评价及序贯Meta分析方案DOI: 10.1186/s13643-025-03011-x
Chinese medicine IF: 05.700Volume 20, Issue 1No.23Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition靶向脂肪小分子通过SIRT3驱动的线粒体自噬和炎症小体抑制缓解肥胖中的异常脂肪组织重塑DOI: 10.1186/s13020-025-01253-4
BMC public health IF: 03.600Ahead of Print.No.24Association between BMI trajectories and metabolic syndrome in postmenopausal women: a cross-sectional study from NHANES 1999-2018绝经后女性BMI轨迹与代谢综合征的关联：基于NHANES 1999-2018的横断面研究DOI: 10.1186/s12889-025-25480-4
BMC nephrology IF: 02.400Ahead of Print.No.25Abdominal obesity-dependent association between composite upper- and lower-body muscle strength index and incident chronic kidney disease: a nationwide multicenter study腹型肥胖依赖性关联：复合上下肢肌肉力量指数与新发慢性肾脏病的全国多中心研究DOI: 10.1186/s12882-025-04683-2
Obesity IF: 04.700Ahead of Print.No.26Artificial Intelligence Across the Obesity Continuum: From Mechanistic Insights to Global Precision Prevention and Therapy人工智能贯穿肥胖全周期：从机制解析到全球精准预防与治疗DOI: 10.1002/oby.70095
Science translational medicine IF: 14.600Volume 17, Issue 828No.27A bioinspired mineralized collagen scaffold promotes enthesis healing and activates Gli1 expression in preclinical models仿生矿化胶原支架促进止点愈合并激活Gli1表达的临床前模型研究DOI: 10.1126/scitranslmed.ado6948
PloS one IF: 02.600Volume 20, Issue 12No.28Multi-dimensional analysis of the global burden of colorectal cancer disease from 1990 to 2021 and prediction of future trends: A comprehensive study based on the GBD database1990年至2021年结直肠癌全球疾病负担的多维度分析与未来趋势预测：一项基于GBD数据库的综合研究DOI: 10.1371/journal.pone.0337216
PloS one IF: 02.600Volume 20, Issue 12No.29GV effects of diabetes mellitus on clinical outcomes of patients with acute heart failure: A systematic review and meta-analysis糖尿病对急性心力衰竭患者临床结局的影响：一项系统综述与荟萃分析DOI: 10.1371/journal.pone.0338653
JCH IF: 02.500Volume 27thejournalofclinicalhypertension, Issue 12, Page e70189-e70191No.30The Prognostic Value of Insulin Resistance Indices for Major Adverse Cardiovascular Events in Young and Middle-Aged Patients With Hypertension胰岛素抵抗指数对年轻及中年高血压患者主要不良心血管事件的预后价值DOI: 10.1111/jch.70192
Immunological investigations IF: 02.400Ahead of Print.No.31DOCK2 in Disease: Emerging Insights and Research AdvancesDOCK2在疾病中的作用：新见解与研究进展DOI: 10.1080/08820139.2025.2596074
Immunological investigations IF: 02.400Ahead of Print.No.32The Therapeutic Targeting Effect of Toll-Like Receptors and Their Related Signaling Pathways in Cardiomyopathy心肌病中Toll样受体及其相关信号通路的治疗靶向作用DOI: 10.1080/08820139.2025.2583276
Hepatology international IF: 06.100Ahead of Print.No.33Revisiting diabetes and mortality in ALD-ACLF: methodological and clinical considerations再议ALD-ACLF中糖尿病与死亡率：方法学与临床考量DOI: 10.1007/s12072-025-10987-0
Int J Clin Pharm IF: 03.200Ahead of Print.No.34Long-term safety, effectiveness, and cost of rapamycin- vs. everolimus-eluting stents in acute coronary syndrome: a real-world cohort study急性冠状动脉综合征中雷帕霉素与依维莫司洗脱支架的长期安全性、有效性和成本：一项真实世界队列研究DOI: 10.1007/s11096-025-02066-z
Food & function IF: 05.400Ahead of Print.No.35Camel milk exosomes alleviate hyperglycemia by regulating the hepatic mitochondrial complex I activity, hepatic metabolome, and gut microbiota in high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic mice骆驼奶外泌体通过调节肝脏线粒体复合物I活性、肝脏代谢组和肠道菌群缓解高脂饮食与链脲佐菌素诱导的糖尿病小鼠高血糖DOI: 10.1039/d5fo02492g
Crit Rev Food Sci Nutr IF: 08.800Ahead of Print.No.36Food structure-mediated stomach-brain neural signaling controls gastric emptying食物结构介导的胃-脑神经信号调控胃排空DOI: 10.1080/10408398.2025.2598814
Renal failure IF: 03.000Volume 47, Issue 1No.37From glycemic variability to digital signal biomarker: a prognostic and precision medicine framework for sepsis-associated acute kidney injury从血糖变异性到数字信号生物标志物：一个脓毒症相关急性肾损伤的预后与精准医学框架DOI: 10.1080/0886022X.2025.2591465
Analytical chemistry IF: 06.700Ahead of Print.No.38Precision Strike at Lipid Droplets by Spherical Nano-Browning Agents Promotes Obesity Remission球形纳米褐变剂精准靶向脂滴促进肥胖缓解DOI: 10.1021/acs.analchem.5c04828
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.39Explainable machine learning-driven predictive modelling of incident cognitive impairment in individuals with early-stage cardiovascular-kidney-metabolic syndrome: Insights from a longitudinal CHARLS cohort study可解释机器学习驱动的早期心血管-肾脏-代谢综合征患者新发认知障碍预测模型：基于CHARLS纵向队列研究的启示DOI: 10.1111/dom.70346
Health psychology review IF: 09.700Ahead of Print.No.40Effectiveness of text message-delivered health behaviour intervention on HbA1c change in adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised controlled trials短信传递的健康行为干预对2型糖尿病成人患者HbA1c变化的有效性：一项随机对照试验的系统综述与荟萃分析DOI: 10.1080/17437199.2025.2595126
Biomed Environ Sci IF: 04.100Volume 38, Issue 11No.41Overweight Modified the Associations between Long-Term Exposure to Ambient Fine Particulate Matter and Its Constituent and the Risk of Type 2 Diabetes in Rural China超重修饰了农村地区长期暴露于环境细颗粒物及其组分与2型糖尿病风险的关联DOI: 10.3967/bes2025.136
Ann Clin Transl Neurol IF: 03.900Ahead of Print.No.42The McCance Brain Care Score and Mortality: Evidence From a Large-Scale Population-Based CohortMcCance脑护理评分与死亡率：来自大规模基于人群队列的证据DOI: 10.1002/acn3.70256
World journal of hepatology IF: 02.500Volume 17, Issue 11No.43Non-invasive blood biomarkers for assessment of liver fibrosis in metabolic dysfunction-associated steatotic liver disease代谢功能障碍相关脂肪性肝病中评估肝纤维化的非侵入性血液生物标志物DOI: 10.4254/wjh.v17.i11.110080
Medicine IF: 01.400Volume 104, Issue 49No.44Adverse effects of iodixanol: A retrospective safety study utilizing FAERS database signal analysis碘克沙醇的不良反应：基于FAERS数据库信号分析的回顾性安全性研究DOI: 10.1097/MD.0000000000044714
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.45Association between angiopoietin-1 and metabolic dysfunction-associated steatotic liver disease: a cross‑sectional study血管生成素-1与代谢相关脂肪性肝病的关联：一项横断面研究DOI: 10.1186/s13098-025-02046-3
Food science & nutrition IF: 03.800Volume 13, Issue 12No.46Comparative Study of Hypoglycemic Effects and Mechanisms of Crude and Wine-Processed Polysaccharides From Polygonatum sibiricum黄精生品与酒制品多糖降糖作用及机制的比较研究DOI: 10.1002/fsn3.71216
Hepatic medicine IF: 01.800Volume 17, Issue No.47Mapping the Intellectual Landscape: A 20-Year Bibliometric Analysis of Mechanisms in Metabolic Dysfunction-Associated Steatotic Liver Disease描绘知识版图：代谢功能障碍相关脂肪性肝病机制的20年文献计量分析DOI: 10.2147/HMER.S562237
Medicine IF: 01.400Volume 104, Issue 49No.48Sex differences in the association between fatty liver index and biological aging: A mediation analysis of insulin resistance in a cross-sectional study脂肪肝指数与生物衰老关联中的性别差异：一项关于胰岛素抵抗中介作用的横断面研究DOI: 10.1097/MD.0000000000046152
Comprehensive physiology IF: 05.200Volume 15, Issue 6No.49Insulin as an Accelerator and Brake of Aging: From Molecular Landscape to Clinical Interventions胰岛素作为衰老的加速器与制动器：从分子图谱到临床干预DOI: 10.1002/cph4.70079
Medicine IF: 01.400Volume 104, Issue 49No.50Heavy metals and mortality in cardiovascular-kidney-metabolic syndrome: Insights from the NHANES cohort重金属与心血管-肾脏-代谢综合征死亡率：基于NHANES队列的见解DOI: 10.1097/MD.0000000000046298
Medicine IF: 01.400Volume 104, Issue 49No.51Pre-PCI SGLT2 inhibitors and contrast-induced nephropathy in acute myocardial infarction: A meta-analysis急性心肌梗死患者术前应用SGLT2抑制剂与对比剂肾病：一项荟萃分析DOI: 10.1097/MD.0000000000044215
Medicine IF: 01.400Volume 104, Issue 49No.52Atrial overdrive pacing in drug-refractory postinfarction electrical storm case report心房超速起搏治疗药物难治性心肌梗死后电风暴病例报告DOI: 10.1097/MD.0000000000046384
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.53Plasma corin levels provide minimal prognostic utility in left atrial reverse remodeling after catheter ablation of atrial fibrillation: an observational study血浆Corin水平对心房颤动导管消融术后左心房逆向重构的预后价值有限：一项观察性研究DOI: 10.3389/fendo.2025.1717422
BMC nephrology IF: 02.400Ahead of Print.No.54Effect of statin therapy on renal and lipid outcomes in CKM syndrome stage 2: a meta-analysis of randomized controlled trials他汀类药物治疗对心血管-肾脏-代谢综合征2期患者肾脏及血脂结局的影响：一项随机对照试验的荟萃分析DOI: 10.1186/s12882-025-04645-8
Future science OA IF: 02.100Volume 11, Issue 1No.55Obesity-induced gut microbiota transplantation promotes the occurrence and development of hepatocellular carcinoma肥胖诱导的肠道菌群移植促进肝细胞癌的发生与发展DOI: 10.1080/20565623.2025.2599729
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.56The therapeutic effect of curcumin in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of animal studies姜黄素治疗代谢功能障碍相关脂肪性肝病的疗效：一项动物实验的系统评价和荟萃分析DOI: 10.3389/fphar.2025.1714245
Frontiers in nutrition IF: 05.100Volume 12, Issue No.57Association between triglyceride glucose-body mass index and long-term adverse outcomes in individuals with heart failure: a retrospective cohort study甘油三酯葡萄糖-体重指数与心力衰竭患者长期不良结局的关联：一项回顾性队列研究DOI: 10.3389/fnut.2025.1688566
J Gastroenterol Hepatol IF: 03.400Ahead of Print.No.58Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice胡椒碱对肥胖型和消瘦型非酒精性脂肪肝病小鼠模型的影响DOI: 10.1111/jgh.70201
Medicine IF: 01.400Volume 104, Issue 49No.59Association between fatty liver index and cardiovascular-renal-metabolic syndrome risk: Nonlinear relationship based on NHANES 2011-2020 and mediating effect analysis of TyG, SII, and SIRI脂肪肝指数与心血管-肾脏-代谢综合征风险之间的关联：基于NHANES 2011-2020的非线性关系及TyG、SII、SIRI的中介效应分析DOI: 10.1097/MD.0000000000046342
Quant Imaging Med Surg IF: 02.300Volume 15, Issue 12No.60A preliminary study of subcortical gray matter nucleus volumetric and morphological changes in diabetic retinopathy糖尿病视网膜病变患者亚皮层灰质核团体积与形态变化的初步研究DOI: 10.21037/qims-24-1964
Medicine IF: 01.400Volume 104, Issue 49No.61Causal association between modifiable risk factors and aortic aneurysm and aortic dissection: A comprehensive Mendelian randomization study可改变风险因素与主动脉瘤及主动脉夹层的因果关联：一项全面的孟德尔随机化研究DOI: 10.1097/MD.0000000000043134
Frontiers in oncology IF: 03.300Volume 15, Issue No.62Radiation therapy alleviates Doege-Potter syndrome accompanied with severe aortic valve insufficiency: a case report and literature review放疗缓解伴严重主动脉瓣关闭不全的Doege-Potter综合征：一例病例报告及文献综述DOI: 10.3389/fonc.2025.1681861
J Dermatolog Treat IF: 03.900Volume 36, Issue 1No.63Clinical efficacy of platelet-rich fibrin in chronic wound healing: a retrospective study富血小板纤维蛋白在慢性伤口愈合中的临床有效性：一项回顾性研究DOI: 10.1080/09546634.2025.2598185
Journal of pain research IF: 02.500Volume 18, Issue No.64Gabapentinoids-Induced Rhabdomyolysis/Myopathy: Clinical Characteristics, Management, Outcomes, and Critical Safety Alerts加巴喷丁类药物诱发横纹肌溶解/肌病：临床特征、管理、结果及关键安全警示DOI: 10.2147/JPR.S547736
Drug Des Devel Ther IF: 05.100Volume 19, Issue No.65Canagliflozin as a Potential Preclinical Therapy for Tuberous Sclerosis Complex: Inhibition of Tsc2 (-/-) Cell Proliferation via Cell Cycle Arrest and Mitochondrial Dysfunction卡格列净作为结节性硬化症的潜在临床前疗法：通过细胞周期阻滞和线粒体功能障碍抑制Tsc2 (-/-)细胞增殖DOI: 10.2147/DDDT.S525749
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.66The pathogenesis of diabetic kidney disease and the therapeutic potential of bioactive substances糖尿病肾病的发病机制与生物活性物质的治疗潜力DOI: 10.3389/fphar.2025.1669424
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.67Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review百合属植物的传统用途、营养特性、植物化学代谢物、药理特性及潜在应用：一项系统综述DOI: 10.3389/fphar.2025.1713957
Clin Cosmet Investig Dermatol IF: 02.200Volume 18, Issue No.68Diagnostic Challenge: Prolonged Misdiagnosis of Perianal Herpes in an Immunosuppressed Transplant Patient诊断挑战：一例免疫抑制移植患者肛周疱疹的长期误诊DOI: 10.2147/CCID.S572519
Frontiers in medicine IF: 03.000Volume 12, Issue No.69Association between parity and adverse maternal and neonatal outcomes: a population-based cross-sectional study产次与不良母婴结局相关性的横断面研究DOI: 10.3389/fmed.2025.1697655
Clinical interventions in aging IF: 03.700Volume 20, Issue No.70Serum Expression of PDCD4 and ADAM10 in Elderly Patients with Atherosclerotic Acute Myocardial Infarction and Their Combined Predictive Value for Poor Prognosis老年动脉粥样硬化性急性心肌梗死患者血清PDCD4与ADAM10的表达及其对不良预后的联合预测价值DOI: 10.2147/CIA.S550861
Transl Androl Urol IF: 01.700Volume 14, Issue 11No.71Association of body roundness index with prostate cancer: a population-based cross-sectional study using NHANES data身体圆度指数与前列腺癌的关联：一项基于NHANES数据的横断面研究DOI: 10.21037/tau-2025-372
World journal of hepatology IF: 02.500Volume 17, Issue 11No.72Epidemiology and clinical features of alcoholic liver disease in Hainan Province, China中国海南省酒精性肝病的流行病学及临床特征DOI: 10.4254/wjh.v17.i11.112430
Biomedical optics express IF: 03.200Volume 16, Issue 9No.73Glucose detection using a tilted fiber Bragg grating coated with a GO-PBA composite layer使用涂覆GO-PBA复合层的倾斜光纤布拉格光栅进行葡萄糖检测DOI: 10.1364/BOE.571410
Biomedical optics express IF: 03.200Volume 16, Issue 9No.74Three-dimensional transformer-enhanced multi-scale global co-attention network for precise diabetic macular edema segmentation in OCT volumes用于OCT体积图像中精确分割糖尿病性黄斑水肿的三维Transformer增强多尺度全局共注意力网络DOI: 10.1364/BOE.564842
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.75Methodological panorama of clinical trials for diabetic foot ulcers: a scope review of design, implementation and reporting糖尿病足溃疡临床试验的方法学全景：关于设计、实施与报告的范围综述DOI: 10.3389/fendo.2025.1710850
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.76Discovery and serological validation of DAMP-derived B-cell epitopes as diagnostic biomarkers for diabetic nephropathy基于DAMP来源的B细胞表位发现与血清学验证：糖尿病肾病诊断新标志物DOI: 10.3389/fendo.2025.1652922
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.77The regulatory effects of realgar and cinnabar on glucose metabolism in mice雄黄与朱砂对小鼠葡萄糖代谢的调节作用DOI: 10.3389/fendo.2025.1658148
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.78The bidirectional association between obstructive sleep apnea and diabetic kidney disease: systematic review and meta-analysis阻塞性睡眠呼吸暂停与糖尿病肾病之间的双向关联：系统综述与荟萃分析DOI: 10.3389/fendo.2025.1715997
Quant Imaging Med Surg IF: 02.300Volume 15, Issue 12No.79Evaluation of ascending aorta and radial artery elasticity in patients with type 2 diabetes mellitus via velocity vector imaging应用速度向量成像评估2型糖尿病患者升主动脉和桡动脉弹性DOI: 10.21037/qims-2025-967
Int J Nurs Sci IF: 03.100Volume 12, Issue 6No.80Development and validation of a stroke risk prediction model using regional healthcare big data and machine learning利用区域医疗大数据和机器学习开发与验证卒中风险预测模型DOI: 10.1016/j.ijnss.2025.10.011
Diabetes Metab Syndr Obes IF: 03.000Volume 18, Issue No.81The Association Between Diabetes Mellitus and Perianal Abscess: A Meta-Analysis糖尿病与肛周脓肿的关联：一项荟萃分析DOI: 10.2147/DMSO.S543521
Translational pediatrics IF: 01.700Volume 14, Issue 11No.82Challenges and strategies in ICU nursing for pediatric patients post-craniopharyngioma surgery: a narrative review儿童颅咽管瘤术后ICU护理的挑战与策略：一项叙述性综述DOI: 10.21037/tp-2025-524
Frontiers in physiology IF: 03.400Volume 16, Issue No.83Potential pathways for natural active ingredients to intervene in diabetic kidney disease: targeting macrophage infiltration天然活性成分干预糖尿病肾病的潜在途径：靶向巨噬细胞浸润DOI: 10.3389/fphys.2025.1723762
Folia Neuropathologica IF: 01.600Ahead of Print.No.84Factors influencing hemorrhagic transformation after mechanical thrombectomy for acute anterior circulation large vessel occlusion stroke and prediction modeling影响急性前循环大血管闭塞卒中机械取栓后出血转化的因素分析及预测模型构建DOI: 10.5114/fn.2025.155824
Advanced materials IF: 26.800Ahead of Print.No.85Lattice-Reconstructed Ru-Clusters on FeOOH-Based Self-Adaptive Artificial Peroxisome with Programmed ROS Regulation for Infectious and Inflammatory Chronic Wounds基于FeOOH的具有程序化ROS调控能力的自适应性人工过氧化物酶体负载晶格重构钌簇用于感染性和炎症性慢性伤口DOI: 10.1002/adma.202520395
Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 1No.86Review on the Gut-Kidney Axis Mechanism and Therapeutic Strategies in Diabetic Nephropathy糖尿病肾病肠-肾轴机制与治疗策略综述DOI: 10.1002/dmrr.70115
Medicine IF: 01.400Volume 104, Issue 49No.87Impact of aging on colon cancer burden: A cross-sectional analysis of nationally representative data老龄化对结肠癌疾病负担的影响：一项基于全国代表性数据的横断面分析DOI: 10.1097/MD.0000000000046650
Medicine IF: 01.400Volume 104, Issue 49No.88Predictive model development for invasive syndrome in type 2 diabetes mellitus patients with Klebsiella pneumoniae liver abscess: A 5-year multi-center retrospective case-control study2型糖尿病合并肺炎克雷伯菌肝脓肿患者发生侵袭综合征的预测模型开发：一项为期5年的多中心回顾性病例对照研究DOI: 10.1097/MD.0000000000046456
Medicine IF: 01.400Volume 104, Issue 49No.89Management of severe diabetic foot using modified transverse bone transport: A retrospective study of Wagner grade 3 to 4 cases应用改良横向骨搬移技术治疗重度糖尿病足：一项Wagner 3-4级病例的回顾性研究DOI: 10.1097/MD.0000000000045387
Medicine IF: 01.400Volume 104, Issue 49No.90Management of a difficult airway for multispace infection of the floor of the mouth: A case report口腔底多间隙感染困难气道的管理：一例报告DOI: 10.1097/MD.0000000000046405
Medicine IF: 01.400Volume 104, Issue 49No.91Nonlinear association and predictive value of stress hyperglycemia ratio for 28-day in-hospital mortality in patients with acute hypoxemic respiratory failure应激性高血糖比值与急性低氧性呼吸衰竭患者28天院内死亡率的非线性关联及预测价值DOI: 10.1097/MD.0000000000046367
Medicine IF: 01.400Volume 104, Issue 49No.92Uric acid-to-high-density lipoprotein ratio and diabetes mellitus in stroke survivors: A cross-sectional analysis of NHANES 1998 to 2018尿酸与高密度脂蛋白比值和卒中幸存者的糖尿病：基于NHANES 1998-2018数据的横断面分析DOI: 10.1097/MD.0000000000045639
Medicine IF: 01.400Volume 104, Issue 49No.93The association of stress hyperglycemia ratio (SHR) with arterial stiffness: A cross-sectional study应激性高血糖比值（SHR）与动脉僵硬度的关联：一项横断面研究DOI: 10.1097/MD.0000000000046211
Medicine IF: 01.400Volume 104, Issue 49No.94Does diabetes increase the risk of meniscal injury?: A two-sample Mendelian randomization study糖尿病是否会增加半月板损伤的风险？：一项两样本孟德尔随机化研究DOI: 10.1097/MD.0000000000046263
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J Am Vet Med Assoc IF: 01.800Ahead of Print.No.32Intra-articular methylprednisolone acetate does not induce hyperinsulinemia or hyperglycemia in metabolically normal horses关节内注射醋酸甲基泼尼松龙不会引起代谢正常马匹的高胰岛素血症或高血糖DOI: 10.2460/javma.25.08.0566
The Journal of arthroplasty IF: 03.800Volume 41, Issue 1No.33In Reply "As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients Who Have Type II Diabetes"答复：“术前仅暴露三个月司美格鲁肽即与2型糖尿病患者全膝关节置换术后不良事件减少相关”DOI: 10.1016/j.arth.2025.09.029
The Journal of arthroplasty IF: 03.800Volume 41, Issue 1No.34Letter to Editor on "As Few as Three Months of Preoperative Semaglutide Exposure Prior to Total Knee Arthroplasty Is Associated With Reduced Postoperative Adverse Events in Patients Who Have Type II Diabetes"致编辑的信：全膝关节置换术前仅三个月司美格鲁肽使用与2型糖尿病患者术后不良事件减少相关DOI: 10.1016/j.arth.2025.09.031
Nature communications IF: 15.700Volume 16, Issue 1No.35GLP-1R associates with VAPB and SPHKAP at ERMCSs to regulate β-cell mitochondrial remodelling and functionGLP-1R在ERMCSs与VAPB及SPHKAP结合以调控β细胞线粒体重塑与功能DOI: 10.1038/s41467-025-66115-x
Drug discoveries & therapeutics IF: 01.500Ahead of Print.No.36Modulatory effects of ingesting dietary fiber and protein before carbohydrates on postprandial interstitial glucose responses膳食纤维和蛋白质在碳水化合物之前摄入对餐后间质葡萄糖反应的调节作用DOI: 10.5582/ddt.2025.01099
Diabetes & metabolic syndrome IF: 03.400Ahead of Print.No.37Prevalence of isolated nocturnal hypertension among patients with type 2 diabetes mellitus2型糖尿病患者中孤立性夜间高血压的患病率DOI: 10.1016/j.dsx.2025.103353
J Vet Med Sci IF: 01.100Ahead of Print.No.38Effectiveness of gabapentin in combination therapy for phenobarbital-responsive sialadenosis in a Toy Poodle加巴喷丁联合疗法对玩具贵宾犬苯巴比妥反应性唾液腺肿大的疗效评估DOI: 10.1292/jvms.25-0179
Surgery IF: 02.700Volume 189, Issue No.39Overscreening of patients on glucagon-like peptide-1 receptor agonists: A second "epidemic" of thyroid cancer overdiagnosis?GLP-1受体激动剂使用者的过度筛查：甲状腺癌过度诊断的第二个“流行病”？DOI: 10.1016/j.surg.2025.109868
Scientific reports IF: 03.900Ahead of Print.No.40Erythrocytosis and thromboembolic risks associated with SGLT2 inhibitors in type 2 diabetes2型糖尿病中SGLT2抑制剂相关的红细胞增多症与血栓栓塞风险DOI: 10.1038/s41598-025-31726-3
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Revue de l'infirmièreVolume 74, Issue 316No.42[Protocol for monitoring and managing diabetics treated with insulin via an external insulin pump according to an ePEP plan]基于ePEP计划的外置胰岛素泵糖尿病患者监测与管理方案DOI: 10.1016/j.revinf.2025.10.032
Korean Circulation Journal IF: 03.100Ahead of Print.No.43Cardiovascular Implications in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review代谢相关脂肪性肝病（MASLD）的心血管影响：前沿综述DOI: 10.4070/kcj.2025.0212
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.44Efficacy and safety of metformin versus empagliflozin on chronic kidney disease progression (MET-EMPA-CKD): a randomized controlled trial比较二甲双胍与恩格列净对延缓慢性肾脏病进展的有效性和安全性：一项随机对照试验DOI: 10.1186/s13098-025-02040-9
Internal medicine IF: 01.100Ahead of Print.No.45Diabetic Ketoacidosis Triggered by Retropharyngeal Abscess Complicated by Descending Necrotizing Mediastinitis: A Case Report咽后脓肿诱发糖尿病酮症酸中毒并发下行性坏死性纵隔炎：病例报告DOI: 10.2169/internalmedicine.6175-25
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Int J Behav Nutr Phys Act IF: 05.500Ahead of Print.No.47Creating healthy habits for Maryland preschoolers (CHAMP): a cluster-randomized controlled trial among childcare centers为马里兰州学龄前儿童建立健康习惯：一项在托育中心开展的整群随机对照试验DOI: 10.1186/s12966-025-01824-6
BMC public health IF: 03.600Ahead of Print.No.48The association between animal‑based and plant‑based protein intake with sleep quality, mood, anxiety, depression and stress among elderly: a cross-sectional study动物性与植物性蛋白质摄入与老年人睡眠质量、情绪、焦虑、抑郁和压力的关联：一项横断面研究DOI: 10.1186/s12889-025-25857-5
J Health Popul Nutr IF: 02.800Ahead of Print.No.49Evaluating the predictive power of the body roundness index (BRI) versus traditional obesity measures for female infertility: a hybrid approach using regression models and machine learning algorithms on cross-sectional data评估身体圆度指数（BRI）对比传统肥胖指标对女性不孕症的预测能力：一项基于横断面数据，结合回归模型与机器学习算法的混合研究DOI: 10.1186/s41043-025-01179-5
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Obesity surgery IF: 03.100Ahead of Print.No.52From Body Mass Index to Biology: Reconciling Diagnostic Clarity and Surgical Eligibility in Obesity Care从身体质量指数到生物学评估：在肥胖症治疗中协调诊断清晰度与手术适应症DOI: 10.1007/s11695-025-08411-5
Int J Behav Med IF: 01.700Ahead of Print.No.53The Longitudinal Examination of Habitual Sleep Duration in Relation to Weight Gain Risk Behaviors and Body Composition Changes Among College Students: Findings From Project STARLIT大学生习惯性睡眠时长与体重增加风险行为及体成分变化的纵向研究：来自Project STARLIT项目的发现DOI: 10.1007/s12529-025-10424-4
Communications biology IF: 05.100Ahead of Print.No.54miR-299a-5p is a mediator of fibrosis in diabetic kidney disease by regulating follistatin and cripto-1miR-299a-5p 通过调控 follistatin 和 cripto-1 介导糖尿病肾病纤维化DOI: 10.1038/s42003-025-09271-6
Scientific reports IF: 03.900Volume 15, Issue 1No.55Bioactive compounds from Sargassum horneri attenuates inflammation and obesity regulating by Nrf2/HO-1 and AMPK signaling pathways马尾藻生物活性成分通过调节Nrf2/HO-1和AMPK信号通路减轻炎症和肥胖DOI: 10.1038/s41598-025-27131-5
Nature communications IF: 15.700Ahead of Print.No.56Inhibition of adipocyte lipolysis by vaspin impairs thermoregulation in vivovaspin抑制脂肪细胞脂解，损害体内体温调节功能DOI: 10.1038/s41467-025-66950-y
Nature communications IF: 15.700Ahead of Print.No.57Reading the immune clock: a machine learning model predicts mouse immune age from cellular patterns读取免疫时钟：机器学习模型通过细胞模式预测小鼠免疫年龄DOI: 10.1038/s41467-025-67393-1
Scientific reports IF: 03.900Ahead of Print.No.58Prevalence and associated factors of overweight and obesity among people living with HIV on antiretroviral therapy in a national hospital in Benin贝宁国家医院接受抗逆转录病毒治疗的HIV感染者中超重和肥胖的患病率及相关因素DOI: 10.1038/s41598-025-06449-0
Nature communications IF: 15.700Ahead of Print.No.59PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasisPTEN调控迷走神经-胰岛素信号以优化自主神经输出，从而决定外周炎症和代谢稳态DOI: 10.1038/s41467-025-67192-8
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Surg Obes Relat Dis IF: 03.800Ahead of Print.No.61Revisional single anastomosis duodeno-ileal bypass with sleeve gastrectomy after failed adjustable gastric band or sleeve gastrectomy: a meta-analysis of efficacy and safety修正性单吻合口十二指肠回肠旁路联合袖状胃切除术治疗可调节胃束带或袖状胃切除术失败后：一项有效性和安全性的荟萃分析DOI: 10.1016/j.soard.2025.10.018
Canadian journal of surgery IF: 02.200Volume 68, Issue 6suppl2No.622025 Canadian Surgery Forum: Sept. 17-20, 20252025年加拿大外科学术论坛：2025年9月17日至20日DOI: 10.1503/cjs.019325
Obesity IF: 04.700Ahead of Print.No.63Re: "Lifestyle Behavioral Weight-Loss Treatment for Binge-Eating Disorder in Patients With Obesity: Where's the Harm?"肥胖患者暴食障碍的生活方式行为减重治疗：其害何在DOI: 10.1002/oby.70110
Obesity IF: 04.700Ahead of Print.No.64Response to Akçay回应AkçayDOI: 10.1002/oby.70109
Drug discoveries & therapeutics IF: 01.500Ahead of Print.No.65Disproportionality and time-to-onset analyses of drug-induced weight gain using the Japanese Adverse Drug Event Report database基于日本药品不良事件报告数据库的药物诱导体重增加不成比例分析与时间到发作分析DOI: 10.5582/ddt.2025.01096
Biosystems IF: 01.900Ahead of Print.No.66Obesity, body heat loss, and efficiency in movement肥胖、体热散失与运动效率的关联DOI: 10.1016/j.biosystems.2025.105673
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Journal of affective disorders IF: 04.900Ahead of Print.No.68High ultra-processed food intake is associated with altered brain perfusion, depressive symptomatology, and increased inflammatory profile超高加工食品摄入与大脑灌注异常、抑郁症状及促炎状态相关DOI: 10.1016/j.jad.2025.120845
Cochrane Database Syst Rev IF: 09.400Volume 12, Issue No.69School feeding programs for improving the physical and psychological health of school children experiencing socioeconomic disadvantage学校供餐计划对改善社会经济劣势学童身心健康的效果DOI: 10.1002/14651858.CD014794.pub2
Current biology IF: 07.500Ahead of Print.No.70High-fat food reinforces risk taking by suppressing defensive neurons高脂食物通过抑制防御神经元来强化风险行为DOI: 10.1016/j.cub.2025.11.020
Surgery IF: 02.700Ahead of Print.No.71Weighing the impact of bariatric surgery: A meta-analysis of long-term outcomes of Roux-en-Y gastric bypass and sleeve gastrectomy评估减重手术影响：Roux-en-Y胃旁路术与袖状胃切除术长期结局的荟萃分析DOI: 10.1016/j.surg.2025.109934
Biomedicine & pharmacotherapy IF: 07.500Ahead of Print.No.72ENT1 inhibition enhances weight control and metabolic health in diet-induced obesityENT1抑制促进饮食诱导性肥胖的体重控制与代谢健康DOI: 10.1016/j.biopha.2025.118848
J Environ Manage IF: 08.400Ahead of Print.No.73How has the cost-of-living crisis impacted the transition to healthy diets from sustainable food systems?生活成本危机如何影响了从可持续食品系统向健康饮食的转变？DOI: 10.1016/j.jenvman.2025.128185
BMJ open IF: 02.300Volume 15, Issue 12No.74Effects of glucagon-like peptide-1 analogues on hard binary outcomes for patients at increased risk of cardiovascular events: a protocol for a systematic review with network meta-analysis and Trial Sequential Analysis胰高血糖素样肽-1类似物对心血管事件风险增加患者硬终点结局的影响：一项结合网络荟萃分析与试验序贯分析的系统评价方案DOI: 10.1136/bmjopen-2024-098205
Current opinion in pharmacology IF: 04.200Ahead of Print.No.75From one-size-fits-all to phenotype-based pharmacotherapy: How far are we in obesity management?从“一刀切”到表型导向的药物治疗：我们在肥胖管理中走了多远？DOI: 10.1016/j.coph.2025.102589
Diabetology & metabolic syndrome IF: 03.900Ahead of Print.No.76Molecular cross-talk via extracellular vesicles for the characterization of young subjects with type 1 diabetes unravels new potential markers of insulin resistance and double diabetes基于细胞外囊泡的分子对话表征年轻1型糖尿病患者，揭示胰岛素抵抗与双重糖尿病的新潜在标志物DOI: 10.1186/s13098-025-02042-7
Pregnancy Hypertension IF: 02.900Volume 43, Issue No.77Cardiovascular phenotype in women 1–3 years after hypertensive pregnancy disorders: Impact of sex-independent and pregnancy-specific risk factors妊娠期高血压疾病后1-3年女性的心血管表型：性别非依赖性与妊娠特异性风险因素的影响DOI: 10.1016/j.preghy.2025.101404
Cardiovasc Endocrinol Metab IF: 01.100Ahead of Print.No.78Genetic evidence for the causal relationship between metabolic diseases and primary aldosteronism: insights from Mendelian randomization analysis代谢疾病与原发性醛固酮增多症存在因果关系的遗传学证据：来自孟德尔随机化分析的启示DOI: 10.1097/XCE.0000000000000350
Cornea IF: 02.100Ahead of Print.No.79Reply to Cornea-D-25-00755回复 Cornea-D-25-00755DOI: 10.1097/ICO.0000000000004054
Revista Brasileira de Enfermagem IF: 01.200Volume 78, Issue suppl 4No.80Manual for nursing consultation with people living with Diabetes Mellitus: implementation science糖尿病患者护理咨询手册：实施科学DOI: 10.1590/0034-7167-2024-0179
Rev Assoc Med Bras (1992) IF: 01.300Volume 71, Issue 11No.81Comments: "Effect of long-term negative energy on appetite hormone levels in individuals with prediabetes and diabetes"长期能量负平衡对糖尿病前期及糖尿病患者食欲激素水平的影响DOI: 10.1590/1806-9282.20250818
Brazilian Journal of BiologyVolume 85, Issue No.82Bridging the gap between point-of-care and laboratory standards: comparative evaluation of MedSenso and DSA glucometers against Cobas analyzers for accurate diabetes monitoring填补即时检测与实验室标准间的差距：MedSenso与DSA血糖仪相较于Cobas分析仪在糖尿病精确监测中的评估比较DOI: 10.1590/1519-6984.284558
JBRA IF: 01.900Volume 29, Issue 4No.83Spermiological injuries of humans and rats in diabetes linked oxidative stress: A curative approach by ex vivo study using aqueous-ethanol extract of Aloe vera (L.)糖尿病相关氧化应激所致人和大鼠精子学损伤：芦荟水乙醇提取物离体研究的治疗途径DOI: 10.5935/1518-0557.20250034
Chemistry & biodiversity IF: 02.500Ahead of Print.No.84Antidiabetic and Toxicological Evaluation of Ehretia asperula Leaf Extract in Diabetic Mice粗糠树叶片提取物在糖尿病小鼠中的抗糖尿病作用及毒性评价DOI: 10.1002/cbdv.202501933
PloS one IF: 02.600Volume 20, Issue 12No.85Emergency department visits for ambulatory care sensitive conditions by persons with Rheumatoid Arthritis: A population-based study类风湿关节炎患者因门诊照护敏感状况的急诊就诊：一项基于人群的研究DOI: 10.1371/journal.pone.0337003
PloS one IF: 02.600Volume 20, Issue 12No.86Global burden and future projections of non-communicable diseases (2000-2050): Progress toward SDG 3.4 and disparities across regions and risk factors非传染性疾病的全球负担与未来预测（2000-2050年）：实现SDG 3.4目标的进展及区域与风险因素间的差异DOI: 10.1371/journal.pone.0336036
Journal of pediatric psychology IF: 02.100Ahead of Print.No.87Self-management behaviors mediate the relationship between distress and glycemic levels in adolescents with type 1 diabetes自我管理行为介导1型糖尿病青少年困扰与血糖水平之间的关系DOI: 10.1093/jpepsy/jsaf106
Clin J Am Soc Nephrol IF: 07.100Ahead of Print.No.88Sex-Specific Outcomes in The Peritoneal Dialysis Outcomes and Practice Patterns Study腹膜透析预后与实践模式研究中的性别特异性结局DOI: 10.2215/CJN.0000000937
J Clin Endocrinol Metab IF: 05.100Ahead of Print.No.89Implementation of a Spanish-Language, Direct-to-Patient Primary Aldosteronism Testing Program一项西班牙语直接面向患者的原发性醛固酮增多症测试项目的实施DOI: 10.1210/clinem/dgaf663
J Am Geriatr Soc IF: 04.500Ahead of Print.No.90Burden of Hypoglycemia and Hyperglycemia in Insulin-Treated Veterans Affairs Nursing Home Residents接受胰岛素治疗的退伍军人事务部养老院居民的低血糖与高血糖负担DOI: 10.1111/jgs.70229
JBRA IF: 01.900Volume 29, Issue 4No.91A review on herbal interventions and nanotechnological advancements for managing polycystic ovarian syndrome应用草药干预与纳米技术进步治疗多囊卵巢综合征的综述DOI: 10.5935/1518-0557.20250042
Restor Neurol Neurosci IF: 01.600Ahead of Print.No.92Exploring the Ketogenic Diet as Adjunctive Therapy in Multiple Sclerosis: A Review探索生酮饮食作为多发性硬化辅助疗法的综述DOI: 10.1177/09226028251404071
Prim Care Companion CNS DisordVolume 27, Issue 6No.93Serotonin Syndrome With Quetiapine, Rizatriptan, Gabapentin, and Propranolol喹硫平、利扎曲普坦、加巴喷丁与普萘洛尔所致血清素综合征DOI: 10.4088/PCC.25cr03919
Georgian Medical NewsVolume 2025, Issue 367No.94THE FIRST ATTEMPT IN ARMENIA OF EASYGO-TYPE ENDOSCOPIC SURGERY FOR LUMBAR SPINAL CANAL STENOSIS在亚美尼亚开展EasyGo型内镜手术治疗腰椎管狭窄症https://pubmed.ncbi.nlm.nih.gov/41370695
JMIR research protocols IF: 01.500Volume 14, Issue No.95Short-Term Effects of Nonnutritive Sweetener (Sucralose and Saccharin) Consumption on Glycemic Control and Gut Microbiota in Patients With Type 2 Diabetes: Protocol for a Double-Blind, Randomized, Placebo-Controlled, Crossover Trial非营养性甜味剂（三氯蔗糖与糖精）短期摄入对2型糖尿病患者血糖控制及肠道菌群的影响：一项双盲、随机、安慰剂对照、交叉试验方案DOI: 10.2196/82695
Revista Brasileira de Enfermagem IF: 01.200Volume 78, Issue 6No.96Nursing consultation based on self-care supported by people with Diabetes Mellitus: an experience report基于支持性自我护理的糖尿病护理咨询：一篇经验报告DOI: 10.1590/0034-7167-2024-0277
JBRA IF: 01.900Volume 29, Issue 4No.97Seminal parameters of patients with Type 2 Diabetes Mellitus undergoing Assisted Reproduction: A retrospective analysis接受辅助生殖的2型糖尿病患者精液参数：一项回顾性分析DOI: 10.5935/1518-0557.20250044
PloS one IF: 02.600Volume 20, Issue 12No.98Comparative effects of combined aerobic and resistance training versus high-intensity interval training on insulin resistance, glycaemic control, body composition and quality of life in type 2 diabetes: A 12-week randomised controlled trial有氧联合抗阻训练与高强度间歇训练对2型糖尿病患者胰岛素抵抗、血糖控制、身体成分及生活质量的比较效果：一项为期12周的随机对照试验DOI: 10.1371/journal.pone.0336898
JMIR formative research IF: 02.100Volume 9, Issue No.99Changes in the Neighborhood Built Environment and Chronic Health Conditions in Washington, DC, in 2014-2019: Longitudinal Analysis华盛顿特区2014-2019年邻里建成环境的变迁与慢性健康状况：一项纵向分析DOI: 10.2196/74195
J Am Acad Orthop Surg IF: 02.800Ahead of Print.No.100Impact of Prior Joint Arthroplasty on Reoperation Rate Following Lumbar Spinal Fusion先前关节置换对腰椎融合术后再手术率的影响DOI: 10.5435/JAAOS-D-25-00846
Cancer research communications IF: 03.300Ahead of Print.No.101Transcriptomic analyses of normal human pancreata reveal the presence of cancer subtypes that correlate with acinar ductal metaplasia and donor ancestry正常人类胰腺转录组学分析揭示癌症亚型存在，其与腺泡导管化生及供体祖先相关DOI: 10.1158/2767-9764.CRC-25-0411
ABCD IF: 01.800Volume 38, Issue No.102Gastric sleeve and gastric bypass: changes in weight after two-year follow-up - which is more effective?胃袖状切除术与胃旁路术：两年随访后的体重变化——哪种更有效？DOI: 10.1590/0102-67202025000045e1914
Journal of proteome research IF: 03.600Ahead of Print.No.103Untargeted Urinary Proteomics Uncovers Nephroprotective and Systemic Adaptations after Obesity Surgery-Induced Weight Loss无靶向尿液蛋白质组学揭示肥胖手术诱导减重后的肾脏保护作用和系统适应性变化DOI: 10.1021/acs.jproteome.5c00500
Journal of Postgraduate Medicine IF: 01.200Ahead of Print.No.104Report of two cases of lipedema: An under-recognized, misdiagnosed, and under-reported disorder in India印度两例脂水肿病例报告：一个被低估、误诊和少报的疾病DOI: 10.4103/jpgm.jpgm_273_25
Cell reports IF: 06.900Ahead of Print.No.105ESAT-6 and CFP-10 reactive IgG in patients with tuberculosis inhibits intracellular bacteria结核病患者体内针对ESAT-6和CFP-10的抗体可抑制细胞内结核菌DOI: 10.1016/j.celrep.2025.116653
NEJM IF: 78.500Volume 393, Issue 23No.106Oral Semaglutide in Adults with Overweight or Obesity. Reply口服司美格鲁肽用于超重或肥胖成人：回复DOI: 10.1056/NEJMc2515109
JMIR research protocols IF: 01.500Volume 14, Issue No.107Smartphone-Based Physical Activity Program to Reduce "Chemo-Brain" Symptoms and Improve Health in Cancer Survivors With and Without Type 2 Diabetes: Protocol for a Single-Arm Pre-Post Pilot Trial基于智能手机的体力活动项目用于减轻“化疗脑”症状并改善伴有或不伴有2型糖尿病的癌症幸存者健康：一项单臂前后测试试点试验方案DOI: 10.2196/79739
NEJM IF: 78.500Ahead of Print.No.108Generic Liraglutide - Overlooked but Not Forgotten通用利拉鲁肽——被忽视但未被遗忘DOI: 10.1056/NEJMp2515668
West African journal of medicineVolume 42, Issue 7No.109Evaluation of Microalbuminuria Level to Determine Diabetic Nephropathy Among Type 2 Diabetic Patients in Zaria, Nigeria评估尼日利亚Zaria地区2型糖尿病患者微量白蛋白尿水平以确定糖尿病肾病https://pubmed.ncbi.nlm.nih.gov/41370621
Microscopy and microanalysis : IF: 03.000Volume 31, Issue 6No.110A New Quantitative Metric for Precise Classification of Diabetic Podocyte Injury Using Scanning Electron Microscopy使用扫描电子显微镜对糖尿病足细胞损伤进行精确分类的新定量指标DOI: 10.1093/mam/ozaf122
Revista Brasileira de Enfermagem IF: 01.200Volume 78, Issue 6No.111Overweight/obesity among health professionals and associated factors卫生专业人员中超重/肥胖的患病率及相关因素DOI: 10.1590/0034-7167-2024-0254
Eur J Endocrinol IF: 05.200Ahead of Print.No.112Adrenal - adipose tissue crosstalk in health and disease健康与疾病状态下的肾上腺-脂肪组织交互作用DOI: 10.1093/ejendo/lvaf252
Georgian Medical NewsVolume 2025, Issue 367No.113PHARMACOKINETIC AND PHARMACODYNAMIC ALTERATIONS OF LOCAL ANESTHETICS IN PATIENTS WITH SYSTEMIC DISORDERS: A NARRATIVE REVIEW全身性疾病患者局部麻醉药的药代动力学和药效学改变：一篇叙述性综述https://pubmed.ncbi.nlm.nih.gov/41370685
PloS one IF: 02.600Volume 20, Issue 12No.114Metabolic dysfunction-associated steatohepatitis is the leading indication for adult liver transplantation in Saudi Arabia代谢功能障碍相关脂肪性肝炎成为沙特阿拉伯成人肝移植的首要适应症DOI: 10.1371/journal.pone.0338438
Neurology IF: 08.500Volume 106, Issue 1No.115Association Between GLP-1 Receptor Agonist Use and Epilepsy Risk in Type 2 Diabetes2型糖尿病患者中使用GLP-1受体激动剂与癫痫风险的关联DOI: 10.1212/WNL.0000000000214509
JAMA Network Open IF: 09.700Volume 8, Issue 12No.116Risk Factors for West Nile Neuroinvasive Disease and Mortality in the US, 2013-20242013-2024年美国西尼罗河神经侵袭性疾病及其死亡率的危险因素DOI: 10.1001/jamanetworkopen.2025.48229
Internal and emergency medicine IF: 03.800Ahead of Print.No.117Metformin as a potential adjunct in the treatment of mild-to-moderate ulcerative colitis: a double-blind, randomized, placebo-controlled pilot study二甲双胍作为轻中度溃疡性结肠炎的潜在辅助治疗：一项双盲、随机、安慰剂对照的初步研究DOI: 10.1007/s11739-025-04222-9
Am J Clin Dermatol IF: 08.800Ahead of Print.No.118Nutrition and Psoriasis: The Latest Evidence and How to Approach Nutrition in Clinical Practice营养与银屑病：最新证据及临床实践中如何应用营养干预DOI: 10.1007/s40257-025-00992-2
Irish journal of medical science IF: 01.600Ahead of Print.No.119Emergency laparoscopic "hybrid" intraperitoneal on-lay mesh (IPOM +) repair of incarcerated umbilical hernia in patient with BMI 62 and small bowel obstruction; a case based review急诊腹腔镜“混合”腹腔内补片植入术修复BMI 62患者合并小肠梗阻的嵌顿性脐疝：一例病例回顾DOI: 10.1007/s11845-025-04191-0
Epigenetics IF: 03.200Volume 20, Issue 1No.120Strength of evidence for paternal influence on offspring epigenome in observational human studies: a systematic review and risk-of-bias appraisal for non-randomized exposures观察性人类研究中父代对子代表观基因组影响的证据强度：一项针对非随机暴露的系统综述与偏倚风险评估DOI: 10.1080/15592294.2025.2594322
Pediatric obesity IF: 02.700Volume 21, Issue 1No.121The Appetitive Responses to a Meal Are Not Affected by Its Carbohydrate Content in Adolescents With Obesity: A Pilot Study在肥胖青少年中，一餐的碳水化合物含量不影响其食欲反应：一项初步研究DOI: 10.1111/ijpo.70077
Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.122Gremlin-1 is associated with obesity but not polycystic ovary syndrome: Insights from a body mass index-matched analysis of bone morphogenetic protein pathway components, a cross-sectional studyGremlin-1与肥胖相关，但与多囊卵巢综合征无关：基于体重指数匹配分析骨形态发生蛋白通路组分的启示DOI: 10.1002/ijgo.70725
Int J Gynaecol Obstet IF: 02.400Ahead of Print.No.123Epidemiological trends in uterine corpus malignancies in Belarus: A 30-year analysis (1993-2022)白俄罗斯子宫体恶性肿瘤的流行病学趋势：一项30年分析（1993-2022年）DOI: 10.1002/ijgo.70743
Surgical endoscopy IF: 02.700Ahead of Print.No.124Subclinical renal injury in obesity following bariatric surgery: insights from a prospective cohort肥胖患者减重手术后亚临床肾损伤：一项前瞻性队列研究的启示DOI: 10.1007/s00464-025-12464-z
Cells IF: 05.200Volume 14, Issue 23No.125Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review培养中人类脂肪前体细胞的热源性分化：一项系统综述DOI: 10.3390/cells14231907
Cells IF: 05.200Volume 14, Issue 23No.126Orthobiologics and Peptide Therapy for Central Nervous System Repair in Neurodegenerative Conditions正生物制剂与肽疗法用于神经退行性疾病的中枢神经系统修复DOI: 10.3390/cells14231853
Journal of neurochemistry IF: 04.000Volume 169, Issue 12No.127Altered Glut4, IRAP, and Brain Insulin Signaling in a Mouse Model of Epilepsy and Contributions to Glucose Transport in Neurons and Astrocytes癫痫小鼠模型中Glut4、IRAP及脑胰岛素信号发生改变及其在神经元和星形胶质细胞葡萄糖转运中的作用DOI: 10.1111/jnc.70320
Cells IF: 05.200Volume 14, Issue 23No.128Reciprocal Paracrine Signaling and Dynamic Coordination of Transitional States in the Alveolar Epithelial Type 2 Cells and Associated Alveolar Lipofibroblasts During Homeostasis, Injury and Repair稳态、损伤与修复期间，肺泡上皮2型细胞与相关肺泡脂质成纤维细胞中过渡状态的旁分泌信号互作与动态协同DOI: 10.3390/cells14231869
Molecular biology reports IF: 02.800Volume 53, Issue 1No.129Protective effects of ethanolic lychee (Litchi chinensis Sonn.) seed extract against adipogenesis and inflammation in 3T3-L1 cells荔枝籽乙醇提取物对3T3-L1细胞脂肪生成及炎症的保护作用DOI: 10.1007/s11033-025-11353-x
Blood Pressure IF: 02.300Ahead of Print.No.130Dual-impedance cardiography for the assessment of arterial stiffness: Associations with blood pressure, cardiometabolic risk factors, and preclinical atherosclerosis in midlife adults应用双导抗心动描记法评估动脉硬度：与血压、心脏代谢风险因素及中年人群亚临床动脉粥样硬化的关联DOI: 10.1080/08037051.2025.2600733
JAAPA IF: 00.800Ahead of Print.No.131Screening and management of metabolic dysfunction-associated steatotic liver disease (MASLD)代谢功能障碍相关性脂肪性肝病（MASLD）的筛查与管理DOI: 10.1097/01.JAA.0000000000000296
Langenbeck's archives of surgery IF: 01.800Ahead of Print.No.132Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review肢端肥大症患者术后口服葡萄糖耐量试验中生长激素谷值与胰岛素样生长因子1水平不一致的长期临床控制：一项回顾性观察性研究及文献综述DOI: 10.1007/s00423-025-03951-x
Cardiovascular Drugs and Therapy IF: 03.100Ahead of Print.No.133Natriuretic Peptides as Multisystem Regulators: From Clinical Biomarkers to Therapeutic Targets in Cardio-immunology利钠肽作为多系统调节剂：从心脏免疫学中的临床生物标志物到治疗靶点DOI: 10.1007/s10557-025-07821-y
Cells IF: 05.200Volume 14, Issue 23No.134β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategiesβ细胞线粒体功能障碍：潜在机制与治疗策略DOI: 10.3390/cells14231861
Iranian journal of immunology IF: 01.100Volume 22, Issue 4No.135Diagnostic Utility of Anti-Cyclic Citrullinated Peptide Antibodies Versus Rheumatoid Factor in Libyan Patients with Rheumatoid Arthritis: A Cross-Sectional Study抗环瓜氨酸肽抗体与类风湿因子在利比亚类风湿关节炎患者中的诊断效用比较：一项横断面研究DOI: 10.22034/iji.2025.108275.3090
Nutrition reviews IF: 04.900Ahead of Print.No.136Elucidating the Probiotic Potential of Lactobacillus and Bifidobacterium Species in Modulating Glucose Metabolism and Inflammation in Gestational Diabetes Mellitus: A Scoping Review阐明乳酸杆菌和双歧杆菌在调节妊娠期糖尿病葡萄糖代谢和炎症中的益生潜力：一项范围综述DOI: 10.1093/nutrit/nuaf238
Nanoscale IF: 05.100Ahead of Print.No.137Properties of AgNPs stabilized with polyvinylpyrrolidone relevant to antidiabetic agents聚乙烯吡咯烷酮稳定的银纳米颗粒作为抗糖尿病药物的相关特性DOI: 10.1039/d5nr03452c
JAMA Cardiology IF: 14.100Ahead of Print.No.138Rationale, Design, and Baseline Clinical Characteristics of the Ziltivekimab Cardiovascular Outcomes Trial: Interleukin-6 Inhibition and Atherosclerotic Event Rate ReductionZiltivekimab心血管结局试验的原理、设计与基线临床特征：白细胞介素-6抑制与动脉粥样硬化事件发生率降低DOI: 10.1001/jamacardio.2025.4491
JAMA surgery IF: 14.900Ahead of Print.No.139Glucagon-Like Peptide 1 Receptor Agonist Use and Vertebral Fracture Risk in Type 2 Diabetes2型糖尿病患者中GLP-1受体激动剂使用与椎体骨折风险研究DOI: 10.1001/jamasurg.2025.5372
Aging cell IF: 07.100Ahead of Print.No.140Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction酮生成对于热量限制的代谢适应是非必需的DOI: 10.1111/acel.70318
Acta diabetologica IF: 02.900Ahead of Print.No.141Advances in diabetic wound healing: from pathophysiology to emerging therapies从病理生理学到新兴疗法：糖尿病伤口愈合的进展DOI: 10.1007/s00592-025-02629-6
Diabetologia IF: 10.200Ahead of Print.No.142Gestational glycaemia reflects lifelong glycaemia: the Pune Maternal Nutrition Study妊娠期血糖水平反映终生血糖水平：浦那母婴营养研究DOI: 10.1007/s00125-025-06625-x
Mammalian genome IF: 02.700Volume 37, Issue 1No.143A quality framework for cryopreserved rodent disease models: INFRAFRONTIER quality principles in EMMA archiving and distribution冷冻保存啮齿类疾病模型的质量框架：EMMA存档和分发中的INFRAFRONTIER质量原则DOI: 10.1007/s00335-025-10174-4
JACC IF: 22.300Ahead of Print.No.144Obesity-Associated Cardiovascular Risk and Benefit From PCSK9 Inhibition: A Prespecified Analysis From FOURIER肥胖相关心血管风险与PCSK9抑制的获益：FOURIER试验预设分析DOI: 10.1016/j.jacc.2025.10.036
Diabetes IF: 07.500Ahead of Print.No.145Type 2 Diabetes Genetic Risk and Type 1 Diabetes Heterogeneity and Progression2型糖尿病遗传风险与1型糖尿病的异质性及进展DOI: 10.2337/db25-0711
Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.146GLP-1 from the distal gut is dispensable for body weight and glucose regulation but slows small intestinal transit in female mice远端肠道来源的GLP-1对体重和葡萄糖调节非必需但能减缓雌性小鼠的小肠转运DOI: 10.1152/ajpendo.00158.2025
Clin Orthop Relat Res IF: 04.400Ahead of Print.No.147Is RAGE Expression in Flexor Tendon Synovium Associated With Carpal Tunnel Syndrome in Patients With Diabetes?屈肌腱滑膜中的RAGE表达是否与糖尿病患者的腕管综合征相关？DOI: 10.1097/CORR.0000000000003800
Cells IF: 05.200Volume 14, Issue 23No.148Alternative Splicing (AS) Provides an Alternative Mechanism for Regulating GLIS3 Expression and Activity可变剪接（AS）为调控GLIS3表达和活性提供了一种替代机制DOI: 10.3390/cells14231912
Cells IF: 05.200Volume 14, Issue 23No.149Advanced Glycation End Products Promote PGE(2) Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC-NF-κB Pathway晚期糖基化终末产物通过RAGE/TLR4介导的PKC-NF-κB通路促进Ca9-22细胞产生PGE2DOI: 10.3390/cells14231911
Cells IF: 05.200Volume 14, Issue 23No.150ST32da, a Novel Salvia miltiorrhiza-Derived ATF3 Inducer, Alleviates Obesity-Related Diabetic Nephropathy in Mouse ModelsST32da：一种源自丹参的新型ATF3诱导剂，可缓解小鼠模型中的肥胖相关糖尿病肾病DOI: 10.3390/cells14231893
Cells IF: 05.200Volume 14, Issue 23No.151Histone Deacetylase Inhibition Enhances AQP3 Levels in Human Corneal Epithelial Cells and Corneal Wound Healing in Normoglycemic and Diabetic Male Mice组蛋白去乙酰化酶抑制增强人角膜上皮细胞AQP3水平及正常血糖和糖尿病雄性小鼠角膜伤口愈合DOI: 10.3390/cells14231880
Cells IF: 05.200Volume 14, Issue 23No.152Role of Angiogenesis in Retinal Diseases and New Advances in Drug Development血管新生在视网膜疾病中的作用及药物研发新进展DOI: 10.3390/cells14231849
Cells IF: 05.200Volume 14, Issue 23No.153Cellular and Molecular Mechanisms of Wound Repair: From Biology to Therapeutic Innovation伤口修复的细胞与分子机制：从生物学到治疗创新DOI: 10.3390/cells14231850
J Gerontol A Biol Sci Med Sci IF: 03.800Ahead of Print.No.154Macronutrient content and quality, and risk of multimorbidity in the UK biobank宏量营养素含量与质量，及其与英国生物样本库参与者多病共患风险的关系DOI: 10.1093/gerona/glaf267
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.155Assessing Awareness and Knowledge Gaps in Diabetic Distress Among Qatar's Healthcare Providers: A Cross-Sectional Study评估卡塔尔医疗工作者对糖尿病相关困扰的认知与知识缺口：一项横断面研究DOI: 10.1002/edm2.70117
J Feline Med Surg IF: 02.100Ahead of Print.No.156EXPRESS: Guidelines for nutritional management of feline diabetes mellitus: a proposed classification system integrating medical considerations猫糖尿病管理营养指南：整合医疗考量提出新的分类系统DOI: 10.1177/1098612X251409019
Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 1No.157Association of the Endothelial Nitric Oxide Synthase (eNOS) G894T Gene Polymorphism With Type 2 Diabetes Mellitus in a Tunisian Population内皮型一氧化氮合酶(eNOS) G894T基因多态性与突尼斯人群2型糖尿病的关联性研究DOI: 10.1002/edm2.70122
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.158Effectiveness and safety of saroglitazar in managing dyslipidaemia and liver enzymes in patients with type 2 diabetes, MASLD, and Stage 3 chronic kidney disease: A 12-month observational study沙格列扎治疗2型糖尿病、代谢相关脂肪性肝病及3期慢性肾脏病患者血脂异常与肝酶的疗效与安全性：一项为期12个月的观察性研究DOI: 10.1111/dom.70370
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.159Aldosterone antagonist combined with a SGLT2 inhibitor versus SGLT2 inhibitor monotherapy: An updated meta-analysis醛固酮拮抗剂联合SGLT2抑制剂与SGLT2抑制剂单药治疗的对比：一项更新版荟萃分析DOI: 10.1111/dom.70363
Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.160No causal link between the supply of GLP-1 receptor agonists and antidepressants: Real-world evidence from the Australian Pharmaceutical Benefits SchemeGLP-1受体激动剂供应与抗抑郁药无因果联系：澳大利亚药物福利计划的真实世界证据DOI: 10.1111/dom.70376
Inquiry IF: 02.300Volume 62, Issue No.161A Blurry Bottom Line: The Economics of Declining Medicare Payment Trends in Ophthalmology Subspecialties, 2003 to 2024日益模糊的财务前景：眼科亚专科医疗保险支付趋势下降的经济学分析（2003-2024年）DOI: 10.1177/00469580251399357
Endocrinol Diabetes Metab Case Rep IF: 00.700Volume 2025, Issue 4No.162Acute rectal calcinosis following parathyroidectomy in a patient with primary hyperparathyroidism and preoperative hypercalcaemic crisis一例术前存在高钙危象的原发性甲状旁腺功能亢进症患者甲状旁腺切除术后发生急性直肠钙质沉着DOI: 10.1530/EDM-25-0100
Pediatric obesity IF: 02.700Volume 21, Issue 1No.163Central Adiposity, Rather Than in Utero Exposure to Maternal Obesity or Gestational Diabetes, Predicts Metabolic Syndrome Risk in Children Aged 4-10 Years中心性肥胖而非子宫内暴露于母体肥胖或妊娠糖尿病可预测4-10岁儿童代谢综合征风险DOI: 10.1111/ijpo.70066
Minerva Obstet Gynecol IF: 01.000Volume 77, Issue 5No.164Antiandrogens and insulin sensitizers in PCOS management抗雄激素药物和胰岛素增敏剂在多囊卵巢综合征管理中的应用DOI: 10.23736/S2724-606X.25.05822-1
Cells IF: 05.200Volume 14, Issue 23No.165The Interplay Between Esophageal Adenocarcinoma and Its Tumor Microenvironment: Toward Innovative Therapies食管腺癌与其肿瘤微环境的相互作用：迈向创新疗法DOI: 10.3390/cells14231895
The Clinical journal of pain IF: 03.100Ahead of Print.No.166An Ecological Momentary Assessment Study Examining the Efficacy of Third-wave Cognitive Behavioral Therapies on Different Indices of Pain-related Outcomes评估第三代认知行为疗法对不同疼痛相关结局指标有效性的生态瞬时评估研究DOI: 10.1097/AJP.0000000000001350
Food science & nutrition IF: 03.800Volume 13, Issue 12No.167Effects of Angelica archangelica Extract on Overactive Bladder: A Pilot Randomized Controlled Trial白芷提取物对膀胱过度活动症的影响：一项初步随机对照试验DOI: 10.1002/fsn3.71258
Frontiers in nutrition IF: 05.100Volume 12, Issue No.168Barriers and facilitators to lifestyle behavior change and goal setting in adolescents with polycystic ovary syndrome多囊卵巢综合征青少年生活方式行为改变和目标设定中的障碍与促进因素DOI: 10.3389/fnut.2025.1628853
JAACAP openVolume 3, Issue 4No.169The Effect of Bariatric Surgery on Quality of Life and Depression减重手术对生活质量和抑郁的影响DOI: 10.1016/j.jaacop.2025.02.001
Front Glob Womens Health IF: 02.400Volume 6, Issue No.170Bladder prolapse (cystocele) among African, Asian, and Middle Eastern women: a clinical and socio-cultural perspective非洲、亚洲和中东女性的膀胱脱垂（膀胱膨出）：临床与社会文化视角DOI: 10.3389/fgwh.2025.1696375
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.171A surge in fulminant idiopathic intracranial hypertension cases within 1 year from the coronavirus disease 2019 pandemic lockdown: A case series新型冠状病毒病2019大流行封锁一年内爆发性特发性颅内高压病例激增：病例系列报道DOI: 10.4103/sjopt.sjopt_5_24
Frontiers in physiology IF: 03.400Volume 16, Issue No.172Web-based high-intensity bodyweight interval training improves metabolic health and physical fitness outcomes in middle-aged men with obesity during the COVID-19 pandemicCOVID-19大流行期间，基于网络的高强度自重间歇训练改善肥胖中年男性的代谢健康与体能DOI: 10.3389/fphys.2025.1711436
Pediatric obesity IF: 02.700Volume 21, Issue 1No.173BMI Percentile Cutoffs for Overweight and Obesity Are Set Too High in Terms of Adiposity and Metabolic Markers for Asian Children and Adolescents针对亚洲儿童和青少年的肥胖与代谢标志物而言，现行超重与肥胖的BMI百分位切点设置过高DOI: 10.1111/ijpo.70075
British journal of nutrition IF: 03.000Ahead of Print.No.174Individual and environmental factors affect the consumption of ultra-processed foods among Brazilian adolescents: results from the National School Health Survey个体与环境因素影响巴西青少年超加工食品消费：全国学生健康调查结果DOI: 10.1017/S0007114525105898
Medicine IF: 01.400Volume 104, Issue 49No.175Chronic kidney disease and cardiovascular risk: Pathophysiology and interventional approaches - systematic review慢性肾脏病与心血管风险：病理生理学及干预策略——系统性综述DOI: 10.1097/MD.0000000000046189
BMC nutrition IF: 02.200Ahead of Print.No.176The association between dietary acid load and Kidney/Liver function in morbidly obese bariatric candidates饮食酸负荷与病态肥胖减重手术候选者肝肾功能之关联DOI: 10.1186/s40795-025-01216-w
Cardiology in Review IF: 02.300Ahead of Print.No.177Atherosclerotic Cardiovascular Disease in South Asians: Epidemiology, Risk Factors, and Management南亚人动脉粥样硬化性心血管疾病：流行病学、风险因素与管理DOI: 10.1097/CRD.0000000000001144
Curēus IF: 01.300Volume 17, Issue 12No.178Severe Adverse Effects of Tirzepatide Overdose Requiring Intensive Care Unit Admission and Complex Rehabilitation替尔泊肽过量导致需入住重症监护室及复杂康复的严重不良反应DOI: 10.7759/cureus.98681
Journal of pain research IF: 02.500Volume 18, Issue No.179Comparative Cardiovascular Safety of Duloxetine and Gabapentin in Patients with Hip Osteoarthritis髋关节骨关节炎患者中度洛西汀与加巴喷丁心血管安全性的比较研究DOI: 10.2147/JPR.S557621
Int J Anal Chem IF: 01.700Volume 2025, Issue No.180A Comparative Study in Metformin Tablet Quality Assessment: LC-MS and LC-MS/MS Method Quantification of N-Nitroso-Dimethylamine in the Presence of Dimethyl Formamide二甲双胍片剂质量评估的比较研究：使用LC-MS和LC-MS/MS方法在二甲基甲酰胺存在下定量N-亚硝基二甲胺DOI: 10.1155/ianc/5625153
Lab on a chip IF: 05.400Ahead of Print.No.181Clog-free all-aqueous microfluidic fabrication of hydrogel microfibers governed by a universal scaling law受普适性标度律支配的无堵塞全水相微流体制备水凝胶微纤维DOI: 10.1039/d5lc01007a
Indian J Crit Care Med IF: 01.500Volume 29, Issue 11No.182Role of Urinary Biomarkers TIMP-2 and IGFBP7 in Predicting Acute Kidney Injury in Critically Ill Trauma Patients: A Prospective Observational Study尿液生物标志物TIMP-2和IGFBP-7在预测危重创伤患者急性肾损伤中的作用：一项前瞻性观察性研究DOI: 10.5005/jp-journals-10071-25090
Clinical ophthalmology IF: 02.200Volume 19, Issue No.183Comparison of Amniotic Membrane Extract and Insulin Eye Drops for the Management of Persistent Epithelial Defects: A Multicenter Retrospective Study羊膜提取物滴眼液与胰岛素滴眼液治疗持续性上皮缺损的疗效比较：一项多中心回顾性研究DOI: 10.2147/OPTH.S561775
Obesity pillarsVolume 16, Issue No.184The impact of ultra-processed foods on pediatric health超加工食品对儿童健康的影响DOI: 10.1016/j.obpill.2025.100203
World journal of hepatology IF: 02.500Volume 17, Issue 11No.185Roles of short-chain fatty acids in metabolic dysfunction-associated steatotic liver disease and metabolic dysfunction-associated steatohepatitis短链脂肪酸在代谢功能障碍相关脂肪性肝病和代谢功能障碍相关脂肪性肝炎中的作用DOI: 10.4254/wjh.v17.i11.113756
World journal of hepatology IF: 02.500Volume 17, Issue 11No.186Beyond bones: Revisiting the role of vitamin D in chronic liver disease超越骨骼：再审视维生素D在慢性肝病中的作用DOI: 10.4254/wjh.v17.i11.112315
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.187Decoding metabolic dysfunction in cancer: foundations for early detection and personalized therapeutics解码癌症中的代谢功能障碍：为早期检测与个性化治疗奠定基础DOI: 10.3389/fendo.2025.1693142
Microbiota and hostVolume 3, Issue 1No.188Diet-Microbiota-Host Interactions in Regulation of Cardiometabolic Homeostasis: Emerging Mechanisms and Therapeutic Potential饮食-微生物群-宿主相互作用在调节心脏代谢稳态中的作用：新机制与治疗潜力DOI: 10.1530/mah-25-0008
Pediatric obesity IF: 02.700Volume 21, Issue 1No.189Inflammatory Dietary Pattern Associated With Metabolic Biomarkers, Blood Pressure and Anthropometric Indicators in Brazilian Adolescents炎症性膳食模式与巴西青少年的代谢生物标志物、血压和人体测量指标相关DOI: 10.1111/ijpo.70079
Journal of experimental biology IF: 02.600Ahead of Print.No.190Insulin-like peptide has antagonistic pleiotropic effects on male combat traits and survival traits胰岛素样肽对雄性战斗特征和生存特征具有拮抗性多效作用DOI: 10.1242/jeb.251318
Medicine IF: 01.400Volume 104, Issue 49No.191Adipokines and adiposity indices as predictors of glycemic status, insulin resistance, and metabolic dysfunction-associated steatotic liver disease in apparently healthy adults脂肪因子和肥胖指数作为预测看似健康成人血糖状态、胰岛素抵抗和代谢功能障碍相关性脂肪性肝病的指标DOI: 10.1097/MD.0000000000046498
Lipids in health and disease IF: 04.200Ahead of Print.No.192Prevalence, correlates of dyslipidaemia, and 10-year cardiovascular risk among people living with HIV and people without HIV adults in Rwanda: insights from the NCOHIRWA cohort study卢旺达成人HIV感染者与未感染者中血脂异常的患病率、相关因素及10年心血管风险：来自NCOHIRWA队列研究的启示DOI: 10.1186/s12944-025-02813-1
Obesity pillarsVolume 16, Issue No.193Dietary supplement considerations during glucagon-like Peptide-1 receptor agonist treatment: A narrative review胰高血糖素样肽-1受体激动剂治疗期间的膳食补充剂考量：一篇叙事性综述DOI: 10.1016/j.obpill.2025.100209
Int J Dermatol IF: 03.200Ahead of Print.No.194Glucagon-Like Peptide-1 Receptor Agonists Are Associated With Reduced Disease Severity and Pain in Hidradenitis Suppurativa: A Retrospective Study胰高血糖素样肽-1受体激动剂与化脓性汗腺炎疾病严重程度及疼痛减轻相关：一项回顾性研究DOI: 10.1111/ijd.70191
Medicine IF: 01.400Volume 104, Issue 49No.195Assessing the shadows: A meta-analysis of GLP-1 agonists and suicidal ideation阴影评估：一项关于GLP-1激动剂与自杀意念的Meta分析DOI: 10.1097/MD.0000000000046173
Muscle & nerve IF: 03.100Ahead of Print.No.196Management of Small Fiber Neuropathy: A Clinical Perspective小纤维神经病的管理：临床视角DOI: 10.1002/mus.70086
Curēus IF: 01.300Volume 17, Issue 11No.197A Case of Slowly Progressive Type 1 Diabetes Mellitus (SPIDDM, Probable) Successfully Managed With Oral Semaglutide for Glycemic Control and Weight Management Accompanied by Changes in Eating Behavior口服司美格鲁肽成功管理一例缓慢进展性1型糖尿病（SPIDDM，可能）患者的血糖控制和体重，并伴有饮食行为改变DOI: 10.7759/cureus.96335
Cardiology in Review IF: 02.300Ahead of Print.No.198Bridging Cardiorenal and Hepatic Disease: The Emerging Role of SGLT2 Inhibitors in Cirrhosis连接心肾与肝脏疾病：SGLT2抑制剂在肝硬化中的新兴作用DOI: 10.1097/CRD.0000000000001141
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.199Acceleration of moyamoya disease after anti-vascular endothelial growth factor intravitreal injections抗血管内皮生长因子玻璃体内注射后烟雾病的加速进展DOI: 10.4103/sjopt.sjopt_272_23
J Res Health Sci IF: 01.400Volume 26, Issue 1No.200The Association Between Opium Consumption, Diabetes, and Hypertension Among Male Participants in the Tabari Cohort Population: A Cross-sectional Study鸦片消费、糖尿病与高血压之间的关联：基于Tabari队列男性参与者的横断面研究DOI: 10.34172/jrhs.11343
Medicine IF: 01.400Volume 104, Issue 49No.201Association between triglyceride-glucose index, inflammation, and mitral annular calcification甘油三酯-葡萄糖指数、炎症与二尖瓣环钙化之间的关联DOI: 10.1097/MD.0000000000046313
Iranian journal of immunology IF: 01.100Volume 22, Issue 4No.202The Immunoregulatory Role of Programmed Death-Ligand 1 in Wound Healing Dynamics程序性死亡配体-1在伤口愈合动态中的免疫调节作用DOI: 10.22034/iji.2025.107588.3070
JAHA IF: 05.300Ahead of Print.No.203Relations of Artificial Intelligence Vascular Age With Cardiometabolic Disease Progression: The Framingham Heart Study人工智能血管年龄与心脏代谢疾病进展的关系：Framingham心脏研究DOI: 10.1161/JAHA.125.044872
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.204Foot Temperature Measurement in People With Diabetes: Validation of a Non-Contact Thermal Device糖尿病患者足部温度测量：一种非接触式热成像设备的验证DOI: 10.1177/19322968251398863
Prep Biochem Biotechnol IF: 01.900Ahead of Print.No.205Stabilization of gold nanoparticles (Rp@AuNPs) by Ruellia patula extract for broad-spectrum antimicrobial, anti-inflammatory and anti-diabetic activities利用 Ruellia patula 提取物稳定金纳米颗粒 (Rp@AuNPs) 以获取广谱抗菌、抗炎和抗糖尿病活性DOI: 10.1080/10826068.2025.2596060
Kaohsiung J Med Sci IF: 03.100Ahead of Print.No.206Metabolic Dysfunction-Associated Steatotic Liver Disease After Hepatitis C Virus Cure丙型肝炎病毒治愈后的代谢功能障碍相关脂肪性肝病DOI: 10.1002/kjm2.70155
Hypertension IF: 08.200Ahead of Print.No.207Impact of Age, Sex, and Race on Primary Aldosteronism Test Interpretations年龄、性别与种族对原发性醛固酮增多症检测结果解读的影响DOI: 10.1161/HYPERTENSIONAHA.125.25855
J Res Pharm Pract IF: 00.800Volume 14, Issue 4No.208Associations between Patients' Demographics and Chronic Medication Utilization in Internal Medicine: Cross-sectional Study内科患者人口统计学特征与慢性药物使用的关联：一项横断面研究DOI: 10.4103/jrpp.jrpp_61_25
Frontiers in pharmacology IF: 04.800Volume 16, Issue No.209Thiamine as a putative natural modulator of PPARγ: exploring a nutrient-based approach for type 2 diabetes硫胺素作为PPARγ的推定天然调节剂：探索治疗2型糖尿病的营养学方法DOI: 10.3389/fphar.2025.1712511
Journal of pregnancy IF: 02.200Volume 2025, Issue No.210High Risk of Anxiety and Depression in Women With Different Types of Pregnancy Complications in France: A Cross-Sectional Study法国不同类型妊娠并发症女性焦虑与抑郁的高风险：一项横断面研究DOI: 10.1155/jp/9221290
International journal of exercise scienceVolume 18, Issue 5No.211The Effect of High-Intensity Interval Training on Visceral Adipose Tissue in Type 2 Diabetes: A Systematic Review高强度间歇训练对2型糖尿病患者内脏脂肪组织影响的系统综述DOI: 10.70252/YEUF2363
Surgical case reports IF: 00.700Volume 11, Issue 1No.212Spontaneous Closure of Bronchopleural Fistula after Right Upper Lobectomy without Invasive Interventions-A Case Report右肺上叶切除术后支气管胸膜瘘未经侵入性干预自发闭合一例报告DOI: 10.70352/scrj.cr.25-0432
Case reports in medicine IF: 00.800Volume 2025, Issue No.213Delayed-Onset Hypoglycemia After Levofloxacin Use in a Diabetic Patient糖尿病患者使用左氧氟沙星后的迟发性低血糖DOI: 10.1155/carm/3220993
Biotechnology reportsVolume 48, Issue No.214Investigating a new Dillenia ovata endophytic bacteria to produce antioxidants and anti-diabetes activity in vitro and in vivo研究新型Dillenia ovata内生细菌以在体外和体内产生抗氧化和抗糖尿病活性DOI: 10.1016/j.btre.2025.e00921
Current hepatology reportsVolume 24, Issue 1No.215Met-ALD and ALD- Does Differentiating These Impact Management and Clinical Outcomes?区分Met-ALD与ALD：是否影响治疗策略与临床结局？DOI: 10.1007/s11901-025-00712-8
Indian J Crit Care Med IF: 01.500Volume 29, Issue 11No.216Maternal and Fetal Outcomes in Pregnant Women Admitted to the Intensive Care Unit with A/H1N1pdm or SARS-CoV-2 Infection: A Retrospective Study入住重症监护室的A/H1N1pdm或SARS-CoV-2感染孕妇的母婴结局：一项回顾性研究DOI: 10.5005/jp-journals-10071-25075
Journal of diabetes research IF: 03.400Volume 2025, Issue No.217QTc Interval and Its Associated Factors in Patient With Type 2 Diabetic Mellites2型糖尿病患者QTc间期及其相关因素DOI: 10.1155/jdr/8664620
Journal of diabetes research IF: 03.400Volume 2025, Issue No.218RETRACTION: Short-Chain Fatty Acid Propionate Alleviates Akt2 Knockout-Induced Myocardial Contractile Dysfunction撤回：短链脂肪酸丙酸减轻Akt2基因敲除诱导的心肌收缩功能障碍DOI: 10.1155/jdr/9829275
Res Pract Thromb Haemost IF: 03.400Volume 9, Issue 7No.219Evaluation of kidney function and damage in patients with hemophilia B-insights from the B-Natural studyB型血友病患者肾功能与损伤评估——来自B-Natural研究的启示DOI: 10.1016/j.rpth.2025.103181
Journal of medical casesVolume 16, Issue 12No.220Atypical Presentation of Gangrenous Cholecystitis in a Patient With Diabetes Mellitus糖尿病患者不典型坏疽性胆囊炎表现一例DOI: 10.14740/jmc4291
World journal of hepatology IF: 02.500Volume 17, Issue 11No.221Redefining fatty liver as metabolic dysfunction-associated steatotic liver disease: Implications of nomenclature changes for patients with diabetes将脂肪肝重新定义为代谢功能障碍相关脂肪性肝病：命名变更对糖尿病患者的临床意义DOI: 10.4254/wjh.v17.i11.112573
World journal of hepatology IF: 02.500Volume 17, Issue 11No.222Liver as a metabolic sensor in gestational diabetes: Implications for offspring's liver and diabetes risk肝脏作为妊娠期糖尿病的代谢传感器：对子代肝脏和糖尿病风险的影响DOI: 10.4254/wjh.v17.i11.110185
Curēus IF: 01.300Volume 17, Issue 12No.223Group Education and Communities of Practice: A Sustainable Model for Promoting Healthy Habits and Valuing Professional Work团体教育与实践社区：一个促进健康习惯与认可专业价值的可持续模式DOI: 10.7759/cureus.98688
Plast Reconstr Surg Glob Open IF: 01.800Volume 13, Issue 12No.224Combined Vacuum-assisted Closure Therapy and CACIPLIQ20 for Chronic Wound Management真空辅助闭合疗法联合CACIPLIQ20治疗慢性伤口DOI: 10.1097/GOX.0000000000007341
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.225Artifactual hypoglycemia caused by Raynaud's phenomenon: A case report with literature review雷诺现象导致的人为性低血糖：病例报告及文献回顾DOI: 10.3389/fendo.2025.1695633
Frontiers in endocrinology IF: 04.600Volume 16, Issue No.226Associations between neutrophil-lymphocyte ratio with all-cause mortality, major adverse vascular events and progression of diabetic kidney disease in type 2 diabetes mellitus中性粒细胞-淋巴细胞比率与2型糖尿病患者全因死亡率、主要不良血管事件及糖尿病肾病进展的关联DOI: 10.3389/fendo.2025.1695139
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.227Clinical insights into mitochondrial retinopathy: A case report on m.3243A>G mutation and macular dystrophy线粒体视网膜病变的临床洞见：一例m.3243A>G突变与黄斑营养不良的病例报告DOI: 10.4103/sjopt.sjopt_314_24
Saudi journal of ophthalmology IF: 01.200Volume 39, Issue 4No.228Posterior scleritis in an 18-year-old female with primary familial brain calcification syndrome: Incidental finding or association?18岁女性原发性家族性脑钙化综合征患者出现后巩膜炎：偶然发现还是存在关联？DOI: 10.4103/sjopt.sjopt_116_24
ERJ open research IF: 04.000Volume 11, Issue 6No.229Circadian variability in breath volatiles is affected by the timing of inhaled corticosteroids in asthma吸入糖皮质激素的用药时间影响哮喘患者呼出挥发性有机化合物的昼夜变化DOI: 10.1183/23120541.00277-2025
Pediatric diabetes IF: 05.600Volume 2025, Issue No.230Revealing Monogenic Diabetes: Clinical and Genetic Features of Pediatric MODY Cases in Türkiye: Single Center Experience揭示单基因糖尿病：土耳其儿童MODY病例的临床与遗传学特征——单中心经验DOI: 10.1155/pedi/4035026
Int J Nurs Sci IF: 03.100Volume 12, Issue 6No.231Comment on Numsang et al. (2025) 'Effects of a culture-specific behavior modification program on glycated hemoglobin and blood pressure among adults with diabetes and hypertension: A randomized controlled trial'关于Numsang等人（2025）《针对成年糖尿病及高血压患者的特异性文化行为修正项目对糖化血红蛋白与血压的影响：一项随机对照试验》的述评DOI: 10.1016/j.ijnss.2025.10.012
Curēus IF: 01.300Volume 17, Issue 11No.232Electron Microscopy in Renal Biopsy Interpretation: When and Why It Still Matters电子显微镜在肾活检解读中的作用：为何它仍然至关重要DOI: 10.7759/cureus.96311
Curēus IF: 01.300Volume 17, Issue 11No.233Influence of Diabetes Mellitus on Metabolic and Hormonal Interactions Promoting Aggressive Prostate Cancer糖尿病对代谢和激素相互作用促进侵袭性前列腺癌的影响DOI: 10.7759/cureus.96338
Curēus IF: 01.300Volume 17, Issue 11No.234Type 3 Sturge-Weber Syndrome Presenting With Concurrent Epilepsy and Migraine以癫痫与偏头痛共现为表现的3型斯特奇-韦伯综合征DOI: 10.7759/cureus.96262
Curēus IF: 01.300Volume 17, Issue 11No.235Hindfoot Nailing for Ankle Fractures in High-Risk Elderly Patients: A Retrospective Analysis of Clinical and Radiological Outcome高危老年患者踝部骨折行足跟骨内固定的临床与影像学结果回顾性分析DOI: 10.7759/cureus.96358
Curēus IF: 01.300Volume 17, Issue 11No.236From Commensal to Pathogen: Unveiling Klebsiella pneumoniae subsp. ozaenae as a Cause of Meningitis and a Literature Review从共生菌到病原体：揭示肺炎克雷伯菌鼻硬结亚种作为脑膜炎的病因及文献回顾DOI: 10.7759/cureus.96255
Curēus IF: 01.300Volume 17, Issue 11No.237Role of C-reactive Protein (CRP) Levels and Glycemic Control in Outcome of Diabetic Foot Ulcer HealingC反应蛋白(CRP)水平与血糖控制在糖尿病足溃疡愈合结局中的作用DOI: 10.7759/cureus.96342
Curēus IF: 01.300Volume 17, Issue 11No.238Coexistence of Maturity-Onset Diabetes of the Young Type 3 (MODY 3) and Diabetic Ketoacidosis: A Report of a Rare Case青少年发病的成人型糖尿病3型与糖尿病酮症酸中毒共存：一例罕见病例报告DOI: 10.7759/cureus.96360
Curēus IF: 01.300Volume 17, Issue 11No.239Cardiorenal Safety Markers With Injectable Glucagon-Like Peptide-1 (GLP-1) Agonists in Type 2 Diabetes: A Network Meta-Analysis2型糖尿病患者使用注射用胰高血糖素样肽-1（GLP-1）受体激动剂的心肾安全性标记：一项网络Meta分析DOI: 10.7759/cureus.96162
Curēus IF: 01.300Volume 17, Issue 11No.240Anemia in Heart Failure: A Systematic Review of Prevalence and Prognostic Impact心力衰竭中的贫血：患病率与预后影响的系统综述DOI: 10.7759/cureus.96363
Curēus IF: 01.300Volume 17, Issue 11No.241Prospective Evaluation of the Society for Vascular Surgery (SVS) Wound, Ischemia, and Foot Infection (WiFi) Classification for Predicting Amputation Risk in Diabetic Foot Ulcers at a South Indian Tertiary Care Center前瞻性评估血管外科学会（SVS）伤口、缺血及足部感染（WIfI）分类对南印度三级医疗中心糖尿病足溃疡截肢风险的预测能力DOI: 10.7759/cureus.96361
Front Clin Diabetes Healthc IF: 02.200Volume 6, Issue No.242GLP-1 agonists and exercise: the future of lifestyle prioritizationGLP-1激动剂与运动：生活方式干预的未来优先方向DOI: 10.3389/fcdhc.2025.1720794
J Am Coll Health IF: 01.500Ahead of Print.No.243Systemic arterial hypertension, dyslipidemia, diabetes mellitus, obesity, and physical inactivity in nursing students: a prospective longitudinal study护理专业学生系统性动脉高血压、血脂异常、糖尿病、肥胖与体力活动不足：一项前瞻性纵向研究DOI: 10.1080/07448481.2025.2593305
Pediatric obesity IF: 02.700Volume 21, Issue 1No.244Beyond Gestational Diabetes: Maternal and Offspring Health and Lifestyle 3 Years Postnatally in a Secondary Analysis of the UPBEAT Trial Cohort超越妊娠期糖尿病：UPBEAT试验队列二次分析揭示产后3年的母婴健康与生活方式DOI: 10.1111/ijpo.70076
Journal of materials chemistry IF: 05.700Ahead of Print.No.245A super absorbent decellularized human amniotic membrane microgel for chronic wound healing and accelerated skin regeneration一种用于慢性伤口愈合和加速皮肤再生的超吸收性去细胞人羊膜微凝胶DOI: 10.1039/d5tb02039e
Journal of medicinal chemistry IF: 06.800Ahead of Print.No.246Sulfanylbenzamides with Unique Side Chains to Improve Metabolic Stability, Pharmacokinetics, and Anti-HIV Activity具有独特侧链的磺硫基苯甲酰胺类化合物可改善代谢稳定性、药代动力学和抗HIV活性DOI: 10.1021/acs.jmedchem.5c00748
Pediatric obesity IF: 02.700Volume 21, Issue 1No.247Components of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping以进食障碍为结局的青少年行为干预方案构成要素：结合干预图谱的系统综述DOI: 10.1111/ijpo.70074
European Journal of Immunology IF: 03.700Volume 55, Issue 12No.248IL-10- and IL-13-Biased T Cell Responses to SARS-CoV-2 Vaccination in Diabetes糖尿病患者接种SARS-CoV-2疫苗后出现IL-10和IL-13偏向性T细胞反应DOI: 10.1002/eji.70112
Acta Oncologica IF: 02.200Volume 64, Issue No.249Revisiting insulin resistance in human cancer cachexia - a systematic review and meta-analysis重新审视人类癌症恶病质中的胰岛素抵抗——一项系统综述和荟萃分析DOI: 10.2340/1651-226X.2025.44280
Obesity IF: 04.700Ahead of Print.No.250Real-World Evidence on Weight Loss and Safety With Semaglutide in Obesity Telehealth: A Large Retrospective Cohort Study司美格鲁肽在肥胖远程医疗中的减重效果与安全性真实世界证据：一项大型回顾性队列研究DOI: 10.1002/oby.70120
Acta Obstet Gynecol Scand IF: 03.100Ahead of Print.No.251Risk factors for shoulder dystocia-related brachial plexus injuries: A case-control study肩难产相关臂丛神经损伤的风险因素：一项病例对照研究DOI: 10.1111/aogs.70116
Aust N Z J Obstet Gynaecol IF: 01.700Ahead of Print.No.252Clinical Outcomes and Women's Experiences of the 'OMGP' Model of Care新型产科医学助产士团队实践（OMGP）模式的临床结局与患者体验DOI: 10.1111/ajo.70086
JMIR research protocols IF: 01.500Ahead of Print.No.253Effectiveness of metformin prolonged-release on achievement of optimal glycemic control in gestational diabetes mellitus: Protocol for a pilot, randomized, double-blind, clinical trial二甲双胍缓释剂治疗妊娠期糖尿病血糖达标效果：一项随机双盲临床试验方案DOI: 10.2196/79855
J Diabetes Sci Technol IF: 03.700Ahead of Print.No.254Diabetes Conferences Should Go Green!糖尿病会议应当走向绿色！DOI: 10.1177/19322968251383916
J Res Health Sci IF: 01.400Volume 26, Issue 1No.255The Association Between Health Literacy and General Health in Women With Gestational Diabetes: A Cross-sectional Study妊娠期糖尿病患者健康素养与总体健康水平的关联：一项横断面研究DOI: 10.34172/jrhs.11438
Prog Biomed Eng (Bristol) IF: 07.700Volume 3, Issue 2No.256Optical sensors for continuous glucose monitoring用于连续葡萄糖监测的光学传感器DOI: 10.1088/2516-1091/abe6f8
Medicine IF: 01.400Volume 104, Issue 49No.257Two decades of mortality trends in pancreatic cancer and diabetes mellitus: A retrospective cross-sectional study of the United States population (1999-2020)胰腺癌与糖尿病死亡率趋势二十年回顾：基于美国人口（1999-2020）的横断面研究DOI: 10.1097/MD.0000000000046372
Lancet Reg Health Am IF: 07.600Volume 54, Issue No.258Rapid weight gain in first 2 years of life and BMI trajectories from 3 to <10 years: a population-based longitudinal study of 1.7 million Brazilian children生命前两年快速增重与3至10岁BMI轨迹的关联研究：一项针对170万巴西儿童的基于人群的纵向研究DOI: 10.1016/j.lana.2025.101326
Heart Failure Reviews IF: 04.200Volume 31, Issue 1No.259The impact of oral semaglutide on cardiovascular events in patients with type 2 diabetes: review of results from the SOUL trial口服司美格鲁肽对2型糖尿病患者心血管事件的影响：SOUL试验结果回顾DOI: 10.1007/s10741-025-10579-y
NMCD IF: 03.700Ahead of Print.No.260Sex-specific associations of anthropometric markers with prediabetes in the general population普通人群中人体测量标志物与糖尿病前期的性别特异性关联DOI: 10.1016/j.numecd.2025.104515
233
Diabetes Mellitus(DM)
糖尿病
104
Obesity
肥胖症
75
Insulin
胰岛素
29
Type 2 diabetes mellitus(T2DM)
2型糖尿病
14
Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA)
胰高血糖素样肽-1受体激动剂
13
Semaglutide
司美格鲁肽
12
Hypoglycemic Agents
降糖药
12
Metabolic Syndrome
代谢综合征
10
Diabetic Kidney Disease(DKD)
糖尿病肾脏病
9
Gestational Diabetes Mellitus(GDM)
妊娠糖尿病
8
Metformin
二甲双胍
7
Diabetic Foot
糖尿病足
5
Gabapentin
加巴喷丁
5
Type 1 diabetes mellitus(T1DM)
1型糖尿病
5
Liraglutide
利拉鲁肽
4
Tirzepatide
替尔泊肽
4
Diabetic Neuropathies
糖尿病性神经病变
4
Diabetic acidosis
糖尿病性酸中毒
3
Diabetic Retinopathy
糖尿病视网膜病
3
Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i)
钠-葡萄糖协同转运蛋白2抑制剂
3
Dapagliflozin
达格列净
3
Dipeptidyl-Peptidase IV Inhibitors(DPP-4i)
二肽基肽酶-4抑制剂
2
Sitagliptin
西他列汀
2
Dulaglutide
度拉糖肽
2
Empagliflozin
恩格列净
2
Pregabalin
普瑞巴林
1
Diabetes Complications
糖尿病并发症
1
Canagliflozin
卡格列净
1
Exenatide
艾塞那肽
1
Albiglutide
阿必鲁肽
1
Lixisenatide
利司那肽
编辑：韩玉莲
审校：韩玉莲
临床结果临床研究
2025-12-02
·雪球
$AxsomeTherapeutics(AXSM)$当大家都在追逐新机制、新分子实体的时候，有这样一家公司，把已经上市的老药来开发创新药物，并在CNS神经系统疾病领域取得了成功。这家公司就是AxsomeTherapeutics。01公司简介AxsomeTherapeutics是一家生物制药公司，致力于开发针对治疗选择有限的中枢神经系统（CNS）疾病的新疗法。通过开发具有新机制的治疗方案，公司正在改变治疗中枢神经系统疾病的方法。公司核心产品为Availability用于重度抑郁症，Simbravo用于偏头痛治疗以及Senosi用于嗜睡症治疗。023季度业绩总览营收：Q3总净销售额1.71亿美元（同比增长63%）；其中Availability销售额1.36亿美元（同比增长69%，环比增长14%），Sunosi销售额3300万美元（同比增长35%），Symbravo（第二季度末推出，首完整季度）销售额210万美元。在研项目：AXS-05治疗阿尔茨海默病激越的补充新药申请已提交给美国食品药品监督管理局。预计AXS-12治疗发作性睡病猝倒的新药申请将于2025年第四季度提交。预计2025年第四季度启动Senosi托治疗儿童和青少年注意缺陷多动障碍的3期临床试验。正在推进多项针对暴食症、轮班工作障碍、与白天过度嗜睡相关的重度抑郁症、纤维肌痛和戒烟的创新后期项目。当前治疗领域：重度抑郁（MDD）、阻塞性睡眠呼吸暂停（Obstructivesleepapnea，OSA）、偏头痛（Migraine）。重点开发领域：阿尔兹海默、嗜睡症（Narcolepsy）、纤维肌痛综合征（Fibromyalgia）未来有机会的领域：注意力缺陷多动障碍、暴食症、轮班工作障碍、伴有白天过度嗜睡的MDD、戒烟03研发管线-160亿美金销售峰值潜力公司管线的预计销售峰值超过160亿美元。获批适应症：Auvelity/AXS-05（MDD）10-30亿，Symbravo（偏头痛）5-10亿，Sunosi/Solriamfetol（OSA）3-5亿。在研适应症：AXS-05（ADagitation）15-30亿，AXS-05（戒烟）5-10亿，AXS-12（嗜睡症）5-10亿，AXS-14（纤维肌痛综合征）5-10亿，Solriamfetol(轮班工作障碍，SWD)3-5亿，Solriamfetol(暴食症，BED)5-10亿，Solriamfetol(注意力缺陷多动障碍，ADHD)10-30亿，Solriamfetol(伴有白天过度嗜睡的MDD，MDDwithEDS)10-15亿。Auvelity/AXS-05（右美沙芬/安非他酮）Auvelity（右美沙芬/安非他酮）是一种2022年在美国获批的新型口服复方抗抑郁药，用于治疗成人重度抑郁症（MDD）。Auvelity并非全新化合物，而是将两种已知成分组合，产生了“1+1>2”的效果。右美沙芬通常用作止咳药。在抗抑郁治疗中，它被认为是一种NMDA受体拮抗剂和σ-1受体激动剂。这种对大脑谷氨酸系统的调节作用，与传统抗抑郁药（如SSRIs）的作用路径不同。安非他酮：一种成熟的抗抑郁药，同时也是一个关键的“增效剂”。它通过抑制肝脏中的CYP2D6代谢酶，显著减缓右美沙芬在体内的分解，从而提高其血药浓度和疗效。在关键的III期临床试验中，Auvelity展现出以下特点：快速起效：与安慰剂相比，接受Auvelity治疗的患者在第1周就在抑郁评分量表上显示出具有统计学意义的改善。显著改善：在第6周，Auvelity组患者抑郁症状的改善程度显著优于安慰剂组。Auvelity销售额持续增长。阿尔兹海默激越适应症拓展：阿尔茨海默病患者中，高达70%的患者会出现激越，其特征是情绪障碍、言语和身体上的攻击性、易怒等。AD的激越与认知能力加速下降、照护者负担增加、过早进入疗养院和死亡率增加有关。目前关于AD激越症状的药物治疗主要是使用抗抗精神病药物如奥氮平、喹硫平、利培酮等，或者使用安定类药物镇静。但长期使用会有导致患者出现嗜睡、口干、异常运动、代谢综合征等不良反应。并且一些研究发现他们与痴呆患者死亡风险增加有关。所以AD患者的激越症状控制一直是AD治疗中很大的未满足需求。AXS-05被认为能够调节与阿尔茨海默病相关的神经递质和受体的功能（谷氨酸、σ-1受体、去甲肾上腺素和多巴胺）。2020年6月AXS-05获FDA突破性疗法认定，2024年12月完成三项关键III期试验（ADVANCE-1、ACCORD-1、ACCORD-2），2025年已经提交新药申请。ADVANCE-1：研究结果显示，与安慰剂组相比，AXS-05治疗组患者的CMAI总分在统计学上显著降低，达到主要终点。AXS-05组总分平均降低15.4分，安非他酮组为10.0分（p<0.001），安慰剂组为11.5分（p=0.010），具有统计学意义的平均值降低。与基线水平相比，AXS-05组患者躁动的平均百分比降低了48%，安慰剂组为38%。同时，AXS-05在CMAI总分上也优于安非他酮治疗组（p<0.001）。ACCORD-2：研究结果显示，与安慰剂相比，AXS-05显著延迟了AD躁动复发时间(复发时间风险比为0.276；P=0.001)。此外，接受AXS-05治疗的患者中，8.4%出现AD躁动复发，而改用安慰剂的患者中，28.6%出现AD躁动复发(P=0.001)。值得注意的是，与安慰剂相比，AXS-05还显著降低了基于临床总体严重程度印象(CGI-S)评分的AD总体严重程度恶化程度(P<0.001)。Sunosi（Solriamfetol）Sunosi（Solriamfetol）是一种主要用于治疗发作性睡病或阻塞性睡眠呼吸暂停(OSA)引起的成人白天过度嗜睡的处方药，于2019年获批。作为一种多巴胺和去甲肾上腺素再摄取抑制剂，通过增加大脑中这两种神经递质的水平来促进觉醒。Sunosi（solriamfetol）的3期临床试验数据主要来自TONES研究项目，该项目包括四项随机安慰剂对照试验，证实了其在治疗发作性睡病（Narcolepsy）和阻塞性睡眠呼吸暂停（OSA）相关白天过度嗜睡（EDS）中的有效性。在为期12周的临床研究中，采用患者整体印象变化量表（PGIc）得分评估，大约68%-74%服用75mg剂量Sunosi的患者、大约78%-90%服用150mg剂量Sunosi的患者报告其整体临床状况有所改善。在第12周，与安慰剂组相比，Sunosi150mg剂量治疗发作性睡病患者以及所有剂量治疗OSA患者在维持清醒试验（MWT）的第1测试阶段（大约服药后1小时）至第5测试阶段（大约服药后9小时）评估的清醒度均表现出改善。轮班工作障碍/SWD，暴食症/BED,注意力缺陷多动障碍/ADHD),伴有白天过度嗜睡的MDD（MDDwithEDS）多适应拓展潜力。注意力缺陷多动障碍/ADHD：注意缺陷多动障碍（ADHD）是一种常见的神经发育障碍，主要表现为与年龄不符的注意力不集中、多动和冲动，可能影响学业、工作及人际关系。临床试验结果表明，在第6周时AISRS评分大幅降低17.7分，表明与基线相比，多动症症状改善了45%（p=0.039）。与安慰剂相比，达到临床反应（AISRS评分降低230%）的患者比例显著更高（p=0.024）。在第6周时，通过CGI-S总分衡量的整体多动症严重程度有所改善（p=0.017）。伴有白天过度嗜睡的MDD（MDDwithEDS）：在美国，重度抑郁障碍（MDD）是最常见的精神疾病之一，每年影响约2100万成年人。大约50%的MDD患者还伴有白天过度嗜睡（EDS），但目前对此尚无获批的治疗方法。预计在2025年第四季度启动重度抑郁症伴发嗜睡症的3期临床试验。暴食症/BED：正在进行3期临床，2026年读出顶线数据。轮班工作障碍/SWD：轮班工作障碍（SWD）是指在非7点至18点的工作时段工作时，白天过度嗜睡以及夜间睡眠持续性失眠的综合症状。solriamfetol治疗轮班工作障碍的SUSTAIN三期试验的初步结果预计于2026年公布。Symbravo（meloxicam和rizatriptan）2025年1月30日，SYMBRAVO（meloxicam和rizatriptan）正式获得美国食品药品监督管理局（FDA）批准，适用于伴或不伴先兆的偏头痛成人患者的急性治疗。SYMBRAVO的上市标志着偏头痛治疗领域的一项重要突破，为数千万患者提供了一种更快速、更持久的治疗选择。SYMBRAVO结合了两种作用机制，从不同途径阻断偏头痛。Rizatriptan可以选择性激动颅内血管和神经上的5-HT1B/1D受体，促使过度扩张的血管收缩，并抑制神经源性炎症和疼痛传导。meloxicam是一种非甾体抗炎药，可以抑制前列腺素合成以镇痛抗炎。SYMBRAVO的获批基于三项大规模3期临床试验——MOMENTUM、INTERCEPT和MOVEMENT的研究数据。这些试验共涉及数千名患者，累计用于超过两万次偏头痛发作的治疗，结果均显示出其显著的疗效和安全性。MOMENTUM试验（针对中重度偏头痛）：结果表明，SYMBRAVO组患者在给药2小时后，疼痛缓解率和最烦人症状（如畏光、畏声、恶心）缓解率均显著高于安慰剂组。此外，77%的患者在24小时内无需额外使用其他止痛药，显示出持久的疗效。INTERCEPT试验（针对初始疼痛较轻的偏头痛）：数据显示，SYMBRAVO在轻度偏头痛患者中同样表现出优异疗效，85%的患者在24小时内未使用补救治疗，进一步证实了其广泛适用性。MOVEMENT长期安全性试验：该研究涵盖706名患者，最长治疗时间达12个月，每位患者每月至少接受2次偏头痛治疗。研究结果显示，SYMBRAVO的长期使用安全性良好，未发现新的严重不良反应。AXS-12(reboxetine)去甲肾上腺素和多巴胺在睡眠-觉醒调节中都发挥着重要作用，并且在清醒时维持肌肉张力（去甲肾上腺素）。AXS-12（瑞波西汀）抑制这两种神经递质的再摄取，改善大脑中去甲肾上腺素和皮质多巴胺的信号传导。瑞波西汀过去用抑郁症的治疗，公司现在把它开发为治疗嗜睡症的创新药物。嗜睡症是一种罕见且使人衰弱的神经疾病，在美国约有18.5万人受其影响。其特征表现为猝倒、白天过度嗜睡（EDS）、临睡幻觉、睡眠瘫痪以及清醒时肌肉张力突然减弱或丧失，夜间睡眠紊乱。约70%的患者会出现猝倒症状。2024年3月25日，Axsome宣布AXS-12（瑞波西汀）治疗发作性睡病的III期SYMPHONY研究达到了主要终点，即AXS-12可以显著降低发作性睡病患者的猝倒频率。结果显示，与安慰剂组相比，AXS-12组患者每周猝倒发作频率较基线显著降低（-83%vs.-66%，p=0.018）。并且，在第1周时AXS-12即可迅速降低患者的猝倒发作频率（-56%vs.-31%，p=0.007）。此外，AXS-12不仅提高了达到猝倒缓解（定义为猝倒发作频率降低100%）的患者比例（33%vs.9.5%，p=0.008）还增加了无猝倒症状的天数（+84.5%vs.+22.6%，p=0.014）。2025年4季度将提交NDA。AXS-14(esreboxetine，艾司瑞博西汀)AXS-14是瑞博西汀消旋体中更具效力且更具选择性的对映体，它能抑制去甲肾上腺素的再摄取，从而增强去甲肾上腺素的活性并降低疼痛信号传导。纤维肌痛的疼痛被认为部分是由下行镇痛系统信号传导失调所导致的。公司已于2025年一季度向美国FDA提交了新药上市申请。但是2025年6月9日收到FDA拒绝受理函（RTF）。美国食品药品监督管理局（FDA）表示，经过初步审查，发现新药申请（NDA）不够完整，无法进行实质性审查。具体来说，FDA认为提交的两项安慰剂对照试验中的第二项并不充分且未得到良好控制，因为其主要终点是在第8周，且采用了灵活剂量的设计。因此公司计划2025年4季度发起新的3期临床试验。04总结Axsome的成功，关键在于将“临床未满足需求”、“差异化的产品力”和“高效的商业化”三者形成了闭环。它不追求最前沿、最热门但风险极高的全新靶点，而是致力于解决临床医生和患者切实面临的、缺乏有效治疗手段的痛点，并通过专利和剂型创新构建自己的壁垒。我们可以将Axsome的策略总结为以下几点：聚焦明确且艰难的大赛道：专注中枢神经系统疾病。这类疾病患者群体庞大（如抑郁症、阿尔茨海默病激越），但病理复杂、新药研发失败率高。Axsome的成功证明了，在这个巨头逐渐退出的领域，坚持创新能获得巨大回报。追求“巧”而非“全”的研发创新：其核心产品并非完全从零开始发现新靶点，而是通过对已知药物或靶点的创新性组合或重新定位来创造新价值。这降低了早期研发风险，加快了开发速度。Axsome公司在2025年9月也曾公开表示，在推动现有管线的同时，也对其他业务发展机会持开放态度。强调商业化与管线的紧密协同：公司不仅会研发，也擅长销售。对已上市产品如Auvelity，采用直接面向消费者的营销并结合销售团队扩张来驱动增长。在管线规划上，他们也注重后续产品能复用已有的商业渠道和医生关系。构建有层次和协同性的产品管线：公司管线涵盖从成熟市场到新兴领域，从核心大单品到潜力补充产品的多层次布局。这使得公司发展既有即时的现金流支持，又有长远的增长预期。对中国生物科技公司的启示：对于寻求差异化发展的中国生物科技公司，Axsome的路径提供了可参考的范式：选择合适的细分赛道：可考虑在CNS、自身免疫等存在大量未满足需求、且国内竞争格局尚未固化的领域深耕。建立差异化的研发策略：关注成熟靶点的新组合、新剂型、新适应症，利用AI辅助设计等工具，走“微创新”或“组合创新”的路径。以终为始规划管线：在研发早期就考虑未来的商业化路径，思考产品如何与市场现有方案竞争、如何进入医保、如何组织销售力量。构建可持续的现金流：通过license-in/out、与大型药企合作、或推动核心产品尽快上市，来支撑更长期的研发投入。
临床3期财报
2025-11-27
·探针资本
2025 年11月17日，灵北（Lundbeck）宣布，中国国家药品监督管理局药品审评中心（CDE）已正式受理了该公司就偏头痛治疗药物eptinezumab提交的新药上市申请（NDA），用于成人偏头痛的预防性治疗。在中国提交新药上市申请（NDA）的同时，灵北也在日本、韩国等国家同步提交了上市许可申请。该产品采用每12周通过静脉注射一次方案，是目前给药间隔最长的预防性用药，也展示出偏头痛临床管理未来愈发重视患者用药友好、缓解效果突出的方向。
一、偏头痛（Migraine）：患者庞大，仅次于三高人群的隐形疾病负担
偏头痛（Migraine）是一类以反复发作的中重度搏动性头痛为主要特征的神经系统疾病，其病程可持续数十年，对患者日常生活工作造成显著负担。与人们普遍理解的普通头痛不同，偏头痛是一种由中枢神经系统异常兴奋与疼痛调控失衡引发的疾病，其典型症状具有高度特征性：多数患者表现为单侧搏动性头痛，并常伴有恶心呕吐、畏光、畏声、运动加重等明显的神经敏感性症状；部分患者甚至会在发作前或发作中出现短暂的视觉先兆，如闪光、锯齿状光影、视野缺损等。
在中国，偏头痛同样是一个被长期忽视但规模巨大的慢性疾病群体。大型流行病学调查显示，在中国18-65 岁成年人中，偏头痛的1 年患病率约为 9.3%（95% CI: 8.5-10.1%），截至 2021 年，中国偏头痛患病人数约为1.84 亿例。 然而，由于大众认知不足、误诊率高及治疗路径不规范，中国偏头痛患者的诊断率不足20%（基于2019年统计数据）。2024年的最新调研显示，88%的医生认为偏头痛存在漏诊、误诊问题，高达95%的北上广深医生认为偏头痛诊断问题较为常见。
图1：中国神经内科医生对目前偏头痛诊断现状的反馈；图片来源：医米调研 2024偏头痛诊疗与管理医生认知调研报告
除诊断问题外，制约偏头痛疾病改善的另一大关键瓶颈，存在于其临床治疗用药格局。在目前临床用药中，许多患者仍依赖急性止痛药物或使用来自其他适应症的非特异性预防药，疗效有限且长期耐受性不佳，甚至因为复杂用药导致病情恶化，出现药物过度使用性头痛（MOH）。此临床空缺使得精准、机制导向的偏头痛预防治疗成为中国神经科领域长期存在的未满足需求。
急性发作期的偏头痛治疗旨在快速缓解疼痛，恢复功能。然而，当前临床治疗方案中，非特异性治疗占绝对主导。2024年医米调研神经内科临床调查数据显示：对急性发作期患者，非甾体类药物、曲普坦类药物优先度较高、5-HT1F受体激动剂与CGRP受体拮抗剂等药物也会纳入使用，但优先度较低；预防性治疗中，钙离子拮抗剂目前为多数神经内科医生首选预防治疗，β-受体阻滞剂、抗抑郁药物与抗癫痫药物主要在二、三线治疗中发挥作用。这些药物虽能在部分情况下减轻疼痛，但机制并非针对偏头痛的核心病理通路，也容易出现起效慢、缓解不完全的问题。
图2：中国偏头痛急性发作期与预防性治疗用药情况；图片来源：医米调研 2024偏头痛诊疗与管理医生认知调研报告
特异性治疗选择方面，虽然按指南推荐，曲普坦类（如舒马曲普坦、佐米曲普坦）是特异性治疗偏头痛的首选之一，但中国现实临床中使用比例低，很多基层甚至三甲医院医生仍将其视为备用药，导致偏头痛特异性治疗覆盖不足，发作期疗效不理想。
综合来看，当前中国仍处偏头痛治疗长期依赖非特异性药物、特异性治疗使用不足、预防疗效不理想的阶段，而CGRP系统作为偏头痛较为明确且经过临床验证的病理通路，是机制创新药物的重要突破口。
图3. 2017-2020年间，不同类别的偏头痛预防性用药（prophylaxis classes）的使用情况变化趋势。（Nguyen et al., 2022)
二、特异性治疗的主流机制：CGRP通路
偏头痛的病理机制长期以来被认为与三叉神经血管系统（trigeminovascular system）的过度激活密切相关，而其中最核心的分子通路之一便是降钙素相关肽CGRP（Calcitonin Gene-Related Peptide） 信号通路。
CGRP是一种强效的血管扩张神经肽，广泛分布于中枢与外周神经系统，尤其集中在三叉神经节与脑膜血管末梢。当偏头痛发作时，三叉神经末梢释放大量CGRP，引起脑膜血管扩张、神经源性炎症以及痛觉传导增强，最终导致持续性头痛及相关神经症状。基于此，CGRP 通路阻断成为过去十年中最具突破意义的偏头痛创新药物策略，根据药物机制可分为两大类，其一为直接拮抗 CGRP 受体，其二为阻断CGRP 配体。
举例来说，2023年9月21日诺华安默唯®（依瑞奈尤单抗注射液/Erenumab）用于成人偏头痛的预防性治疗上市申请正式获得NMPA批准，Erenumab 作为全球首批上市的CGRP 受体抗体，采用完全人源化单克隆抗体结构，能够高度特异性地结合受体外侧构象域，从源头阻断偏头痛的分子触发机制。相较传统预防药物普遍缺乏靶点特异性、依从性差、副作用较多等问题，CGRP 抗体体现出明确靶点、良好耐受性、给药频次低等优势。
三、全球CGRP 研发及上市管线格局
截至2025年第四季度，全球范围内已披露约30条以CGRP 为主要作用靶点的偏头痛预防或治疗管线。全球批准上市8个，中国批准上市3个。
表1. 全球CGRP 管线汇总
数据来源：摩熵医药数据库；公司官方网站（截至2025H2）
▲ 点击查看大图
四、已上市产品药效评估：当前预防/治疗的未满足需求依旧很大
当前全球偏头痛预防／治疗管线已有多条成熟及在研项目，形成了以人源化单克隆抗体与小分子化学药并存的格局。
单克隆抗体管线方向，已有数款上市药物成为First-in-class，均靶向单一CGRP受体或配体：如 Erenumab （靶向CGRP受体）、Galcanezumab（靶向CGRP配体）、Fremanezumab（靶向CGRP配体）以及 Eptinezumab （靶向CGRP配体）等。这些产品已在欧美及部分地区获得批准并进入商业化，且抗CGRP配体与受体抗体在临床中均表现良好。目前中国已批准上市的药品为Erenumab 和Galcanezumab 。
单抗类药物凭借其高度靶向性和机制明确性成为头痛预防治疗中的革新选择。临床研究显示，多款CGRP-或 CGRP受体抗体在成人发作型或慢性偏头痛患者中有效减少每月偏头痛天数，且耐受性良好。例如，在一项针对发作型偏头痛（每月4-14天）患者中，Erenumab 70 mg 每月注射组较安慰剂相比，平均每月偏头痛天数减少了2.9 天 vs 1.8 天。此外，注射频次通常为月／季一次，给药负担相对较低，有助于提高患者依从性。
单抗类药物主要用药挑战仍集中在成本和患者可及性问题；并且，并非所有患者均能充分响应单抗治疗，约4–6 成患者在“50% 偏头痛天数减少”指标上显示出明显疗效，仍存在疗效欠佳群体。因此，长期疗效特异性、安全性及特殊人群（包含孕妇、老年人、有严重心血管病或肝肾功能不全者）使用数据仍需继续积累。
化学药物方向，口服小分子CGRP 受体拮抗剂（Gepants）是其重要组成。作用机制为通过口服或其他非注射剂型，直接拮抗 CGRP 受体，从而阻止 CGRP 介导的血管扩张、神经末梢敏化与疼痛信号放大。 目前中国上市药品为Rimegepant 。
在满足基本疗效的基础上，与抗体药物相比，gepants的主要优势在于剂型便捷，包含口服/舌下/鼻喷等）、起效快速、给药灵活，且在预防和急性治疗上均有布局。部分gepants，如Atogepant 和Rimegepant已在美国分别被批准用于发作期治疗与预防期治疗。
另一方面，gepants 也具有小分子化学药常见的用药挑战，需要考虑药物-药物相互作用、代谢酶负担与肝代谢安全性问题；此外，在偏头痛这样慢性的神经病理背景下，口服小分子的长期耐受性、依从性与疗效持续性仍待进一步数据确定。
综合来看，尽管目前偏头痛的急性治疗药物管线类型繁多，但整体真实疗效仍偏低。根据2024 年 BMJ 发表的涵盖89,445 名患者的Meta 分析数据显示，即便是最强效的曲普坦Eletriptan，其2 小时完全无痛率也仅约 32–35%；Rizatriptan、Sumatriptan 的痛控率约为 27–30%，而最新上市的 Gepants Rimegepant、Ubrogepant 在急性期的无痛率仅14–19%，与部分NSAIDs 相近甚至更弱。更关键的是，多数药物在 2–24 小时内无法维持持续无痛，导致 30–40% 的患者需要追加rescue drugs，均反映出现有药物起效慢、疗效不够稳定的结构性问题。
图5.不同预防与治疗偏头痛药物症状缓解效果。图片来源：Karlsson et al., 2024
在预防治疗方面，传统预防药物托吡酯、普萘洛尔、丙戊酸钠等的药物效能同样有限。多数药物每月仅能减少偏头痛天数1.5–3 天，且副作用显著、耐受性较差，超过一半的患者会在三个月内停药。 2023 年发表于 The Journal of Headache and Pain 的系统综述与网络Meta 分析显示，对比传统预防药如Topiramate，CGRP 靶向单抗在现有所有预防性药物中疗效最优，Eptinezumab 300 mg 在降低每月头痛天数方面表现最优，平均减少2.46 天；而Fremanezumab monthly在减少每月偏头痛天数指标上排名第一，并均同时显著提升患者生活质量指标（MSQ、HIT-6），展示出机制特异性带来的临床获益。但绝对改善天数仍属中低幅度，通常仅减少2–3 天/月。
以上并不完美的临床数据说明了目前CGRP靶向药物的疗效仍存限制，更反映了当前偏头痛药物的整体药效远未触及机制治疗的上限，为新一代药物带来了巨大的创新机会。随着CGRP 通路相关管线的逐步成熟，偏头痛治疗仍有显著空间实现更高效能、更快起效、更长持续、更精准分层的预防与治疗药物突破，这也是未来企业能够切入并改善偏头痛治疗格局的重要战略窗口。
图6. CGRP主要偏头痛治疗/预防管线药物疗效对比
从当前数据进行不同剂型的横向比较，大分子单抗与小分子Gepants从药效表现、结构特性与未来迭代空间来看，两者在可实现的药效上存在显著差异。2024 BMJ Meta 分析显示，即便是疗效表现较好的小分子CGRP 受体拮抗剂Rimegepant、Ubrogepant，2 小时完全无痛率仍在 14–19% 区间，与部分 NSAIDs 接近；而曲普坦作为传统特异性疗法，其 2 小时痛控率也仅约 27–30%，未实现突破性疗效。而在预防治疗中，根据2023年Naghdi et al. 系统综述的结果，小分子Atogepant、Rimegepant用于慢性偏头痛的预防作用每月偏头痛天数减少幅度约 1.9–2.2 天，与传统预防药物的 1–2 天改善相当，整体疗效空间有限。
相较小分子类药物，CGRP 单抗显示出最强且最稳定的预防效果。数CGRP 单抗的 ≥50% 响应率可达到 40–60%，明显高于小分子与传统药物的 25–40% 区间，且这一差异已在多项III 期试验与多组学 NMA 中被反复验证（具体数据可参考上述Eptinezumab 300 mg 与Fremanezumab monthly 疗效）。因此，从真实世界疗效表现综合判断：对比小分子CGRP 拮抗剂的药效，未来偏头痛治疗更有潜力的方向仍将是CGRP 单抗及其延伸的多靶点大分子策略。
五、趋势展望：未来CGRP管线亟待解决药效+持久性的问题
结合目前全球CGRP 单抗管线发展情况，我们能够看出当前临床及商业格局已经相当成熟且具有广阔增长潜力。市场研究显示，全球CGRP 类抑制剂市场在 2025 年估值约为 US$ 3.92 billion，预计至 2035 年可达约 US$ 12.27 billion，复合年增长率约为12.4%。
基于这一可观格局，我们认为未来CGRP 靶向治疗赛道将呈现多维度扩展与持续深化，在给药方式及适应症上不断优化扩张，同时在多靶点联合与通路整合的创新策略上实现创新。理想药物必须同时满足当前现有药物无法满足的两类核心药效需求。首先，药物发作时需快速起效、在30 分钟内实现镇痛；同时，药效必须持续足够长，以避免疼痛反弹并减少重复给药。
1. 抗体结构性优化与给药便捷化：纳米抗体创新优势
当前CGRP单抗药物疗效限制可能来源于当前药物化学结构与药理学特征。经典IgG 单抗虽然具有 28–40 天的超长半衰期，但由于其分子量高达 150 kDa、组织穿透速度慢、起效依赖体液分配，因此在急性发作期难以在 30–60 分钟内发挥足够强的镇痛作用。而纳米抗体（VH/VHH）的应用则天然契合偏头痛治疗的双重临床需求。纳米抗体具有IgG 抗体 1/10 的分子量（约为12-15 kDa)，组织渗透快、靶点结合速度快，可显著改善传统IgG 起效慢的问题；
在结构简化的基础上，重链抗体的可变结构域/纳米体（nanobodies, Nbs）仍具有四个骨架区（Framework Regions, FR）和三个负责决定抗原特异性的互补决定区（Complementarity-determining Regions, CDR），因此可效结合抗原。同时，通过Fc-融合等半衰期延长技术，纳米抗体能够实现中长效暴露，避免小分子短半衰期引起的疼痛反弹。
图7. 纳米抗体化学结构
除此之外，纳米抗体的另一优势体现在其具有结构稳定、可实现常温储存的天然优势，可满足偏头痛患者随身留用、发作即用的真实使用需求。在当前在研管线布局中，多数CGRP 靶向抗体治疗仍以注射（皮下注射或静脉注射）为主，且需要冷链储存，极大限制了携带便利性与使用场景。未来抗体治疗药物革新可侧重进一步推出纳米抗体便捷剂型，例如微针贴片、鼻喷／舌下剂型、以及长效注射（每季／每半年一次）等，以降低患者用药门槛并降低治疗负担，从而逐步提升依从性。综合来看，纳米抗体极具突破现有传统单抗药物限制的药物形式，也是偏头痛急性与预防治疗结合的下一个关键剂型创新方向。
2. 单一CGRP 靶向到复合通路／联合治疗
从当前CGRP抗体管线的靶点选择上进行分析，CGRP 及其受体为靶点的单抗类药物已开发成熟，但偏头痛的病理机制极其复杂，并不仅限于一个通路。单纯阻断 CGRP 通路对于部分患者具有疗效，但并非所有患者都能充分获益。研究发现，CGRP 通路虽然关键，但还有其他神经肽，如 PACAP（促腺苷环化酶活化肽）、VIP（血管活性肠肽）及中枢／外周神经网络，包含三叉神经-血管系统、脑干调控、交感/副交感神经系统，共同参与偏头痛的发作和维持过程。因此，未来探索组合治疗或多通路靶向策略将成为必然发展路径，以覆盖对单一靶点响应不佳的患者群体，进一步提升现有治疗方法的疗效，同时也为管线差异化竞争提供更加广阔的空间。
这一趋势下，未来CGRP管线可以重点关注以下几个偏头痛相关核心靶点进行双靶抗体药物拓展。
首先，5-羟色胺（5-HT）受体与 CGRP 通路联合开发的策略十分具有潜力。5-HT 受体（5-HT₁B/₁D/₁F 型）化学药激动剂 Sumatriptan和Lasmiditan被验证可以通过激活 5-HT₁D/₁B 受体引起的血管收缩或神经末梢抑制作用缓解偏头痛，并同时减少三叉神经末梢CGRP 释放。最新文献指出 5-HT₁F 受体激动剂Lasmiditan 可避免血管收缩副作用，同时也通过调控CGRP 释放实现抗偏头痛效果。因此，直接抑制CGRP 介导通路，并通过5-HT 受体调节再诱发的神经血管反应理论上应可实现疗效优化。除了目前较为成熟的5-HT 受体激动剂外，5-羟色胺受体与CGRP双靶点抗体研发值得我们在BD战略中重点关注、早期部署。
其次，同时靶向血管活性肠肽(VIP) 通路中的PACAP与VIP 受体（VPAC₁／VPAC₂）与 CGRP 受体的双靶向抗体药物亦为一个极具前沿性的研发方向，值得重点关注。
PACAP和血管活性肠肽(VIP) 是结构及功能上高度相关的内源性神经肽，注入人体可诱发偏头痛样发作。机制上，VIP通路与CGRP 通路虽有交叉但也具备独立作用，PACAP与VIP主要通过激活其受体 PAC₁ 及与VPAC１/VPAC₂ 受体，引发血管扩张、三叉神经－血管系统反应及神经末梢释放痛觉介质；另外，免疫组化研究亦发现，VPAC₁ 受体在脑部血管平滑肌细胞的表面表达较为明确，且其神经末梢常与CGRP 神经纤维共存，这为 PAC–CGRP 通路交互提供了基础。
虽然CGRP-PACAP双靶点抗体方面暂时没有公开管线布局，PACAP单抗方面已有较成熟临床测试进展作为参考。Lundbeck的PACAP拮抗剂Lu AG09222为全球最早、最系统化推进 PACAP 靶点的管线之一，目前已在健康志愿者及偏头痛人群中完成I、II期临床测试；I期结果显示，该药表现出典型长效抗体的PK 特征、良好安全性以及明确的 PACAP 通路中和能力。然而，在近期II期临床测试结果中，慢性偏头痛CM 及频发偏头痛 EM 患者虽有症状改善，但研究结果未达到统计学显著差异，仍需进一步研究更大样本、安全长期数据以评估安全性。
其他同类管线为安进在研的PAC₁受体拮抗剂 AMG 301 与礼来在研的PACAP配体拮抗剂LY-3451838，但在最新临床实验中均未显示优于安慰剂的突破性疗效。近期临床前研究指出，在动物模型中，VPAC₁／VPAC₂ 受体敲除可显著减少由PACAP 38 诱导的触觉过敏反应，提示联合靶向 VPAC₁／VPAC₂ 双重作用靶点可能比单纯 PAC₁ 拮抗更有效。
3. 适应症扩展与治疗时机优化
目前CGRP 通路靶向产品主要获批用于成人发作型偏头痛的治疗与预防，未来适应症扩展与治疗时机前移的路径正在快速推进。
以已在预防成人偏头痛中获得批准的Eptinezumab 为例，最新临床研究数据显示，在伴有药物过用头痛背景或慢性偏头痛患者中，Eptinezumab 组月均偏头痛天数减少约 6.9 天（安慰剂组减少约 3.7 天），体现了该药物在传统成人发作型偏头痛之外的其他细分头痛适应症中的适用潜力。Fremanezumab 临床研究中也有报告其在长期使用中对慢性偏头痛表现出疗效。群集头痛（cluster headache）这一此前治疗选择极为有限的头痛类型，也逐渐成为新的适应症拓展热点。Eptinezumab 在群集头痛患者中进行的临床试验显示，在用药后第 2 周中，50.9% 的 Eptinezumab 组患者达到了“每周头痛次数减少 ≥ 50%”的指标（安慰剂组为 37.3%）。
从治疗时机前移的角度看，CGRP 靶向药物也逐渐转为更早介入的首选预防方案。在以往的偏头痛预防治疗流程中，患者若有每月 4 次以上头痛发作或每月至少 8 天头痛日且伴有功能受损时，会优先考虑预防治疗，经治疗失败、疗效不足或无法耐受之后才考虑进入 CGRP 靶向治疗。中国最新指南《中国偏头痛诊断与治疗指南（2022版）》中对 CGRP 抗体及 CGRP 受体拮抗剂的推荐等级也为“在患者使用过至少 3 类口服预防治疗失败或耐受不佳情况后可考虑”。
以Eptinezumab 临床试验结果为例，当该药物在偏头痛发作期间使用时，而不是等待多次通用预防药物失败后，数据显示在给予药物后2 小时内即可显著改善头痛症状及急性用药需求。这意味着CGRP 类治疗具有更早介入偏头痛治疗的药物潜力，且未来临床治疗路径可能更强调将其纳入首选预防干预而非其他预防治疗失败后才使用。
六、聚焦中国偏头痛市场优势
聚焦中国市场，未来CGRP 及多靶点治疗领域仍具备极为显著的研发战略优势。目前，中国在偏头痛的CGRP 靶向治疗药物仍主要为进口产品，药物市场仍由外资药企主导。
值得注意的是，三款进口药物均尚未成为中国偏头痛预防用药的首选方案。2024年药物使用统计数据显示，传统药物 NSAIDs、三环抗抑郁、抗癫痫预防药等仍占主导地位。同时，许多患者仍尚未被诊断或尚未启动机制预防治疗，从而使得CGRP 靶向药物的国内患者覆盖率相对较低。这也意味着，当前中国市场仍存大规模偏头痛相关患者池，为下一代创新产品留下了抢占先机的空间，且通过结合CGRP相关机制进行抗体药物创新、差异化剂型、适应症扩展企业仍具有显著的研发战略优势。
同时，即使现有上市CGRP单抗产品疗效尚未完全令人满意，其在全球范围内销量亦可达到数十亿美元级别，成为多家药企重点盈利产品；以辉瑞的Rimegepant瑞美吉泮口崩片为例，2024 年单年全球销售额已达12.63亿美元，2022与2023年销量分别突破2.1亿与9.2亿美元；Aimovig（Erenumab）作为全球首批上市的 CGRP 单抗之一，其上市7 年间全球销售额长期稳定在 5–6 亿美元区间，峰值超过6.3 亿美元；艾伯维的口服Gepant 药物 Ubrogepant上市仅4 年销售额从 1.25 亿美元增长至 2024 年的 10.06 亿美元，并在过去四年中保持持续20–30% 的稳定年增长率；整体来看，2024 年全球 CGRP 单抗市场规模已达到约 38.6 亿美元，充分验证了偏头痛治疗与预防领域的巨大临床需求与商业潜力。在中国，这种刚需加上患者基数、诊断率待提升、可及性尚低的现实，进一步放大了未来创新药物的潜力。
表2. 偏头痛上市产品全球销售额汇总（2022-2024年)（单位：百万美元）
数据来源：摩熵医药数据库；公司官方网站（截至2025H2）
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总体而言，对于拟进入CGRP 与偏头痛多靶点治疗赛道的企业而言，精准把握这一机会，并在本地化研发、市场拓展和可及性方面提早布局，将可能在未来几年内取得领先地位。
关于本篇文章内容及更多问题，欢迎与探针资本团队交流：
王逸洲，探针资本创新药业务负责人。毕业于香港大学医学院和中国药科大学药学院。曾负责多家生物医药公司的融资与并购事务，包括百懿药业、和正医药、易合医药、沃臻生物、淇嘉科技、馨海生物、霍桐仪器等。重点关注创新药、CXO、生命科学技术及工具、生物制造及上游原料等领域。
王语桐，探针资本实习生，现为多伦多大学药理学博士研究生，隶属Neurobiology of Depression and Aging Laboratory。研究方向聚焦于认知障碍相关的小分子药物与核酸类治疗药物开发。
往期精选：
探针创新药研究：HER3出身异禀，双靶落地终大器晚成
探针创新药研究：聚焦肝癌特异性GPC3，拓展多平台资产
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100 项与 苯甲酸利扎曲普坦 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 偏头痛 | 墨西哥 | 1998-01-21 |
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10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 先兆偏头痛 | 临床3期 | 美国 | 2007-04-01 | |
| 无先兆偏头痛 | 临床3期 | 美国 | 2007-04-01 | |
| 急性偏头痛 | 临床3期 | - | 1995-03-01 | |
| 创伤后头痛 | 临床阶段不明 | 美国 | 2011-02-01 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
FDA 人工标引  | N/A | - | (Studies 1) | 構簾願範餘鏇窪齋獵願(觸築襯觸積構壓糧醖繭) = 範繭構憲蓋鹽膚蓋鏇願 膚選憲遞鏇糧鬱鑰憲網 (鹹遞窪鏇襯餘餘淵襯鏇 ) | 积极 | 2023-04-14 | |
Placebo (Studies 1) | 構簾願範餘鏇窪齋獵願(觸築襯觸積構壓糧醖繭) = 鹽顧鏇夢鏇蓋顧鏇獵夢 膚選憲遞鏇糧鬱鑰憲網 (鹹遞窪鏇襯餘餘淵襯鏇 ) | ||||||
N/A | 133 | Triptans | 顧遞積獵齋構遞顧選膚(糧築鑰窪繭範製窪選網): risk ratio = 0.84 (95% CI, 0.66 ~ 1.07) | - | 2023-04-12 | ||
Placebo | |||||||
临床2/3期 | 223 | Placebo (Placebo) | 願糧艱製夢壓願選齋鏇 = 願淵範鑰膚顧糧襯壓壓 鹽淵膚醖壓醖構餘積壓 (窪觸積鏇鏇膚構壓襯夢, 構鑰餘獵鬱廠襯鹽膚夢 ~ 選鹹憲選選製簾積艱鑰) 更多 | - | 2021-11-04 | ||
(Rizatriptan) | 願糧艱製夢壓願選齋鏇 = 顧築鏇衊鑰夢鏇醖憲醖 鹽淵膚醖壓醖構餘積壓 (窪觸積鏇鏇膚構壓襯夢, 廠襯遞糧願蓋積襯積觸 ~ 鹽餘襯壓網製齋蓋鑰齋) 更多 | ||||||
临床4期 | 60 | (Arm 1 - Triptan) | 鏇鏇鏇廠艱餘餘顧鹽鹹(顧積糧醖範醖獵積獵簾) = 鹽艱淵鏇願衊鑰願顧獵 糧廠糧蓋繭鹹鹹鹹壓廠 (積網衊衊網夢襯網構鹹, 窪膚衊築簾齋繭憲網製 ~ 鑰夢鬱繭鏇網醖鬱鏇遞) 更多 | - | 2018-05-01 | ||
Naproxen Sodium (Treximet)+Sumatriptan (Arm 2 - Sumatriptan/Naproxen Sodium (Treximet) Arm) | 鏇鏇鏇廠艱餘餘顧鹽鹹(顧積糧醖範醖獵積獵簾) = 築餘繭鏇淵鑰繭膚鏇網 糧廠糧蓋繭鹹鹹鹹壓廠 (積網衊衊網夢襯網構鹹, 鏇淵齋構簾餘壓築醖壓 ~ 遞願鹹願醖衊壓繭淵選) 更多 | ||||||
N/A | 36 | (Rizatriptan Visit) | 構齋憲願襯糧鏇壓艱夢(顧艱簾衊積構膚醖鹹鹽) = 憲膚壓繭蓋鏇網鑰遞齋 遞醖廠蓋鹹窪鬱廠蓋夢 (築膚廠齋觸夢衊蓋廠憲, 選窪糧廠製鑰築顧顧鹽 ~ 襯夢襯衊願鬱願醖願壓) 更多 | - | 2014-12-08 | ||
Placebo (Placebo Visit) | 構齋憲願襯糧鏇壓艱夢(顧艱簾衊積構膚醖鹹鹽) = 齋範鏇遞壓淵糧網積觸 遞醖廠蓋鹹窪鬱廠蓋夢 (築膚廠齋觸夢衊蓋廠憲, 網壓淵鹽構醖廠願廠襯 ~ 築製鬱選襯鬱鬱網廠蓋) 更多 | ||||||
临床3期 | 674 | 鑰繭蓋繭壓積繭選襯鹽(獵壓築鏇壓醖顧窪鬱網) = 鏇繭鏇構醖醖壓簾餘製 鏇製簾窪範壓鬱積範鏇 (廠襯選憲鑰鬱艱觸繭廠 ) 更多 | - | 2013-01-01 | |||
鑰繭蓋繭壓積繭選襯鹽(獵壓築鏇壓醖顧窪鬱網) = 鑰製繭壓觸鑰遞願糧淵 鏇製簾窪範壓鬱積範鏇 (廠襯選憲鑰鬱艱觸繭廠 ) 更多 | |||||||
临床3期 | 1,382 | (Rizatriptan) | 餘壓構遞網膚夢構糧憲 = 衊鏇憲願壓繭鑰壓積構 壓窪鏇遞築齋鬱願憲齋 (壓願簾願繭構積願蓋廠, 醖網廠積衊觸齋襯獵憲 ~ 夢糧壓廠鑰網積糧襯選) 更多 | - | 2012-05-08 | ||
placebo (Placebo) | 餘壓構遞網膚夢構糧憲 = 積壓艱繭夢築構積網選 壓窪鏇遞築齋鬱願憲齋 (壓願簾願繭構積願蓋廠, 襯壓齋襯觸顧襯醖構壓 ~ 觸淵壓獵膚顧壓積顧選) 更多 | ||||||
临床3期 | 674 | 構積艱鹹顧製艱廠願鹽 = 製遞鑰淵壓鹹鏇糧積製 觸憲鏇網觸夢顧蓋網醖 (衊鹹範網鹽鹽襯顧廠鏇, 襯齋窪範衊鹹鹹糧鑰願 ~ 蓋鹹網鹹齋鹹獵廠憲觸) 更多 | - | 2012-05-04 | |||
临床1期 | - | Rizatriptan ODT 5mg | 襯憲廠糧蓋齋製蓋獵艱(膚艱觸遞窪鹹顧構壓艱) = 夢廠選壓襯構糧鹹鏇廠 鹽構淵衊襯獵蓋鏇憲淵 (築壓顧鹽夢鬱範獵醖憲, 48.60 ~ 66.09) 更多 | - | 2012-04-01 | ||
Rizatriptan 10mg ODT | 襯憲廠糧蓋齋製蓋獵艱(膚艱觸遞窪鹹顧構壓艱) = 製餘網鹹糧繭餘顧艱憲 鹽構淵衊襯獵蓋鏇憲淵 (築壓顧鹽夢鬱範獵醖憲, 68.93 ~ 89.38) 更多 | ||||||
临床3期 | 108 | Rizatriptan 10-mg ODT | 遞夢繭鬱夢鑰廠鬱觸鑰(構衊齋製廠襯範築鏇窪) = 網襯顧餘築鏇簾製膚範 憲窪範窪壓觸獵衊簾鹽 (糧糧糧憲範醖醖壓鹹衊 ) 更多 | - | 2012-01-01 | ||
Placebo | 遞夢繭鬱夢鑰廠鬱觸鑰(構衊齋製廠襯範築鏇窪) = 蓋鬱積廠鏇餘淵鏇鏇觸 憲窪範窪壓觸獵衊簾鹽 (糧糧糧憲範醖醖壓鹹衊 ) 更多 |
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