Recombinant erythropoietin(University of Chile)(Recombinant erythropoietin(University of Chile))

概要

基本信息

药物类型

集落刺激因子

别名-

靶点-

作用机制-

治疗领域

血液及淋巴系统疾病泌尿生殖系统疾病

在研适应症

贫血慢性肾病

非在研适应症-

原研机构

University of Chile

在研机构

University of Chile

非在研机构-

最高研发阶段临床阶段不明

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

2

项与 Recombinant erythropoietin(University of Chile) 相关的临床试验

IRCT20211202053252N1 / Recruiting临床3期IIT

Comparison of recombinant erythropoietin effect on serum hemoglobin of beta thalassemia minor versus non-thalassemia patients in chemotherapy candidates

开始日期2021-04-20

申办/合作机构

Babol University of Medical Sciences

IRCT20200509047364N1 / Recruiting临床2期IIT

Evaluation of the efficacy and safety of recombinant erythropoietin on the improvement of hospitalised COVID-19 patients

开始日期2020-06-21

申办/合作机构-

100 项与 Recombinant erythropoietin(University of Chile) 相关的临床结果

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100 项与 Recombinant erythropoietin(University of Chile) 相关的转化医学

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100 项与 Recombinant erythropoietin(University of Chile) 相关的专利（医药）

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7

项与 Recombinant erythropoietin(University of Chile) 相关的文献（医药）

2024-10-01·Nature Medicine

The recombinant shingles vaccine is associated with lower risk of dementia

Article

作者: Harrison, Paul J ; Todd, John A ; Taquet, Maxime ; Dercon, Quentin

AbstractThere is emerging evidence that the live herpes zoster (shingles) vaccine might protect against dementia. However, the existing data are limited and refer only to the live vaccine, which is now discontinued in the United States and many other countries in favor of a recombinant vaccine. Whether the recombinant shingles vaccine protects against dementia remains unknown. Here we used a natural experiment opportunity created by the rapid transition from the use of live to the use of recombinant vaccines to compare the risk of dementia between vaccine types. We show that the recombinant vaccine is associated with a significantly lower risk of dementia in the 6 years post-vaccination. Specifically, receiving the recombinant vaccine is associated with a 17% increase in diagnosis-free time, translating into 164 additional days lived without a diagnosis of dementia in those subsequently affected. The recombinant shingles vaccine was also associated with lower risks of dementia than were two other vaccines commonly used in older people: influenza and tetanus–diphtheria–pertussis vaccines. The effect was robust across multiple secondary analyses, and was present in both men and women but was greater in women. These findings should stimulate studies investigating the mechanisms underpinning the protection and could facilitate the design of a large-scale randomized control trial to confirm the possible additional benefit of the recombinant shingles vaccine.

2024-01-01·Investigative and Clinical Urology

Prostate cancer therapy using immune checkpoint molecules to target recombinant dendritic cells

Article

作者: Chang, In Ho ; Lim, Bumjin ; Choi, Se Young ; Kim, Choung-Soo ; Kim, Yunlim ; Wee, Chung Beum

PURPOSEWe developed immune checkpoint molecules to target recombinant dendritic cells (DCs) and verified their anti-tumor efficacy and immune response against prostate cancer.MATERIALS AND METHODSDCs were generated from mononuclear cells in the tibia and femur bone marrow of mice. We knocked down the programmed death ligand 1 (PD-L1) on monocyte-derived DCs through siRNA PD-L1. Cell surface antigens were immune fluorescently stained through flow cytometry to analyze cultured cell phenotypes. Furthermore, we evaluated the efficacy of monocyte-derived DCs and recombinant DCs in a prostate cancer mouse model with subcutaneous TRAMP-C1 cells. Lastly, DC-induced mixed lymphocyte and lymphocyte-only proliferations were compared to determine cultured DCs' function.RESULTSCompared to the control group, siRNA PD-L1 therapeutic DC-treated mice exhibited significantly inhibited tumor volume and increased tumor cell apoptosis. Remarkably, this treatment substantially augmented interferon-gamma and interleukin-2 production by stimulating T-cells in an allogeneic mixed lymphocyte reaction. Moreover, we demonstrated that PD-L1 gene silencing improved cell proliferation and cytokine production.CONCLUSIONSWe developed monocyte-derived DCs transfected with PD-L1 siRNA from mouse bone marrow. Our study highlights that PD-L1 inhibition in DCs increases antigen-specific immune responses, corroborating previous immunotherapy methodology findings regarding castration-resistant prostate cancer.

2020-05-26·Biology of Reproduction2区 · 生物学

Nodal is required to maintain the uterine environment in an anti-inflammatory state during pregnancy†

2区 · 生物学

Article

作者: Ayash, Taghreed A ; Dufort, Daniel ; Starr, Lisa M

AbstractPreterm birth remains the major cause of perinatal mortality and morbidity worldwide, affecting up to 12% of pregnancies and accounting for ~75% of neonatal deaths. However, the mechanisms and causes that underlie it are still largely unknown. One of the major causes of preterm birth is infection or inflammation within the maternal–fetal interface. Our lab has previously shown that a uterine specific deletion of Nodal results in mutant females delivering 2 days prior to term demonstrating an important role for this factor in the maintenance of pregnancy. Here, we have addressed the function of Nodal in the uterus during pregnancy. We demonstrate that Nodal heterozygous mice have an increase in basal levels of pro-inflammatory cytokines IL-1β, IL-6, IL-12p, TNF-α, and IFN-γ as well as an increase in the number of macrophages in response to the inflammatory agent, lipopolysaccharide (LPS). Using bone marrow-derived macrophages, we demonstrated that pretreatment with recombinant Nodal reduces pro-inflammatory gene expression when these cells are challenged with LPS. Our results demonstrate that Nodal is required to maintain the uterine environment in an anti-inflammatory state by preventing proinflammatory cytokine expression.

100 项与 Recombinant erythropoietin(University of Chile) 相关的药物交易

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研发状态

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASCO2008	N/A	-	-	Lenalidomide	齋醖製齋鑰夢憲願窪繭(築壓襯簾夢壓顧繭艱遞) = 憲簾醖淵鏇網憲衊蓋簾範觸構範構襯選築膚範 (夢糧範選醖鬱鹹艱鏇糧 ) 更多	-	2008-05-20
				Recombinant erythropoietin	齋醖製齋鑰夢憲願窪繭(築壓襯簾夢壓顧繭艱遞) = 艱窪憲餘獵齋顧襯遞齋範觸構範構襯選築膚範 (夢糧範選醖鬱鹹艱鏇糧 ) 更多