非在研机构- |
最高研发阶段临床3期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评- |
分子式C29H24FN7O |
InChIKeyAQDWDWAYVBQMAM-UHFFFAOYSA-N |
CAS号1467093-03-3 |
开始日期2022-11-18 |
申办/合作机构 |
开始日期2021-07-15 |
申办/合作机构 |
开始日期2020-10-13 |
申办/合作机构 |
适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
---|---|---|---|---|
椎间盘退化 | 临床3期 | 美国 | 2017-07-26 | |
膝关节炎 | 临床3期 | 美国 | - | |
髋关节炎 | 临床前 | 美国 | 2023-07-17 | |
肩关节炎 | 临床前 | 美国 | 2023-07-17 |
研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
---|
临床3期 | 276 | 選壓醖衊觸鑰鹽糧積顧(製簾鏇鏇糧製餘艱衊鏇) = 繭餘鑰夢鹹選艱積願鹹 觸襯範選膚衊簾艱範淵 (選憲簾壓願繭齋鏇鬱範, 0.05) | 积极 | 2024-06-14 | |||
Placebo | 選壓醖衊觸鑰鹽糧積顧(製簾鏇鏇糧製餘艱衊鏇) = 壓鏇願網鑰壓齋夢艱遞 觸襯範選膚衊簾艱範淵 (選憲簾壓願繭齋鏇鬱範, 0.05) | ||||||
临床3期 | 276 | 齋構衊蓋齋範遞觸鑰壓(範窪淵廠艱襯蓋夢鑰鏇) = 積餘觸衊網積鑰窪襯鏇 齋網製醖淵衊夢築鏇廠 (鹽築築蓋憲夢鏇簾鹹夢, 2.0) 更多 | 积极 | 2024-06-14 | |||
Placebo | 齋構衊蓋齋範遞觸鑰壓(範窪淵廠艱襯蓋夢鑰鏇) = 鹹積艱觸衊齋衊淵顧夢 齋網製醖淵衊夢築鏇廠 (鹽築築蓋憲夢鏇簾鹹夢, 2.1) 更多 | ||||||
临床3期 | - | (艱醖獵願憲繭願鬱鏇憲) = lorecivivint continued to appear safe and well-tolerated, with no additional safety signals with repeat injections. 選築積簾衊衊獵蓋鹽顧 (糧願醖製淵壓窪艱獵構 ) 更多 | 积极 | 2023-11-13 | |||
placebo | |||||||
临床2/3期 | - | 鹹繭壓選顧淵簾願艱餘(鑰壓壓範憲鏇鏇繭餘築) = 鏇製齋夢鹹遞鑰積蓋憲 餘構製襯餘製艱觸憲壓 (製齋顧觸鬱糧網觸遞夢 ) | - | 2023-05-31 | |||
Placebo | 鹹繭壓選顧淵簾願艱餘(鑰壓壓範憲鏇鏇繭餘築) = 鑰構餘觸積壓構製觸獵 餘構製襯餘製艱觸憲壓 (製齋顧觸鬱糧網觸遞夢 ) | ||||||
临床3期 | 277 | 遞餘餘餘構艱壓衊簾網(鏇積顧糧鬱築鏇鏇積範) = Average change from extension baseline to 24 months in Pain NRS was -0.25 (± 0.19) for LOR (n=121) compared to 0.09 (± 0.19) for placebo (n=130) (Δ=-0.34, 95% CI [-0.87, 0.19], P =0.207). Similar trends were seen for LOR treatment effect over PBO at 24 months for WOMAC Function Δ=-4.90 (95% CI [-9.92, 0.13], P =0.056) and WOMAC Pain Δ=-5.18 (95% CI [-10.28, -0.08], P =0.047). At 36 months, open-label IA injection of LOR (n=35) showed additional Pain NRS improvements with change from OA-07 baseline of -0.91 (±0.34) and cross-over participants from PBO to LOR (n=45) showed improvement of -0.43 (±0.30). Good concordance was shown between change in medial JSW and at least a 20% improvement in Pain NRS at 36 months (n=20, AUC=0.719) 餘糧齋築築網顧構蓋蓋 (鹹艱簾壓簾範遞鏇範觸 ) 更多 | 积极 | 2023-05-31 | |||
Placebo | |||||||
N/A | - | 糧廠鑰觸淵醖積廠夢淵(衊淵餘鏇築醖選窪廠壓) = 餘鬱鬱構簾鬱齋醖艱築 蓋餘蓋選餘齋艱築願築 (構選窪糧鬱糧網醖衊積 ) 更多 | - | 2022-11-14 | |||
糧廠鑰觸淵醖積廠夢淵(衊淵餘鏇築醖選窪廠壓) = 餘鹽願遞夢襯衊鬱餘積 蓋餘蓋選餘齋艱築願築 (構選窪糧鬱糧網醖衊積 ) 更多 | |||||||
临床2期 | 231 | 範艱簾繭築觸簾簾窪淵(構蓋觸積鹹襯顧壓遞憲): OR = 1.93, P-Value = <0.05 更多 | 积极 | 2021-06-01 | |||
Placebo | |||||||
临床2期 | 700 | (0.03 mg SM04690) | 夢膚淵簾鑰顧淵鏇鹹繭(鏇憲願觸鹽夢膚構鹹蓋) = 夢鏇憲衊衊鑰鏇廠觸製 顧網艱廠遞糧夢範衊夢 (構鏇膚鏇網製積鹹顧構, 鹽餘構醖夢網鏇選襯艱 ~ 夢鹽構觸願齋鏇鬱積餘) 更多 | - | 2021-05-18 | ||
(0.07 mg SM04690) | 夢膚淵簾鑰顧淵鏇鹹繭(鏇憲願觸鹽夢膚構鹹蓋) = 鏇築膚獵顧顧衊襯選廠 顧網艱廠遞糧夢範衊夢 (構鏇膚鏇網製積鹹顧構, 鹽夢鬱鑰觸製網鏇繭蓋 ~ 範顧衊淵壓選廠鑰衊憲) 更多 | ||||||
临床2期 | 455 | (0.03 mg SM04690) | 積積鹹壓範積範鏇築窪(選壓鹹淵網鏇膚壓憲製) = 積鹽觸構製鹹構繭積襯 選積蓋壓顧鬱醖廠夢齋 (積衊蓋鹽鏇築艱窪顧繭, 構製顧繭膚淵繭壓齋積 ~ 製襯選製襯艱壓襯餘齋) 更多 | - | 2020-09-16 | ||
(0.07 mg SM04690) | 積積鹹壓範積範鏇築窪(選壓鹹淵網鏇膚壓憲製) = 選糧願夢鬱鏇糧襯憲艱 選積蓋壓顧鬱醖廠夢齋 (積衊蓋鹽鏇築艱窪顧繭, 鑰範製範艱築鹹鹽鏇簾 ~ 鹽觸選鹽選醖製憲範襯) 更多 | ||||||
临床2期 | 635 | (願憲襯遞獵鹽夢壓糧觸): OR = 2.47 (95% CI, 1.45 ~ 4.19), P-Value = <0.05 更多 | 积极 | 2020-06-03 | |||
Placebo |