更新于：2024-12-14
Cloxacillin Sodium
氯唑西林钠
更新于：2024-12-14
概要
基本信息
药物类型 小分子化药 |
别名 (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid、(3-(o-chlorophenyl)-5-methyl-4-isoxazolyl)penicillin、6-(3-(o-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid + [10] |
靶点 |
作用机制 PBPs抑制剂(细菌青霉素结合蛋白家族抑制剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 加拿大 (1963-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C19H20ClN3NaO6S |
InChIKeyKNNWTOJBVOKDPC-VICXVTCVSA-N |
CAS号7081-44-9 |
关联
9
项与 氯唑西林钠 相关的临床试验Investigating the effect of a topical gel containing Sumac extract and Cloxacillin on diabetic foot ulcer: a double-blind placebo-controlled trial
Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial
Effect of using Cloxacillin as an Antibiotic Lock Solution versus placebo on prevention of catheter-associated infection in hemodialysis patients: a single-blind randomized clinical trial
100 项与 氯唑西林钠 相关的临床结果
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100 项与 氯唑西林钠 相关的转化医学
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100 项与 氯唑西林钠 相关的专利（医药）
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2,207
项与 氯唑西林钠 相关的文献（医药）2025-02-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
Cu surface plasmon resonance promoted charge transfer in S-scheme system enhanced visible light photocatalytic hydrogen evolution
Article
作者: Shen, Yuandong ; Cui, Hao ; Wang, Ke ; Zhou, Tong ; Qiu, Zhishi ; Zhao, Jianhong ; Qiu, Guoyang ; Zhao, Chunting ; Zhan, Weijie ; Zhang, Yumin ; Yang, Nan ; Liu, Qingju ; Yang, Xingyan ; Liu, Feng
Reasonably constructing nanocomposite photocatalysts with fast charge transfer and broad solar response capabilities is significant for efficiently converting solar energy into chemical energy. Cu modifies P25/CeO2 heterojunctions prepared by photodeposition (P25 is commercial TiO2). The local surface plasmon resonance (LSPR) effect caused by Cu nanoparticles broadens the spectral response range and generates significant photothermal effects. After 90 s of irradiation, the temperature of 9.5 %Cu-P25/CeO2 increases to 148.1 °C. The photocatalytic hydrogen evolution rate (HER) of 9.5 %Cu-P25/CeO2 under visible light (λ = 400 nm) reaches 1538.2 μmol h-1 g-1, which is 158.6 times, 17.7 times, and 2.5 times higher than that of Cerium dioxide (CeO2), P25, and P25/CeO2, respectively. This catalyst has stronger light absorption, easier carrier transfer, and separation. This study guides the construction of efficient hydrogen evolution photocatalysts.
2025-02-01VETERINARY RESEARCH COMMUNICATIONS
Etiology and antimicrobial resistance of subclinical mastitis pathogens Staphylococcus aureus, Streptococcus spp. and Enterococcus spp. in sheep milk
Article
作者: Badea, Corina ; Gligor, Alexandru ; Imre, Kálmán ; Costinar, Luminița ; Iancu, Ionica ; Degi, Janos ; Pascu, Corina ; Iorgoni, Vlad ; Nichita, Ileana ; Igna, Violeta ; Popa, Sebastian Alexandru ; Herman, Viorel
The present study investigates the prevalence and etiology of subclinical mastitis in Țurcana sheep flocks located in south-western Romania. Milchtest and California Mastitis Test (CMT), were used for the detection of subclinical mastitis. A number of 360 milk samples across three lactation phases were analyzed. Subclinical mastitis was identified in 146 (40.6%) of sheep milk samples. Only milk samples (n = 146) collected from sheep diagnosed with subclinical mastitis were considered for microbiological analyses. Thus, Staphylococcus aureus (129/146; 88.4%) was identified as the predominant pathogen followed by Streptococcus spp. (14/146; 9.6%) Enterococcus spp. (7/146; 4.8%), Pseudomonas aeruginosa (6/146; 4.1%) and Klebsiella pneumoniae (5/146; 3.4%). Antimicrobial susceptibility of isolated strains of Staphylococcus aureus, Streptococcus spp. and Enterococcus spp. was also tested. The results showed varying resistance patterns depending on the farm and microorganism. In heard A the highest resistance of Staphylococcus aureus was identified to polymyxin B (79.7%) followed by novobiocin (73.4%) and tetracycline (45.3%); Streptococcus spp. to streptomycin (100%), novobiocin (100%), tetracycline (100%) and Enterococcus spp. to tylosin (100%), streptomycin (75.0%) and tetracycline (75.0%). In herd B, Staphylococcus aureus showed high resistance rates to polymyxin B (86.3%), novobiocin (74.5%) and cloxacillin (39.2%); Streptococcus spp. strains to streptomycin (100%), novobiocin (100%), tetracycline (100%) and Enterococcus spp. to gentamicin (100%), streptomycin (66.7%) and erythromycin (66.7%). The obtained preliminary results indicate a potential risk that future treatments of sheep mastitis may not be effective, and demonstrated that raw unpasteurized milk can harbor antimicrobial resistance pathogens posing a threat to public health. However, further investigations involving molecular research on resistance genes are required to draw comprehensive conclusions.
2024-12-11JOURNAL OF CLINICAL MICROBIOLOGY
Evaluation of the QIAstat-Dx BCID GN and GPF kits for direct identification and antimicrobial resistance prediction from blood culture bottles
Article
作者: Tan, Chai Yuin ; Ng, Sally ; Osman, Nur A'tikah Binte ; Yah, Jing Yan ; Chew, Ka Lip
ABSTRACT:
Rapid multiplex PCR kits have been used for rapid identification of blood culture isolates and prediction of antimicrobial resistance. We performed an evaluation of the QIAstat-Dx BCID GN and GPF research use only (RUO) kits on positive blood culture bottles using routine laboratory testing as the reference standard. Positive blood culture bottles between November 2023 and January 2024 were tested with QIAstat-Dx BCID GN and GPF kits based on initial Gram stain results and compared against routine identification and phenotypic susceptibility testing. A total of 174 monomicrobial blood cultures were included in the final analysis. The 174 monomicrobial blood cultures composed of 129 BCID GN tests and 45 BCID GPF tests. The majority of on-target Gram-negative organisms in monomicrobial cultures were identified. One
Escherichia coli
isolate was not identified as such, although the pan-Enterobacterales target was positive. All on-target Gram-positive organisms in monomicrobial cultures were identified. Overall sensitivity and specificity of
tem/shv
for detection of aminopenicillin resistance in
E. coli
was 94.7% (18/19) and 95.8% (23/24). The presence/absence of
ctx-m
and
ampC
had 100% sensitivity and specificity for identification of third-generation cephalosporin resistance in
E. coli
and
Klebsiella pneumoniae
. The combination of
blaZ
and
mecA
gene detection was fully predictive of phenotypic susceptibility results to penicillin and cloxacillin for
Staphylococcus aureus
. Overall, the QIAstat-Dx BCID GN and GPF kits were able to identify on-target pathogens. Detected resistance mechanisms were highly predictive of β-lactam resistance. Prediction of resistance for non-β-lactam antimicrobial was more variable.
IMPORTANCE:
This is one of the first evaluations of the QIAstat BCID kit and demonstrates high levels of correlation for both identification and antimicrobial resistance prediction.
100 项与 氯唑西林钠 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 葡萄球菌感染 | 加拿大 | 1963-12-31 |
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