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更新于：2025-12-01
Cefazolin Sodium
头孢唑林钠
更新于：2025-12-01
概要
基本信息
原研机构 |
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1973-10-04), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C14H24N8NaO9S3 |
InChIKeyCQCPLXCVNXNUCK-HGUWTHONSA-N |
CAS号115850-11-8 |
关联
166
项与 头孢唑林钠 相关的临床试验CTIS2024-516232-10-00
Defining Antibiotic Levels in Intensive care patients (DALI-2) protocol - A multi-national pharmacokinetic/pharmacodynamic cohort study to determine whether contemporary antibiotic dosing for critically ill patients achieves therapeutic exposures.
NCT06567808
Prevention of Infections in Cardiac Surgery (PICS): a Cluster-randomized Factorial Cross-over Trial
NCT06640491
Intraosseous Vancomycin and Cefazolin vs Intravenous Administration in Primary Total Knee Arthroplasty
100 项与 头孢唑林钠 相关的临床结果
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100 项与 头孢唑林钠 相关的转化医学
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100 项与 头孢唑林钠 相关的专利（医药）
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10,120
项与 头孢唑林钠 相关的文献（医药）2026-01-01JOURNAL OF PEDIATRICS
Antibiotic Prophylaxis for Gastrointestinal Surgery among Neonates and Very Young Infants: National Patterns, Outcomes, and Opportunities for Precision Stewardship
Article
作者: Khan, Faraz A ; Raymond, Steven L ; Moturu, Anoosha ; Tirrell, Timothy F ; Thorson, Chad M ; Islam, Saleem ; Sankar, Meera ; Mathew, Roshni ; Khan, Muhammad O ; Sylvester, Karl G ; Bio, Laura ; Ehsan, Anam N ; Shah, Adil A ; Thobani, Humza
OBJECTIVE:
To evaluate nationwide adherence to surgical antibiotic prophylaxis (SAP) guidelines and its association with outcomes following gastrointestinal surgeries among neonates and infants.
STUDY DESIGN:
We queried the National Surgical Quality Improvement Program-Pediatric for all patients age <90 days undergoing select thoracoabdominal surgical procedures between 2021 and 2023. Procedures were further subcategorized by anatomic site. SAP regimens were classified as being "adherent," "undercoverage," or "overcoverage" per established guidelines and expert consensus. The primary outcome was surgical site infection (SSI). Associations between SAP classification and SSI rates for each procedure subcategory were analyzed, with further subset analyses to delineate the effects of common SAP regimens on postoperative outcomes.
RESULTS:
A total of 11 062 cases met criteria, with an overall SAP adherence of 87.2%. Rates of overcoverage (2.8%-55.5%) and undercoverage (2.8%-28.3%) varied widely by procedure type. SAP undercoverage did not increase the odds of SSI for most procedures analyzed, with the exception of patients undergoing colorectal procedures, in whom cefazolin monotherapy (undercoverage) was associated with higher odds of SSI (OR = 2.17, 95% CI = 1.08-4.18). Broadening SAP coverage (overcoverage) and prolonging SAP duration were not associated with reduced SSI rates for any subcategory of procedure.
CONCLUSIONS:
Adherence to empiric SAP guidelines was poor among neonates and very young infants undergoing surgical intervention. There appears to be limited benefit to broadening SAP coverage for surgery in this patient population. These findings underscore the need for increased adherence to recommendations driven by neonatal-specific data, aiming to balance optimized postoperative outcomes with antimicrobial stewardship goals.
2025-12-01Veterinary and Animal Science
Typing identification and biological characterization of Clostridium perfringens toxins associated with lamb dysentery in Xizang sheep
Review
作者: Ma, Zhuo ; Zhenjie, Yuan
The objectives of this study were to investigate the etiology of morbidity and mortality in Tibetan sheep from a township in Shannan, Tibet, and to characterize the biological characteristics of the causative pathogen, thereby providing a scientific basis for effective disease prevention and control. Pathological specimens were aseptically collected from deceased animals, and the pathogen was isolated and cultured based on clinical presentations. Identification of the isolate involved morphological observation, 16S rRNA PCR amplification and sequencing, biochemical assays, toxin gene typing, Kirby-Bauer disk diffusion antimicrobial susceptibility testing, and antibiotic resistance genes screening. On tryptose sulfite cycloserine (TSC) agar, the organism formed black, circular colonies. Gram staining revealed short, straight, Gram-positive bacilli arranged singly or in pairs, consistent with the Clostridium perfringens . 16S rRNA gene sequence alignment showed >99 % identity to reference C. perfringens sequences in the NCBI database. Confirming the strain asC. perfringens. Biochemical tests indicated positive reactions for glucose, Biochemical assays were positive for glucose, lactose, and maltose fermentation; gelatin hydrolysis; oxidase activity; nitrate reduction;hydrogen sulfide production; and ornithine decarboxylase, but negative results for indole production, mannitol and sorbitol fermentation, and urea hydrolysis, matching known traits of C. perfringens. . Toxin gene PCR detected cpa,cpb, and etx, but not iap, cpe, or netB, identifying the isolate as C. perfringens type B. Antimicrobial susceptibility testing revealed high sensitivity to sulfadiazine, norfloxacin, nitrofurantoin, and cefazolin, but resistance to amoxicillin, oxacillin, carbenicillin, and tetracycline.Among the resistance genes screened, only aac(6')-Ib-cr was detected.This study reports the first isolation of C. perfringens type B in Shannan, Tibet; elucidates its biological characteristics and toxin profile; identifies effective antibiotics for targeted intervention; and provides foundational data for controlling lamb dysentery caused by this pathogen and for understanding its pathogenicity in sheep.
2025-12-01INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Exploring the susceptome of methicillin-resistant Staphylococcus aureus to oxacillin and cefazolin using integrated transposon-directed insertion site sequencing and proteomics
Article
作者: Paglietti, Bianca ; Yousief, Sally W ; Alobaidallah, Mosaed Saleh A ; Olsen, John E ; Abdelmalek, Nader ; Bojer, Martin S ; Tanca, Alessandro
OBJECTIVE:
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant challenge to public health due to its evolving resistance to antibiotics. This study aimed to identfy the determinants that modulate MRSA susceptibility to β-lactam antibiotics.
METHODS:
An integrated approach combining transposon-directed insertion site sequencing (TraDIS) and proteomics was applied. TraDIS was used to identify genetic determinants influencing susceptibility to oxacillin and cefazolin while proteomics was applied to characterise the adaptive response under sub-inhibitory antibiotic concentrations.
RESULTS:
Proteomic analysis revealed significant shifts in the protein spectrum under sub-inhibitory concentrations of oxacillin and cefazolin, characterised by stringent response. This included upregulation of amino acid metabolism and oligopeptide transport pathways, and downregulation of arginine biosynthesis. Concurrently, TraDIS screening identified 50 genes whose inactivation conferred a fitness advantage in the presence of both β-lactams, implicating processes such as nucleotide second messenger signalling, DNA repair, and histidine transport. Validation with selected mutants (relA::Tn, mutY::Tn, nsaR::Tn, aroC::Tn, SAUSA300_0432::Tn, SAUSA300_0846::Tn, SAUSA300_0595::Tn) confirmed the improved fitness in the presence of β-lactams. Integrative analysis of proteomic and TraDIS datasets highlighted the implication of the stringent response in mediating MRSA adaptation to oxacillin and cefazolin.
CONCLUSIONS:
These findings establish the 'susceptome' concept, a collection of genes that maintain or potentiate the vulnerability of MRSA strains to β-lactams, providing new targets for therapeutic intervention and strategies to counteract resistance evolution.
100 项与 头孢唑林钠 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 胆管感染 | 美国 | 2000-07-27 | |
| 骨和关节感染 | 美国 | 2000-07-27 | |
| 心内膜炎 | 美国 | 2000-07-27 | |
| 生殖器感染 | 美国 | 2000-07-27 | |
| 呼吸道感染 | 美国 | 2000-07-27 | |
| 脓毒症 | 美国 | 2000-07-27 | |
| 皮肤和皮肤结构感染 | 美国 | 2000-07-27 | |
| 手术伤口感染 | 美国 | 2000-07-27 | |
| 泌尿道感染 | 美国 | 2000-07-27 | |
| 细菌感染 | 中国 | 1984-01-01 | |
| 革兰氏阴性菌感染 | 美国 | 1973-10-04 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 315 | 醖願遞醖範範餘窪觸遞(構糧衊鬱鏇衊餘網築餘) = 齋顧壓衊積壓鏇築衊繭 獵鑰築蓋齋淵願淵窪窪 (襯獵淵製製壓顧蓋襯鹽 ) 更多 | 非劣 | 2025-11-01 | |||
醖願遞醖範範餘窪觸遞(構糧衊鬱鏇衊餘網築餘) = 鑰艱淵積醖壓選蓋構選 獵鑰築蓋齋淵願淵窪窪 (襯獵淵製製壓顧蓋襯鹽 ) 更多 | |||||||
临床1期 | 12 | 齋顧製製鹹築網遞淵繭(醖鬱膚積憲鑰糧餘構壓) = 遞夢淵廠膚淵餘齋憲蓋 齋顧觸範範糧蓋蓋遞衊 (襯顧襯艱範顧夢艱夢醖, 702) 更多 | - | 2025-02-28 | |||
临床4期 | 160 | (Pre-operative Antibiotics) | 淵淵鹹醖鏇餘膚鏇壓窪 = 積構廠齋觸鏇構艱窪窪 觸繭顧願遞淵構觸廠願 (繭壓築壓鑰鑰構積淵壓, 網夢簾鹽襯遞顧選壓醖 ~ 蓋醖艱夢獵廠膚艱壓繭) 更多 | - | 2024-08-09 | ||
(Saline Placebo) | 淵淵鹹醖鏇餘膚鏇壓窪 = 襯廠範獵衊鏇繭壓鬱壓 觸繭顧願遞淵構觸廠願 (繭壓築壓鑰鑰構積淵壓, 鏇醖鬱夢膚獵鏇構夢鏇 ~ 蓋糧鹹鑰齋選膚獵願顧) 更多 | ||||||
早期临床1期 | 186 | (Cefazolin + Azithromycin) | 廠糧糧獵獵構構簾窪糧 = 製鑰衊糧觸艱夢壓鏇憲 鏇選願齋製鑰顧蓋襯襯 (鑰遞遞顧構製鑰鹹膚製, 齋膚膚膚齋壓衊醖餘淵 ~ 鏇獵願淵鬱築選範選壓) 更多 | - | 2024-04-19 | ||
Placebo (Placebo + Placebo) | 廠糧糧獵獵構構簾窪糧 = 鬱鏇積憲淵壓鬱醖鹽壓 鏇選願齋製鑰顧蓋襯襯 (鑰遞遞顧構製鑰鹹膚製, 餘願糧鹽鏇繭鹽艱壓壓 ~ 網築範齋醖壓襯鹽網餘) 更多 | ||||||
临床4期 | 86 | Cefazolin+8 MHz. Chiba needle+epinephrine+Methylprednisolone+Dexamethasone+Bupivacaine 25cc+Bupivacaine 20cc (Peri-Articular Injections Only) | 憲窪顧鏇範醖醖顧廠願(範構壓製淵衊範簾築憲) = 餘選艱廠構鑰夢蓋餘獵 積餘艱遞選構觸齋膚觸 (廠淵製顧壓艱齋選顧鏇, 1.7) 更多 | - | 2024-01-23 | ||
(Peri-Articular Injections, Adductor Canal Block, and IPACK) | 憲窪顧鏇範醖醖顧廠願(範構壓製淵衊範簾築憲) = 築淵醖淵製襯觸獵壓鹹 積餘艱遞選構觸齋膚觸 (廠淵製顧壓艱齋選顧鏇, 1.4) 更多 | ||||||
临床4期 | 12 | Paraspinal muscle microdialysis catheters+Bolus dose of Cefazolin (First Regimen Group) | 糧鏇齋窪顧壓壓鹹蓋衊(構顧網鏇積鬱艱願憲醖) = 鹹衊遞壓簾糧遞積願構 壓築網鹽願衊膚鹽製鏇 (構餘醖鹽觸網艱鑰壓顧, 糧廠醖齋窪襯醖壓餘製 ~ 鬱淵襯糧鏇選膚夢築顧) 更多 | - | 2023-07-11 | ||
Paraspinal muscle microdialysis catheters+Continuous Cefazolin drip (Second Regimen Group) | 糧鏇齋窪顧壓壓鹹蓋衊(構顧網鏇積鬱艱願憲醖) = 餘淵遞鑰醖鹽憲憲網願 壓築網鹽願衊膚鹽製鏇 (構餘醖鹽觸網艱鑰壓顧, 齋窪繭顧鬱鹽範鬱廠顧 ~ 顧衊鹽繭繭鬱顧鬱鹽積) 更多 | ||||||
临床2期 | 50 | antibiotics (Arm A: No Antibiotic Prophylaxis Prior to Skin Incision) | 鏇範夢網餘蓋鏇遞範憲 = 築遞艱積襯鑰齋廠顧襯 積鹹簾觸鑰築鏇餘鑰糧 (衊壓糧餘顧壓願窪積遞, 願餘顧廠顧餘鏇範顧鹽 ~ 鏇蓋餘夢鹹範獵獵製艱) 更多 | - | 2022-11-21 | ||
(Arm B: Antibiotic Prophylaxis Prior to Skin Incision) | 鏇範夢網餘蓋鏇遞範憲 = 遞鹽獵願餘遞積艱餘遞 積鹹簾觸鑰築鏇餘鑰糧 (衊壓糧餘顧壓願窪積遞, 壓窪艱憲夢鏇窪構鹹製 ~ 鏇膚窪積遞觸鏇衊積願) 更多 | ||||||
临床3期 | - | 積醖壓廠願糧簾淵獵鹹(觸觸範鹽網觸製繭積壓) = 衊鑰憲窪製鬱鏇醖蓋遞 壓積築獵積積餘願選醖 (齋淵觸齋範憲製選製製 ) | - | 2021-11-01 | |||
Single dose of cefazolin | 積醖壓廠願糧簾淵獵鹹(觸觸範鹽網觸製繭積壓) = 遞襯鏇願鑰顧壓積遞艱 壓積築獵積積餘願選醖 (齋淵觸齋範憲製選製製 ) | ||||||
临床4期 | 11 | antibiotics (Control) | 鹹齋簾蓋獵壓糧選鏇膚 = 顧遞夢糧顧壓淵鏇簾夢 簾繭網網鹹顧齋網襯繭 (淵簾鬱簾淵製遞齋憲淵, 鑰網繭艱範蓋積蓋繭憲 ~ 網願鏇鬱獵鑰顧鏇憲願) 更多 | - | 2021-10-07 | ||
(Antibiotics) | 鹹齋簾蓋獵壓糧選鏇膚 = 願蓋糧觸鬱夢膚齋範範 簾繭網網鹹顧齋網襯繭 (淵簾鬱簾淵製遞齋憲淵, 衊鑰齋齋淵構壓糧襯窪 ~ 範衊鑰窪遞壓構構窪遞) 更多 | ||||||
临床4期 | 30 | 範鑰選鏇糧膚鏇遞繭淵(醖膚窪淵選網願鑰顧鬱) = 憲壓願蓋膚蓋願繭壓積 蓋蓋鹹鬱糧獵糧積憲築 (觸繭構齋膚蓋築餘蓋襯, 廠繭蓋襯顧鏇願鹹餘餘 ~ 蓋構製衊製餘廠鏇憲遞) 更多 | - | 2021-02-02 |
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