Sodium selenate(Sodium selenate) - 药物靶点：Akt-1 x PI3Ks x PP2A_在研适应症：额颞痴呆，进行性核上性麻痹，阿尔茨海默症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

Akt-1 x PI3Ks x PP2A

作用方式

抑制剂、刺激剂

作用机制

Akt-1抑制剂(丝氨酸/苏氨酸蛋白激酶AKT抑制剂)、PP2A刺激剂(蛋白质磷酸酶2A刺激剂)、PI3K family 抑制剂(Phosphatidylinositol 3-kinase family inhibitors)

治疗领域

神经系统疾病内分泌与代谢疾病眼部疾病+ [1]

在研适应症

额颞痴呆进行性核上性麻痹阿尔茨海默症+ [1]

非在研适应症-

原研机构

Velacor Therapeutics Pty Ltd.

在研机构

JSW Lifesciences GmbH

Monash University

University of Melbourne

非在研机构

Velacor Therapeutics Pty Ltd.

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (欧盟)

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结构/序列

分子式H2NaO4Se

InChIKeyPRKRTJSKTGAVMH-UHFFFAOYSA-N

CAS号13410-01-0

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关联

7

项与 Sodium selenate 相关的临床试验

ACTRN12623000446662

/ Not yet recruiting临床2期

A Phase 2 Randomised Controlled Trial of Sodium Selenate as a Disease Modifying Treatment for Chronic Drug-resistant Temporal Lobe Epilepsy

开始日期2023-10-01

申办/合作机构

Alfred Health

ACTRN12620000236998

/ Recruiting临床2期

A Phase 2b Randomised Controlled Trial of Sodium Selenate as a Disease Modifying Treatment for Possible Behavioural Variant Fronto-temporal Dementia

开始日期2021-08-17

申办/合作机构

Alfred Health

ACTRN12620001254987

/ Recruiting临床2期

A Phase 2 Randomised Controlled Trial of Sodium Selenate as aDisease Modifying Treatment for Probable Progressive SupranuclearPalsy

开始日期2021-07-29

申办/合作机构

Alfred Health

100 项与 Sodium selenate 相关的临床结果

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100 项与 Sodium selenate 相关的转化医学

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100 项与 Sodium selenate 相关的专利（医药）

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1,640

项与 Sodium selenate 相关的文献（医药）

2025-07-01·Separation and Purification Technology

Study on oxidative leaching of multi-component in copper anode slime enhanced by hydrogen peroxide

作者: Yang, Yang ; Song, Jianfei ; Yang, Guanjiang ; Xu, Wenqing ; Zhu, Tingyu ; Wang, Xue

Improving leaching rate is crucial in the hydrometallurgical recovery of valuable metals from copper anode slime.The complexity of the composition makes it challenging to clarify the leaching behavior of multiple components, and there is limited research available on this topic.Here, H₂O₂ was selected to enhance the leaching performance, and the leaching behaviors of Cu, Se, Te, and Ag were systemically investigated by using a real copper anode slime sample.Indicate that H₂O₂ significantly improves the leaching efficiency of multiple components.Under the optimum conditions, the leaching efficiencies of Cu, Se, Ag, and Te were 96.18%, 90.58%, 80.21%, and 66.72%, resp.As the concentration of H₂O₂ increases, the multiple components were leached in a specific order: Cu₂Te > Cu₂Se > Ag₂Te > Ag₂Se.Based on the XPS and XRD results, along with thermodn. and kinetic calculations, a two-step oxidative leaching reaction mechanism for copper anode slime was proposed.The oxidative leaching process can be divided into two stages.In the first stage, metallic compounds undergo oxidative separation, wherein, copper and silver are converted into soluble Cu²⁺ and Ag⁺ while selenium and tellurium are transformed into insoluble Se⁰ and TeO₂.In the second stage, the Se⁰ and TeO₂ are further converted into soluble H₂SeO₃/H₂SeO₄ and H₆TeO₆.The results of this work offer theor. guidance for designing oxidative leaching technol. for copper anode slime.

2025-06-01·Chemosphere

Magnetite/reduced graphene oxide composites: A sustainable strategy for selenium immobilization and improved corn growth

Article

作者: Golchin, Ahmad ; Misaghi, Mehran ; Sarmasti, Khatereh ; Bostani, Amir

This study investigated the effectiveness of magnetite/reduced graphene oxide (MRGO) in immobilizing selenium (Se) in contaminated soils and its impact on corn (Zea mays) growth and nutrient uptake. A factorial experiment was conducted in a completely randomized design with three replications under greenhouse conditions. Soil samples were contaminated with sodium selenate at Se concentrations of 0, 2, 4, 8, 16, and 32 mg/kg, equilibrated for two months, and subsequently treated with MRGO at 0, 0.25, 0.5, and 1 %, followed by a three-month incubation period. Corn plants were then cultivated from the seedling stage to the vegetative phase, and growth parameters, along with Se and nutrient concentrations in roots and shoots, were analyzed. MRGO significantly enhanced Se immobilization, increasing retention from 62-71 % to 82-90 % at 1 % MRGO. Se exhibited a biphasic effect on plant growth, promoting growth at 2 mg/kg but inducing toxicity at concentrations exceeding 4 mg/kg, leading to reduced biomass and nutrient uptake. MRGO mitigated Se toxicity by lowering Se accumulation in roots and shoots. However, in Se-free soils, higher MRGO levels negatively affected plant growth, likely due to nutrient adsorption. Trends in potassium (K), iron (Fe), and zinc (Zn) mirrored plant growth, peaking at 2 mg/kg Se and 1 % MRGO, whereas P (P) exhibited an inverse root-shoot distribution. These findings underscore MRGO's potential for Se immobilization in contaminated soils, improving plant performance at optimal Se levels. However, its application in Se-deficient soils requires careful management to prevent nutrient depletion (P, K, Zn, and Fe) and long-term declines in soil fertility.

2025-04-01·Environmental Pollution

Selenium nanoparticles affected growth and secondary metabolism in chicory seedlings epigenetically by modifying DNA methylation and transcriptionally by upregulating DREB1A transcription factor and stimulating genes involved in phenylpropanoid metabolism

Article

作者: Oraghi Ardebili, Zahra ; Iranbakhsh, Alireza ; Mokhtarabadi, Elham ; Saadatmand, Sara ; Ebadi, Mostafa

In this biosafety risk assessment project, the molecular and physiological responses of chicory seedlings to the introduction of selenate (0, 0.1, 0.5, 1, and 5 mgl^-1) or nanoscale red elemental Se product (nSe) into the culture medium were investigated. The application of nSe at low concentrations improved the fresh weight of shoots and roots, while 5 mgl^-1 nSe caused severe phytotoxicity. Molecular analysis confirmed partially different epigenetic responses to nSe and selenate. DNA hypomethylation is an important mechanism by which Se exerts its influence at the pre-transcriptional level. With increasing nSe concentration, the transcription factor DREB1A (dehydration-responsive element-binding) showed a linear upward trend. The use of nSe contributed to the transcriptional upregulation of the genes for phenylalanine ammonia-lyase (PAL), hydroxycinnamoyl-CoA: quinate-hydroxycinnamoyl transferases (HQT) and hydroxycinnamoyl-CoA: shikimate/quinate-hydroxycinnamoyl transferase (HCT). Proline concentrations were increased in both leaves and roots in response to the nano-supplement. Cytotoxicity of Se at toxic concentrations decreased protein levels, in contrast to the positive nSe treatments, 0.1 and 0.5. Notably, nSe supplementation acted as an efficient elicitor, stimulating the accumulation of phenylpropanoid derivatives, including caffeic acid, chlorogenic acid, and cichoric acid metabolites. The concentration of ascorbate and glutathione displayed a similar upward trend in response to the nSe supplementation. Further comprehensive comparative molecular studies in different stress-sensitive and tolerant species are necessary to gain a better understanding of the underlying mechanisms. This will allow for the optimization of functional protocols for nSe-based supplements to meet the expectations of sustainable agriculture.

100 项与 Sodium selenate 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	A12CE01	DB11068

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
额颞痴呆	临床前	澳大利亚	Monash University	2024-10-11
进行性核上性麻痹	临床前	澳大利亚	Monash University	2023-10-13
癫痫	临床前	澳大利亚	Monash University	-
阿尔茨海默症	药物发现	澳大利亚	Velacor Therapeutics Pty Ltd.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AAIC2021	N/A	痴呆 hyperphosphorylated tau	12	Sodium selenate 15mg tds	繭製獵選鏇衊艱衊蓋積(憲製醖鏇鹹願顧餘齋構) = n=3 鏇蓋淵蓋夢觸糧鬱夢醖 (艱繭窪構鬱選憲淵膚衊 ) 更多	-	2021-12-31
AAIC2020	N/A	额颞痴呆 hyperphosphorylated tau	15	Sodium selenate 15mg	(範鹹蓋餘積醖鹽鏇觸製) = n=4 齋積醖積網窪窪鹽構廠 (鹹願膚選鹹觸構積淵遞 ) 更多	-	2020-12-07