Sodium selenate(Sodium selenate) - 药物靶点：Akt-1 x PI3K family x PP2A_在研适应症：额颞痴呆，进行性核上性麻痹，阿尔茨海默症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

Akt-1 x PI3K family x PP2A

作用机制

Akt-1抑制剂(丝氨酸/苏氨酸蛋白激酶AKT抑制剂)、PP2A刺激剂(蛋白质磷酸酶2A刺激剂)、Phosphatidylinositol 3-kinase family inhibitors

治疗领域

神经系统疾病内分泌与代谢疾病眼部疾病+ [1]

在研适应症

额颞痴呆进行性核上性麻痹阿尔茨海默症+ [1]

非在研适应症-

原研机构

Velacor Therapeutics Pty Ltd.

在研机构

Monash University

University of MelbourneJSW Lifesciences GmbH

非在研机构

Velacor Therapeutics Pty Ltd.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (欧盟)

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结构

分子式H2NaO4Se

InChIKeyPRKRTJSKTGAVMH-UHFFFAOYSA-N

CAS号13410-01-0

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关联

7

项与 Sodium selenate 相关的临床试验

ACTRN12623000446662 / Not yet recruiting临床2期

A Phase 2 Randomised Controlled Trial of Sodium Selenate as a Disease Modifying Treatment for Chronic Drug-resistant Temporal Lobe Epilepsy

开始日期2023-10-01

申办/合作机构

Alfred Health

ACTRN12620000236998 / Recruiting临床2期

A Phase 2b Randomised Controlled Trial of Sodium Selenate as a Disease Modifying Treatment for Possible Behavioural Variant Fronto-temporal Dementia

开始日期2021-08-17

申办/合作机构

Alfred Health

ACTRN12620001254987 / Recruiting临床2期

A Phase 2 Randomised Controlled Trial of Sodium Selenate as aDisease Modifying Treatment for Probable Progressive SupranuclearPalsy

开始日期2021-07-29

申办/合作机构

Alfred Health

100 项与 Sodium selenate 相关的临床结果

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100 项与 Sodium selenate 相关的转化医学

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100 项与 Sodium selenate 相关的专利（医药）

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803

项与 Sodium selenate 相关的文献（医药）

2024-10-01·Environmental Pollution

Selenate simultaneously alleviated cadmium and arsenic accumulation in rice (Oryza sativa L.) via regulating transport genes

Article

作者: Tao, Yanjin ; Wan, Yanan ; Huang, Siyu ; Fan, Yu ; Wang, Qi ; Li, Huafen ; Liu, Zhe ; Wang, Qiqi ; Qi, Hao

Cadmium (Cd) and arsenic (As) have contrasting biogeochemical behaviors in paddy soil, which posed an obstacle for reducing their accumulation in rice (Oryza sativa L.) simultaneously. In this study, selenate exhibited a more effective ability than selenite on simultaneous alleviation of Cd and As accumulation in rice under Cd-As co-exposure, and the mechanisms need to be further investigated. The results showed that selenate significantly decreased the root Cd and As contents by 59%-83% and 43%-72% compared to Cd-As compound exposure, respectively. Correspondingly, it significantly down-regulated the expression of uptake-related genes OsNramp5 (87.1%) and OsLsi1 (95.5%) in rice roots. Decreases in Cd (64.5%) and As (16.2%) contents in shoots were also found after selenate addition. Moreover, selenate may promoted the reduction of As(V) to As(Ⅲ) and As(III) efflux to the external medium, resulting in decreased As accumulation and As(Ⅲ) proportion in rice shoots and roots. In addition, selenate could promote the binding of Cd (by 14%-24%) and As (by 9%-15%) in the cell wall, and significantly reduced the oxidative stress by elevating levels of antioxidant enzymes (by 10%-105%) and thiol compounds (by 6%-210%). Additionally, selenate significantly down-regulated the expression of OsNramp1 (49.3%) and OsLsi2 (82.1%) associated with Cd and As transport in rice. These findings suggest selenate has the potential to be an effective material for the simultaneous reduction of Cd and As accumulation in rice under Cd-As co-contamination.

2024-09-01·Journal of Environmental Sciences

Effect of inorganic arsenic in paddy soil on the migration and transformation of selenium species in rice plants

Article

作者: Wang, Ze ; Li, Hong ; Zhu, Xi ; Fu, Fengfu ; Wang, Kaiteng ; Yang, Guidi ; Ying, Kaiyang ; Qu, Can ; Wu, Yongchen ; Pokhrel, Ganga Raj

Selenium (Se) in paddy rice is one of the significant sources of human Se nutrition. However, the effect of arsenic (As) pollution in soil on the translocation of Se species in rice plants is unclear. In this research, a pot experiment was designed to examine the effect of the addition of 50 mg As/kg soil as arsenite or arsenate on the migration of Se species from soil to indica Minghui 63 and Luyoumingzhan. The results showed that the antagonism between inorganic As and Se was closely related to the rice cultivar and Se oxidation state in soil. Relative to the standalone selenate treatment, arsenite significantly (p < 0.05) decreased the accumulation of selenocystine, selenomethionine and selenate in the roots, stems, sheaths, leaves, brans and kernels of both cultivars by 21.4%-100.0%, 40.0%-100.0%, 41.0%-100%, 5.4%-96.3%, 11.3%-100.0% and 26.2%-39.7% respectively, except for selenocystine in the kernels of indica Minghui 63 and selenomethionine in the leaves of indica Minghui 63 and the stems of indica Luyoumingzhan. Arsenate also decreased (p < 0.05) the accumulation of selenocystine, selenomethionine and selenate in the roots, stems, brans and kernels of both cultivars by 34.9%-100.0%, 30.2%-100.0%, 11.3%-100.0% and 5.6%-39.6% respectively, except for selenate in the stems of indica Minghui 63. However, relative to the standalone selenite treatment, arsenite and arsenate decreased (p < 0.05) the accumulation of selenocystine, selenomethionine and selenite only in the roots of indica Minghui 63 by 45.5%-100.0%. Our results suggested that arsenite and arsenate had better antagonism toward Se species in selenate-added soil than that in selenite-added soil; moreover, arsenite had a higher inhibiting effect on the accumulation of Se species than arsenate.

2024-07-01·Protoplasma

Selenium nanoparticles conferred drought tolerance in tomato plants by altering the transcription pattern of microRNA-172 (miR-172), bZIP, and CRTISO genes, upregulating the antioxidant system, and stimulating secondary metabolism

Article

作者: Ebadi, Mostafa ; Ahmadvand, Rahim ; Iranbakhsh, Alireza ; Neysanian, Maryam ; Ardebili, Zahra Oraghi

Drought stress is one of the major limiting factors for the production of tomato in Iran. In this study, the efficiency of selenate and Se nanoparticle (SeNP) foliar application on tomato plants was assessed to vestigate mitigating the risk associated with water-deficit conditions. Tomato plants were treated with SeNPs at the concentrations of 0 and 4 mg L^-1; after the third sprays, the plants were exposed to water-deficit conditions. The foliar spraying with SeNPs not only improved growth, yield, and developmental switch to the flowering phase but also noticeably mitigated the detrimental risk associated with the water-deficit conditions. Gene expression experiments showed a slight increase in expression of microRNA-172 (miR-172) in the SeNP-treated plants in normal irrigation, whereas miR-172 displayed a downregulation trend in response to drought stress. The bZIP transcription factor and CRTISO genes were upregulated following the SeNP and drought treatments. Drought stress significantly increased the H₂O₂ accumulation that is mitigated with SeNPs. The foliar spraying with Se or SeNPs shared a similar trend to alleviate the negative effect of drought stress on the membrane integrity. The applied supplements also conferred drought tolerance through noticeable improvements in the non-enzymatic (ascorbate and glutathione) and enzymatic (catalase and peroxidase) antioxidants. The SeNP-mediated improvement in drought stress tolerance correlated significantly with increases in the activity of phenylalanine ammonia-lyase, proline, non-protein thiols, and flavonoid concentrations. SeNPs also improved the fruit quality regarding K, Mg, Fe, and Se concentrations. It was concluded that foliar spraying with SeNPs could mitigate the detrimental risk associated with the water-deficit conditions.

100 项与 Sodium selenate 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	A12CE01	DB11068

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
额颞痴呆	临床前	澳大利亚	Monash University	2024-10-11
进行性核上性麻痹	临床前	澳大利亚	Monash University	2023-10-13
癫痫	临床前	澳大利亚	Monash University	-
阿尔茨海默症	药物发现	澳大利亚	Velacor Therapeutics Pty Ltd.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AAIC2021	N/A	痴呆	12	Sodium selenate 15mg tds	襯蓋簾獵鏇顧艱廠選觸(膚積鹽鏇鹹艱廠範鏇顧) = n=3 憲醖衊膚積廠顧積壓願 (遞構獵淵網膚製衊顧醖 ) 更多	-	2021-12-31
AAIC2020	N/A	额颞痴呆	15	Sodium selenate 15mg	(鑰選壓壓願範襯襯齋醖) = n=4 蓋築憲膚遞築選製糧襯 (憲獵餘窪網鬱構觸衊醖 ) 更多	-	2020-12-07