Sodium selenate(Sodium selenate) - 药物靶点：Akt-1 x PI3Ks x PP2A_在研适应症：额颞痴呆，进行性核上性麻痹，阿尔茨海默症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

靶点

Akt-1 x PI3Ks x PP2A

作用方式

抑制剂、刺激剂

作用机制

Akt-1抑制剂(丝氨酸/苏氨酸蛋白激酶AKT抑制剂)、PP2A刺激剂(蛋白质磷酸酶2A刺激剂)、PI3K family 抑制剂(Phosphatidylinositol 3-kinase family inhibitors)

治疗领域

神经系统疾病内分泌与代谢疾病眼部疾病+ [1]

在研适应症

额颞痴呆进行性核上性麻痹阿尔茨海默症+ [1]

非在研适应症-

原研机构

Velacor Therapeutics Pty Ltd.

在研机构

JSW Lifesciences GmbH

Monash University

University of Melbourne

非在研机构

Velacor Therapeutics Pty Ltd.

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (欧盟)

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结构/序列

分子式H2NaO4Se

InChIKeyPRKRTJSKTGAVMH-UHFFFAOYSA-N

CAS号13410-01-0

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关联

7

项与 Sodium selenate 相关的临床试验

ACTRN12623000446662

/ Not yet recruiting临床2期

A Phase 2 Randomised Controlled Trial of Sodium Selenate as a Disease Modifying Treatment for Chronic Drug-resistant Temporal Lobe Epilepsy

开始日期2023-10-01

申办/合作机构

Alfred Health

ACTRN12620000236998

/ Recruiting临床2期

A Phase 2b Randomised Controlled Trial of Sodium Selenate as a Disease Modifying Treatment for Possible Behavioural Variant Fronto-temporal Dementia

开始日期2021-08-17

申办/合作机构

Alfred Health

ACTRN12620001254987

/ Recruiting临床2期

A Phase 2 Randomised Controlled Trial of Sodium Selenate as aDisease Modifying Treatment for Probable Progressive SupranuclearPalsy

开始日期2021-07-29

申办/合作机构

Alfred Health

100 项与 Sodium selenate 相关的临床结果

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100 项与 Sodium selenate 相关的转化医学

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100 项与 Sodium selenate 相关的专利（医药）

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1,639

项与 Sodium selenate 相关的文献（医药）

2025-04-01·Environmental Pollution

Selenium nanoparticles affected growth and secondary metabolism in chicory seedlings epigenetically by modifying DNA methylation and transcriptionally by upregulating DREB1A transcription factor and stimulating genes involved in phenylpropanoid metabolism

Article

作者: Oraghi Ardebili, Zahra ; Iranbakhsh, Alireza ; Mokhtarabadi, Elham ; Saadatmand, Sara ; Ebadi, Mostafa

In this biosafety risk assessment project, the molecular and physiological responses of chicory seedlings to the introduction of selenate (0, 0.1, 0.5, 1, and 5 mgl^-1) or nanoscale red elemental Se product (nSe) into the culture medium were investigated. The application of nSe at low concentrations improved the fresh weight of shoots and roots, while 5 mgl^-1 nSe caused severe phytotoxicity. Molecular analysis confirmed partially different epigenetic responses to nSe and selenate. DNA hypomethylation is an important mechanism by which Se exerts its influence at the pre-transcriptional level. With increasing nSe concentration, the transcription factor DREB1A (dehydration-responsive element-binding) showed a linear upward trend. The use of nSe contributed to the transcriptional upregulation of the genes for phenylalanine ammonia-lyase (PAL), hydroxycinnamoyl-CoA: quinate-hydroxycinnamoyl transferases (HQT) and hydroxycinnamoyl-CoA: shikimate/quinate-hydroxycinnamoyl transferase (HCT). Proline concentrations were increased in both leaves and roots in response to the nano-supplement. Cytotoxicity of Se at toxic concentrations decreased protein levels, in contrast to the positive nSe treatments, 0.1 and 0.5. Notably, nSe supplementation acted as an efficient elicitor, stimulating the accumulation of phenylpropanoid derivatives, including caffeic acid, chlorogenic acid, and cichoric acid metabolites. The concentration of ascorbate and glutathione displayed a similar upward trend in response to the nSe supplementation. Further comprehensive comparative molecular studies in different stress-sensitive and tolerant species are necessary to gain a better understanding of the underlying mechanisms. This will allow for the optimization of functional protocols for nSe-based supplements to meet the expectations of sustainable agriculture.

2025-02-01·Chemistry & Biodiversity

Selenium Enhances Growth, Phenolic Compounds, Antioxidant Capacity in Brassica Oleracea Var. Italica

Article

作者: Soltani, Forouzandeh ; Wiesner‐Reinhold, Melanie ; Babalar, Mesbah ; Saeedi, Mahboobeh ; Baldermann, Susanne ; Mastinu, Andrea

AbstractSelenium is a micronutrient element that is beneficial for the growth and development of plants. It has antioxidant, anticancer, and antiviral properties that are essential for human and animal health. Low‐consumption mineral elements such as selenium can be included in the diet from various sources. To investigate the growth and phytochemical attributes of a broccoli cultivar “Heracklion”, an experiment with five levels of selenium concentration (0, 5, 10, 15, 20 mg/L sodium selenate) was carried out in a randomized complete block design with 3 replications in the field condition. With increasing the concentration of sodium selenate in the foliar application, the accumulation of sodium selenate in broccoli increased and the highest amount (1.47 mg/kg dry weight) was measured at 20 mg/L of sodium selenate. The highest amount of photosynthetic pigments in leaves was recorded at 15 mg/L of sodium selenate. In the case of glucosinolates, with increasing selenium concentration up to 20 mg/L concentration, glucoraphanin, 4‐methoxy glucobrassicin, and aliphatic glucosinolates increased in leaves. It could be demonstrated that foliar application of selenium at 10 mg/L led to an improvement of secondary metabolites, especially glucoraphanin, both in leaves and florets, and could also have a positive effect on human nutrition.

2025-01-01·Journal of Environmental Management

Effects of selenate on greenhouse gas release and microbial community variations during swine manure composting

Article

作者: Zhao, Mengxiang ; Ren, Xiuna ; Zhao, Jiarui ; Ding, Yongzhen ; Qin, Yilang ; Xi, Bin ; Xiao, Ziling ; Wang, Quan

Co-composting of livestock manure and selenate is an effective means to produce selenium-rich organic fertilizer. However the effect of selenate on greenhouse gas emission during composting is still unknown. To probe the influences of selenate on greenhouse gas and microbial community changes during swine manure composting. Various dose of selenate were added to the fresh swine manure and wheat straw for 80 days aerobic composting, sequentially labeled as T1 (control) to T6 (0, 1, 2, 3, 4 and 5 mg kg^-1). Results indicated that selenate generally increased the nitrous oxide (N₂O) and ammonia (NH₃) emissions while presented varying impacts on methane (CH₄) emissions. Compared with the control, adding 2 and 5 mg kg^-1 selenate reduced the CH₄ emission by 39.60% and 13.75%, respectively, while other concentrations presented opposite results. Meanwhile, adding 2 mg kg^-1 selenate could reduce the global warming potential and improve the compost maturity. According to the microbial results, adding 2 mg kg^-1 selenate enhanced the richness and variety of the microbes and might influence Proteobacteria, Chloroflexi, Actinobacteria and Methylococcaceae_unclassified to decrease the global warming potential.

100 项与 Sodium selenate 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	-	A12CE01	DB11068

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
额颞痴呆	临床前	澳大利亚	Monash University	2024-10-11
进行性核上性麻痹	临床前	澳大利亚	Monash University	2023-10-13
癫痫	临床前	澳大利亚	Monash University	-
阿尔茨海默症	药物发现	澳大利亚	Velacor Therapeutics Pty Ltd.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AAIC2021	N/A	痴呆 hyperphosphorylated tau	12	Sodium selenate 15mg tds	憲窪鹽窪鏇鹹糧顧膚鏇(獵願鬱築鏇製繭鏇觸齋) = n=3 鑰膚醖壓鹽廠鬱夢廠淵 (餘獵簾獵鑰網淵鏇鬱衊 ) 更多	-	2021-12-31
AAIC2020	N/A	额颞痴呆 hyperphosphorylated tau	15	Sodium selenate 15mg	(製鑰衊壓齋憲鏇鏇蓋夢) = n=4 築衊獵蓋廠淵廠鑰淵網 (鏇範鹹淵網積遞淵蓋憲 ) 更多	-	2020-12-07