Virapinib(Virapinib) - 在研适应症：新型冠状病毒感染，蜱传脑炎病毒感染，猴痘_专利_临床

概要

基本信息

药物类型

化学药

别名-

靶点-

作用机制-

治疗领域

感染神经系统疾病呼吸系统疾病+ [1]

在研适应症

新型冠状病毒感染蜱传脑炎病毒感染猴痘

非在研适应症-

原研机构

Karolinska Institutet

在研机构

Karolinska Institutet

非在研机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

关联

100 项与 Virapinib 相关的临床结果

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100 项与 Virapinib 相关的转化医学

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100 项与 Virapinib 相关的专利（医药）

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1

项与 Virapinib 相关的文献（医药）

2024-09-01·Molecular Therapy

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

Article

作者: Murga, Matilde ; Häggblad, Maria ; Carreras-Puigvert, Jordi ; Hühn, Daniela ; Corman, Alba ; Schlegel, Jan ; Wright, Shane C ; Lafarga, Miguel ; Lidemalm, Louise ; Barz, Myriam ; Klingström, Jonas ; Porebski, Bartlomiej ; Jarvius, Malin ; Lapins, Maris ; Christ, Wanda ; Haraldsson, Martin ; Ilmain, Juliana ; Sezgin, Erdinc ; Bhabha, Gira ; Fernandez-Capetillo, Oscar ; Lauschke, Volker M

Several viruses hijack various forms of endocytosis in order to infect host cells. Here, we report the discovery of a molecule with antiviral properties that we named virapinib, which limits viral entry by macropinocytosis. The identification of virapinib derives from a chemical screen using high-throughput microscopy, where we identified chemical entities capable of preventing infection with a pseudotype virus expressing the spike (S) protein from SARS-CoV-2. Subsequent experiments confirmed the capacity of virapinib to inhibit infection by SARS-CoV-2, as well as by additional viruses, such as mpox virus and TBEV. Mechanistic analyses revealed that the compound inhibited macropinocytosis, limiting this entry route for the viruses. Importantly, virapinib has no significant toxicity to host cells. In summary, we present the discovery of a molecule that inhibits macropinocytosis, thereby limiting the infectivity of viruses that use this entry route such as SARS-CoV2.

100 项与 Virapinib 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
新型冠状病毒感染	临床前	瑞典	Karolinska Institutet	2024-07-02
蜱传脑炎病毒感染	临床前	瑞典	Karolinska Institutet	2024-07-02
猴痘	临床前	瑞典	Karolinska Institutet	2024-07-02