Intranasal insulin(The Johns Hopkins University)(Intranasal insulin(The Johns Hopkins University)) - 药物靶点：INSR_在研适应症：多发性硬化症_专利_临床

概要

基本信息

药物类型

激素

别名-

靶点

INSR

作用方式

激动剂

作用机制

INSR激动剂(胰岛素受体激动剂)

治疗领域

免疫系统疾病神经系统疾病其他疾病

在研适应症

多发性硬化症

非在研适应症

艾滋病痴呆复合征认知功能障碍

原研机构

The Johns Hopkins University

在研机构

The Johns Hopkins University

非在研机构-

权益机构-

最高研发阶段临床2期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

4

项与 Intranasal insulin(The Johns Hopkins University) 相关的临床试验

ChiCTR2400091690

/ SuspendedN/AIIT

Study on the Effects of Intranasal Insulin Administration on Postoperative Delirium in Elderly Patients

开始日期2024-11-01

申办/合作机构-

ChiCTR2400089093

/ Suspended临床4期IIT

Effect of intranasal insulin pretreatment on postoperative delirium in elderly orthopedic surgery patients with preoperative mild cognitive impairment: a single-center, prospective, double-blind randomized controlled clinical study

开始日期2024-09-10

申办/合作机构-

ChiCTR2400084380

/ Suspended临床1期IIT

A prospective cohort study and nested case-control study of intranasal insulin for postoperative delirium in elderly patients with hip fracture

开始日期2024-06-01

申办/合作机构-

100 项与 Intranasal insulin(The Johns Hopkins University) 相关的临床结果

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100 项与 Intranasal insulin(The Johns Hopkins University) 相关的转化医学

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100 项与 Intranasal insulin(The Johns Hopkins University) 相关的专利（医药）

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21

项与 Intranasal insulin(The Johns Hopkins University) 相关的文献（医药）

2025-08-01·SLEEP MEDICINE

Intranasal insulin enhances postoperative sleep quality and delirium in middle-aged cardiac surgery patients: A randomized controlled trial

Article

作者: Cao, Lei ; Wang, Wei ; Yang, Guiying ; Chen, Fang ; Ding, Jinping ; Li, Hong ; Yang, Ming ; Liang, Yan ; Du, Zhiyong ; Xiao, Cheng ; Jiang, Xuetao ; Lu, Tong

BACKGROUND:

Postoperative delirium (POD) remains a significant complication following cardiopulmonary bypass (CPB) surgery, particularly in middle-aged patients who constitute the majority of this surgical population. While intranasal insulin (INI) has shown neuroprotective potential in aging cohorts, its efficacy in younger surgical patients and its underlying mechanisms remain under explored. This study investigates whether INI mitigates POD through sleep-wake cycle modulation.

METHOD:

It is a single-center prospective randomized, double-blinded controlled trial from March 4, 2024 to October 18, 2024. 76 middle-aged patients (45-65 years) undergoing elective CPB surgery were randomized to receive INI (20 IU) or placebo preoperatively and on postoperative days 1-2. The primary outcome was POD incidence (CAM-ICU criteria). Secondary outcomes included Mini-Mental State Examination (MMSE) scores, actigraphy-derived sleep metrics (sleep efficiency [SE], total sleep time [TST]). Analyses followed intention-to-treat principles.

RESULTS:

INI significantly reduced POD incidence (17.1 % vs. 38.9 %, RR = 3.45, p = 0.037) and improved cognitive recovery, as evidenced by higher MMSE scores at postoperative day 5 with a difference of 1.71 (95 % CI, 0.19 to 3.23; p = 0.027). Sleep analysis revealed robust improvements in the INI group: SE increased by 21.3 % (78.2 ± 12.1 % vs. 64.5 ± 15.3 %, p = 0.031), and TST extended by 27.1 % (6.1 ± 1.2h vs. 4.8 ± 1.5h, p = 0.033) on postoperative day 1. No significant differences were observed in hospital length of stay (p = 0.893), highlighting the specificity of INI's sleep-mediated effects.

CONCLUSION:

This trial demonstrates that INI stabilizes postoperative sleep architecture, leading to reduced POD incidence and enhanced cognitive recovery in middle-aged CPB patients. These findings position INI as a targeted intervention for perioperative neurocognitive protection, particularly in populations vulnerable to circadian disruption.

CLINICAL TRIAL REGISTRATION:

ChiCTR 2400081444. Registered March 1, 2024, http://www.chictr.org.cn.

2024-10-01·Cognitive Neurodynamics

Intranasal insulin effect on cognitive and/or memory impairment: a systematic review and meta-analysis

Review

作者: Martínez-García, Irene ; Cavero-Redondo, Iván ; Saz-Lara, Alicia ; Álvarez-Bueno, Celia ; Pascual-Morena, Carlos ; Gómez-Guijarro, María Dolores

Supplementary Information:

The online version contains supplementary material available at 10.1007/s11571-024-10138-5.

2024-09-01·AGE AND AGEING

Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial

Article

作者: Liu, Yan-hong ; Mi, Weidong ; Sun, Miao ; Cao, Jiangbei ; Huo, Yuting ; Ma, Yu-long ; Ruan, Xianghan ; Zhang, Xiaoying ; Zhou, Zhikang ; Liu, Min ; Liu, Siyuan

Abstract:

Background:

Postoperative cognitive impairment are common neural complications in older surgical patients and exacerbate the burden of medical care on families and society.

Methods:

A total of 140 older patients who were scheduled for elective orthopaedic surgery or pancreatic surgery with general anaesthesia were randomly assigned to Group S or Group I with a 1:1 allocation. Patients in Group S and Group I received intranasal administration of 400 μL of normal saline or 40 IU/400 μL of insulin, respectively, once daily from 5 minutes before anaesthesia induction until 3 days postoperatively. Perioperative cognitive function was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment-Basic (MoCA-B) at 1 day before and 3 days after surgery and postoperative delirium (POD) incidence was assessed using the 3-minute Diagnostic Interview for CAM (3D-CAM) on postoperative days 1–3. Serum levels of interleukin-6 (IL-6), tumour necrosis factor α (TNF-α), S100-β and C-reactive protein (CRP) were measured on the first day after surgery.

Results:

Insulin treatment significantly increased postoperative MMSE and MoCA-B scores in group I than in group S (P < 0.001, P = 0.001, respectively), decreased the incidence of POD within the 3-day postoperative period in Group I than in Group S (10.9% vs 26.6%, P = 0.024), and inhibited postoperative IL-6 and S100-β levels in Group I compared to Group S (P = 0.034, P = 0.044, respectively).

Conclusions:

Intranasal insulin administration is thus suggested as a potential therapy to improve postoperative cognition in older patients undergoing surgery. However, a more standardized multi-centre, large-sample study is needed to further validate these results.

100 项与 Intranasal insulin(The Johns Hopkins University) 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
艾滋病痴呆复合征	临床2期	美国	The Johns Hopkins University	2017-08-01
认知功能障碍	临床2期	美国	The Johns Hopkins University	2017-08-01
多发性硬化症	临床2期	-	The Johns Hopkins University	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03081117 (CTgov)	临床1/2期	认知功能障碍 \| 艾滋病痴呆复合征	21	Insulin, intranasal (Insulin, Intranasal)	醖廠鏇簾醖糧窪遞夢壓(製鑰製糧廠簾築艱鬱膚) = 壓憲觸鏇鏇構選夢壓鹹淵選蓋廠襯窪獵淵窪網 (艱淵窪醖窪觸鏇廠壓淵, 0.67) 更多	-	2021-07-07
				Placebo, intranasal (Placebo, Intranasal)	醖廠鏇簾醖糧窪遞夢壓(製鑰製糧廠簾築艱鬱膚) = 膚醖蓋糧簾積衊淵簾範淵選蓋廠襯窪獵淵窪網 (艱淵窪醖窪觸鏇廠壓淵, 0.40) 更多
AAIC2006	N/A	阿尔茨海默症 plasma insulin \| CSF insulin \| plasma beta amyloid ... 更多	-	Placebo	鏇壓餘鏇襯觸觸鬱淵觸(觸鹽鏇憲鏇觸淵夢簾範) = 繭膚顧鏇壓壓製醖蓋壓餘鹹鏇構顧積餘艱膚壓 (淵壓繭齋獵鏇襯夢簾獵 )	-	2006-07-01
				Intranasal insulin treatment (20 IU)	鏇壓餘鏇襯觸觸鬱淵觸(觸鹽鏇憲鏇觸淵夢簾範) = 鏇窪壓積艱淵淵鑰鬱簾餘鹹鏇構顧積餘艱膚壓 (淵壓繭齋獵鏇襯夢簾獵 )