Long-acting HIV Pre-Exposure Prophylaxis Integrated With Community-based Sexual and Reproductive Health in South Africa (LAPIS): A Hybrid (1a) Cluster Randomised Controlled Phase 3B Trial of Effectiveness and Implementation

The goal of this hybrid (1a) Cluster Randomised Controlled Trial phase 3B trial is to evaluate the effectiveness and implementation of offering a choice of HIV Pre-Exposure Products (PrEP) through community-based sexual and reproductive health services, on PrEP uptake and retention, and population prevalence of sexually transmissible HIV amongst adolescents and young adults living in rural South Africa.
Researchers will compare adding the choice of long-acting PrEP, i.e. two monthly injectable cabotegravir (CAB LA) or dapiravine vaginal ring and HIV post exposure prophylaxis packs to daily oral PrEP integrated with community-based SRH in the 20 intervention clusters with standard of care (SoC), daily oral PrEP integrated with community-based SRH in the 20 control clusters, on uptake and retention on PrEP. We hypothesise that offering a choice of long-acting or oral PrEP and PEP within the community-based delivery of SRH services will overcome the challenges and barriers to effective use of oral daily PrEP and lead to a population-level effect on uptake and retention on PrEP and thus the prevalence of sexually transmissible HIV amongst 15-30 year olds living in rural KwaZulu-Natal, South Africa.

开始日期2024-02-27

申办/合作机构-

NCT06807736

/ RecruitingN/AIIT

PrEPared to Choose (PtC): An Implementation Study of the Delivery of Cabotegravir Long-acting Injectable Pre-exposure Prophylaxis (PrEP) as an HIV Prevention Product Option Within a PrEP Choice Context in a Real World Setting in Cape Town.

The goal of this clinical trial is to offer adolescents and young people in Cape Town, South Africa different HIV pre-exposure prophylaxis (PrEP) products and describe how they use these products over an 18-month period. The study has both clinical and implementation primary aims. The primary clinical aim is short and long-term persistence on PrEP. Persistence is defined as the length of time that a participant shows continuous use of a PrEP product as intended, without stopping PrEP or switching to another PrEP product. The primary implementation aim involves the determination of factors that either enable or serve as a barrier to PrEP uptake and continuation.
Participants will be offered a choice between three antiretroviral-containing PrEP products: (1) a Tenofovir-based oral tablet that needs to be taken daily; (2) a vaginal ring containing Dapivirine that provides HIV protection for up to one month; and (3) an intramuscular injection containing Cabotegravir that provides HIV protection for up to two months. Participants will be able to use the same product throughout the study, switch between products, or stop and restart on PrEP at any point.
The study will be offered from two study sites: the first is a mobile clinic that rotates on a fixed schedule across the study area and the second is a fixed-location government primary healthcare clinic. The study will be open to confirmed HIV-negative individuals, including adolescent girls and young women (aged 15-29 years), young gender and sexually diverse populations aged 15-29 years (including men who have sex with men, transgender people, and non-binary people), and their collective sexual partners (including heterosexual, cisgender men) of any age.

开始日期2024-02-13

申办/合作机构

Desmond Tutu Hiv Foundation

[+2]

NCT05416021

/ Completed临床1期

A Phase I, Open-Label, Randomized, Crossover Trial to Investigate the Relative Bioavailability of the 25 mg Dapivirine Vaginal Ring-004 Inserted Every 30 Days and 100 mg DPV Ring-008 Inserted for 90 Days in Healthy Female Participants

A Phase I, Open-Label, Randomized, Crossover Trial to Investigate the Relative Bioavailability of the 25 mg Dapivirine Vaginal Ring-004 inserted every 30 days and 100 mg Dapivirine Vaginal Ring-008 inserted for 90 days in Healthy Female Participants

开始日期2022-08-01

申办/合作机构

INC Research Holdings, Inc.

100 项与 Dapivirine 相关的临床结果

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100 项与 Dapivirine 相关的转化医学

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100 项与 Dapivirine 相关的专利（医药）

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269

项与 Dapivirine 相关的文献（医药）

2026-06-01·JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Comment on “Higher Acceptability of the Monthly Dapivirine Ring versus Daily Oral Pre-exposure Prophylaxis Among Adolescent Girls and Young Women in Sub-Saharan Africa in the REACH Trial”

Article

作者: Sah, Shyam Sundar ; Kumbhalwar, Abhishek

2026-03-01·BMJ Global Health

Values and preferences of female sex workers in Zimbabwe for long-acting injectable pre-exposure prophylaxis and the dapivirine vaginal ring: results of a mixed-methods research study

Article

作者: Maguma, Jasper ; Cowan, Frances M ; Baggaley, Rachel ; Machingura, Fortunate ; Rodolph, Michelle ; Chabata, Sungai T ; d'Elbée, Marc ; Kujeke, Tatenda

Introduction:

Female sex workers (FSWs) in sub-Saharan Africa are at high risk of HIV acquisition. Here we explore the values and preferences of Zimbabwean FSW for long-acting pre-exposure prophylaxis (PrEP).

Methods:

We employed mixed methods; focus group discussions (FGD) (n=15), a respondent-driven sampling (RDS) survey (n=4444) from 22 sites across Zimbabwe and a nested discrete choice experiment (DCE) (n=435) conducted in 4/22 sites in 2021. Purposively selected FSWs aged 18 or over who reported being HIV negative were eligible for inclusion in FGDs. Analysis of self-reported HIV negative survey participants was RDS-II weighted. DCE analysis estimated relative preferences. Qualitative and quantitative data were triangulated.

Results:

Median age of survey participants was 28 years with IQR of 23–34 years. There was strong concordance across methods by product, provider, service and individual characteristics. Most FSWs indicated that they preferred long-acting injectable (LAI) PrEP to either oral PrEP or dapivirine vaginal ring (DVR). Most were interested in using LAI PrEP (74.1%; n=1835/2392), a few the DVR (10.9%, n=230/2392), and 2.4% (59/2392) and 13.5% (268/2392) either or neither of the two options, respectively. There was little trust in public sector healthcare providers, with most FSWs opting to access PrEP through programmes designed for sex workers (and stating they would miss a prescription refill/repeat injection if the public sector was the only available option). Injectable PrEP addressed privacy and adherence concerns to some extent, although FSWs felt that 6-monthly would be preferable to less frequent injections. Issues of privacy (related to PrEP and being a FSW), confidentiality and respect emerged as key qualitative themes.

Conclusions:

FSW had a strong preference for LAI PrEP, but ensuring product choice and user privacy was key. FSW in Eastern and Southern Africa should therefore be prioritised for PrEP choices, with ongoing monitoring and evaluation of services to make sure they are acceptable, effective and evolve as products and delivery options become available.

2026-03-01·Lancet HIV

Safety, acceptability, and adherence to dapivirine vaginal ring and oral pre-exposure prophylaxis for HIV prevention in the second trimester of pregnancy: a multicountry, open-label, phase 3b randomised trial

Article

作者: McClure, Tara ; Balkus, Jennifer ; Hillier, Sharon L ; Nakabiito, Clemensia ; Stoner, Marie ; Mgodi, Nyaradzo M ; Dadabhai, Sufia ; Mabuza, Carlotta ; Gadama, Luis ; Piper, Jeanna M ; Chakhtoura, Nahida ; Hawley, Imogen ; Rossi, Lisa ; Rooney, James F ; Mayo, Ashley J ; Noguchi, Lisa ; Anderson, Peter L ; Mhlanga, Felix G ; Chappell, Catherine ; Balan, Ivan ; Kemel, Lena ; Scheckter, Rachel ; Davis, Jontraye ; Livant, Edward ; Fairlie, Lee ; Levy, Lisa ; Song, Mei ; Richardson, Barbra A ; Makanani, Bonus ; Manalo, Maricel ; Fowler, Mary Glenn ; Blanchette, Cheryl ; Musara, Petina ; Katz, Ariana ; Rosenberg, Zeda ; van der Straten, Ariane ; Szydlo, Daniel W ; Cleland, Naana ; Brown, Amanda ; Bunge, Katherine ; Chirenje, Z. Mike ; Singh, Devika ; Duran, Luis ; Young, Alinda ; Johnson, Abraham ; Taha, Taha E ; Harrell, Tanya ; Beigi, Richard H. ; Rausch, Dianne M ; Gous, Hermien ; Montgomery, Elizabeth ; Richardson, Barbra ; Senn, Teri ; Gadama, Luis A ; Hendrix, Craig ; Black, Roberta ; Marzinke, Mark A ; Riddler, Sharon A ; Seyama, Linly

BACKGROUND:

Pregnant women are at a four times higher risk of HIV per coital act than non-pregnant women. MTN-042/DELIVER was a phase 3b randomised study of dapivirine vaginal ring (DVR) and oral pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate-emtricitabine to assess safety, adherence, and acceptability when used during pregnancy. Our hypothesis was that both DVR and oral PrEP would be safe and well tolerated when started early in the second trimester and continued until delivery.

METHODS:

In MTN-042/DELIVER, an open-label, phase 3b randomised trial, healthy pregnant women without HIV and aged 18-40 years from Malawi, South Africa, Uganda, and Zimbabwe were enrolled and randomly allocated (4:1) to open-label monthly DVR PrEP or daily oral PrEP. Women were enrolled between 12 weeks' and 29 weeks' gestation. Product use continued until delivery or 42 weeks' gestation. The primary outcomes for safety following exposure to study product were a composite of all serious adverse events, including maternal deaths, all grade 3 or higher adverse events, and pregnancy outcomes stratified as term (≥37⁺⁰ weeks), preterm (<37⁺⁰ weeks), and pregnancy loss before 20 weeks' gestation. Pregnancy complications and adverse events were summarised with descriptive statistics. This study is registered with ClinicalTrials.gov, NCT03965923.

FINDINGS:

Between July 12, 2022, and Jan 12, 2023, 251 mothers were enrolled, with 202 randomly allocated to receive DVR PrEP and 49 to receive oral PrEP. The median age was 24·0 years (IQR 22·0-29·0) and the median gestational age was 23·7 weeks (19·9-26·3). 28 mothers (11%) had safety events under the composite study primary outcome (all serious adverse events plus all grade 3 or higher adverse events), none of which was related to product use. No maternal deaths or HIV seroconversions occurred. There were 247 pregnancy outcomes of which 233 (94%) were at term (≥37⁺⁰ weeks). Pregnancy complications were uncommon, and none was infectious.

INTERPRETATION:

Adverse pregnancy outcomes related to DVR and oral PrEP use were uncommon among women starting PrEP in the second trimester. These findings support the use of these preventive approaches during pregnancy.

FUNDING:

US National Institutes of Health.

项与 Dapivirine 相关的新闻（医药）

2026-05-19

·cidrz.org

CIDRZ CHEP Pays Courtesy Call on Central Province Health Office During Lenacapavir Training in Kabwe.

CIDRZ’s Controlling HIV Epidemic Project (CHEP) paid a courtesy call on the Central Province Health Office in Kabwe as part of ongoing activities related to the transitioning of the Zambia Integrated Health (ZIH) program, from Pact Inc. to CIDRZ. During the same period, CIDRZ, in collaboration with the Ministry of Health, is conducting a Trainer of Trainers (ToT) workshop focused on the rollout of pre-exposure prophylaxis (PrEP) products, namely, cabotegravir, Dapivirine Vaginal Ring (DVR) and Lenacapavir, a groundbreaking HIV prevention intervention described by experts as the closest alternative to an HIV vaccine. The PrEP workshop aims to equip frontline healthcare workers with the knowledge and skills required to effectively deliver the different PrEP products as Zambia strengthens efforts towards HIV epidemic control. The CHEP delegation was led by Ms Francheskie Vélez, Director of the Health Coordination Office at the U.S. Embassy in Zambia and included CHEP Chief of Party Dr Maurice Musheke. Speaking during the visit, Ms Vélez reaffirmed the U.S. Government’s commitment, through the U.S. Embassy in Zambia, to strengthening partnerships with local organisations to implement life-saving health interventions. She noted that CIDRZ had been identified as an ideal local partner as the U.S. Government shifts focus on prioritising local organisations to lead and sustain public health programmes. Ms Vélez also thanked the Provincial Health Office for hosting the team and supporting the successful implementation of the training programme in Kabwe. The Provincial Health Director, Dr Elijah Mutoloki, was represented by Dr Mwanja Kakusa, the Provincial Clinical Care Specialist for Central Province, who welcomed the delegation and expressed appreciation for selecting Kabwe as the host district for the training. Dr Kakusa noted that the Training of Trainers workshop was particularly important because Central Province had not been included in the previous training. She added that the healthcare workers participating in the training would play a critical role in cascading the knowledge and skills acquired to other healthcare workers across the province. Dr Kakusa further stated that the training would strengthen the province’s HIV response by enhancing healthcare workers’ capacity to deliver innovative HIV prevention services as the province seeks to achieve epidemic control. CIDRZ continues to work closely with the Ministry of Health, the U.S. Government through the U.S. Embassy in Zambia, and other partners to support evidence-based interventions that improve health outcomes and advance Zambia’s HIV response.

临床研究

2026-04-22

·cidrz.org

CIDRZ, Ministry of Health Train HIV Specialists in Advanced PrEP Delivery to Strengthen Prevention Efforts.

To strengthen HIV prevention efforts, the Controlling HIV Epidemic Project (CHEP), under the Centre for Infectious Disease Research in Zambia (CIDRZ), in collaboration with the Ministry of Health and with financial support from the United States Department of State, conducted a six-day Training of Trainers (ToT) workshop on the delivery of different pre-exposure prophylaxis (PrEP) products. The training which was held in Ndola, brought together HIV healthcare specialists from CIDRZ, the Copperbelt Provincial Health Office, Ndola Teaching Hospital, Copperbelt District Health Offices, and the United States Department of State. Participants were drawn from Eastern, Western, Lusaka, and Copperbelt provinces. The training was officially opened by Copperbelt Provincial Health Director, Dr Charles Mwinuna, and focused on equipping participants with the skills required to deliver combination HIV prevention services. Particular emphasis was placed on oral PrEP, Cabotegravir (2-month injectable PrEP), Lenacapavir (6-month injectable PrEP), and the Dapivirine Vaginal Ring (DVR), a long-acting, user-controlled PrEP product designed to reduce the risk of acquiring HIV during vaginal sex. Meanwhile, Dr Paul Mwale, Copperbelt Provincial Advanced HIV Disease (AHD) and Injectable PrEP Coordinator under the Ministry of Health, led a session outlining the mandate of the HIV Prevention Programme, which aims to achieve epidemic control and end AIDS by 2030. He highlighted national targets, including reducing new HIV infections from 28,000 to 15,000 by 2026 and increasing PrEP uptake among key and priority populations to 220,000 annually, emphasising the need for accelerated efforts to meet both national and global goals. In another session, Dr Monica Chibesakunda, CIDRZ’s HIV Testing and Prevention Lead, trained participants on HIV testing services, stressing their role in both preventing new infections and linking individuals to care. She emphasised adherence to national HIV testing guidelines for PrEP initiation and the importance of providing tailored prevention services based on individual risk. Other sessions covered demand generation for PrEP, scheduling PrEP clinical visits, managing beneficiaries who missed appointments, switching beneficiaries between PrEP products, pharmacovigilance, and comprehensive data documentation. The training also addressed the link between Gender-Based Violence (GBV), Intimate Partner Violence (IPV), and HIV risk. Facilitators underscored the importance of integrating GBV and IPV screening into HIV services to support comprehensive, client-centred care. The workshop concluded with participants committing to cascade the knowledge gained and strengthen HIV prevention services, contributing to Zambia’s goal of ending AIDS as a public health threat by 2030.

临床研究

2023-01-18

·PipelineReview

Janssen and Global Partners to Discontinue Phase 3 Mosaico HIV Vaccine Clinical Trial

Independent, scheduled review of Phase 3 Mosaico study finds investigational vaccine regimen lacks efficacy in preventing HIV No vaccine-related safety issues identified LEIDEN, THE NETHERLANDS I January 18, 2023 I The Janssen Pharmaceutical Companies of Johnson & Johnson, together with a consortium of global partners, today announced the results of an independent, scheduled data review of the Phase 3 Mosaico study (also known as HPX3002/HVTN706) of Janssen’s investigational HIV vaccine regimen. The study’s independent Data and Safety Monitoring Board (DSMB) determined that the regimen was not effective in preventing HIV infection compared to placebo among study participants. No safety issues with the vaccine regimen were identified. In light of the DSMB’s determination, the Mosaico clinical trial will be discontinued. Participant notifications and further analyses of the data are underway. Throughout the trial, study investigators have ensured that any individuals who contracted HIV received prompt HIV treatment and care. “We are disappointed with this outcome and stand in solidarity with the people and communities vulnerable to and affected by HIV,” said Penny Heaton, M.D., Global Therapeutic Area Head, Vaccines, Janssen Research & Development, LLC. “Though there have been significant advances in prevention since the beginning of the global epidemic, 1.5 million people acquired HIV in 2021 alone, underscoring the high unmet need for new options and why we have long worked to tackle this global health challenge. We remain steadfast in our commitment to advancing innovation in HIV, and we hope the data from Mosaico will provide insights for future efforts to develop a safe and effective vaccine. We are grateful to our Mosaico partners and the study investigators, staff and participants.” About the Phase 3 Mosaico Study Mosaico, a Phase 3 study of Janssen’s investigational HIV vaccine regimen, began in 2019, and completed vaccinations in October 2022. The study included approximately 3,900 cisgender men and transgender people who have sex with cisgender men and/or transgender people, who represent groups and populations vulnerable to HIV, at over 50 trial sites in Argentina, Brazil, Italy, Mexico, Peru, Poland, Puerto Rico, Spain and the United States. The study evaluated an investigational vaccine regimen containing a mosaic-based adenovirus serotype 26 vector (Ad26.Mos4.HIV) administered during four vaccination visits over one year. A mix of soluble proteins (Clade C/Mosaic gp140, adjuvanted with aluminum phosphate) was also administered at visits three and four. The Mosaico DSMB analysis, based on the data available to date, indicated that the regimen does not protect against HIV and the study is not expected to meet its primary endpoint. No safety issues with the vaccine regimen were identified. In light of this, the study will be discontinued, and further analyses are underway. The DSMB’s determination follows the primary analysis of the Phase 2b Imbokodo study, which was announced in August 2021 and found that a similar investigational HIV vaccine regimen did not provide sufficient protection against HIV in a population of young women in sub-Saharan Africa. The investigational vaccine regimen used in the Imbokodo study was found to have a favorable safety profile. The Mosaico study was led by a global public-private partnership including the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), the HIV Vaccine Trials Network (HVTN), the U.S. Army Medical Research and Development Command (USAMRDC), and Janssen Vaccines & Prevention B.V. Since 2005, Janssen Vaccines & Prevention B.V. has been participating as a sub-grantee in the NIH-supported Integrated Preclinical/Clinical AIDS Vaccine Development (IPCAVD) program under grants AI066305, AI078526, AI096040 and AI128751 (Principal Investigator, Prof. Dan Barouch). Johnson & Johnson’s Commitment to HIV Johnson & Johnson has been committed to the fight against HIV for decades, playing a key role in bringing nine therapeutics to people living with HIV and continuing to drive innovation in HIV prevention and care. In January 2021, the dapivirine ring, a discreet long-acting HIV prevention method specifically developed for women by the International Partnership for Microbicides (IPM) and based on Janssen’s compound, was recommended by the World Health Organization as an additional prevention choice for women with a substantial chance of contracting HIV as part of combination prevention approaches. In July 2021 , Zimbabwe became the first country to approve the use of the dapivirine ring among women ages 18 and older, with South Africa following suit in March 2022 . Additional regulatory decisions are pending. Johnson & Johnson also works with vulnerable communities on the frontlines of the HIV epidemic, and has supported collaborative initiatives like the DREAMS Partnership in sub-Saharan Africa, the MenStar Coalition , and the New Horizons Collaborative . To learn more about Johnson & Johnson’s commitment to combatting HIV, please visit jnj.com/hiv . About Johnson & Johnson At Johnson & Johnson, we believe good health is the foundation of vibrant lives, thriving communities, and forward progress. That’s why for more than 135 years, we have aimed to keep people well at every age and every stage of life. Today, as the world’s largest diversified healthcare products company, we are committed to using our reach and size for good. We strive to improve access and affordability, create healthier communities, and put a healthy mind, body, and environment within reach of everyone, everywhere. We are blending our heart, science, and ingenuity to profoundly change the trajectory of health for humanity. About the Janssen Pharmaceutical Companies of Johnson & Johnson At Janssen, we’re creating a future where disease is a thing of the past. We’re the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular, Metabolism & Retina; Immunology; Infectious Diseases & Vaccines; Neuroscience; Oncology; and Pulmonary Hypertension. Learn more at http://www.janssen.com and follow us at http://www.twitter.com/JanssenGlobal and www.twitter.com/JanssenUS . Janssen Vaccines & Prevention, B.V. and Janssen Research & Development, LLC are part of the Janssen Pharmaceutical Companies of Johnson & Johnson. SOURCE: Johnson & Johnson

疫苗临床2期临床3期临床结果

100 项与 Dapivirine 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D11246	Dapivirine	G01AX17	DB08639

研发状态

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适应症	最高研发状态	国家/地区	公司	日期
HIV感染	临床3期	肯尼亚	INC Research Holdings, Inc.	2011-07-01
HIV感染	临床3期	肯尼亚	International Partnership for Microbicides	2011-07-01
HIV感染	临床3期	马拉维	INC Research Holdings, Inc.	2011-07-01
HIV感染	临床3期	卢旺达	INC Research Holdings, Inc.	2011-07-01
HIV感染	临床3期	卢旺达	International Partnership for Microbicides	2011-07-01
HIV感染	临床3期	南非	INC Research Holdings, Inc.	2011-07-01
HIV感染	临床3期	津巴布韦	INC Research Holdings, Inc.	2011-07-01
获得性免疫缺陷综合征	临床2期	南非	International Partnership for Microbicides	2009-07-01
获得性免疫缺陷综合征	临床2期	南非	INC Research Holdings, Inc.	2009-07-01
避孕	临床1期	美国	International Partnership for Microbicides	2018-07-17

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临床结果

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03965923 (MTN-042/DELIVER, Pubmed \| Lancet HIV)	临床3期	HIV感染	251	Dapivirine vaginal ring	顧築窪選鏇範鑰憲積窪(製糧蓋夢憲淵鬱艱醖觸) = 觸膚製廠餘醖製範齋鹽壓獵鏇艱鏇鑰遞廠衊積 (窪廠選願鬱鬱鹽餘夢艱 ) 更多	积极	2026-03-01
NCT03965923 (MTN-042/DELIVER, Pubmed \| Lancet HIV)	临床3期	HIV感染	545	Dapivirine vaginal ring	構鬱艱壓鹹蓋夢築鹹觸(餘窪積艱願構鹹積顧憲) = 窪衊鬱簾壓範醖選夢鹽糧積願遞鑰襯廠範鬱選 (糧襯網願繭廠襯廠簾簾 ) 更多	积极	2025-11-01
				Oral PrEP (tenofovir disoproxil fumarate plus emtricitabine)	構鬱艱壓鹹蓋夢築鹹觸(餘窪積艱願構鹹積顧憲) = 糧廠淵遞鹽鑰鬱餘鬱繭糧積願遞鑰襯廠範鬱選 (糧襯網願繭廠襯廠簾簾 ) 更多
NCT04140266 (MTN-043, Pubmed \| Lancet HIV)	临床3期	母乳喂养	197	Dapivirine vaginal ring (DVR)	簾鹹醖夢鹹遞憲窪鑰艱(膚鹽鏇糧觸糧鏇簾鬱廠) = 醖醖鹽簾襯獵顧積鬱廠衊築構餘遞構選鏇壓鏇 (築顧壓積範壓範製醖壓 )	积极	2025-03-01
NCT01617096 (MTN-020/ASPIRE, Pubmed \| J Infect Dis)	临床3期	HIV感染	-	Dapivirine Vaginal Ring	憲糧鬱構餘簾壓簾製鬱(淵鏇鑰鹽製網鑰壓積選) = 繭簾觸鑰獵窪鑰壓鑰選選鏇糧鬱鹽獵觸衊窪衊 (鑰選壓獵憲夢衊衊憲醖, 1.8 ~ 3.1)	积极	2024-04-12
				Placebo	憲糧鬱構餘簾壓簾製鬱(淵鏇鑰鹽製網鑰壓積選) = 鹹淵網顧醖衊蓋淵選簾選鏇糧鬱鹽獵觸衊窪衊 (鑰選壓獵憲夢衊衊憲醖, 2.9 ~ 4.4)
NCT01539226 (The Ring Study, Pubmed \| BMJ Open) 人工标引	N/A	HIV感染	197	Dapivirine vaginal ring / placebo vaginal ring	鑰製鏇糧夢鏇鹹製獵餘(顧築觸範範壓積觸糧鑰) = 襯製鹽遞壓襯獵築蓋鑰壓選顧獵壓繭觸窪襯觸 (構積觸夢網衊鹽糧鏇鬱, 44.7 ~ 60.3) 更多	不佳	2024-04-08
				Dapivirine vaginal ring	鑰製鏇糧夢鏇鹹製獵餘(顧築觸範範壓積觸糧鑰) = 膚襯製衊繭艱艱艱壓簾壓選顧獵壓繭觸窪襯觸 (構積觸夢網衊鹽糧鏇鬱 )
NCT01617096 (MTN-020/ASPIRE \| ASPIRE \| MTN-020, CTgov)	临床3期	HIV感染	2,629	Dapivirine Vaginal Ring (Dapivirine Vaginal Ring)	淵願顧夢鬱觸衊繭蓋襯 = 鬱鏇遞糧夢繭糧製鏇鬱鏇鏇醖鹹製蓋齋餘築襯 (糧積夢鹹繭齋築齋鬱鬱, 構鑰遞築醖鹹衊廠襯築 ~ 壓廠範壓鏇願壓鬱齋獵) 更多	-	2022-12-16
				Placebo Ring (Placebo Ring)	淵願顧夢鬱觸衊繭蓋襯 = 願願衊衊獵襯鹽膚餘鬱鏇鏇醖鹹製蓋齋餘築襯 (糧積夢鹹繭齋築齋鬱鬱, 鹹鏇夢鹹窪獵憲齋遞網 ~ 觸蓋觸齋獵選齋繭淵襯) 更多
NCT02862171 \| NCT01539226 (The Ring Study and DREAM, Pubmed)	临床3期	HIV感染	-	Dapivirine Vaginal Ring-004 (DVR)	顧餘築選襯壓顧獵範膚(製鑰遞蓋繭蓋選鹹齋鑰) = 製襯願夢窪鏇鏇廠醖衊壓網構獵製簾鹽蓋選獵 (鏇遞觸醖製網糧壓襯齋 )	-	2022-11-08
NCT00799058 (CTgov)	临床1/2期	HIV感染	128	dapivirine gel 4759 (Dapivirine Gel 4759)	廠遞窪網觸製鏇壓蓋餘 = 鹽鹽鹹築積遞膚選鏇範淵願壓獵鏇選壓壓網夢 (鹹構鏇範糧築選齋壓簾, 獵醖鹹繭艱積範艱積醖 ~ 選選餘網遞觸鹽憲構艱) 更多	-	2022-10-25
				dapivirine 4789 (Dapivirine Gel 4789)	廠遞窪網觸製鏇壓蓋餘 = 遞鹽襯蓋繭廠顧網選窪淵願壓獵鏇選壓壓網夢 (鹹構鏇範糧築選齋壓簾, 網遞窪築鬱鬱顧淵廠鑰 ~ 鏇獵觸繭鬱鑰遞窪鑰繭) 更多
NCT02862171 (DREAM, CTgov)	临床3期	HIV感染	941	Dapivirine Vaginal Ring-004	壓醖膚選夢鑰蓋遞積構 = 鹽觸艱網廠醖襯廠夢糧獵顧範夢構鹽繭觸廠糧 (衊網積壓構選糧淵鬱壓, 淵廠艱夢壓範選鹹製齋 ~ 網廠繭製膚廠鑰鏇網衊) 更多	-	2022-10-25
NCT02858037 (HOPE, CTgov)	临床3期	HIV感染	1,456	Dapivirine Vaginal Ring	製鏇範艱膚鹽憲壓顧壓 = 壓選選餘淵獵艱憲衊簾鏇艱齋餘鹽廠夢蓋憲廠 (襯積壓鏇簾構顧簾觸餘, 廠獵艱醖艱觸齋選鹹範 ~ 襯願積壓範夢獵齋顧顧) 更多	-	2022-10-25