更新于：2024-11-18
Cefoperazone Sodium/Sulbactam Sodium
头孢哌酮钠/舒巴坦钠
更新于：2024-11-18
概要
基本信息
药物类型 小分子化药 |
别名 Cefoperazone Sodium and Sulbactam、Cefoperazone Sodium and Sulbactam Sodium、Cefoperazone Sodium and Sulbactam Sodium(2:1) + [26] |
作用机制 PBPs抑制剂(细菌青霉素结合蛋白家族抑制剂)、β-lactamase抑制剂(β-内酰胺酶抑制剂)、细胞壁抑制剂 |
治疗领域 |
非在研适应症- |
原研机构 |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1986-04-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C25H27N9NaO8S2 |
InChIKeyNMANBWFYJSWTBZ-WERGMSTESA-N |
CAS号62893-20-3 |
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关联
9
项与 头孢哌酮钠/舒巴坦钠 相关的临床试验Preventive Effect of Prophylactic Oral Antibiotics Against Cholangitis After Kasai Portoenterostomy in Biliary Atresia: a Randomized Controlled Trial
注射用头孢哌酮钠舒巴坦钠（3:1）在中国健康人体中的药代动力学研究
Epidemiological Study on Drug-induced Coagulation Disorder Caused by Cefoperazone Sulbactam Sodium and Construction of Prediction Model
100 项与 头孢哌酮钠/舒巴坦钠 相关的临床结果
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100 项与 头孢哌酮钠/舒巴坦钠 相关的转化医学
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100 项与 头孢哌酮钠/舒巴坦钠 相关的专利（医药）
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96
项与 头孢哌酮钠/舒巴坦钠 相关的文献（医药）2024-10-06Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Article
作者: Huang, H ; Tan, Q X ; Wei, J ; Xue, J ; Shen, H J ; Wang, C
Objective: To investigate the changes of the distribution and drug resistance profile of bacteria from ICU children with lower respiratory tract infection (LRTI) in Suzhou City, Jiangsu Province from 2017 to 2022. Methods: From January 2017 to December 2022, a cross-sectional observational study on the bacterial spectrum analysis among intensive care unit (ICU) children with LRTI was conducted in Children's Hospital of Soochow University. The bacteria was cultivated by culture methods from sputum samples, and identified by MALDI-TOF mass spectrometry. Drug sensitivity tests were performed by the VITEK2 Compact fully automated analysis system and the paper slide method. The χ2 test or Fisher's exact probability was used to analyze the changes of the distribution of sputum culture-positive bacteria and drug resistance in ICU children. Results: The overall detection rate of sputum culture was 42.06% (1 182/2 810). Staphylococcus aureus (25.63%,303/1 182), Acinetobacter baumannii (13.62%,161/1 182) and Haemaphilus influenzae (13.28%,157/1 182) were the top three. Proportions of Acinetobacter baumannii (17.90% vs. 11.02%,χ²=11.17, P=0.001), especially carbapenem-resistant Acinetobacter baumannii (43.70% vs. 23.50%, χ²=15.21, P<0.001) increased significantly from 2020 to 2022. However, the proportions of Haemophilus influenzae (8.50% vs. 16.19%, χ²=14.27, P<0.001), Streptococcus pneumoniae (8.50% vs. 15.92%, χ²=13.42, P<0.001) and extended-spectrum-lactamase producing Escherichia coli (8.89% vs. 18.00%, χ²=5.45, P=0.025) decreased. Drug resistant results showed that Acinetobacter baumannii was obviously more resistant to imipenem (χ²=4.43, P=0.035) and levofloxacin (χ²=12.53, P<0.001), while more sensitive to minocycline (χ²=8.34, P=0.004). Escherichia coli showed a significant increase in resistance to piperacillin tazobactam (χ²=8.29, P=0.008) and cefoperazone sulbactam (χ²=5.07, P=0.024) from 2020 to 2022; Klebsiella pneumoniae consistently maintained a resistance rate of more than 60% to first and second-generation cephalosporins, and remain susceptible to quinolones and carbapenems. Staphylococcus aureus remained highly susceptible to levofloxacin (drug resistance rate: 2.31%,7/303) and sulfamethoxazole/trimethoprim (drug resistance rate: 4.95%,15/303) from 2020 to 2022. Conclusion: Higher detection and resistance rates of Acinetobacter baumannii from sputum culture in ICU children from 2020 to 2022 were explored. Resistance of Escherichia coli to β-lactamase inhibitor combinations was more serious. Regular monitoring the changes of the etiology of respiratory tract infections in ICU Children is particularly important for the prevention and treatment of multidrug-resistant bacterial infections.
2024-02-01Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
A case of <italic>Elizabethkingia meningoseptica</italic> septicemia
Article
作者: Ye, Tinghua ; Pan, Xinling ; Shi, Yunzhen ; Wu, Lihua ; Hong, Li
A 82-year-old man was admitted to hospital with fever, unresponsiveness, elevated hypersensitive C-reactive protein and neutrophile granulocyte. Ceftriaxone was administrated by intravenous dripping in the emergency room, but the effect was not satisfactory. Following his admission to the ward, cefoperazone sulbactam were given. Elizabethkingia meningoseptica was identified by blood culture and further confirmed by 16S rRNA sequencing. The lumbar puncture showed that cerebrospinal fluid pressure was 80 mmH2O (1 mmH2O=0.0098 kPa) and biochemical results were normal. After 11 days of cefoperazone sulbactam treatment, the patient was discharged with negative blood culture. The hypersensitive C-reactive protein and neutrophile granulocyte had also declined. The patient received levofloxacin tablets for anti-infection treatment for 14 d after discharge. No signs of infection were observed in three months' following up.
2023-07-01Microbial drug resistance (Larchmont, N.Y.)
Article
作者: Li, Guanghui ; Du, Fangling ; Chen, Jiao ; Zhang, Qi ; Liu, Yang ; Liu, Peng ; Wan, Fen ; Cheng, Zhibin ; Shao, Yanting
Acinetobacter baumannii is a highly antibiotic-resistant pathogen causing nosocomial severe life-threatening infections, especially in critically ill patients. Capsular polysaccharide is a major virulence factor of A. baumannii both in vitro and in vivo. In this study, 220 isolates were collected in the hospital. The prevalent capsular types of A. baumannii were determined using polymerase chain reaction, and the clinical characteristics of infections were analyzed. The virulence of these strains was determined by serum-killing resistance, biofilm formation, and Galleria mellonella survival assays. Twenty-eight isolates (12.7%) carried KL2, and 22 isolates (10%) carried the types KL10, KL14, KL22, and KL52. Compared with non-KL2 (KL10, KL14, KL22, and KL52) isolates, KL2 isolates had significantly higher resistance to all antimicrobials except tigecycline, cefoperazone-sulbactam, or colistin. Seventy-five percent of KL2 A. baumannii and 72.7% of non-KL2 were highly virulent using a G. mellonella model. Biofilm formation was significantly different between the KL2 and non-KL2 groups. The biofilm production of non-KL2 A. baumannii was significantly stronger than that of KL2 A. baumannii. These findings highlight the role of KL2 as a powerful factor for drug resistance and virulence of A. baumannii.
100 项与 头孢哌酮钠/舒巴坦钠 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | 头孢哌酮钠/舒巴坦钠 | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 中国 | 2004-04-30 | |
| 感染 | 日本 | 1986-04-30 |
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临床结果
临床结果
适应症
分期
评价
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N/A | 157 | 鑰遞鬱襯壓鬱範製窪顧(鏇遞齋衊鹽淵築願糧製) = 淵鬱遞壓觸獵餘鑰鹽築 鏇鏇築鏇壓獵簾顧簾膚 (廠衊衊鑰遞襯簾製淵衊 ) | 积极 | 2018-06-01 | |||
临床4期 | 307 | 顧遞構壓壓衊築鏇艱積(積襯憲醖蓋齋襯製鬱膚) = The incidence of treatment-related adverse events was 6.5% and 16.4% in the cefoperazone-sulbactam and ceftazidime-amikacin-metronidazole groups, respectively, with more discontinuations due to treatment-related adverse events in the comparator arm (3.2% vs. 9.9%) 蓋夢糧觸積淵襯醖衊觸 (憲餘襯簾壓鬱襯築憲衊 ) | 积极 | 2008-06-01 | |||
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