更新于：2024-11-04
Enoxacin
依诺沙星
更新于：2024-11-04
概要
基本信息
药物类型 小分子化药 |
别名 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid、1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid、Enoxacin (USAN/INN) + [39] |
作用机制 细菌DNA旋转酶复合体抑制剂、Bacterial Top II抑制剂(细菌拓扑异构酶II抑制剂)、Bacterial top IV抑制剂(细菌拓扑异构酶IV抑制剂) |
治疗领域 |
在研适应症 |
非在研适应症- |
原研机构 |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1991-12-31), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (欧盟) |
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结构
分子式C15H17FN4O3 |
InChIKeyIDYZIJYBMGIQMJ-UHFFFAOYSA-N |
CAS号74011-58-8 |
关联
1
项与 依诺沙星 相关的临床试验A Randomized, Double-blind, Parallel Group, Single Centre, Phase 1b/2 Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Three Orally Administered Doses of Enoxacin (200mg Twice Daily, 400mg Twice Daily and 600mg Twice Daily) in Adults With Amyotrophic Lateral Sclerosis
100 项与 依诺沙星 相关的临床结果
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100 项与 依诺沙星 相关的转化医学
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100 项与 依诺沙星 相关的专利（医药）
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1,128
项与 依诺沙星 相关的文献（医药）2024-12-01ENVIRONMENTAL POLLUTION
Toxicological mechanisms and molecular impacts of tire particles and antibiotics on zebrafish
Article
作者: Li, Tong ; Fenech, Adam ; Wen, Jingya ; Gao, Jiaxuan ; Pu, Qikun ; Li, Yu ; Ding, Xiaowen ; Liu, Yajing
Tire microplastics (TMPs) and antibiotics are emerging pollutants that widely exist in water environments. The coexistence of these pollutants poses severe threats to aquatic organisms. However, the toxicity characteristics and key molecular factors of the combined exposure to TMPs in aquatic organisms remain unknown. Therefore, the joint toxicity of styrene-butadiene rubber TMPs (SBR-TMPs) and 32 antibiotics (macrolides, fluoroquinolones, β-lactams, sulfonamides, tetracyclines, nitroimidazoles, highly toxic antibiotics, high-content antibiotics, and common antibiotics) in zebrafish was investigated using a full factorial design, molecular docking, and molecular dynamics simulation. Sixty-four combinations of antibiotics were designed to investigate the hepatotoxicity of the coexistence of SBR-TMPs additives and antibiotics in zebrafish. Results indicated that low-order effects of antibiotics (e.g., enoxacin-lomefloxacin and ofloxacin-enoxacin-lomefloxacin) had relatively notable toxicity. The van der Waals interaction between additives and zebrafish cytochrome P450 enzymes primarily affected zebrafish hepatotoxicity. Zebrafish hepatotoxicity was also affected by the ability of SBR-TMPs to adsorb antibiotics, the relation between antibiotics, the affinity of antibiotics docking to zebrafish cytochrome P450 enzymes, electronegativity, atomic mass, and the hydrophobicity of the antibiotic molecules. This study aimed to eliminate the joint toxicity of TMPs and antibiotics and provide more environmentally friendly instructions for using different chemicals.
2024-08-01CHEMOSPHERE
Distribution and ecological risk assessment of antibiotics in different freshwater aquaculture ponds in a typical agricultural plain, China
Article
作者: Zhang, Lu ; Li, Yong ; Wang, Cong ; Wei, Huimin ; Wang, Zhi ; Cheng, Yiting
Freshwater aquaculture serves as a significant focal point for antibiotic contamination, yet understanding antibiotic distribution across different aquaculture models and stages remains limited. This study evaluated antibiotic pollution in three distinct freshwater aquaculture models: rice-crayfish coculture, fish aquaculture, and crab-crayfish aquaculture, during various aquaculture stages. Of the 33 target antibiotics, 16 antibiotics were detected, with the total concentrations ranging from 111.81 ng/L to 15,949.05 ng/L in water and 10.11 ng/g to 8986.30 ng/g in sediment. Among these antibiotics, erythromycin and lomefloxacin are prohibited for use in Chinese aquaculture. Dominant antibiotics in water included lincomycin, enrofloxacin, and enoxacin, whereas in sediment, oxytetracycline and erythromycin were predominant. Notably, lincomycin emerged as a dominant antibiotic in aquaculture for the first time. The concentrations of these dominant antibiotics were high compared to other aquaculture settings and exhibited elevated ecological risk. Critical periods for antibiotic contamination in water and sediment were found to be incongruent, occurring during the rainy season in July for water and the dry season in October for sediment. Notably, the rice-crayfish coculture model exerts a good effect in reducing antibiotic pollution. Overall, these findings offer valuable evidence for the healthful and sustainable advancement of aquaculture.
2024-06-01Environmental research
Enhanced degradation of enoxacin using ferrihydrite-catalyzed heterogeneous photo-Fenton process
Article
作者: Tian, Lin ; Zhang, Liwen ; Dong, Deming ; Guo, Zhiyong ; Wang, Liting ; Wei, Shikun
The ferrihydrite-catalyzed heterogeneous photo-Fenton reaction shows great potential for environmental remediation of fluoroquinolone (FQs) antibiotics. The degradation of enoxacin, a model of FQ antibiotics, was studied by a batch experiment and theoretical calculation. The results revealed that the degradation efficiency of enoxacin reached 89.7% at pH 3. The hydroxyl radical (∙OH) had a significant impact on the degradation process, with a cumulative concentration of 43.9 μmol L-1 at pH 3. Photogenerated holes and electrons participated in the generation of ∙OH. Eleven degradation products of enoxacin were identified, with the main degradation pathways being defluorination, quinolone ring and piperazine ring cleavage and oxidation. These findings indicate that the ferrihydrite-catalyzed photo-Fenton process is a valid way for treating water contaminated with FQ antibiotics.
100 项与 依诺沙星 相关的药物交易
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研发状态
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 细菌感染 | 美国 | 1991-12-31 |
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