金刚烷胺/奥司他韦/利巴韦林(Amantadine/Oseltamivir/Ribavirin) - 药物靶点：DRDs x IMPDH x NMDA receptor x RNAP x RNGTT x neuraminidase_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Amantadine/ribavirine/oseltamivir、Oseltamivir/amantadine/ribavirin、Oseltamivir/ribavirin/amantadine

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靶点

DRDs x IMPDH x NMDA receptor x RNAP x RNGTT x neuraminidase

作用方式

激动剂、抑制剂、拮抗剂

作用机制

DRDs激动剂(多巴胺受体家族激动剂)、IMPDH抑制剂(肌苷-5 '-磷酸脱氢酶（IMPDH）家族抑制剂)、NMDA receptor拮抗剂(谷氨酸[NMDA]受体复合体拮抗剂)

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治疗领域

感染呼吸系统疾病

在研适应症-

非在研适应症

甲型流感病毒感染

原研机构

National Institutes of Health

在研机构-

非在研机构

Adamas Pharmaceuticals LLC

最高研发阶段终止临床2/3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式C8H12N4O5

InChIKeyIWUCXVSUMQZMFG-AFCXAGJDSA-N

CAS号36791-04-5

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关联

3

项与金刚烷胺/奥司他韦/利巴韦林相关的临床试验

NCT01227967

/ Completed临床2期IIT

A Randomized Double-Blind Phase 2 Study Comparing the Efficacy, Safety, and Tolerability of Combination Antivirals (Amantadine, Ribavirin, Oseltamivir) Versus Oseltamivir for the Treatment of Influenza in Adults at Risk for Complications

Seasonal influenza is responsible for many hospitalizations and deaths each year, despite effective antiviral treatments. Some individuals have medical conditions such as heart or lung diseases that make them particularly at risk of severe influenza infections that may result in hospitalization or death. Oseltamivir (Tamiflu) is used most often to treat flu, but there are still many hospitalizations, complications, and deaths even with treatment. This study evaluated the use of combination antivirals (amantadine, oseltamivir, and ribavirin) compared to oseltamivir alone in the treatment of influenza in an at-risk population.

开始日期2010-09-01

申办/合作机构

National Institute of Allergy & Infectious Diseases

NCT00979251

/ Completed临床2期

A Randomized Open Label Study Comparing the Efficacy, Safety, and Tolerability of Oral Administration of Amantadine and Ribavirin With Oseltamivir Versus Oseltamivir to Influenza A Virus Infected Immunocompromised Subjects

This Phase 2, open label, randomized study will investigate the virologic benefit, clinical efficacy, safety, and tolerability of amantadine and ribavirin with oseltamivir (TCAD) versus oseltamivir monotherapy for the treatment of all strains of influenza A in immunocompromised adult and pediatric subjects.

开始日期2009-09-01

申办/合作机构

Adamas Pharmaceuticals LLC

NCT00867139

/ Completed临床1/2期IIT

A Pilot, Randomized Study Comparing the Safety, Tolerability and Pharmacokinetics of Combination Therapy (Amantadine, Ribavirin, Oseltamivir) Versus Neuraminidase Inhibitor Monotherapy to Influenza Virus Infected Immunocompromised Patients

The purpose of this study is to assess the safety and tolerability of triple combination antiviral drug (TCAD) for use in immunocompromised patients with Influenza A infection, and to gain data on the effectiveness of TCAD

开始日期2009-03-01

申办/合作机构

Fred Hutchinson Cancer Research Center

100 项与金刚烷胺/奥司他韦/利巴韦林相关的临床结果

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100 项与金刚烷胺/奥司他韦/利巴韦林相关的转化医学

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100 项与金刚烷胺/奥司他韦/利巴韦林相关的专利（医药）

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27

项与金刚烷胺/奥司他韦/利巴韦林相关的文献（医药）

2024-01-01·Trends in Hearing

The Impact of Hearing Aids on Listening Effort and Listening-Related Fatigue - Investigations in a Virtual Realistic Listening Environment

Article

作者: Heeren, J. ; Wagener, K. ; Gordon, C. ; Schulte, M. ; Meis, M. ; Latzel, M. ; Mirkovic, B. ; Crowhen, D. ; Blümer, M.

Participation in complex listening situations such as group conversations in noisy environments sets high demands on the auditory system and on cognitive processing. Reports of hearing-impaired people indicate that strenuous listening situations occurring throughout the day lead to feelings of fatigue at the end of the day. The aim of the present study was to develop a suitable test sequence to evoke and measure listening effort (LE) and listening-related fatigue (LRF), and, to evaluate the influence of hearing aid use on both dimensions in mild to moderately hearing-impaired participants. The chosen approach aims to reconstruct a representative acoustic day (Time Compressed Acoustic Day [TCAD]) by means of an eight-part hearing-test sequence with a total duration of approximately 2½ h. For this purpose, the hearing test sequence combined four different listening tasks with five different acoustic scenarios and was presented to the 20 test subjects using virtual acoustics in an open field measurement in aided and unaided conditions. Besides subjective ratings of LE and LRF, behavioral measures (response accuracy, reaction times), and an attention test (d2-R) were performed prior to and after the TCAD. Furthermore, stress hormones were evaluated by taking salivary samples. Subjective ratings of LRF increased throughout the test sequence. This effect was observed to be higher when testing unaided. In three of the eight listening tests, the aided condition led to significantly faster reaction times/response accuracies than in the unaided condition. In the d2-R test, an interaction in processing speed between time (pre- vs. post-TCAD) and provision (unaided vs. aided) was found suggesting an influence of hearing aid provision on LRF. A comparison of the averaged subjective ratings at the beginning and end of the TCAD shows a significant increase in LRF for both conditions. At the end of the TCAD, subjective fatigue was significantly lower when wearing hearing aids. The analysis of stress hormones did not reveal significant effects.

2017-04-01·The FASEB Journal2区 · 生物学

Adiponectin association with T‐cadherin protects against neointima proliferation and atherosclerosis

2区 · 生物学

Article

作者: Maeda, Norikazu ; Masuda, Shigeki ; Sekimoto, Ryohei ; Mori, Takuya ; Ranscht, Barbara ; Kita, Shunbun ; Nishizawa, Hitoshi ; Obata, Yoshinari ; Shimomura, Iichiro ; Fukuda, Shiro ; Fujishima, Yuya ; Funahashi, Tohru ; Yamaoka, Masaya ; Matsuda, Keisuke

Adiponectin, an adipocyte-derived protein abundant in the circulation, is thought to be protective against atherosclerosis. However, it is not fully understood how the association of adiponectin with vascular cells and its antiatherogenic effect are connected. In this study, T-cadherin was essential for accumulation of adiponectin in the neointima and atherosclerotic plaque lesions, and the adiponectin-T-cadherin association protected against vascular injury. In the apolipoprotein E-knockout (ApoE-KO) mice, adiponectin and T-cadherin colocalized on endothelial cells and synthetic smooth muscle cells in the aortic intima. Notably, aortic adiponectin protein disappeared in T-cadherin/ApoE double-knockout (Tcad/ApoE-DKO) mice with significant elevation of blood adiponectin concentration. Furthermore, in Tcad/ApoE-DKO mice, carotid artery ligation resulted in a significant increase of neointimal thickness compared with ApoE-KO mice. Finally, on a high-cholesterol diet, Tcad/ApoE-DKO mice increased atherosclerotic plaque formation, despite a 5-fold increase in plasma adiponectin level compared with that in ApoE-KO mice. In vitro, knockdown of T-cadherin from human aortic smooth muscle cells (HASMCs) with synthetic phenotype significantly reduced adiponectin accumulation on HASMCs and negated the inhibitory effect of adiponectin on proinflammatory change. Collective evidence showed that adiponectin accumulates in the vasculature via T-cadherin, and the adiponectin-T-cadherin association plays a protective role against neointimal and atherosclerotic plaque formations.-Fujishima, Y., Maeda, N., Matsuda, K., Masuda, S., Mori, T., Fukuda, S., Sekimoto, R., Yamaoka, M., Obata, Y., Kita, S., Nishizawa, H., Funahashi, T., Ranscht, B., Shimomura, I. Adiponectin association with T-cadherin protects against neointima proliferation and atherosclerosis.

2014-08-01·Global Spine Journal

Traumatic Dissection of Four Brain-Supplying Arteries without Neurologic Deficit

作者: Powerski, Maciej ; Heining, Sandro ; Nolte, Christian H. ; Ertel, Wolfgang ; Pröscholdt, Florian

Study Design Case report and review of the literature. Objectives Case report of a traumatic dissection of all major brain-supplying arteries resulting from a horseback-riding accident. Overview of the literature on diagnostic and therapeutic recommendations. Methods Case presentation. For the discussion, handpicked articles and PubMed database research with the keywords “dissection,” “vertebral artery,” “spine trauma,” “computed tomography,” “magnetic resonance imaging,” and “angiography” were used. Results Despite high-energy induced acute lesion of all four cervical arteries, this 45-year-old patient did not demonstrate signs of microemboli nor suffer from stroke. Conclusion In case of high-energy trauma of the head and/or the neck, emergency physicians must consider traumatic cervical artery dissection (TCAD). Thus, emergency care algorithms should routinely include computed tomography angiography and magnetic resonance imaging. Although the incidence of TCAD-induced stroke is low, antiplatelet therapy is recommended in the presence of TCAD.

100 项与金刚烷胺/奥司他韦/利巴韦林相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
甲型流感病毒感染	临床3期	美国	Adamas Pharmaceuticals LLC	-
甲型流感病毒感染	临床3期	美国	Adamas Pharmaceuticals LLC	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01227967 (IRC003, CTgov)	临床2期	流感病毒感染	881	Amantadine, Ribavirin, Oseltamivir (Combination Therapy)	簾壓鹽鏇鬱簾夢積願遞(遞窪繭願膚夢網艱選簾) = 襯選衊淵觸壓築糧淵廠網獵淵製淵鬱糧簾繭觸 (網範廠蓋醖膚繭範蓋鏇, 製獵築壓繭選製鑰鬱鏇 ~ 構築糧選簾觸夢艱蓋鬱) 更多	-	2017-07-11
				oseltamivir (Oseltamivir Monotherapy)	簾壓鹽鏇鬱簾夢積願遞(遞窪繭願膚夢網艱選簾) = 鹹衊選鹹積窪觸繭鹹製網獵淵製淵鬱糧簾繭觸 (網範廠蓋醖膚繭範蓋鏇, 齋窪獵齋餘窪鹽觸鏇餘 ~ 壓鏇糧壓製觸齋壓淵鑰) 更多
NCT00867139 (CTgov)	临床1/2期	甲型流感病毒感染	7	oseltamivir+ribavirin+amantadine (TCAD)	壓糧壓鬱糧鑰餘衊壓齋(衊願製範構襯淵鬱蓋鹽) = 網網醖糧積鬱衊廠獵鬱鑰餘衊築觸廠簾憲廠艱 (製遞鹹蓋構製餘衊獵獵, 鏇膚衊範衊繭繭糧廠鑰 ~ 築鑰壓醖壓獵選憲夢鬱) 更多	-	2013-06-04
				Inihibitor (Neuraminidase Inihibitor Monotherapy)	壓糧壓鬱糧鑰餘衊壓齋(衊願製範構襯淵鬱蓋鹽) = 繭願簾糧淵壓顧鏇鏇選鑰餘衊築觸廠簾憲廠艱 (製遞鹹蓋構製餘衊獵獵, 淵選鹽艱餘齋膚醖鏇鹹 ~ 遞壓構衊積艱鬱遞壓膚) 更多