乳酸铵(Ammonium Lactate) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名

Ammonium (+-)-lactate、Ammonium lactate (USAN)、Lactic acid ammonium salt

+ [3]

靶点-

作用机制-

治疗领域

遗传病与畸形皮肤和肌肉骨骼疾病其他疾病

在研适应症-

非在研适应症

寻常鳞癣干燥症

原研机构

Bristol Myers Squibb Co.

在研机构-

非在研机构

Sun Pharmaceutical Industries, Inc.

最高研发阶段撤市

首次获批日期

美国 (1985-04-24),

寻常鳞癣干燥症

最高研发阶段(中国)-

特殊审评-

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结构

分子式C3H9NO3

InChIKeyRZOBLYBZQXQGFY-UHFFFAOYSA-N

CAS号515-98-0

关联

7

项与乳酸铵相关的临床试验

IRCT20171009036672N2 / Completed临床2期IIT

Formulation and Evaluation of the Moisturizing Effect of Ammonium Lactate 12% Lotion on Dermatological Disease of the Uremic Patients

开始日期2022-03-20

申办/合作机构-

NCT04858139 / Unknown status临床2期IIT

"Exploration de l'Effet Sur le métabolisme cérébral de l'Administration de Lactate après Accident Vasculaire cérébral Chez l'Homme" (French Title)

In this exploratory randomized double blind placebo controled trial, lactate solution or placebo will be administered to acute ischemic stroke patients selected for endovascular treatment (EVT) without intravenous thrombolysis. The treatment will be administered within one hour after EVT. Primary outcome measures will be lactate and metabolite concentrations in the ischemic lesion, in the penumbra and contralaterally, evaluated by magnetic resonance spectroscopy(MRS). Secondary outcome measures will be evolution of the ischemic penumbra, clinical outcome at 3 months.The trial will end when 10 patients per group have completed the study.

开始日期2021-05-27

申办/合作机构

Centre Hospitalier Universitaire Vaudois

NCT04127513 / Completed临床3期

Comparison of Efficacy and Safety Between Moisturising Cream Containing 12% Ammonium Lactate AND 10% Urea in Geriatric With Xerosis Cutis: Double Blind Randomised Controlled Trial

This study aims to compare the efficacy and safety between moisturizing cream containing 12% ammonium lactate and 10% urea in geriatric with xerosis cutis. A double-blind randomized controlled trial with matching paired subject was conducted on 40 residents of a nursing home in Jakarta. Specified symptom sum score (SRRC), skin capacitance (SCap), transepidermal water loss (TEWL), and side effects were measured at baseline, week-2 and week-4 after therapy, and week-5 one week after therapy cessation. After a week of preconditioning, each subject received two different moisturizing creams to be applied on separate lower limbs.

开始日期2017-04-01

申办/合作机构

University of Indonesia

100 项与乳酸铵相关的临床结果

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100 项与乳酸铵相关的转化医学

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100 项与乳酸铵相关的专利（医药）

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48

项与乳酸铵相关的文献（医药）

2023-08-01·Journal of the American Academy of Dermatology

Association of confluent and reticulated papillomatosis with obesity and resolution after treatment with doxycycline: A retrospective cohort study

Article

作者: D′Ovidio, Tyler J. ; Kuo, Alyce M. ; Kamat, Samir ; Fenner, Justine ; Zatorski, Nicole ; Zhou, Rebecca Z. ; Silverberg, Nanette B.

Confluent and reticulated papillomatosis (CARP) presents with hyperpigmented macules and papules in a net-like distribution, usually confluent over the central chest, back, and neck, and reticulated as it spreads out centrifugally over the outer trunk and upper extremities.The authors conducted an institution review board e approved retrospective chart review between 2009 and 2020 within the Mount Sinai Health System, and medical records of patients identified through a database search for CARP diagnoses were reviewed for demographics, clin. findings, treatments, and treatment response.Treatments included systemic antibiotics (minocycline, doxycycline, and azithromycin), topical antibiotics, and other topicals, including ammonium lactate and corticosteroids.CARP is common not only in adolescents, as previously described, but also in adults, and associated with obesity (48%), which was noted with more than twice the frequency than the 22% in New York City.Minocycline is the treatment of choice for CARP, and clin. response can confirm the clin. diagnosis.In this study, CARP treated with doxycycline 100 mg twice a day had similar response and lower recurrence rates than minocycline 100 mg twice a day but a longer course of treatment.To our knowledge, this study describes the largest cohort of patients with CARP to date, which supports using doxycycline or minocycline for CARP management.Patients with CARP were more likely to be overweight or obese.

2023-03-01·Pediatric Dermatology

A case of eruptive lichen spinulosus after toxic epidermal necrolysis

Article

作者: Rojek, Nathan W. ; Birmingham, Suzanne W. ; Lee, Bonnie A. ; Phong, Celine H.

AbstractWe report a case of a 13‐year‐old boy who presented with eruptive monomorphic white papules on the trunk and arms involving regions previously affected by toxic epidermal necrolysis (TEN). Biopsy revealed compact keratin involving the hair follicle and sparse mixed perivascular infiltrate, findings consistent with lichen spinulosus. Improvement was noted after treatment with ammonium lactate 12% lotion. While cutaneous dyschromia and xerosis are common after TEN, lichen spinulosus has not yet been described in the literature. It is important for providers to be aware of any potential cutaneous sequelae of TEN that can affect quality of life in order to best counsel their patients.

2023-02-01·Skin Health and Disease

Ichthyosis vulgaris: An updated review

Review

作者: Kumar, Gaurav ; Jaffar, Huda ; Shakir, Zobia ; Ali, Iman Fatima

AbstractIchthyosis vulgaris is an inherited, non‐syndromic form of ichthyosis that presents with skin problems. Making up more than 95% cases of ichthyosis, ichthyosis vulgaris is caused by heterozygous loss‐of‐function mutation of the filaggrin gene, raising the fragility and permeability of the stratum corneum. It typically presents in infancy as xerosis, skin lesions, keratosis pilaris, palmoplantar hyper linearity, scaly dermatosis, and erythroderma, clearly identifiable by age 5. Although majority of patients have a normal lifespan, possible complications include a vitamin D deficiency and auditory problems due to scaling in the ears, besides a drop in quality of life due to dermatological changes. Urea‐based creams with 10% urea, ceramides, and other ceramides are often the first line therapy in ichthyosis vulgaris. There is no known curative treatment for ichthyosis vulgaris, but lifelong treatment can alleviate the symptoms. Urea‐based creams are highly therapeutic, whereas ammonium lactate 12% lotion with a physiological lipid‐based repair cream can help with scaling and dryness. There is also evidence in favour of propylene glycol solutions. Risankizumab, an anti‐interleukin‐23 drug, and enhancement of natural moisturizing factors are also two highly promising solutions that require additional research. This review aims to provide updates on the manifestation, evaluation, and treatment of ichthyosis vulgaris.

100 项与乳酸铵相关的药物交易

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