In this exploratory randomized double blind placebo controled trial, lactate solution or placebo will be administered to acute ischemic stroke patients selected for endovascular treatment (EVT) without intravenous thrombolysis. The treatment will be administered within one hour after EVT. Primary outcome measures will be lactate and metabolite concentrations in the ischemic lesion, in the penumbra and contralaterally, evaluated by magnetic resonance spectroscopy(MRS). Secondary outcome measures will be evolution of the ischemic penumbra, clinical outcome at 3 months.The trial will end when 10 patients per group have completed the study.

开始日期2021-05-27

申办/合作机构

Centre Hospitalier Universitaire Vaudois

NCT04127513 / Completed临床3期

Comparison of Efficacy and Safety Between Moisturising Cream Containing 12% Ammonium Lactate AND 10% Urea in Geriatric With Xerosis Cutis: Double Blind Randomised Controlled Trial

This study aims to compare the efficacy and safety between moisturizing cream containing 12% ammonium lactate and 10% urea in geriatric with xerosis cutis. A double-blind randomized controlled trial with matching paired subject was conducted on 40 residents of a nursing home in Jakarta. Specified symptom sum score (SRRC), skin capacitance (SCap), transepidermal water loss (TEWL), and side effects were measured at baseline, week-2 and week-4 after therapy, and week-5 one week after therapy cessation. After a week of preconditioning, each subject received two different moisturizing creams to be applied on separate lower limbs.

开始日期2017-04-01

申办/合作机构

University of Indonesia

100 项与乳酸铵相关的临床结果

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100 项与乳酸铵相关的转化医学

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100 项与乳酸铵相关的专利（医药）

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项与乳酸铵相关的文献（医药）

2023-08-01·Journal of the American Academy of Dermatology

Association of confluent and reticulated papillomatosis with obesity and resolution after treatment with doxycycline: A retrospective cohort study

Article

作者: Zatorski, Nicole ; Zhou, Rebecca Z. ; D′Ovidio, Tyler J. ; Kamat, Samir ; Kuo, Alyce M. ; Fenner, Justine ; Silverberg, Nanette B.

Confluent and reticulated papillomatosis (CARP) presents with hyperpigmented macules and papules in a net-like distribution, usually confluent over the central chest, back, and neck, and reticulated as it spreads out centrifugally over the outer trunk and upper extremities.The authors conducted an institution review board e approved retrospective chart review between 2009 and 2020 within the Mount Sinai Health System, and medical records of patients identified through a database search for CARP diagnoses were reviewed for demographics, clin. findings, treatments, and treatment response.Treatments included systemic antibiotics (minocycline, doxycycline, and azithromycin), topical antibiotics, and other topicals, including ammonium lactate and corticosteroids.CARP is common not only in adolescents, as previously described, but also in adults, and associated with obesity (48%), which was noted with more than twice the frequency than the 22% in New York City.Minocycline is the treatment of choice for CARP, and clin. response can confirm the clin. diagnosis.In this study, CARP treated with doxycycline 100 mg twice a day had similar response and lower recurrence rates than minocycline 100 mg twice a day but a longer course of treatment.To our knowledge, this study describes the largest cohort of patients with CARP to date, which supports using doxycycline or minocycline for CARP management.Patients with CARP were more likely to be overweight or obese.

2023-03-01·Pediatric dermatology

A case of eruptive lichen spinulosus after toxic epidermal necrolysis

Article

作者: Rojek, Nathan W. ; Phong, Celine H. ; Lee, Bonnie A. ; Birmingham, Suzanne W.

Abstract:

We report a case of a 13‐year‐old boy who presented with eruptive monomorphic white papules on the trunk and arms involving regions previously affected by toxic epidermal necrolysis (TEN). Biopsy revealed compact keratin involving the hair follicle and sparse mixed perivascular infiltrate, findings consistent with lichen spinulosus. Improvement was noted after treatment with ammonium lactate 12% lotion. While cutaneous dyschromia and xerosis are common after TEN, lichen spinulosus has not yet been described in the literature. It is important for providers to be aware of any potential cutaneous sequelae of TEN that can affect quality of life in order to best counsel their patients.

2023-02-01·Skin health and disease

Ichthyosis vulgaris: An updated review

Review

作者: Shakir, Zobia ; Ali, Iman Fatima ; Kumar, Gaurav ; Jaffar, Huda

Abstract:

Ichthyosis vulgaris is an inherited, non‐syndromic form of ichthyosis that presents with skin problems. Making up more than 95% cases of ichthyosis, ichthyosis vulgaris is caused by heterozygous loss‐of‐function mutation of the filaggrin gene, raising the fragility and permeability of the stratum corneum. It typically presents in infancy as xerosis, skin lesions, keratosis pilaris, palmoplantar hyper linearity, scaly dermatosis, and erythroderma, clearly identifiable by age 5. Although majority of patients have a normal lifespan, possible complications include a vitamin D deficiency and auditory problems due to scaling in the ears, besides a drop in quality of life due to dermatological changes. Urea‐based creams with 10% urea, ceramides, and other ceramides are often the first line therapy in ichthyosis vulgaris. There is no known curative treatment for ichthyosis vulgaris, but lifelong treatment can alleviate the symptoms. Urea‐based creams are highly therapeutic, whereas ammonium lactate 12% lotion with a physiological lipid‐based repair cream can help with scaling and dryness. There is also evidence in favour of propylene glycol solutions. Risankizumab, an anti‐interleukin‐23 drug, and enhancement of natural moisturizing factors are also two highly promising solutions that require additional research. This review aims to provide updates on the manifestation, evaluation, and treatment of ichthyosis vulgaris.

项与乳酸铵相关的新闻（医药）

2021-06-20

·药事纵横

液相故障排除指南(十五)：pH对保留时间的影响

pH对保留时间的影响问：我的分离似乎对pH的变化非常敏感。这是一种简单的反相方法，我不使用任何离子对试剂。每天的保留时间都有很多变化，这可以追溯到pH值的微小变化。问题是什么？答：从对问题的描述看来，分析物的pKa接近于流动相的pH的。因此，您要处理两种形式的分析物，它们具有截然不同的保留时间。这可以是例如质子化和非质子化形式的酸。分析物带电形式的保留因子比不带电形式的保留因子低得多。两者之间的平衡取决于pH值。流动相的pH值的微小变化会改变两种形式的分析物的比例，从而改变保留时间。结果，必须严格控制pH。由于您已经进行了一些实验，因此您可能已经获得了足够的信息，可以定量地了解保留时间对pH的依赖性。如果不是，请进行一些受控实验以获取此知识。另外，您可以检查方法的历史记录。此类信息应该在方法耐用性测试期间生成。依赖之后，您需要确定可以承受的保留时间波动是多少。然后您可以计算出pH调节的精度。即使在困难的情况下，+ /-0.02 pH单位的精度也应足够。问：很难准确调节pH值。如果只添加一点点酸，则pH会急剧变化。答：不幸的是，这表明您没有使用缓冲液。缓冲液的定义是缓冲少量酸或碱后的pH值，即添加酸或碱后pH值变化很小。维持pH的这种能力称为缓冲能力。它取决于缓冲液的浓度和缓冲离子的pKa。最大缓冲能力是在缓冲离子的pKa处获得的。表1列出了HPLC中常用的某些缓冲液的pKa。请注意，它们是在水中测量的，没有添加有机溶剂。添加有机溶剂后，pKa会发生变化。但是通常，包括您的分析物在内的所有化合物的所有pKa都会经历相同的变化。对于HPLC中常用的缓冲液浓度，缓冲液的pH值应保持在缓冲离子pKa周围的1.5个pH单位之内。对于非常稀的缓冲液（低于5 mM），您可能希望将范围进一步缩小至pKa周围的+/- 1 pH单位。不幸的是，我经常遇到完全忽略缓冲区容量的方法。一个例子是pH 4.5的磷酸二氢钾溶液。这不是缓冲液，而是盐溶液。从表中可以看出，磷酸盐的pKa约为2和7。4.5恰好位于中间，并且在此pH值下磷酸盐都没有缓冲能力。要将pH缓冲在4.5，需要使用其他缓冲液，例如乙酸。类似地，pH 7的乙酸铵溶液不是缓冲液，而是盐溶液。醋酸铵“缓冲液”的使用已变得很普遍，因为醋酸铵是易挥发的，可以与质谱检测器一起使用。但在pH值为7时，它不是缓冲剂，除非您出于其他原因需要加盐，否则不建议将其置于流动相中。问：我可以做些什么来改进此方法？答：如果您使用了错误的缓冲液来达到预期的pH值，则只需从表中选择一种更合适的缓冲液即可。通常，替换不会影响分离，否则，您可能需要进行其他调整。有时，由于检测器的限制，无法替换缓冲区。我们已经提到需要在质谱仪中使用挥发性缓冲液。基于羧酸的缓冲液由于高背景吸收而不太适合低紫外线检测，这会导致过多的噪音。如果除了正在使用的缓冲区之外，找不到其他兼容检测缓冲区，则可能会遇到麻烦。您可以按原样保留保留可变性，也可以在使用的缓冲区的pKa或附近重新开发该方法。这将明显改变色谱图，并且您需要从头开始重新优化该方法。这可能不是一个好消息，但从长远来看，您会过得更好。对于方法开发，我通常建议先选择缓冲液，然后选择一般的pH范围，然后使用溶剂选择性微调分离。这种方法的开发策略是快速且高效的。这也可以防止您在缓冲液pH值上错误定位。您可能需要在下一个方法开发中考虑这种方法。药事纵横投稿须知：稿费已上调，欢迎投稿各位朋友好，觉得本文对您有帮助，请随手点一下下方的在看，以便让你的朋友也能看到哦。