山金车提取物(Arnica Extract) - _专利_临床

概要

基本信息

药物类型

中药

别名-

靶点-

作用机制-

治疗领域

神经系统疾病

在研适应症-

非在研适应症

疼痛

原研机构

Children's Health Care

在研机构-

非在研机构

Children's Health Care

最高研发阶段无进展临床2/3期

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

5

项与山金车提取物相关的临床试验

NCT05283434 / Unknown status临床2/3期IIT

Arnica and the Management of Pain in Acute Musculoskeletal Extremity Injuries

In the Emergency Department, there is no standard of care for pain medication distribution for children with an acute musculoskeletal injury when there is no fracture present. Currently, ibuprofen is a favorable choice for the treatment, but studies have shown concern for delayed healing activity associated with NSAIDs like Ibuprofen. Homeopathic Arnica Montana is a well-established complimentary medicine and may provide a good alternative for managing acute pain from musculoskeletal injuries, especially in children, given the palatability and rarity of side effects. This study aims to compare usual care vs. usual care plus Arnica 1M* (oral) or the placebo for management of pain in acute musculoskeletal extremity injuries without fracture by utilizing a double-blind clinical trial design. The primary outcome is to determine if subjects use less ibuprofen when given Arnica 1M.

开始日期2021-07-15

申办/合作机构-

NCT04677712 / Completed临床4期

MOBI: A Phase 4, Open-Label Study to Assess Effects of Mitigation Treatments on Bruising of CCH-aaes Treatment of Buttock Cellulite in Adult Females

This study will investigate treatments that may mitigate bruising after QWO™ (Collagenase clostridium histolyticum [CCH]-aaes) treatment of cellulite in the buttocks.

开始日期2020-12-28

申办/合作机构

Endo Pharmaceuticals, Inc.

[+4]

NCT04534426 / Completed临床4期IIT

Influence of Different Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus After Extraction of Impacted Third Molar

The present study was to evaluate the effect of topical Arnica and MPSP application with respect to visual analogue scale (VAS) scores, maximal interincisal opening (MIO) and edema values after mandibular impacted third molar removal on days 1, 3, 5 and 10 postoperatively. The following null hypotheses of the present research were determined as follows: usage of topical agents would not influence i) VAS scores, ii) MIO values, and iii) edema values on 1st, 3rd, 5th, and 10th days after the mandibular impacted third molar surgery

开始日期2018-12-01

申办/合作机构

Abant Izzet Baysal University

100 项与山金车提取物相关的临床结果

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100 项与山金车提取物相关的转化医学

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100 项与山金车提取物相关的专利（医药）

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86

项与山金车提取物相关的文献（医药）

2024-08-13·Current Pediatric Reviews

Strategies for Pain Management after Extraction of Primary Teeth: A Systematic Review of Randomized Clinical Trials

Article

作者: Alves, Lívia Araújo ; França, Lucas Santiago ; Rodrigues, Janina ; da Silva, Gabriela Seabra ; Palma, Luiz Felipe ; Tedesco, Tamara Kerber ; Raggio, Daniela Prócida

Background::

In dental extractions, particularly when local anesthesia is used, it usually offers analgesic relief for a few hours. However, pain can become a notable concern in the immediate postoperative period due to the trauma experienced by both soft and hard oral tissues.

Objectives::

This systematic review aimed to evaluate the most effective strategies for managing postoperative pain in primary tooth extractions.

Methods::

Two examiners conducted a search across five electronic databases: MEDLINE (via PubMed), Embase, Scopus, Web of Science, CENTRAL, and OpenGray. Studies were included if they met the following criteria after reviewing their titles and abstracts: they involved children and evaluated pain management following primary tooth extraction. Subsequently, articles that described extractions performed under any form of sedation, were not conducted under local anesthesia, in an outpatient setting, and in children aged 0 to 12 years, or were not randomized controlled trials, were excluded.

Results::

The search yielded 374 relevant articles, of which 9 were included. Among these, 5 utilized preoperative medications as a pain management strategy, one evaluated low-level laser therapy (LLLT) postoperatively, one assessed calendula drops postoperatively, and another explored virtual reality during the procedure and arnica in solution both pre and postoperatively.

Conclusion::

Among all the strategies evaluated, the strategy involving analgesics administered 30 minutes before tooth extractions was supported by better-designed studies. However, there is a high risk of bias.

2024-05-01·Journal of biomaterials applications

New approaches to second-degree burn healing: Polyvinyl alcohol membrane loaded to arnica combined to laser therapy

Article

作者: Gomes, Rodrigo César ; Fanelli, Camilla ; Gianini, Reinaldo José ; Komatsu, Daniel ; Noronha, Irene de Lourdes ; Cardoso, Carolina Silva ; Randazzo-Moura, Priscila ; dos Santos, Nelson Brancaccio ; de Carvalho, Filipe Feitosa

Second-degree burns require greater care, as the damage is more extensive and worrisome and the use of a biomaterial can help in the cell repair process, with better planning, low cost, and better accessibility. Arnica has anti-inflammatory and analgesic properties in skin lesions treatments and laser therapy is another therapeutic alternative for burns. Evaluate the effects of arnica incorporated into PVA associated or not with low intensity laser on burns in rats. PVA and PVA with arnica (PVA+A) were obtained and characterized physicochemically. Through in vivo studies, the effects of PVA and PVA+A with or without the application of laser on the lesions allowed histological and immunohistochemical analyzes. PVA+A was biocompatible and with sustained release of the active, being a promising pharmacological tool and confirmed that laser therapy was effective in accelerating the healing process, due to its potential biomodulator, improving inflammatory aspects, promoting rapid healing in skin lesions.

2024-01-01·Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons

Can Topical Agents (Arnica and Mucopolysaccharide Polysulfate) Reduce Postoperative Pain, Edema and Trismus Following Mandibular Third Molar Surgery?

Article

作者: Akay, Neşet ; Şanal, Koray Onur

BACKGROUND:

Postoperative supplemental maintenance following mandibular third molar surgery remains an area of interest.

PURPOSE:

Topical agents can modulate inflammatory processes. The aim of the present study was to determine if topical application of arnica or mucopolysaccharide polysulfate (MPSP) reduces pain, trismus, and edema following the removal of impacted mandibular third molars.

MATERIALS AND METHODS:

A single center randomized controlled clinical trial was conducted. The patients were randomized into three groups: the control group (standard therapy [ST]: antibiotic + nonsteroidal anti-inflammatory drugs twice a day), the arnica group (arnica + ST), and the MPSP group (MPSP + ST). The patients' pain, trismus, and edema values were measured preoperatively and on postoperative days 1, 3, 5, and 10. Sex, age, and operation time were also included. Analyses included descriptive statistics, analysis of variance, post hoc tests, and determinations of intraclass correlation coefficients. Statistical significance was set at P < .05.

RESULTS:

Sixty patients with a mean age of 26.98 ± 10.88 years were included in the study; 55% were females and 45% were males. The mean operation time was 23.8 ± 3.27 minutes. According to the visual analogue scale scores (in centimeter units), the arnica and MPSP groups felt less pain than the control group until day 5 (0.6 ± 0.88, 3.75 ± 1.16, 4.75 ± 1.29, and 1.05 ± 1.10, respectively, for the arnica group; 0.35 ± 0.59, 3.25 ± 1.62, 5.0 ± 1.65, and 1.50 ± 1.32 for the MPSP group; and 1.30 ± 1.17, 5.75 ± 1.37, 7.05 ± 1.10, and 3.15 ± 1.53 for the control group; P < .05). The trismus was lower on days 1, 3, and 5 in the arnica group (-8.05 ± 2.82, -12.15 ± 3.1, and -2.15 ± 1.81, respectively) than in the control group (-12 ± 3.82, -15.65 ± 4.81, and -4±2.81, respectively) (P < .05). The edema was lower on days 1 and 3 in the MPSP group (0.95 ± 2.2 and 1.75 ± 3.7, respectively) than in the control group (2.45 ± 0.9 and 3.6 ± 0.8, respectively) (P < .05). Arnica and MPSP had similar pain-relieving action, but arnica was more effective at reducing trismus, while MPSP was more effective at reducing edema.

CONCLUSIONS:

Topical application of arnica or MPSP may have a beneficial effect on relieving pain 5 days after surgery, but arnica was also effective at reducing trismus, while MPSP was also effective at reducing edema. Both arnica and MPSP reduced postoperative sequelae.

1

项与山金车提取物相关的新闻（医药）

2022-07-18

·PRNewswire

Taking 'Everybody Deserves A Massage Week' to the Next Level

River Organics, the USDA Certified Organic CBD Company Celebrates National Wellness Week– GLOUCESTER, Va., July 18, 2022 /PRNewswire/ -- River Organics knows better than anyone about the benefits that relief and relaxation can have on the body. This year, River Organics is spreading the word by encouraging everyone to take part in "Everybody Deserves A Massage Week". Continue Reading River Organics, USDA Certified Organic CBD Company, Celebrate National Wellness Week The observed week takes place July 17th through July 23rd and spreads awareness of the many health benefits of massage therapy, including stress relief, sleep improvement, muscle relaxation, pain reduction and more. River Organics strives to educate and motivate massage enthusiasts to receive top-of-the-line experiences, and that's why they have developed a high-quality collection of CBD massage oils. River Organics' massage oils feature hand-seeded and harvested, full-spectrum CBD. Their original massage oil is available in two sizes: a 2oz 600 mg bottle or a 4oz 1,200 mg bottle. In addition to their massage oil, River Organics has introduced their "magic oil" - Extra Strength Pain Relief Oil with Arnica (ESPRO). ESPRO contains a whopping 1500 mg of CBD per ounce, alongside Arnica, an herb also known to decrease inflammation and pain. Adrianne Ryder-Cook Joseph, Founder, and CEO of River Organics says, "CBD is a powerful holistic remedy offering a host of benefits to boost health and wellness. Having a massage with our CBD massage oil and using our ESPRO on those hard-to-release trigger points takes the massage experience to another level. You will float off the table." To celebrate the week, River Organics is offering 30% off their massage and pain relief oils on riverorganics.com. To learn more about River Organics and the benefits of CBD massage oils, visit riverorganics.com/blog/news. Start your CBD journey by following River Organics on Instagram at @riverorganics_. Media contact: Kayla Perez [email protected] 212.777.2220 SOURCE River Organics

100 项与山金车提取物相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
疼痛	临床3期	美国	Children's Health Care	2021-07-15

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ISN WCN2024	N/A	透析血管通路衰竭	-	Local cold with ice and oral analgesics and anti-inflammatories	廠窪膚鑰壓範餘鏇顧齋(醖艱衊鹽構範憲鬱膚遞) = Rapid pain relief and hematoma resorption were observed between the third and seventh day in all patients 範餘築繭鹹壓糧襯壓簾 (製醖繭顧繭網憲艱觸簾 )	-	2024-04-01
NCT04677712 (MOBI, CTgov)	临床4期	挫伤 \| 脂肪团 \| 皮肤疾病	48	CCH-aaes (Cohort 1: CCH-aaes)	夢鏇積範憲餘網膚鹽艱(淵糧艱構膚築網壓網範) = 製鹽糧夢蓋簾網膚積蓋襯壓衊鹹鑰製廠鏇衊築 (築衊鑰觸艱膚憲糧鹹鏇, 網製製廠積構襯餘觸壓 ~ 鑰廠鏇繭艱鹹簾構糧範) 更多	-	2023-08-21
NCT04677712 (MOBI, CTgov)	临床4期	挫伤 \| 脂肪团 \| 皮肤疾病	48	Compression (Cohort 2: CCH-aaes + Compression Garment)	夢鏇積範憲餘網膚鹽艱(淵糧艱構膚築網壓網範) = 餘廠積襯選鑰鬱願鹽壓襯壓衊鹹鑰製廠鏇衊築 (築衊鑰觸艱膚憲糧鹹鏇, 積壓夢壓廠鹹願窪繭憲 ~ 網淵鏇選鏇積糧觸窪網) 更多	-	2023-08-21
NCT00363038 (CTgov)	N/A	挫伤 \| 瘀斑	16	vitamin K+arnica	網糧範鏇窪鑰簾襯憲鑰(築願齋壓淵鹹夢蓋獵遞) = 醖襯餘選襯衊膚襯遞繭製蓋積遞糧遞網鹽壓衊 (觸範積膚觸蓋壓願網鏇, 齋壓夢簾觸選糧繭夢艱 ~ 繭願獵築觸簾簾鹹壓醖) 更多	-	2012-12-04