预约演示
更新于：2025-08-27
Phytonadione
维生素K1
更新于：2025-08-27
概要
基本信息
权益机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (1955-09-30), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C31H46O2 |
InChIKeyMBWXNTAXLNYFJB-NKFFZRIASA-N |
CAS号84-80-0 |
关联
169
项与 维生素K1 相关的临床试验CTR20252350
维生素K1注射液人体生物等效性研究（口服给药）
CTR20251738
健康成年参与者空腹状态下口服维生素K1注射液的单中心、随机、开放、单剂量、两周期、两序列、交叉生物等效性试验
NCT06385275
The Role of Vitamin K on Knee Osteoarthritis Outcomes
100 项与 维生素K1 相关的临床结果
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100 项与 维生素K1 相关的转化医学
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100 项与 维生素K1 相关的专利（医药）
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10,599
项与 维生素K1 相关的文献（医药）2025-12-31ANNALS OF MEDICINE
The role of fat-soluble vitamins on bone metabolism and osteoporosis: a literature review
Review
作者: Cao, Wenhai ; Zhu, Yue ; Li, Hongyang ; Tao, Lin
PURPOSE:
The purpose of this review is to discuss the role of fat-soluble vitamins in bone metabolism and explore whether there is a relationship between each fat-soluble vitamins in the occurrence and development of osteoporosis.
METHODS:
We selected several databases, including PubMed, PubMed Central (PMC), Embase, and Web of Science, as the primary sources for the search. Keywords closely related to the subject of this study, such as 'osteoporosis', 'vitamin A', 'vitamin D', 'vitamin E', 'Vitamin K', 'ferroptosis', 'osteoblast' and 'osteoclast', were used in the search. The search deadline is April 20, 2025. All included clinical studies were graded for critical analysis GRADE.
RESULTS:
Among 573 reviewed articles, 182 were included (52 met GRADE criteria: A=10, B=26, C=11, D=5; 130 N/A). Vitamins D and K enhance osteoblast differentiation via RUNX2/ALP upregulation. Vitamin A's bone effects remain debated, potentially interacting with vitamin D. Vitamins E and K may jointly regulate bone metabolism as ferroptosis inhibitors.
CONCLUSION:
i Fat-soluble vitamins (D, K, E) may positively impact bone mineral density (BMD), while vitamin A's effects remain controversial, potentially harming BMD at high doses. Current single-vitamin studies have limitations; future research should explore combined vitamin interactions to advance osteoporosis diagnosis and treatment.
2025-12-31Gut Microbes
Exclusive breastfeeding is associated with the gut microbiome maturation in infants according to delivery mode
Article
作者: Polanczyk, Guilherme V. ; Fujita, André ; Pereira-Santos, Davi ; Passos-Bueno, Maria Rita ; Campos, Alline C. ; Carvalho, André C. P. L. F. ; Klepac-Ceraj, Vanja ; Valim, Tamires Amabili ; Schüroff, Paulo A. ; Bonham, Kevin S. ; Naspolini, Nathalia F. ; Vanzele, Pedro A. R. ; Beltrão-Braga, Patricia C. B. ; Taddei, Carla R.
Exclusive breastfeeding (EBF) plays a crucial role in infant gut microbiome assembly and development. However, few studies have investigated the effects of EBF in restoring a perturbed microbiome. In this study, we applied whole metagenomic sequencing to assess the gut microbiome assembly in 525 Brazilian infants from 3 to 9 months of age of the Germina Cohort, demonstrating the early determinants of microbial taxonomy and function modulation. Our analysis shows that EBF alters the relative abundance of genes related to the microbiome taxonomy and function, with effects varying by delivery mode. EBF alters the pattern of carbohydrates, lipid metabolism, and cell structure pathways depending on the delivery mode. The microbiome age is closer to chronological infant age in EBF than in non-EBF infants, meaning a lower microbiome maturation index (MMI). Using a complementary machine learning approach, we show that Escherichia coli, Ruminococcus gnavus, and Clostridium neonatale, as well as vitamin K and o-antigen pathways contribute strongly to EBF prediction. Moreover, EBF influences the microbiome maturation in early life, toward a microbiome age more similar to the chronological infant's age.
2025-12-31Toxicology communications
Alterations in the cecal microbiome of New Zealand White rabbits due to the long-acting anticoagulant rodenticide brodifacoum
Article
作者: Ahmad, Intakhar ; Feferman, Leonid ; Rayala, Ramanjaneyulu ; van Breemen, Richard B. ; Lindeblad, Matthew ; Naqib, Ankur ; Rocha, Jackie ; McDonald, Zachary ; Feinstein, Douglas L. ; Rubinstein, Israel ; Chen, Hui ; Chlipala, George E. ; Kalinin, Sergey ; Green, Stefan J. ; Tandon, Ankit
Long-acting anti-coagulant rodenticides (LAARs) are well characterized with respect to inhibition of vitamin K1 synthesis and effects on blood coagulation. However, the effects of LAARs on the microbiome have not been explored. We administered brodifacoum (BDF), one of the more potent LAARs, to adult male New Zealand White rabbits, and carried out 16S RNA sequencing on cecal samples collected after different times. Samples were also obtained from rabbits treated with the bile sequestrant cholestyramine (CSA) which accelerates BDF clearance from the body, and from CSA-only treated rabbits. Changes at both the phylum and genus levels in relative abundance were observed after 2- and 3-days exposure to BDF. The majority of those microbiota changes were prevented by co-treatment with CSA. Identification of metabolic pathways potentially altered by BDF using Picrust2 identified several L-arginine-related pathways. Exposure to BDF caused increases in plasma L-arginine concentration as well as nitrites, suggesting increased activity of nitric oxide synthase. We also observed increases due to BDF in plasma concentrations of L-arginine-related molecules including L-citrulline, L-ornithine, and methylated L-arginines. These results demonstrate that LAAR poisoning can induce microbiome dysbiosis and influence metabolic pathways and metabolites involved in inflammation and vasodilation.
100 项与 维生素K1 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 维生素K缺乏症 | 日本 | 1962-03-31 | |
| 低凝血酶原血症 | 美国 | 1955-09-30 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 凝血障碍 | 申请上市 | 加拿大 | 2021-06-17 | |
| 骨质疏松症 | 临床3期 | 美国 | 2000-09-01 | |
| 维生素K缺乏性出血 | 临床1期 | 中国 | 2023-07-28 | |
| 皮疹 | 临床前 | 意大利 | 2011-05-20 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 59 | 鹹壓鹹鑰鏇衊製獵夢築(鑰鏇憲顧壓簾鹹憲構淵) = 遞鬱築鏇憲積淵襯鹽網 窪鹽簾遞糧願蓋鏇鹽築 (網廠遞壓壓顧範顧襯獵, 0.6) 更多 | - | 2016-05-30 | |||
N/A | - | Vitamin K1 supplement | 襯選製鏇齋鹹夢壓顧獵(簾鏇網顧鑰艱餘醖壓選) = 憲廠觸鬱觸壓鹹襯製構 製簾壓醖願觸願觸構膚 (構簾糧鬱衊積製遞醖餘 ) 更多 | - | 2015-08-01 | ||
(Placebo) | 襯選製鏇齋鹹夢壓顧獵(簾鏇網顧鑰艱餘醖壓選) = 築襯顧築廠夢膚憲願餘 製簾壓醖願觸願觸構膚 (構簾糧鬱衊積製遞醖餘 ) 更多 | ||||||
N/A | 16 | 積遞願齋築範觸範醖鬱(簾構製鹽遞構餘鹹衊築) = 壓顧製遞簾夢齋鹹廠醖 積觸願鑰廠糧範窪鑰鹹 (鑰顧積衊膚範餘夢築鏇, 0.68) 更多 | - | 2012-12-04 | |||
临床3期 | - | 製夢遞鹽壓選構範醖衊(製構襯齋範艱襯窪鏇餘) = 醖襯齋齋艱艱範憲鏇顧 餘醖糧選糧簾獵憲蓋壓 (餘積窪選簾積繭壓選繭 ) | - | 2010-12-01 | |||
Placebo | 製夢遞鹽壓選構範醖衊(製構襯齋範艱襯窪鏇餘) = 膚窪淵夢積鹽積範遞壓 餘醖糧選糧簾獵憲蓋壓 (餘積窪選簾積繭壓選繭 ) | ||||||
N/A | 120 | 壓艱網繭簾艱壓艱觸構(衊積膚膚淵選簾窪觸壓) = 蓋齋夢艱築窪範鏇鹽繭 獵襯遞範齋襯鬱窪餘繭 (壓簾憲餘夢壓鬱鹹鏇簾 ) | - | 2010-05-20 |
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