To determine the time to and rate of hematologic engraftment following unrelated umbilical cord blood transplantation in adults with one or two cord blood units using total body irradiation and fludarabine as the transplant conditioning regimen and cyclosporine/MMF as graft-versus-host disease prophylaxis.

开始日期2009-05-01

申办/合作机构

University of British Columbia

100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的临床结果

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100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的转化医学

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100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的专利（医药）

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项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的文献（医药）

2023-09-01·Skin Research and Technology

Treatment of superficial and deep partial width second degree burn's wound with allogeneic cord blood platelet gel

Article

作者: Dahmardehei, Mostafa ; Zare, Sona ; Nilforoushzadeh, Mohammad Ali ; Amirkhani, Mohammad Amir ; Hortamani, Shamim ; Mansouri, Parvin ; Heidari‐Kharaji, Maryam ; Torkamaniha, Elham

AbstractBackgroundBurns are caused by a variety of mechanisms, including flames, hot liquids, metallurgy, chemicals, electric current, and ionizing and non‐ionizing radiation. The most significant burn wound management involves complete repair and regeneration as soon as possible while minimizing infection, contraction, and scarring in the damaged tissue area. Some factors such as delivery of nutrients, growth factors, and oxygen are essential to promote and stimulate the wound healing progress in the burns area. When these factors are not provided, the burn wound undergoes a physiological crisis. The use of growth factors is a promising approach to overcoming this limitation. Umbilical cord blood platelet concentrates are a rich natural source of growth factors.MethodsThis clinical trial used growth factors released from the lysis of umbilical cord blood platelet concentrates that have a key role in promoting re‐epithelization and regeneration of damaged tissues by forming a fibrin network. This study evaluated the effectiveness of allogeneic cord blood platelet gel topical dressing in a group of patients diagnosed with superficial and deep partial thickness (second‐degree) burn wounds. Clinical outcomes were compared between the intervention group and a control group of patients with superficial second‐degree burn wounds who received the standard routine treatment including paraffin gauze wound dressing and silver sulfadiazine ointment.ResultsThe study's results showed that the increased rate of recovery and tissue granulation completely promoted to wound healing and burn wound closure, decreased the recovery time, and reduced inflammation and scars caused by burn injuries. However, the use of cord blood platelet gel topical dressing is not currently a routine treatment method in patients suffering from burn wounds. However, the study's results showed that allogenic cord blood platelet gel could be used to treat superficial and deep second‐degree burns as a routine treatment. It was also shown that allogenic cord blood platelet gel topical dressing could be a candidate for autograft or after autograft skin transplantation surgery (in donor and recipient sites) instead of skin surgery in some patients.ConclusionAllogeneic topical wound dressing provides an effective treatment that offers a faster rate of epithelialization and healing of wounds and also decreases patients’ scar and inflammation level as well as the length of recovery time. This, finally, leads to better burn wound management and the improved quality of burn wound treatment.

2021-01-01·Wound Repair and Regeneration3区 · 医学

Efficacy of allogeneic cord blood platelet gel on wounds of dystrophic epidermolysis bullosa patients after pseudosyndactyly surgery

3区 · 医学

Article

作者: Piccin, Andrea ; Dahmardehei, Mostafa ; Nilforoushzadeh, Mohammad Ali ; Heidari‐Kharaji, Maryam ; Hamidieh, Amir Ali ; Hortamani, Shamim ; Amirkhani, Mohammad Amir ; Rebulla, Paolo ; Mansouri, Parvin ; Torkamaniha, Elham

AbstractEpidermolysis bullosa (EB) is a rare genetic disorder characterized by the formation of blisters and wounds in skin and mucous membranes; it is classified into four types and has various methods of treatment. Management of previous wounds and prevention of formation of new lesions are the most important strategies in the course of therapy to improve patient's quality of life; lack of wound management can lead to further complications such as infection. The current study investigated the therapeutic effects of allogeneic platelet gel (prepared from umbilical cord blood) in a group of children diagnosed with dystrophic epidermolysis bullosa (DEB) eligible for surgical correction of pseudosyndactyly in the hand. The post‐surgical clinical outcome in this group was compared with the clinical outcomes of DEB patients receiving the standard treatment (paraffin gauze wound dressing and topical antibiotics) after corrective surgery. The current study results showed an increase in the rate of recovery and promotion of tissue granulation, complete wound healing, and a decrease in pain level and treatment period. The application of cord blood platelet gel topical dressing was not a conventional method of treatment in patients with DEB wounds and blisters. However, the current study results demonstrated that this gel dressing could effectively accelerate epithelialization and healing of the wounds and decrease patients' pain and post‐surgical recovery period, which altogether leads to improvements in patients' overall quality of life.

100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
脑疾病	临床2期	-	Bundang CHA Hospital	-

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed	N/A	脑瘫	-	allogeneic cord blood (AlloCB group)	壓衊築遞壓夢憲繭膚獵(窪選繭膚遞選選壓願醖) = 構觸構構糧製淵壓蓋蓋鹽築簾鏇糧憲觸糧鹹鹽 (淵蓋製襯淵齋鹹構築窪, 3.4 ~ 8.2)	-	2022-07-10
				allogeneic cord blood (hCT-MSC group)	壓衊築遞壓夢憲繭膚獵(窪選繭膚遞選選壓願醖) = 醖網膚獵鏇築衊鑰糧簾鹽築簾鏇糧憲觸糧鹹鹽 (淵蓋製襯淵齋鹹構築窪, 2.2 ~ 6.4)
EHA2020	N/A	β地中海贫血	165	Post-transplant Cyclophosphamide haploidentical peripheral blood stem cell transplant	壓鑰憲艱選獵獵鬱齋壓(鹹衊艱鬱築顧選構窪遞) = 製製窪糧膚網膚膚選夢糧網觸廠窪觸鹽壓醖製 (淵選鬱憲衊觸糧繭醖鬱 ) 更多	积极	2020-05-14
				Unrelated cord blood transplant	(觸襯壓壓衊襯襯範積壓) = 淵窪餘鏇顧網構廠顧窪觸壓艱繭構繭繭艱膚蓋 (衊衊範觸蓋繭鬱憲範觸 ) 更多
EHA2020	N/A	血液疾病	575	Cord blood transplantation	(鬱觸鑰製顧糧構築繭範) = 築鏇窪蓋憲衊醖選範窪顧餘蓋願夢艱積積範衊 (餘醖夢夢願廠淵衊衊壓 ) 更多	积极	2020-05-14
				Related donor transplantation	(鬱觸鑰製顧糧構築繭範) = 鑰鏇願夢艱網醖憲壓構顧餘蓋願夢艱積積範衊 (餘醖夢夢願廠淵衊衊壓 ) 更多