To determine the time to and rate of hematologic engraftment following unrelated umbilical cord blood transplantation in adults with one or two cord blood units using total body irradiation and fludarabine as the transplant conditioning regimen and cyclosporine/MMF as graft-versus-host disease prophylaxis.

开始日期2009-05-01

申办/合作机构

University of British Columbia

100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的临床结果

登录后查看更多信息

100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的转化医学

登录后查看更多信息

100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的专利（医药）

登录后查看更多信息

项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的文献（医药）

2023-09-01·Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

Treatment of superficial and deep partial width second degree burn's wound with allogeneic cord blood platelet gel.

Article

作者: Zare, Sona ; Nilforoushzadeh, Mohammad Ali ; Dahmardehei, Mostafa ; Heidari-Kharaji, Maryam ; Amirkhani, Mohammad Amir ; Hortamani, Shamim ; Mansouri, Parvin ; Torkamaniha, Elham

BACKGROUNDBurns are caused by a variety of mechanisms, including flames, hot liquids, metallurgy, chemicals, electric current, and ionizing and non-ionizing radiation. The most significant burn wound management involves complete repair and regeneration as soon as possible while minimizing infection, contraction, and scarring in the damaged tissue area. Some factors such as delivery of nutrients, growth factors, and oxygen are essential to promote and stimulate the wound healing progress in the burns area. When these factors are not provided, the burn wound undergoes a physiological crisis. The use of growth factors is a promising approach to overcoming this limitation. Umbilical cord blood platelet concentrates are a rich natural source of growth factors.METHODSThis clinical trial used growth factors released from the lysis of umbilical cord blood platelet concentrates that have a key role in promoting re-epithelization and regeneration of damaged tissues by forming a fibrin network. This study evaluated the effectiveness of allogeneic cord blood platelet gel topical dressing in a group of patients diagnosed with superficial and deep partial thickness (second-degree) burn wounds. Clinical outcomes were compared between the intervention group and a control group of patients with superficial second-degree burn wounds who received the standard routine treatment including paraffin gauze wound dressing and silver sulfadiazine ointment.RESULTSThe study's results showed that the increased rate of recovery and tissue granulation completely promoted to wound healing and burn wound closure, decreased the recovery time, and reduced inflammation and scars caused by burn injuries. However, the use of cord blood platelet gel topical dressing is not currently a routine treatment method in patients suffering from burn wounds. However, the study's results showed that allogenic cord blood platelet gel could be used to treat superficial and deep second-degree burns as a routine treatment. It was also shown that allogenic cord blood platelet gel topical dressing could be a candidate for autograft or after autograft skin transplantation surgery (in donor and recipient sites) instead of skin surgery in some patients.CONCLUSIONAllogeneic topical wound dressing provides an effective treatment that offers a faster rate of epithelialization and healing of wounds and also decreases patients' scar and inflammation level as well as the length of recovery time. This, finally, leads to better burn wound management and the improved quality of burn wound treatment.

2021-01-01·Wound Repair and Regeneration3区 · 医学

Efficacy of allogeneic cord blood platelet gel on wounds of dystrophic epidermolysis bullosa patients after pseudosyndactyly surgery

3区 · 医学

Article

作者: Piccin, Andrea ; Dahmardehei, Mostafa ; Heidari‐Kharaji, Maryam ; Nilforoushzadeh, Mohammad Ali ; Hamidieh, Amir Ali ; Hortamani, Shamim ; Amirkhani, Mohammad Amir ; Rebulla, Paolo ; Mansouri, Parvin ; Torkamaniha, Elham

AbstractEpidermolysis bullosa (EB) is a rare genetic disorder characterized by the formation of blisters and wounds in skin and mucous membranes; it is classified into four types and has various methods of treatment. Management of previous wounds and prevention of formation of new lesions are the most important strategies in the course of therapy to improve patient's quality of life; lack of wound management can lead to further complications such as infection. The current study investigated the therapeutic effects of allogeneic platelet gel (prepared from umbilical cord blood) in a group of children diagnosed with dystrophic epidermolysis bullosa (DEB) eligible for surgical correction of pseudosyndactyly in the hand. The post‐surgical clinical outcome in this group was compared with the clinical outcomes of DEB patients receiving the standard treatment (paraffin gauze wound dressing and topical antibiotics) after corrective surgery. The current study results showed an increase in the rate of recovery and promotion of tissue granulation, complete wound healing, and a decrease in pain level and treatment period. The application of cord blood platelet gel topical dressing was not a conventional method of treatment in patients with DEB wounds and blisters. However, the current study results demonstrated that this gel dressing could effectively accelerate epithelialization and healing of the wounds and decrease patients' pain and post‐surgical recovery period, which altogether leads to improvements in patients' overall quality of life.

100 项与 Allogeneic cord blood transplantation(Bundang CHA Hospital) 相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
脑疾病	临床2期	-	Bundang CHA Hospital	-

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


Pubmed	N/A	脑瘫	-	allogeneic cord blood (AlloCB group)	獵窪膚願襯願壓齋醖獵(憲齋構壓顧繭憲艱獵願) = 鬱鏇廠夢願簾簾淵顧窪築觸齋膚製鹹繭齋齋顧 (鹹簾鏇構襯衊鏇襯簾淵, 3.4 ~ 8.2)	-	2022-07-10
				allogeneic cord blood (hCT-MSC group)	獵窪膚願襯願壓齋醖獵(憲齋構壓顧繭憲艱獵願) = 鬱憲製壓蓋壓築糧壓鑰築觸齋膚製鹹繭齋齋顧 (鹹簾鏇構襯衊鏇襯簾淵, 2.2 ~ 6.4)
EHA2020	N/A	β地中海贫血	165	Post-transplant Cyclophosphamide haploidentical peripheral blood stem cell transplant	遞艱繭艱淵願窪醖獵願(築鑰餘鑰襯繭餘淵窪選) = 獵膚網艱窪遞淵壓蓋製醖窪廠鑰餘夢夢鬱觸鑰 (製鹽鹽築範夢蓋憲壓夢 ) 更多	积极	2020-05-14
				Unrelated cord blood transplant	(鹽積鏇齋遞網積襯艱鏇) = 鏇廠醖襯鏇壓製簾醖壓獵艱構鏇網願積鬱構鏇 (獵醖夢鏇鑰壓鬱遞遞範 ) 更多
EHA2020	N/A	血液疾病	575	Cord blood transplantation	(鏇鹹築餘積積餘鑰築築) = 鑰獵範構夢鬱艱繭膚構鬱願鏇構顧築積糧齋選 (淵淵衊窪廠鹹齋襯鹽鬱 ) 更多	积极	2020-05-14
				Related donor transplantation	(鏇鹹築餘積積餘鑰築築) = 醖糧鹽鹽壓鹹顧顧膚簾鬱願鏇構顧築積糧齋選 (淵淵衊窪廠鹹齋襯鹽鬱 ) 更多