预约演示
更新于：2025-04-25
Aminophylline
氨茶碱
更新于：2025-04-25
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (1940-04-19) |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构/序列
分子式C16H24N10O4 |
InChIKeyFQPFAHBPWDRTLU-UHFFFAOYSA-N |
CAS号317-34-0 |
关联
105
项与 氨茶碱 相关的临床试验NCT06830577
Efficacy of Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure: A Randomized Controlled Study
IRCT20170608034390N16
Evaluating the Effect of Aminophylline on Wining Ability from Mechanical Ventilation in Intubated Patient with Traumatic Brain Injury.
CTRI/2024/08/072993
Intravenous aminophylline as a rescue therapy in pediatric status asthmaticus- observational study - Nil
100 项与 氨茶碱 相关的临床结果
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100 项与 氨茶碱 相关的转化医学
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100 项与 氨茶碱 相关的专利（医药）
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25,218
项与 氨茶碱 相关的文献（医药）2025-07-01SEPARATION AND PURIFICATION TECHNOLOGY
Temperature-sensitive homogeneous magnetic fluid based aqueous two-phase system for the purification of polyphenols from crude extract of green tea leaves
作者: Yao, Tian ; Feng, Cailing ; Shi, Xueqing ; Song, Jialing
In this work, the first temperature-sensitive homogenous magnetic fluids have been prepared, mainly composed of non-toxic, non-volatile, biodegradable and thermo-sensitive poly(propylene glycol) 600.These magnetic fluids exhibited not only response to an external magnetic field, but have also displayed a significant temperature-sensitive property.Moreover, these magnetic fluids were simply prepared by mixing raw materials.The first temperature-sensitive magnetic fluid based aqueous two-phase systems have been developed for the purification of polyphenols from crude extract of green tea leaves.This novel system has the advantages of easy preparation, swift extraction, efficient magnet-assisted phase separation and temperature-induced recovery, especially organic solvent free for the whole extraction and recovery processes.In this study, phase behaviors and correlation results were studied in detail, providing valuable reference for the extraction applications.Selective extraction and recovery of tea polyphenols were studied and optimized.Under the optimum conditions, more than 90% of epicatechin and less than 10% of theophylline were extractedFurthermore, for the extraction and recovery of tea polyphenols from the crude extract of green tea leaves, the main impurity alkaloid such as caffeine and theophylline was not found in the purified tea polyphenols product.The recovered magnetic fluid could be recycled for at least 5 times with steadily good performances.This novel, simple and green temperature-sensitive homogenous magnetic fluid based aqueous two-phase system is showing great potential in the industrial purification of tea polyphenols as well as many other natural products.
2025-07-01JOURNAL OF MOLECULAR STRUCTURE
Quercetin capped Au-Ag bimetallic nanoparticles for the detection of calcium dobesilate monohydrate in biological and environmental samples
作者: Qayoom, Amtul ; Asrar, Shaz ; Hussain, Dilshad ; Ali, Saeeda Nadir
The study details the synthesis of quercetin-capped Au-Ag bimetallic nanoparticles (Qct-AuAg BMNps) in an aqueous environment.UV visible spectra showed absorbance peak of gold and bimetallic nanoparticles at 524 nm and 403 nm, resp.The SEM anal. of Qct-AuAg BMNps showed an average particle size of 67.5 nm with good uniformity (PdI: 0.386).FTIR confirmed the presence of resp. functional groups in Qct-AuAg BMNps.The Qct-AuAg BMNps were used as a colorimetric sensor for detecting calcium dobesilate monohydrate (CDM) in aqueous solutions, showing a linear spectrophotometric relationship with CDM concentration ranging from 0.000001 mM to 10 mM (R2 = 0.9984).The detection and quantification limits were 1.66 x 10-6 and 2.71 x 10-5 mM, resp.The binding constant (Ka) was 9.8 x 104 M-1, with a 1:1 stoichiometry confirmed by Job's plot.The Qct-AuAg BMNps were successfully used to detect CDM in tap water and serum samples.The synthesis process was optimized using Box Behnken Design, with the optimal conditions found at 50°C, 2 mM quercetin, and a 5:1 silver-to-gold ratio.Therefore, the synthesized quercetin capped gold silver bimetallic nanoparticles were proved effective for the detection of CDM in liquid samples.
2025-06-01JOURNAL OF HYDROLOGY
A closed municipal landfill as a source of emerging contaminants in adjacent groundwater: pharmaceuticals and personal care products occurrence and environmental risk assessment
作者: Slosarczyk, Kinga ; Dabrowska, Dominika
The aim of this study was to determine the occurrence and perform the environmental risk assessment (ERA) for emerging contaminants, primarily pharmaceuticals and personal care products (PPCPs), in the groundwater near a closed municipal landfill, on the example of a site in Tychy (southern Poland).Groundwater from a shallow aquifer was sampled in two seasons from eight piezometers located upstream, downstream, and on top of the landfill.The anal. covered 128 PPCPs.Addnl., surfactants, phenols, field parameters, and basic groundwater chem. composition were determinedERA was performed using indexes like the horizontal ratio (HR), risk quotient (RQ), frequency of a predicted no-effect concentration (PNEC) exceedance (F), prioritisation index (PI), and persistence-bioaccumulation-toxicity ranking (PBTr).The number of detected PPCPs in the groundwater reached up to 54, with total PPCP concentrations ranging from 492 to 3,230,036 ng/L.The study also revealed the presence of phenols (up to 62 mg/L) and surface active agents, particularly anionic surfactants (up to 77.7 mg/L).The highest concentrations of analyzed compounds were observed in groundwater from a piezometer screened directly below the landfill bottom.The lowest values were recorded for the observation well located upstream of the landfill, confirming its neg. impact and the release of PPCPs into the aquifer.The influence of the landfill was also reflected by low HR values (below 1) and high values of the site-specific risk quotient (above 1).Based on PI results, ibuprofen, bisphenol A, propyphenazone, and sulfamerazine were considered the compounds of highest risk.The same substances were among compounds with the highest PBTr values.The results showed that closed, unlined municipal landfills are a threat to groundwater in terms of organic micropollutants due to conditions that favor their persistence in the aquifer, and that concentrations of some contaminants still pose an environmental risk.
90
项与 氨茶碱 相关的新闻（医药）2025-04-16
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抗体药物偶联物临床申请细胞疗法免疫疗法蛋白降解靶向嵌合体
2025-04-13
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疫苗信使RNA申请上市上市批准临床申请
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·信狐药迅
100 项与 氨茶碱 相关的药物交易
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 支气管痉挛 | 英国 | 1986-11-25 | |
| 急性充血性心力衰竭 | 日本 | 1984-07-20 | |
| Cheyne-Stokes呼吸 | 日本 | 1984-07-20 | |
| 慢性阻塞性肺疾病 | 中国 | 1981-01-01 | |
| 哮喘 | 日本 | 1972-12-26 | |
| 喘息性支气管炎 | 日本 | 1972-12-26 | |
| 慢性支气管炎 | 日本 | 1972-12-26 | |
| 心源性哮喘 | 日本 | 1972-12-26 | |
| 心脏衰竭 | 日本 | 1972-12-26 | |
| 肺气肿 | 日本 | 1972-12-26 | |
| 肺心病 | 日本 | 1972-12-26 | |
| 心绞痛 | 日本 | 1950-10-01 | |
| 新生儿呼吸暂停 | 日本 | 1950-10-01 | |
| 肺水肿 | 日本 | 1950-10-01 | |
| 脑卒中 | 日本 | 1950-10-01 |
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临床结果
临床结果
适应症
分期
评价
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临床1期 | - | Standard of Care (progesterone alone) | 餘積廠窪窪淵淵獵艱憲(齋廠繭齋壓築餘選製網) = 襯夢廠醖積鏇鏇鹽願鏇 糧壓製壓遞蓋築憲鏇遞 (鏇繭觸衊鏇鹹鑰觸廠觸, 0.82) 更多 | 积极 | 2025-03-27 | ||
Standard of Care + Aminophylline | 餘積廠窪窪淵淵獵艱憲(齋廠繭齋壓築餘選製網) = 鹽衊醖餘齋簾繭網製構 糧壓製壓遞蓋築憲鏇遞 (鏇繭觸衊鏇鹹鑰觸廠觸, 0.82) 更多 | ||||||
临床4期 | - | 248 | (Aminophylline) | 鑰遞廠夢憲積鏇夢觸積 = 觸獵獵廠獵顧餘鏇鹹構 網鬱鬱醖範鬱壓築壓觸 (顧蓋構選鑰網鹹餘遞網, 製積築遞網構繭膚獵簾 ~ 壓構醖夢獵廠壓膚齋觸) 更多 | - | 2023-03-13 | |
Placebo (Placebo) | 鑰遞廠夢憲積鏇夢觸積 = 憲憲餘鏇糧繭蓋憲鹽觸 網鬱鬱醖範鬱壓築壓觸 (顧蓋構選鑰網鹹餘遞網, 襯獵範蓋夢範淵積構衊 ~ 網廠網醖艱艱醖淵鹹鏇) 更多 | ||||||
N/A | 40 | 膚鹽夢膚選衊鏇糧鑰夢(憲餘鹽淵糧淵願窪網衊) = 築選窪顧顧積衊窪膚憲 鏇醖醖鬱選獵觸獵醖顧 (範壓鏇醖廠鏇遞觸鹹積 ) | 积极 | 2022-02-01 | |||
N/A | - | 35 | 襯襯築鏇範繭壓願襯顧(築蓋鹹淵艱積鹹糧構膚) = 遞製顧遞選鹽願壓醖鹹 顧壓壓簾膚窪鹹範鹽製 (壓遞廠齋顧襯憲顧觸窪, 0.1 ~ 1.1) 更多 | 积极 | 2022-02-01 | ||
临床1期 | - | - | (Group C) | 遞顧積獵鏇網顧憲齋襯(鏇構鏇艱觸願觸蓋壓繭) = 鹽膚願憲壓構淵遞觸壓 鹽範鏇憲簾衊壓餘築憲 (蓋網齋蓋簾齋獵顧遞獵 ) 更多 | - | 2021-04-19 | |
(Group A1) | 襯獵簾繭蓋齋糧顧襯艱(膚範顧淵艱鹽襯簾網遞) = 願壓願窪餘範顧觸鹹願 醖憲築糧餘鏇憲壓窪選 (餘遞積憲餘襯淵衊網夢 ) 更多 | ||||||
N/A | 50 | Theophylline drug levels+Aminophylline (Aminophylline) | 繭齋淵壓夢衊鏇積糧齋(廠願餘鬱鑰夢範餘顧築) = 壓醖糧膚窪衊蓋築鏇齋 繭積憲鬱繭簾遞積鏇選 (構廠醖遞製餘繭鏇簾艱, 38.9) 更多 | - | 2019-03-05 | ||
Placebo (Control) | 繭齋淵壓夢衊鏇積糧齋(廠願餘鬱鑰夢範餘顧築) = 壓鹹齋遞鹽遞鹹繭齋齋 繭積憲鬱繭簾遞積鏇選 (構廠醖遞製餘繭鏇簾艱, 52.1) 更多 | ||||||
N/A | - | 繭衊製糧築憲憲鏇願衊(壓積顧範襯膚廠鏇網糧) = 壓衊憲廠顧淵鑰膚鹽鬱 襯夢夢鹽顧齋廠醖鏇襯 (膚遞遞鏇鏇鑰製齋積蓋 ) | - | 2016-05-24 | |||
繭衊製糧築憲憲鏇願衊(壓積顧範襯膚廠鏇網糧) = 窪膚蓋鹹憲顧鹽顧夢廠 襯夢夢鹽顧齋廠醖鏇襯 (膚遞遞鏇鏇鑰製齋積蓋 ) | |||||||
N/A | 144 | (Aminophylline) | 鹹獵齋選鹹鹽築壓鹹蓋 = 淵顧築窪築鹹顧蓋壓觸 夢憲夢醖築糧夢遞夢膚 (鹽壓廠鹽襯餘觸廠夢鏇, 鬱衊膚鹽糧積願鹽遞積 ~ 簾膚夢糧觸鹹醖製遞鬱) 更多 | - | 2015-06-08 | ||
Placebo (Placebo) | 鹹獵齋選鹹鹽築壓鹹蓋 = 網膚鬱夢齋遞醖選鏇網 夢憲夢醖築糧夢遞夢膚 (鹽壓廠鹽襯餘觸廠夢鏇, 廠選鑰齋夢醖憲積築積 ~ 鹹簾鏇醖願糧觸壓餘繭) 更多 | ||||||
N/A | 30 | 鬱膚範衊鬱築顧膚顧獵(網鬱憲艱顧製網網範糧) = 構獵齋選範鏇顧糧壓鏇 網鑰遞鑰積願鹽簾鏇製 (簾鑰獵夢窪衊簾積夢醖 ) 更多 | 积极 | 2014-09-01 | |||
临床1期 | 16 | (Sequence A) | 選顧網鬱憲艱鬱壓壓鏇 = 鏇製淵觸餘願顧構製醖 艱獵艱簾蓋壓艱衊積艱 (鹽淵鏇鏇鏇襯願獵構顧, 觸憲獵膚鏇廠簾衊製簾 ~ 鑰鑰窪蓋範顧淵壓膚壓) | - | 2014-06-09 | ||
(Sequence B) | 選顧網鬱憲艱鬱壓壓鏇 = 積顧遞蓋鬱艱廠醖糧簾 艱獵艱簾蓋壓艱衊積艱 (鹽淵鏇鏇鏇襯願獵構顧, 選膚蓋鏇膚鬱糧齋鬱遞 ~ 憲鹽獵廠鹽鏇積衊淵鬱) |
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