Icosapent Ethyl

Strategic Initiatives and Refined Business Model Produced Financial and Operating Efficiencies Established Long-Term License and Supply Agreement to Commercialize VAZKEPA® Across Europe and Sustained U.S. Market Leadership for VASCEPA® Franchise Total of 45 Publications (Abstracts, Posters, Manuscripts) Furthering the Expansion of the VASCEPA ® /VAZKEPA® (icosapent ethyl) Body of Knowledge Supported in 2025 DUBLIN, Ireland and BRIDGEWATER, N.J., Feb. 25, 2026 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ: AMRN), a company committed to advancing the science of cardiovascular disease worldwide, today announced financial results for the fourth quarter and full year ended December 31, 2025. “Our performance in the fourth quarter and full year of 2025 confirmed both the initial impact and long-term potential of our strategic initiatives and re-imagined operating model,” said Aaron Berg, President and Chief Executive Officer of Amarin. “We have entered 2026 from an improved position of market, operational, and financial strength. We have maintained our U.S. leading market share for VASCEPA and are actively expanding our presence in Europe for VAZKEPA via our long-term partnership agreement with Recordati S.p.A., strengthening our now fully partnered international commercial strategy. We are a leaner organization, having made great progress in reducing costs and narrowing our losses, while continuing to invest in expanding an already formidable body of scientific knowledge that supports our global VASCEPA/VAZKEPA franchise and its proven ability to reduce cardiovascular risk. While work remains, we are encouraged by our progress and continue to examine strategic actions to maximize future shareholder value and options regarding management of capital.” Q4 2025 Financial Highlights ($ in millions) Q4 2025 Q4 2024 % Change Total Net Revenue $49.2 $62.3 (21)% Operating Expenses $29.5 $43.0 (31)% Operating Loss Operating Margin % * $(6.3) (13)% $(52.5) (84)% (88)% NM Net Loss Net Margin $(1.2) (2)% $(48.6) (78)% (97)% NM Cash $302.6 $294.2 * Operating margin is calculated as operating loss divided by total net revenue. NM – Not Meaningful Peter Fishman, Amarin’s Chief Financial Officer, said, “Our fourth quarter performance reflects our early success in optimizing the Company’s operations and creating what we believe is a more efficient platform for long-term growth. We realized $31 million of the expected $70 million in cost savings from our restructuring initiatives and have incurred nearly all of the $37 - $40 million in restructuring costs. Our cash position improved sequentially and year over year, ending 2025 with total cash and investments of $303 million and no debt. As a direct result of our continued revenue generation and new financial operating profile, our return to positive cash flow in the fourth quarter was ahead of schedule and has positioned us to generate positive cash flow for the full year ahead. We are well positioned to deliver on our operational and strategic priorities in 2026.” Q4 2025 Financial Performance Comparisons to Q4 2024, unless otherwise stated Revenues ($ in millions) Q4 2025 Q4 2024 % Change Product Revenue, net: U.S. Europe Rest-of-World (ROW) $41.1 $2.3 $3.1 $44.2 $4.0 $11.9 (7)% (42)% (74)% Total Product Revenue, net $46.5 $60.1 (23)% Licensing & Royalties $2.7 $2.2 20% Total Net Revenue $49.2 $62.3 (21)% NM - Not Meaningful Total Net Revenue: Decreased $13.1 million, or 21%, due primarily to a decline in ROW sales that reflected a $7.8 million stocking order in last year’s fourth quarter in preparation for a market launch, a decline in net selling price in the U.S., and the effects of the transition of our European sales activities to Recordati that included both supply shipments and direct sales in the 2025 fourth quarter. European sales in the fourth quarter of 2024 included direct sales only; once the transition to a fully partnered sales model is complete, European sales will consist only of supply shipments to Recordati. Royalties increased by $0.5 million due to higher in-market sales generated by our global partners. Operating Expenses Comparisons to Q4 2024, unless otherwise stated ($ in millions) Q4 2025 Q4 2024 % Change COGS $26.1 $71.9 SG&A $20.1 $37.0 R&D $5.4 $6.0 Restructuring $4.1 -- NM Total Operating Expenses * $29.5 $43.0 * Total operating expenses reflect the sum of SG&A, R&D, and Restructuring expenses. NM - Not Meaningful Total Operating Expenses: Decreased $13.5 million, or 31%, primarily due to the impact of the June 2025 Global Restructuring Plan that produced declines in Selling, General, and Administrative expenses (SG&A). Excluding the restructuring charge of $4.1 million ( see discussion below ), Q4 2025 total operating expenses were $25.4 million, representing a decline of 41%. COGS: Decreased $45.8 million, or 64%. COGS in Q4 2024 included a one-time inventory restructuring charge of $36.5 million related to the Company’s efforts to amend supplier agreements to align with then current and expected future demand and a one-time inventory write off. Excluding these one-time charges, Q4 2025 COGS decreased $2.8 million, or 10%, primarily due to lower net product sales. SG&A: Decreased $16.9 million, or 46%, primarily due to a reduction in costs pursuant to the Global Restructuring Plan and other cost optimization initiatives. R&D: Consistent with the prior year period. Restructuring: The Company recognized $4.1 million in Q4 2025 related to the continued implementation of the Global Restructuring Plan associated with the execution of the Recordati Licensing Agreement announced in June 2025. This resulted in the elimination of commercial roles in the Company’s Europe operations, among other operating expense savings across the Company’s global operations. The Company incurred $36.2 million of restructuring charges in full year 2025 and continues to expect total restructuring charges to range from $37 to $40 million, with the remaining charges expected to be realized in early 2026. Additional Q4 2025 Financial Information Comparisons to Q4 2024, unless otherwise stated Operating Loss: Narrowed to $6.3 million from an operating loss of $52.5 million, an improvement of $46.2 million, or 88%. Operating loss in Q4 2025 included restructuring costs of $4.1 million compared to $36.5 million in Q4 2024. Net Loss: Improved to $(1.2) million, or $(0.00) per share, from a net loss of $(48.6) million, or $(0.12) per share. Cash: Reported aggregate cash and investments of $302.6 million, as of December 31, 2025, compared to $294.2 million as of December 31, 2024, reflecting a year-over-year increase of $8.4 million, and compared to $286.6 million as of September 30, 2025, reflecting a sequential increase of $16.0 million. Debt: Remained debt free as of December 31, 2025. Fourth Quarter and Full Year 2025 Earnings Conference Call and Webcast Information Amarin will host a conference call on February 25, 2026, at 8:00 a.m. ET to discuss this information. The conference call can be accessed on the investor relations section of the Company's website at or via telephone by dialing 888-506-0062 within the United States, 973-528-0011 from outside the United States, and referencing conference ID 675507. A replay of the webcast will be made available until August 25,2026. To listen to a replay of the call, dial 877-481-4010 from within the United States and 919-882-2331 from outside of the United States, and reference conference ID 53567. A replay of the call will also be available through the Company's website shortly after the call. About Amarin Amarin is a global pharmaceutical company committed to reducing the cardiovascular disease (CVD) burden for patients and communities and to advancing the science of cardiovascular care around the world. We own and support a global branded product approved by multiple regulatory authorities based on a track record of proven efficacy and safety and backed by robust clinical trial evidence. Our commercialization model includes a direct sales approach in the U.S. and an indirect distribution strategy internationally, through a syndicate of reputable and well-established partners with significant geographic expertise, covering close to 100 markets worldwide. Our success is driven by a dedicated, talented, and highly skilled team of experts passionate about the fight against the world’s leading cause of death, CVD. About VASCEPA®/VAZKEPA® (icosapent ethyl) Capsules VASCEPA (icosapent ethyl) capsules are the first prescription treatment approved by the U.S. Food and Drug Administration (FDA) comprised solely of the active ingredient, icosapent ethyl (IPE), a unique form of eicosapentaenoic acid. VASCEPA was launched in the United States in January 2020 as the first drug approved by the U.S. FDA for treatment of the studied high-risk patients with persistent cardiovascular risk despite being on statin therapy. VASCEPA was initially launched in the United States in 2013 based on the drug’s initial FDA approved indication for use as an adjunct therapy to diet to reduce triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. Since launch, VASCEPA has been prescribed more than twenty-five million times. VASCEPA is covered by most major medical insurance plans. In addition to the United States, VASCEPA is approved and sold in Canada, China, Australia, Lebanon, the United Arab Emirates, Saudi Arabia, Qatar, Bahrain, and Kuwait. In Europe, in March 2021 marketing authorization was granted to icosapent ethyl in the European Union for the reduction of risk of cardiovascular events in patients at high cardiovascular risk, under the brand name VAZKEPA. In April 2021 marketing authorization for VAZKEPA (icosapent ethyl) was granted in the United Kingdom (applying to England, Scotland, Wales, and Northern Ireland). VAZKEPA (icosapent ethyl) is currently approved and sold in Europe in Sweden, Finland, England/Wales, Spain, Netherlands, Scotland, Greece, Portugal, Italy, Denmark and Austria. United States Indications and Limitation of Use VASCEPA is indicated: As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization and unstable angina requiring hospitalization in adult patients with elevated triglyceride (TG) levels (≥ 150 mg/dL) and established cardiovascular disease or diabetes mellitus and two or more additional risk factors for cardiovascular disease. As an adjunct to diet to reduce TG levels in adult patients with severe (≥ 500 mg/dL) hypertriglyceridemia. The effect of VASCEPA on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined. Important Safety Information VASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components. VASCEPA was associated with an increased risk (3% vs 2%) of atrial fibrillation or atrial flutter requiring hospitalization in a double-blind, placebo-controlled trial. The incidence of atrial fibrillation was greater in patients with a previous history of atrial fibrillation or atrial flutter. It is not known whether patients with allergies to fish and/or shellfish are at an increased risk of an allergic reaction to VASCEPA. Patients with such allergies should discontinue VASCEPA if any reactions occur. VASCEPA was associated with an increased risk (12% vs 10%) of bleeding in a double-blind, placebo-controlled trial. The incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel or warfarin. Common adverse reactions in the cardiovascular outcomes trial (incidence ≥3% and ≥1% more frequent than placebo): musculoskeletal pain (4% vs 3%), peripheral edema (7% vs 5%), constipation (5% vs 4%), gout (4% vs 3%), and atrial fibrillation (5% vs 4%). Common adverse reactions in the hypertriglyceridemia trials (incidence >1% more frequent than placebo): arthralgia (2% vs 1%) and oropharyngeal pain (1% vs 0.3%). Adverse events may be reported by calling 1-855-VASCEPA or the FDA at 1-800-FDA-1088. Patients receiving VASCEPA and concomitant anticoagulants and/or anti-platelet agents should be monitored for bleeding. FULL U.S. FDA-APPROVED VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM Europe For further information about the Summary of Product Characteristics (SmPC) for VAZKEPA® in Europe, please visit: Globally, prescribing information varies; refer to the individual country product label for complete information. Use of Non-GAAP Adjusted Financial Information Included in this press release are non-GAAP adjusted financial information as defined by U.S. Securities and Exchange Commission Regulation G. The GAAP financial measure is most directly comparable to each non-GAAP adjusted financial measure used or discussed, and a reconciliation of the differences between each non-GAAP adjusted financial measure and the comparable GAAP financial measure, is included in this press release after the condensed consolidated financial statements. Non-GAAP adjusted net (loss) income was derived by taking GAAP net loss and adjusting it for non-cash stock-based compensation expense, restructuring expense and other one-time expenses. Management uses these non-GAAP adjusted financial measures for internal reporting and forecasting purposes, when publicly providing its business outlook, to evaluate the company’s performance and to evaluate and compensate the company’s executives. The company has provided these non-GAAP financial measures in addition to GAAP financial results because it believes that these non-GAAP adjusted financial measures provide investors with a better understanding of the company’s historical results from its core business operations. While management believes that these non-GAAP adjusted financial measures provide useful supplemental information to investors regarding the underlying performance of the company’s business operations, investors are reminded to consider these non-GAAP measures in addition to, and not as a substitute for, financial performance measures prepared in accordance with GAAP. Non-GAAP measures have limitations in that they do not reflect all the amounts associated with the company’s results of operations as determined in accordance with GAAP. In addition, it should be noted that these non-GAAP financial measures may be different from non-GAAP measures used by other companies, and management may utilize other measures to illustrate performance in the future. Forward-Looking Statements This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including beliefs about Amarin’s key achievements in 2025 and the potential impact and outlook for achievements in 2026 and beyond; Amarin’s 2026 financial outlook and cash position; Amarin’s overall efforts to expand access and reimbursement to VAZKEPA across global markets; expectations regarding potential strategic collaboration and licensing agreements with third parties, including our ability to attract additional collaborators, as well as our plans and strategies for entering into potential strategic collaboration and licensing agreements and the overall potential and future success of VASCEPA/VAZKEPA and Amarin that are based on the beliefs and assumptions and information currently available to Amarin. All statements other than statements of historical fact contained in this press release are forward-looking statements. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission. Amarin’s annual report on Form 10-K for the fiscal year ended 2025 will also be accessible there later this week. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. Amarin undertakes no obligation to update or revise the information contained in its forward-looking statements, whether as a result of new information, future events or circumstances or otherwise. Amarin’s forward-looking statements do not reflect the potential impact of significant transactions the company may enter into, such as mergers, acquisitions, dispositions, joint ventures or any material agreements that Amarin may enter into, amend or terminate. Investors and others should note that Amarin communicates with its investors and the public using the company website ( ), the investor relations website ( ), including but not limited to investor presentations and investor FAQs, U.S. Securities and Exchange Commission filings, press releases, public conference calls and webcasts. Amarin Contact Information Media Inquiries: Tegan Berry Amarin Corporation plc PR@amarincorp.com Investor Inquiries: Devin Sullivan & Conor Rodriguez The Equity Group on Behalf of Amarin devin.sullivan.ext@amarincorp.com or conor.rodriguez.ext@amarincorp.com Investor.relations@amarincorp.com -Tables to Follow- CONSOLIDATED BALANCE SHEET DATA (U.S. GAAP) Unaudited * December 31, 2025 December 31, 2024 (in thousands) ASSETS Current Assets: Cash and cash equivalents $ 134,660 $ 121,038 Restricted cash 201 300 Short-term investments 167,929 173,182 Accounts receivable, net 126,832 122,279 Inventory 195,910 166,048 Prepaid and other current assets 24,350 12,552 Total current assets 649,882 595,399 Property, plant and equipment, net 12 16 Long-term inventory — 64,740 Operating lease right-of-use asset 6,461 7,592 Other long-term assets 1,055 1,213 Intangible asset, net 13,365 16,389 TOTAL ASSETS $ 670,775 $ 685,349 LIABILITIES AND STOCKHOLDERS’ EQUITY Current Liabilities: Accounts payable $ 45,355 $ 40,366 Accrued expenses and other current liabilities 149,104 139,583 Total current liabilities 194,459 179,949 Long-Term Liabilities: Long-term operating lease liability 6,080 7,723 Other long-term liabilities 10,955 11,501 Total liabilities 211,494 199,173 Stockholders’ Equity: Common stock 310,184 305,298 Additional paid-in capital 1,923,801 1,914,750 Treasury stock (67,360 ) (65,326 ) Accumulated deficit (1,707,344 ) (1,668,546 ) Total stockholders’ equity 459,281 486,176 TOTAL LIABILITIES AND STOCKHOLDERS’ EQUITY $ 670,775 $ 685,349 * Unaudited as a standalone schedule; copied from consolidated financial statements CONSOLIDATED STATEMENTS OF OPERATIONS DATA (U.S. GAAP) Unaudited * Three Months Ended December 31, Year Ended December 31, (in thousands, except per share amounts) (in thousands, except per share amounts) 2025 2024 2025 2024 Product revenue, net $ 46,543 $ 60,068 $ 182,753 $ 204,590 Licensing and royalty revenue 2,676 2,238 30,893 24,024 Total revenue, net 49,219 62,306 213,646 228,614 Less: Cost of goods sold 26,050 35,399 92,778 110,758 Less: Cost of goods sold - restructuring inventory — 36,474 — 36,474 Gross margin 23,169 (9,567 ) 120,868 81,382 Operating expenses: Selling, general and administrative (1) 20,059 36,970 115,003 152,310 Research and development (1) 5,371 5,985 19,806 20,869 Restructuring 4,064 — 36,229 — Total operating expenses 29,494 42,955 171,038 173,179 Operating loss (6,325 ) (52,522 ) (50,170 ) (91,797 ) Interest income 2,570 3,371 10,853 13,403 Interest expense (1 ) (3 ) (7 ) (7 ) Other income (expense), net 2,904 (753 ) 3,276 1,201 Loss from operations before taxes (852 ) (49,907 ) (36,048 ) (77,200 ) (Provision for) benefit from income taxes (372 ) 1,289 (2,750 ) (4,983 ) Net loss $ (1,224 ) $ (48,618 ) $ (38,798 ) $ (82,183 ) Loss per share: Basic $ (0.00 ) $ (0.12 ) $ (0.09 ) $ (0.20 ) Diluted $ (0.00 ) $ (0.12 ) $ (0.09 ) $ (0.20 ) Weighted average shares outstanding: Basic 416,000 411,293 414,984 410,937 Diluted 416,000 411,293 414,984 410,937 * Unaudited as a standalone schedule; copied from consolidated financial statements (1) Excluding non-cash stock-based compensation, selling, general and administrative expenses were $105,759 and $138,144 for the years ended December 31, 2025 and 2024, respectively, and research and development expenses were $17,345 and $17,330, respectively, for the same periods. RECONCILIATION OF NON-GAAP NET (LOSS) INCOME Unaudited Three months ended December 31, Year Ended December 31, (in thousands, except per share amounts) (in thousands, except per share amounts) 2025 2024 2025 2024 Net (loss) income for EPS - GAAP $ (1,224 ) $ (48,618 ) $ (38,798 ) $ (82,183 ) Stock-based compensation expense 1,559 3,400 11,705 17,705 Restructuring expense 4,064 — 36,229 — Restructuring Inventory — 36,474 — 36,474 ADS Ratio Change Fees — — 2,015 — Licensing Agreement Fees — — 5,038 — Adjusted net (loss) income for EPS - non-GAAP $ 4,399 $ (8,744 ) $ 16,189 $ (28,004 ) Basic and diluted (Loss) earnings per share: Basic - non-GAAP $ 0.01 $ (0.02 ) $ 0.04 $ (0.07 ) Diluted - non-GAAP $ 0.01 $ (0.02 ) $ 0.04 $ (0.07 ) Weighted average shares: Basic 416,000 411,293 414,984 410,937 Diluted 433,019 411,293 427,104 410,937

DUBLIN and BRIDGEWATER, N.J., Feb. 23, 2026 (GLOBE NEWSWIRE) -- Amarin Corporation plc (NASDAQ: AMRN), a company committed to advancing the science of cardiovascular disease (CVD) worldwide, today issued a call to action for American Heart Month emphasizing a message that cannot wait: the United States has an opportunity to significantly reduce heart attacks, strokes, and cardiovascular deaths by prioritizing the use of proven, existing therapies that are widely available, yet significantly underutilized. Despite decades of scientific advances and clear guideline recommendations, millions of patients at high risk for CVD remain untreated or undertreated. The latest 2026 American Heart Association (AHA) Heart Disease & Stroke Statistics show that CVD remains the leading cause of death in the U.S. and affects nearly half of the adult population. According to the AHA, 130.6 million U.S. adults (48.9%) were living with some form of CVD in 2023. i “We do not need to wait for tomorrow’s breakthroughs to save lives today,” said Aaron Berg, President & CEO of Amarin. “With nearly half the nation affected by CVD, the need to deploy FDA- and EMA‑approved, foundational therapies with a history of reducing cardiovascular events such as heart attacks and strokes has never been greater. A real dent in cardiovascular disease can be made today – simply by using the tools we already have.” An Urgent, Persistent Unmet Need-Despite Available Solutions Guideline‑supported, cost-effective therapies - including statins, ezetimibe, PCSK9 inhibitors, and icosapent ethyl - have a long and established history of robust evidence demonstrating reductions in cardiovascular events. However, real‑world treatment patterns show: i, ii , iii , iv High‑risk patients frequently fail to achieve LDL‑C targets CV event rates among patients treated with statins who have established CV disease accumulate over time, with a cumulative incidence of CV events reaching up to approximately 40% over 10 years Few receive evidence‑based adjunct therapies There are still large gaps in prescribing across health systems Many patients continue taking treatments that lower biomarkers without improving clinical outcomes This disconnect between evidence and practice represents one of the largest, yet immediately fixable unmet needs in modern medicine. Innovation is Encouraging - But Patients Can Benefit From Available Life-Saving Treatments Today While emerging research in pathways such as APOC3, ANGPTL3/4, CETP, and Lp(a) holds promise for the future, most innovations are years away from delivering proven clinical cardiovascular outcomes, reimbursement, and health system adoption. Future innovation is essential, but immediate implementation of existing treatments saves lives. Patients can’t afford to wait years for future evidence while their current cardiovascular risk goes untreated. A 2026 Call to Action: Review, Reassess, Refocus Amarin calls on the cardiovascular community to recommit to data‑driven care and to help patients, payers, and providers make informed decisions based on rigorous and validated clinical studies for currently available therapeutic options. These critical gaps in care represent a national and global crisis of undertreatment in cardiovascular prevention, where patients who should be protected remain exposed. This year, the call to action is clearer than ever : Review, Reassess, Refocus. Review current practice patterns to ensure alignment with latest guideline recommendations. Reassess therapies used primarily for lipid‑parameter changes without proven event reduction. Refocus on therapies backed by rigorous outcomes data to ensure real‑world practice reflects scientific consensus. “This American Heart Month”, says Aaron Berg, “we call on the cardiovascular community to act with urgency by prioritizing approved treatments already proven and widely reimbursed while advancing toward a future where cardiovascular disease is no longer the world’s leading cause of death. We all have a role to play in evolving narratives. Together, we can save lives - right now.” About Amarin Amarin is a global pharmaceutical company committed to reducing the cardiovascular disease (CVD) burden for patients and communities and to advancing the science of cardiovascular care around the world. We own and support a global branded product approved by multiple regulatory authorities based on a track record of proven efficacy and safety and backed by robust clinical trial evidence. Our commercialization model includes a direct sales approach in the U.S. and an indirect distribution strategy internationally, through a syndicate of reputable and well-established partners with significant geographic expertise, covering close to 100 markets worldwide. Our success is driven by a dedicated, talented, and highly skilled team of experts passionate about the fight against the world’s leading cause of death, CV. About VASCEPA®/VAZKEPA® (icosapent ethyl) Capsules VASCEPA (icosapent ethyl) capsules are the first prescription treatment approved by the U.S. Food and Drug Administration (FDA) comprised solely of the active ingredient, icosapent ethyl (IPE), a unique form of eicosapentaenoic acid. VASCEPA was launched in the United States in January 2020 as the first drug approved by the U.S. FDA for treatment of the studied high-risk patients with persistent cardiovascular risk despite being on statin therapy. VASCEPA was initially launched in the United States in 2013 based on the drug’s initial FDA approved indication for use as an adjunct therapy to diet to reduce triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. Since launch, VASCEPA has been prescribed more than twenty-five million times. VASCEPA is covered by most major medical insurance plans. In addition to the United States, VASCEPA is approved and sold in Canada, China, Australia, Lebanon, the United Arab Emirates, Saudi Arabia, Qatar, Bahrain, and Kuwait. In Europe, in March 2021 marketing authorization was granted to icosapent ethyl in the European Union for the reduction of risk of cardiovascular events in patients at high cardiovascular risk, under the brand name VAZKEPA. In April 2021 marketing authorization for VAZKEPA was granted in the United Kingdom (applying to England, Scotland, Wales, and Northern Ireland). VAZKEPA is currently approved and sold in Europe in Sweden, Finland, England/Wales, Spain, Netherlands, Scotland, Greece, Portugal, Italy, Denmark and Austria United States Indications and Limitation of Use VASCEPA is indicated: As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization and unstable angina requiring hospitalization in adult patients with elevated triglyceride (TG) levels (≥ 150 mg/dL) and established cardiovascular disease or diabetes mellitus and two or more additional risk factors for cardiovascular disease. As an adjunct to diet to reduce TG levels in adult patients with severe (≥ 500 mg/dL) hypertriglyceridemia. The effect of VASCEPA on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined. Important Safety Information VASCEPA is contraindicated in patients with known hypersensitivity (e.g., anaphylactic reaction) to VASCEPA or any of its components. VASCEPA was associated with an increased risk (3% vs 2%) of atrial fibrillation or atrial flutter requiring hospitalization in a double-blind, placebo-controlled trial. The incidence of atrial fibrillation was greater in patients with a previous history of atrial fibrillation or atrial flutter. It is not known whether patients with allergies to fish and/or shellfish are at an increased risk of an allergic reaction to VASCEPA. Patients with such allergies should discontinue VASCEPA if any reactions occur. VASCEPA was associated with an increased risk (12% vs 10%) of bleeding in a double-blind, placebo-controlled trial. The incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel or warfarin. Common adverse reactions in the cardiovascular outcomes trial (incidence ≥3% and ≥1% more frequent than placebo): musculoskeletal pain (4% vs 3%), peripheral edema (7% vs 5%), constipation (5% vs 4%), gout (4% vs 3%), and atrial fibrillation (5% vs 4%). Common adverse reactions in the hypertriglyceridemia trials (incidence >1% more frequent than placebo): arthralgia (2% vs 1%) and oropharyngeal pain (1% vs 0.3%). Adverse events may be reported by calling 1-855-VASCEPA or the FDA at 1-800-FDA-1088. Patients receiving VASCEPA and concomitant anticoagulants and/or anti-platelet agents should be monitored for bleeding. FULL U.S. FDA-APPROVED VASCEPA PRESCRIBING INFORMATION CAN BE FOUND AT WWW.VASCEPA.COM Europe For further information about the Summary of Product Characteristics (SmPC) for VAZKEPA® in Europe, please visit: Globally, prescribing information varies; refer to the individual country product label for complete information. Forward-Looking Statements This press release contains forward-looking statements which are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995, including beliefs about Amarin’s key achievements in 2025 and the potential impact and outlook for achievements in 2026 and beyond; Amarin’s 2025 financial outlook and cash position; Amarin’s overall efforts to expand access and reimbursement to VAZKEPA across global markets; expectations regarding potential strategic collaboration and licensing agreements with third parties, including our ability to attract additional collaborators, as well as our plans and strategies for entering into potential strategic collaboration and licensing agreements and the overall potential and future success of VASCEPA/VAZKEPA and Amarin that are based on the beliefs and assumptions and information currently available to Amarin. All statements other than statements of historical fact contained in this press release are forward-looking statements. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. A further list and description of these risks, uncertainties and other risks associated with an investment in Amarin can be found in Amarin's filings with the U.S. Securities and Exchange Commission, including Amarin’s quarterly report on Form 10-Q for the period ending September 30, 2025 and annual report on Form 10-K for the fiscal year ended 2024. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date they are made. Amarin undertakes no obligation to update or revise the information contained in its forward-looking statements, whether as a result of new information, future events or circumstances or otherwise. Amarin’s forward-looking statements do not reflect the potential impact of significant transactions the company may enter into, such as mergers, acquisitions, dispositions, joint ventures or any material agreements that Amarin may enter into, amend or terminate. Investors and others should note that Amarin communicates with its investors and the public using the company website ( ), the investor relations website ( ), including but not limited to investor presentations and investor FAQs, U.S. Securities and Exchange Commission filings, press releases, public conference calls and webcasts. Amarin Contact Information Media Inquiries: Tegan Berry Amarin Corporation plc PR@amarincorp.com Investor Inquiries: Devin Sullivan & Conor Rodriguez The Equity Group on Behalf of Amarin dsullivan@theequitygroup.com or crodriguez@theequitygroup.com Investor.relations@amarincorp.com i Palaniappan LP, Allen NB, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Bansal N, Currie ME, Earlie RS, Fan W, Fetterman JL, Barone Gibbs B, Heard DG,Hiremath S, Hong H, Hyacinth HI, Ibeh C, Jiang T, Johansen MC, Kazi DS, Ko D, Kwan TW, Leppert MH, Li Y, Magnani JW, Martin KA, Martin SS, Michos ED, Mussolino ME, Ogungbe O, Parikh NI, Perez MV, Perman SM, Sarraju A, Shah NS, Springer MV, St-Onge M-P, Thacker EL, Tierney S, Urbut SM, Van Spall HGC, Voeks JH, Whelton SP, Wong SS, Zhao J, Khan SS; on behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Committee. 2026 Heart disease and stroke statistics: a report of US and global data from the American Heart Association. Circulation. Published online January 21, 2026 ii Navar AM, Kolkailah AA, Gupta A, et al. Gaps in Guideline-Based Lipid-Lowering Therapy for Secondary Prevention in the United States: A Retrospective Cohort Study of 322 153 Patients. Circ Cardiovasc Qual Outcomes. 2023;16(8):533-543. doi: 10.1161/CIRCOUTCOMES.122.009787. iii Bradley CK, Kolkailah AA, Shah NP, et al. Uptake of non-statin lipid-lowering therapies for secondary prevention in community practice. J Clin Lipidol. 2023;17(3):412-414. doi: 10.1016/j.jacl.2023.03.006. iv Vijayaraghavan K, Baum S, Desai NR and Voyce SJ. Intermediate and long-term residual cardiovascular risk in patients with established cardiovascular disease treated with statins. Front. Cardiovasc. Med. 2024. 10:1308173. doi: 10.3389/fcvm.2023.1308173