Naftopidil

In this study, 18 Naftopidil (NFPD) binary salts were synthesized and then analyzed via XPS.Among these salts, nine known binary salts were initially investigated via SCXRD, where in every binary complex, the carboxylic acid (-COOH) proton is transferred to N of naftopidil.Afterward, these nine naftopidil salts were examined via XPS, where N 1s binding energies of salts showed a significant binding energy shift (2.1 to 2.6 eV) compared to neutral N 1s binding energies of naftopidil.Later, nine novel complexes were synthesized and explored via XPS.Interestingly, these new crystalline materials also manifest considerable N 1s binding energy shifts (1.9 to 2.4 eV) compared to the neutral N 1s binding energies of naftopidil.After a detailed evaluation of XPS exptl. results, new complexes were predicted as naftopidil salts, and SCXRD studies further confirmed these results.Moreover, all these crystalline materials were also characterized by Powder X-ray diffraction (PXRD) and Fourier Transform IR Spectroscopy (FT-IR).Intermol. interactions are further studied by Hirshfeld Surface Anal. (HSA).