更新于：2023-10-01

Selenium

更新于：2023-10-01

概要

研发状态

概要

基本信息

药物类型

小分子化药

别名

Selenase

靶点-

作用机制-

治疗领域

免疫系统疾病、感染、神经系统疾病+ [5]

在研适应症-

非在研适应症

获得性免疫缺陷综合征、脑损伤、心脏毒性+ [15]

原研机构-

在研机构-

非在研机构

Fundação Oswaldo Cruz

Fresenius Kabi AGbiosyn Corp.

+ [1]

最高研发状态(全球)终止临床3期

首次获批日期(全球)-

最高研发状态(中国)-

特殊审评-

关联

170

项与 Selenium 相关的临床试验

ChiCTR2300075603 / Recruiting早期临床1期

Improvement and therapeutic effect of selenium supplement on autoimmune status in patients with type 1 diabetes

开始日期2023-09-11

申办/合作机构-

IRCT20220614055165N1 / Suspended临床3期

Investigating the effect of high dose of selenium on the Clinical Situation of patients undergoing coronary artery bypass surgery with a pump

开始日期2023-08-23

申办/合作机构-

IRCT20091114002709N62 / Suspended临床3期

The effect of nano-selenium supplementation on JAK2, STAT3, SRC and indoleamine 2,3-dioxygenase gene expression, serum total antioxidant capacity, serum glutathione peroxidase and malondialdehyde levels, and depressive symptoms in patients with major depressive disorder; A triple-blind randomized controlled trial

开始日期2023-08-22

申办/合作机构

Iran University of Medical Sciences & Health Services

100 项与 Selenium 相关的专利（医药）

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14,557

项与 Selenium 相关的文献（医药）

2023-12-01·Journal of enzyme inhibition and medicinal chemistry

Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling.

Article

作者: Samar El-Kalyoubi ; Samiha A El-Sebaey ; Ahmed A El-Sayed ; Moustafa S Abdelhamid ; Fatimah Agili ; Sherin M Elfeky

Nanotechnology-based strategies can overcome the limitations of conventional cancer therapies. Hence, novel series of pyrimidine Schiff bases (4-9) were employed in the synthesis of selenium nanoparticle forms (4NPs-9NPs). All selenium nano-sized forms exerted greater inhibitions than normal-sized compounds, far exceeding 5-fluorouracil activity. Compound 4 showed effective anti-proliferative activity against MCF-7(IC₅₀ 3.14 ± 0.04 µM), HepG-2(IC₅₀ 1.07 ± 0.03 µM), and A549(IC₅₀ 1.53 ± 0.01 µM) cell lines, while its selenium nanoform 4NPs showed excellent inhibitory effects, with efficacy increased by 96.52%, 96.45%, and 93.86%, respectively. Additionally, 4NPs outperformed 4 in selectivity against the Vero cell line by 4.5-fold. Furthermore, 4NPs exhibited strong inhibition of CDK1(IC₅₀ 0.47 ± 0.3 µM) and tubulin polymerase(IC₅₀ 0.61 ± 0.04 µM), outperforming 4 and being comparable to roscovitine (IC₅₀ 0.27 ± 0.03 µM) and combretastatin-A4(IC₅₀ 0.25 ± 0.01 µM), respectively. Moreover, both 4 and 4NPs arrested the cell cycle at G0/G1 phase and significantly forced the cells towards apoptosis. Molecular docking demonstrated that 4 and 4NPs were able to inhibit CDK1 and tubulin polymerase binding sites.

2023-12-01·Dialogues in health

Perception, knowledge, and consumption pattern of dietary supplement used during COVID-19 pandemic among black Africans: Perspective of Nigerians.

Article

作者: Susan J A Holdbrooke ; Bamgboye M Afolabi ; Nkiru A David ; Kafilat O Kareem ; Abideen Salako ; Oluwagbemiga O Aina

The awareness of the health implication of Covid-19 pandemic marked an increase consumption of various dietary and herbal supplements (DHS) for the deterrence and/or prophylaxis against the novel emerging and infectious disease. However, there is little indication of the usefulness or otherwise of their use in alleviating symptoms of COVID-19.

Objectives:

To investigate the pattern and determinants of DHS use among the Nigerian population for the prevention and treatment of COVID-19.

Design:

Cross-sectional questionnaire survey. Setting: Older adolescents and adults residing in Nigeria.

Participants:

Participants (n = 645) residing in the Nigeria were recruited from different geo-political zones and various ethnic groups.

Primary and secondary outcomes:

Prevalence and determinants for the use of different DHS for the prevention and treatment of COVID-19 in Nigeria, and sources of information for DHS use.

Results:

Most participants (425, 65.9%) believed that dietary supplements are necessary during infectious disease outbreak, but a fewer proportion believed that supplements can be used in conjunction with other drugs to treat Covid-19. Vitamin C was the most known (70.0%) and Vitamin A. The least known (0.3%) dietary supplement Approximately half (50.2%) of the study subjects, more than a third (37.8%) and less than a quarter (22.7%) were aware that Folic acid, vitamin D and vitamin E are DS. Herbal dietary supplements mentioned as known by the study participants included Garlic (46.5%), Ginger (44.7%), Tumeric (36.3%), Moringa (40.0%) and Ginseng (26.3%). Citrus fruit as a DS was recognized by fewer (6.5%) study participants and only 1.6% referred to herbal tea as DHS. In all, 571 (88.5%) of the study participants took DHS during the Covid-19 pandemic with males 1.5 times more likely to take DHS than females (χ² = 3.09, P-value = 0.08, OR = 1.54, 95% CI = 0.95, 2.47) during the pandemic. Participants reported lesser consumption of Selenium (27, 4.2%), Iron (20,3.1%), Zinc (61, 9.5%) and calcium (101, 15.7%) to prevent/treat Covid-19. Majority (271, 42.0%) of the study participants mentioned "health worker" as source of information on DHS while 13% mentioned "Social media". The sociodemographic determinants of DHS practices used to prevent/treat COVID-19 during the pandemic included older age group of 61-70 years, widows, secondary level of education and not employed.

Conclusions:

The findings showed widespread use of DHS for the prevention and treatment of COVID-19. The use of DHS in this study was mainly guided by health workers with a marginal role of social media and Mass media. These findings call for a more robust consolidative tactic towards DHS to ensure its proper and safe use.

2023-12-01·Annals of medicine

Progress in the study of nutritional status and selenium in dialysis patients.

Review

作者: Meiran Cao ; Shuai Zheng ; Wenhua Zhang ; Guicai Hu

Malnutrition is very common in patients with chronic kidney disease, especially in those on maintenance dialysis. Malnutrition is one of the major factors affecting survival and death of dialysis patients, and reducing their activity tolerance and immunity. There are numerous and interacting risk factors for malnutrition, such as reduced nutritional intake, increased energy expenditure, hormonal disorders, and inflammation. Selenium, in the form of selenoproteins, is involved in many physiological processes in the body and plays an important role in maintaining redox homeostasis. Oxidative stress and infection are very common in dialysis patients, and selenium levels in dialysis patients are significantly lower than those in the healthy population. It has been shown that there is a correlation between selenium levels in hemodialysis patients and their nutrition-related indicators, and that selenium supplementation may improve malnutrition in patients. However, further studies are needed to support this conclusion and there is a lack of basic research to further characterize the potential mechanisms by which selenium may improve malnutrition in dialysis patients. The purpose of this review is to provide a comprehensive overview of factors associated with malnutrition in dialysis patients and to describe the progress of research on nutritional status and selenium levels in dialysis patients.

项与 Selenium 相关的新闻（医药）

2023-09-19

·Science Daily

Engineers grow full wafers of high-performing 2D semiconductor that integrates with state-of-the-art chips

Researchers have grown a high-performing 2D semiconductor to a full-size, industrial-scale wafer. In addition, the semiconductor material, indium selenide (InSe), can be deposited at temperatures low enough to integrate with a silicon chip. The semiconductor industry today is working to respond to a threefold mandate: increasing computing power, decreasing chip sizes and managing power in densely packed circuits. To meet these demands, the industry must look beyond silicon to produce devices appropriate for the growing role of computing. While unlikely to abandon the workhorse material anytime in the near or distant future, the technology sector will require creative enhancements in chip materials and architectures to produce devices appropriate for the growing role of computing. One of the biggest shortcomings of silicon is that it can only be made so thin because its material properties are fundamentally limited to three dimensions [3D]. For this reason, two-dimensional [2D] semiconductors -- so thin as to have almost no height -- have become an object of interest to scientists, engineers and microelectronics manufacturers. Thinner chip components would provide greater control and precision over the flow of electricity in a device, while lowering the amount of energy required to power it. A 2D semiconductor would also contribute to keeping the surface area of a chip to a minimum, lying in a thin film atop a supporting silicon device. But until recently, attempts to create such a material have been unsuccessful. Certain 2D semiconductors have performed well on their own, but required such high temperatures to deposit they destroyed the underlying silicon chip. Others could be deposited at silicon-compatible temperatures, but their electronic properties -- energy usage, speed, precision -- were lacking. Some fit the bill for temperature and performance but could not be grown to the requisite purity at industry-standard sizes. Now, researchers at the University of Pennsylvania School of Engineering and Applied Science have grown a high-performing 2D semiconductor to a full-size, industrial-scale wafer. In addition, the semiconductor material, indium selenide (InSe), can be deposited at temperatures low enough to integrate with a silicon chip. Deep Jariwala, Associate Professor and Peter and Susanne Armstrong Distinguished Scholar in the Department of Electrical and Systems Engineering (ESE), and Seunguk Song, postdoctoral fellow in ESE, led the study, published recently in Matter. "Semiconductor manufacturing is an industrial-scale manufacturing process," says Jariwala. "You aren't going to have a viable material unless you can produce it on industrial-scale wafers. The more chips you can make in a batch, the lower the price. But the material must also be pure to ensure performance. This is why silicon is so prevalent -- you can make it in large quantities without sacrificing purity." InSe has long shown promise as a 2D material for advanced computing chips because it carries electrical charge exceptionally well. But producing large enough films of InSe has proven tricky because the chemistry of indium and selenium tends to combine in a few different molecular proportions, taking on chemical structures with varying ratios of each element and thus compromising its purity. The team's success hinged on Song's application of a growth technique that overcame the quirks of InSe's atomic structure. "For the purposes of an advanced computing technology, the chemical structure of 2D InSe needs to be exactly 50:50 between the two elements. The resulting material needs a uniform chemical structure over a large area to work," says Song. The team achieved this groundbreaking purity using a growth technique called "vertical metal-organic chemical vapor deposition" (MOCVD). Previous research had attempted to introduce the indium and selenium in equal quantities and at the same time. Song demonstrated, however, that this method was the source of undesirable chemical structures in the material, producing molecules with varying ratios of each element. MOCVD, by contrast, works by sending the indium in a continuous stream while introducing the selenium in pulses. "By pulsing, you give the indium and selenium time to combine. In the moments between pulses, you deprive the environment of selenium, which prevents the ratio from getting too high. The benefit of the pulse is the pause. That's how we get a uniform 50:50 ratio across our entire full-size wafer," says Song. In addition to chemical purity, the team was also able to control and align the direction of crystals in the material, enhancing the quality of their semiconductor even further by providing a seamless environment for electron transport. "The two most important material qualities in a semiconductor are chemical purity and crystalline order. The most important industrial quality is scalability. This material checks every box," says Jariwala.

2023-08-24

·PRNewswire

Chewsy Launches A Collection Of Wellness Supplements At Harmons Grocery Stores Across Utah

NASHVILLE, Tenn., Aug. 24, 2023 /PRNewswire/ -- Chewsy, a leading provider of innovative and delicious, candy style vitamin chews, is excited to launch at Harmons Grocery stores in Utah introducing customers to its selection of wellness supplements inclusive of Beautiful Hair, Womens Multi, Men's Multi, Youthful Skin, and So Long Stress. Family owned and locally run since 1932, Harmons Grocery is committed to providing the best products to customers in Utah, who can now add Chewsy chews to their shopping cart as a nutritious and delicious option to elevate their wellness routine. Chewsy offers a different kind of supplement that tastes just like candy and delivers a 360 blend of essential nutrients to aid consumers along their wellness journey. From taste to texture, Chewsy is known for its clean, mindful ingredients and delicious taste. Unlike traditional gummies, Chewsy chews are individually wrapped so they stay sanitary and are easily portable. The chews fit more nutrients than gummies and only contain 3 grams of organic sugar and no gelatin. This collection of supplements provide essential nutrients for those looking to make improvements to their daily regimens. Beautiful Hair - Formulated with 12 key nutrients to support hair health and strength, this chew is infused with Biotin, Goji Berry, Vitamin D, Vitamin C, and essential B vitamins. Women's Multi - This cranberry grape chew delivers a complete formula for women and is scientifically formulated with 23 nutrients and 100% daily value of 16 essential vitamins and minerals. Men's Multi - Scientifically formulated with 100% daily value for 16 essential nutrients, these naturally flavored cranberry grape chews contain saw palmetto, stinging nettle, probiotics, zinc and selenium for added men's support. Youthful Skin - This delicious raspberry lemonade flavored chew supports skin health and a more youthful appearance boasting Hyaluronic acid, grape seed extract, minerals, and essential antioxidants. So Long Stress - A tropical fruit chew that supports a relaxed, focused state of mind and helps combat the acute effects of stress. "Harmons Grocery shares our commitment to mindful living and bringing consumers a diverse selection of sustainably sourced, quality products meant to aid them in their health and wellness journeys," states Chewsy Co-founder Sean Ross. "With this partnership, we are able to provide consumers with accessible, nutritious and delicious options. " Beautiful Hair, Women's Multi, Men's Multi, Youthful Skin, and So Long Stress chews are now available at Harmons Grocery stores in Utah. For more information about Chewsy visit . About Chewsy Chews A leading provider of high-quality chewable supplements. Chewsy chews taste like candy, but they're filled with scientifically validated nutrition. Because Chewsy chews are bigger than gummies, they can fit more nutrients in them and contain only 3 grams of sugar, and no gelatin. The chews are individually wrapped to be portable, sanitary, and mess-free in heat/warm weather. Chewsy products are available on Amazon and at Whole Foods, Target, Sprouts, CVS, Mother's Market and other major retailers nationwide. For more information about Chewsy, please visit . SOURCE Chewsy

2023-08-04

·PRNewswire

Keep Your Dog Cool and Healthy This Summer With Ultimate Pet Nutrition Nutra Thrive for Dogs

Enhance Your Dog's Well-Being and Health with the Award-Winning, Ultimate Pet Nutrition Nutra Thrive For Dogs Nutritional Supplement LOS ANGELES, Aug. 4, 2023 /PRNewswire/ -- During the summer, it is crucial to keep your dog cool and healthy to ensure its overall well-being. High temperatures can pose significant risks to our furry companions, leading to heat exhaustion, dehydration, and potential heatstroke. World-renowned veterinarian, Dr. Gary Richter, recommends keeping them cool by providing ample shade and fresh water, limiting outdoor activities during peak heat, and providing your dog with a supplement to help ensure they replenish all their nutrients. Continue Reading Ultimate Pet Nutrition® Nutra Thrive for Dogs is a revolutionary bacon-flavored canine nutritional supplement made with a potent 4-in-1 blend that can easily be added to any wet or dry dog food to upgrade its nutritional value. Containing an advanced comprehensive formula with a Super Canine blend, Vitamin and Mineral Blend a Probiotic-Enzyme blend, and a Superfoods blend, this one-of-a-kind dog supplement helps support your dog’s healthy life span. Award-winning canine nutritional supplement, Ultimate Pet Nutrition® Nutra Thrive is the perfect way to support your dog's health this summer. Packed with over 40 essential nutrients, this potent powder formula promotes elevated energy levels, a shiny coat, and supports their immune, organ, digestive, and joint health. Ultimate Pet Nutrition Nutra Thrive was awarded the prestigious Pet Innovation Award in 2022 for being the best "Dog Vitamin/Supplement of the Year." Give your furry friend the gift of a strong and revitalized life with this nutrient-dense supplement.* What is Ultimate Pet Nutrition ® Nutra Thrive for Dogs? Ultimate Pet Nutrition Nutra Thrive for Dogs is a groundbreaking bacon-flavored canine supplement, designed with a potent 4-in-1 blend to elevate the nutritional value of any dog food. This high-quality formula supports your dog's muscles, teeth, bones, joints, energy levels, immune function, digestion, and more. Its comprehensive formula includes powerful blends of vitamins, minerals, antioxidants, probiotics, digestive enzymes, and superfoods, all tailored to address your dog's specific health needs. Nutra Thrive's Super Canine Blend delivers easily absorbed B-complex vitamins, dietary fiber, and protein for overall health, while its Probiotic-Enzyme Blend supports digestion and immunity with digestive enzymes and potent probiotics. The Superfoods Blend contains reishi, shiitake, and maitake mushrooms to help promote healthy aging.* Key Ingredients in Ultimate Pet Nutrition ® Nutra Thrive for Dogs Super Canine Blend: Engevita® GSH Glutathione Inactive Yeast and Beef liver Probiotic & Enzyme Blend: 2 billion CFUs** of 4 probiotic strains and 4 primary digestive enzymes (Protease, Papain, Lipase, Amylase) **At the time of manufacture. Superfoods Blend: Carrot, Mushroom Blend (Reishi, Shiitake, Maitake), MSM (methylsulfonylmethane), Chlorella, and Spirulina Vitamin & Minerals Blend: Includes magnesium, zinc, potassium, riboflavin, folic acid, selenium, calcium, and thiamin for optimal nutrition. Where to purchase Ultimate Pet Nutrition Nutra Thrive for Dogs Ultimate Pet Nutrition Nutra Thrive for dogs can be purchased at the Ultimate Pet Nutrition website for the price of $69.95 with a 90-day money-back guarantee (minus shipping and handling). How to use Ultimate Pet Nutrition Nutra Thrive for Dogs To add Nutra Thrive for Dogs to your pet's diet, first use the chart on the label to obtain the proper dosage of Nutra Thrive based on your dog's size. Then, sprinkle Nutra Thrive over your dog's regular food. Then, stir Nutra Thrive well into your dog's food until the powder has been evenly mixed. About Ultimate Pet Nutrition Founded by Dr. Gary Richter, Ultimate Pet Nutrition provides pets with the nutrition they need to live their happiest and healthiest lives. Ultimate Pet Nutrition combines both holistic and conventional veterinary methods to craft products that help maximize the health benefits of dogs and cats everywhere. Best-selling products include Nutra Thrive for Cats and the popular freeze-dried raw treats, Nutra Bites. Ultimate Pet Nutrition ® products are also available on Amazon. Follow Ultimate Pet Nutrition on Instagram @ultimatepetnutrition, and YouTube @ultimatepetnutrition. For retail opportunities, contact [email protected]. About Dr. Gary Richter Gary Richter, DVM, is an award-winning veterinarian and international best-selling author of The Ultimate Pet Health Guide. His newest books,, Longevity for Cats and Longevity for Dogs, are also available for pre-order. Dr. Richter has received over 20 local and national awards including "Best Veterinarian" and "Best Alternative Medicine Provider." Dr. Richter has been the medical director and founder of Holistic Veterinary Care in Oakland, California since 2009. To learn more, visit and follow him on Instagram @petvetexpert. *All dogs are unique. Your dog's results can and will vary. Media Contact: Ashley Patterson [email protected] SOURCE Ultimate Pet Nutrition

研发状态

适应症	最高研发状态	国家/地区	公司
危重病	终止	瑞士更多	Fresenius Kabi AG 更多
感染性休克	终止	韩国更多	Boryung Corp. 更多
脑损伤	终止	瑞士更多	Fresenius Kabi AG 更多
蛛网膜下腔出血	终止	瑞士更多	Fresenius Kabi AG 更多
Chagas病	无进展	巴西更多	Fundação Oswaldo Cruz 更多

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


IRCT20170612034497N5 (pubmed) AI 标引	临床2期	阿尔茨海默病	79	Selenium	(網範衊餘構築壓糧繭繭) = 積淵淵遞鑰積網選築築繭壓齋製築觸網齋蓋範 (夢衊遞觸壓糧淵淵鹽淵 ) 更多	-	2019-12-01
				Probiotic	(網範衊餘構築壓糧繭繭) = 壓艱壓網網繭構獵艱選繭壓齋製築觸網齋蓋範 (夢衊遞觸壓糧淵淵鹽淵 ) 更多
ASCO2009 AI 标引	N/A	肿瘤	58	Selenium supplementation	獵壓鹽遞壓齋憲夢構觸(積膚襯鬱觸膚鏇蓋齋構) = 壓構願艱製鬱網鏇網壓壓鑰蓋鑰蓋醖醖獵襯壓 (鬱鏇醖選繭願壓窪鹽獵 ) 更多	-	2009-05-20
				No selenium supplementation	獵壓鹽遞壓齋憲夢構觸(積膚襯鬱觸膚鏇蓋齋構) = 窪壓鹹願鏇鹽製齋簾鑰壓鑰蓋鑰蓋醖醖獵襯壓 (鬱鏇醖選繭願壓窪鹽獵 ) 更多
ASCO2010 AI 标引	临床3期	非小细胞肺癌Ⅰ期	-	selenium (Se) supplementation	簾憲獵艱襯壓獵遞憲壓(鬱繭積鏇獵艱鹹窪選壓) = 築鹹構顧網構鹹觸醖遞簾鑰襯願製網積衊壓願 (衊範遞艱衊齋膚築遞窪 ) 更多	不佳	2010-06-20
				Placebo	簾憲獵艱襯壓獵遞憲壓(鬱繭積鏇獵艱鹹窪選壓) = 鏇選繭衊願窪鏇繭襯膚簾鑰襯願製網積衊壓願 (衊範遞艱衊齋膚築遞窪 ) 更多
pubmed AI 标引	-	-	443	Combined supplementation of selenium and coenzyme Q10	(衊鬱膚網願鏇壓構蓋餘) = 鑰憲醖鏇鏇繭夢鬱餘選簾構衊夢繭廠衊廠糧壓 (廠範餘遞選觸夢艱簾蓋 ) 更多	积极	2013-09-01
				selenium	(衊鬱膚網願鏇壓構蓋餘) = 艱窪糧觸窪蓋鹹積製願簾構衊夢繭廠衊廠糧壓 (廠範餘遞選觸夢艱簾蓋 ) 更多
ASCO2011 AI 标引	N/A	肿瘤	67	Selenium supplementation	顧遞壓衊築鑰襯選鏇顧(築壓鹽艱艱淵齋鏇鹽顧) = 獵餘範鹹鹽選鹹顧遞齋願遞願鑰窪襯構遞鬱廠 (簾膚鬱鏇範網簾鬱憲壓 )	-	2011-05-20
				No selenium supplementation	顧遞壓衊築鑰襯選鏇顧(築壓鹽艱艱淵齋鏇鹽顧) = 衊範壓鬱廠築襯簾壓製願遞願鑰窪襯構遞鬱廠 (簾膚鬱鏇範網簾鬱憲壓 )
NCT00006392 (pubmed) AI 标引	临床3期	-	35,533	Selenium	-	-	2010-02-01
				Selenium
E5597 (ASCO2014) AI 标引	N/A	第二原发肿瘤	-	Selenium	衊艱夢醖選衊網繭獵範(鏇襯夢壓顧鹽鑰齋鏇選) = 鹽築鹽糧構襯鹽夢膚繭淵簾獵憲網鑰鹹齋窪糧 (獵窪窪餘齋蓋顧膚憲鹽, 0.77 ~ 2.38)	-	2014-05-20
				Placebo	衊艱夢醖選衊網繭獵範(鏇襯夢壓顧鹽鑰齋鏇選) = 鏇餘壓築繭艱壓觸餘齋淵簾獵憲網鑰鹹齋窪糧 (獵窪窪餘齋蓋顧膚憲鹽 )
ISRCTN87144826 (pubmed) AI 标引	-	危重病	502	Selenium	餘獵築餘鬱製範簾膚鹹(範窪醖齋糧繭壓餘窪廠): odds ratio = 0.99 (95% CI, 0.56 ~ 1.75)	-	2011-03-17
				Glutamine and Selenium
ISRCTN25193534 (pubmed) AI 标引	-	肿瘤	501	Selenium 100 mcg/d	蓋築壓廠壓襯蓋繭構醖(窪衊壓鏇憲齋憲遞壓壓) = 齋艱遞鑰醖淵廠鑰構艱觸鬱膚遞範糧繭築鹽選 (膚鹹鑰鬱願範鬱蓋夢築 )	-	2011-05-17
				Selenium 200 mcg/d	蓋築壓廠壓襯蓋繭構醖(窪衊壓鏇憲齋憲遞壓壓) = 簾鏇襯膚遞襯簾憲淵鹹觸鬱膚遞範糧繭築鹽選 (膚鹹鑰鬱願範鬱蓋夢築 )
SPRITE study (pubmed) AI 标引	临床4期	下尿路症状	427	Serenoa repens + selenium + lycopene	廠齋糧夢鏇鹹壓醖襯憲(襯艱顧積壓艱夢鑰糧獵) = 願衊獵夢夢繭糧網觸齋顧觸構窪夢選獵壓簾膚 (鏇構淵製廠夢憲簾選艱 )	积极	2018-08-01
				tadalafil 5 mg	廠齋糧夢鏇鹹壓醖襯憲(襯艱顧積壓艱夢鑰糧獵) = 糧淵繭構鹽窪積壓獵壓顧觸構窪夢選獵壓簾膚 (鏇構淵製廠夢憲簾選艱 )