Selenium(Selenium) - 药物靶点：survivin_在研适应症：肿瘤_专利_临床

概要

基本信息

药物类型

小分子化药

别名

selenium、Selenase

靶点

survivin

作用方式

抑制剂

作用机制

survivin抑制剂(杆状病毒IAP重复包含蛋白-5抑制剂)

治疗领域

肿瘤

在研适应症

肿瘤

非在研适应症

获得性免疫缺陷综合征脑损伤心脏毒性+ [15]

原研机构-

在研机构

Roswell Park Comprehensive Cancer Center

非在研机构

biosyn Corp.

Fundação Oswaldo Cruz

Boryung Corp.

+ [1]

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

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关联

215

项与 Selenium 相关的临床试验

NCT07334197

/ Not yet recruitingN/AIIT

Effect of Melatonin in Peripartum Cardiomyopathy

This randomized, controlled clinical trial investigates the potential cardioprotective effects of melatonin in women diagnosed with peripartum cardiomyopathy (PPCM). The study aims to determine whether melatonin supplementation improves left ventricular (LV) function, promotes reverse remodeling, and reduces systemic inflammation. Participants receive standardized heart failure therapy with or without adjunctive melatonin, and outcomes are assessed using echocardiographic parameters (including LVEF, LV dimensions, and global longitudinal strain) and inflammatory biomarkers (e.g., CRP, IL-6, TNF-α). The study hypothesizes that melatonin's antioxidant and anti-inflammatory properties will enhance cardiac recovery, improve functional capacity, and potentially reduce morbidity in PPCM patients.

开始日期2026-12-20

申办/合作机构

Tanta University

[+1]

TCTR20260327005

/ Not yet recruiting临床2期IIT

The effects selenium supplementation combined with herbal sauna on ankle brachial index and blood lipid profiles among people with dyslipidemia

开始日期2026-05-01

申办/合作机构

Burapha University

IRCT20251109067930N1

/ Suspended临床2/3期IIT

Studying the effect of oral selenium on the size of non-malignant thyroid nodules

开始日期2025-12-21

申办/合作机构-

100 项与 Selenium 相关的临床结果

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100 项与 Selenium 相关的转化医学

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100 项与 Selenium 相关的专利（医药）

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13,066

项与 Selenium 相关的文献（医药）

2026-12-01·MOLECULAR BIOLOGY REPORTS

Selenium alleviates Staphylococcus aureus-induced mastitis by modulating mitochondrial dynamics and inhibiting the ROS/NLRP3/Pyroptosis pathway

Article

作者: Zhang, Junhao ; Hu, Changmin ; Du, Yanting ; Yang, Jinghan ; Hu, Yanjun ; Qi, Xue ; Jiang, Mingxuan

BACKGROUND:

The pathogenesis of bovine mastitis involves inflammation and cell death, with pyroptosis being a key factor in its development. Currently, antibiotics remain the primary therapeutic option for bovine mastitis, however, the increasing prevalence of antibiotic resistance constitutes a major public health threat. Selenium (Se) has been reported to alleviate inflammation primarily through its antioxidant properties, but the mechanism by which Se regulates pyroptosis in bovine mastitis remains unclear.

METHODS AND RESULTS:

In this study, an in vitro mastitis model was established by infecting MAC-T cells with inactivated Staphylococcus aureus (S. aureus) (MOI = 10, 12 h). The results revealed that the mitochondrial membrane potential of the MAC-T cells in the infection group decreased significantly. Moreover, the accumulation of Reactive oxygen species (ROS) was accompanied by the activation of NOD-like receptor family containing pyrin domain 3 (NLRP3), the expression of the pyroptosis-related genes gasdermin D amino terminal fragment (GSDMD-N), and cysteine aspartate specific protease 1 (cleaved-caspase 1). Pretreatment with Se, the NLRP3 inhibitor MCC950 and the antioxidant N-acetylcysteine (NAC) attenuated mitochondrial damage, ROS accumulation, and the inhibition of pyroptosis. An in vivo mastitis model was established in mice fed a high-selenium diet (containing 1.5 mg/kg Se) and intramammarily injected with inactivated S. aureus (1 × 10⁸ CFU/mL). Histological analysis revealed intact alveolar structure and reduced inflammatory cell infiltration in mice fed the high-selenium diet. The expression of the inflammasome NLRP3 downregulated, and the expression of GSDMD-N, a direct executor of pyroptosis, upregulated.

CONCLUSION:

Our in vitro and in vivo results confirmed that Se alleviate mitochondrial damage and pyroptosis by inhibiting the NLRP3 pathway, ultimately alleviating mastitis.

2026-09-01·BIOMATERIALS

Multifunctional selenium nanoplatforms for synergistic ferroptosis inhibition and immune microenvironment remodeling in oral mucositis

Article

作者: Gao, Runwei ; Liang, Junhao ; Li, Pei ; Li, Sisi ; Ouyang, Qin ; Zhou, Wenhu

Oral mucositis (OM) is a common inflammatory disorder characterized by epithelial barrier destruction, uncontrolled inflammation, and impaired mucosal repair. Despite the complex tissue microenvironment in OM, which is driven by interconnected pathological processes, current therapeutic approaches are hindered by their predominant focus on single factors. In this study, we identified ferroptosis as a key driver of OM progression through clinical sample analysis and mechanistic validation, revealing that disrupted selenium metabolism and decreased Glutathione Peroxidase 4 (GPX4) expression promote lipid peroxidation and epithelial cell death. To address this, we developed a poly (5-hydroxytryptamine)-functionalized selenium nanoparticle system (PST-SeNPs) that integrates mucosal adhesion, antioxidation, and immunoregulation capabilities. The PST-SeNPs exhibited strong mucosal adhesion and deep tissue penetration in oral ulcer regions. Mechanistically, the system synchronously inhibited ferroptosis by restoring GPX4 activity, alleviating oxidative stress, and modulating macrophage polarization toward an anti-inflammatory phenotype, thereby reconstructing the epithelial and immune microenvironments. In vitro and in vivo studies demonstrated that PST-SeNPs effectively reversed the pathological cycle of "oxidative stress-ferroptosis-inflammation," accelerated mucosal healing, and significantly improved therapeutic outcomes compared to conventional selenium formulations. This work establishes the pivotal role of selenium metabolism imbalance and ferroptosis in OM progression and proposes an integrated nanoplatform that synergistically targets epithelial and immune microenvironments.

2026-07-01·MARINE POLLUTION BULLETIN

Elemental analysis of wild Japanese cormorants captured for Ukai fishing in Ishihama coast, Hitachi City, Japan

Article

作者: Nakamoto, Tabito ; Kawase, Keisuke ; Sakagami, Nobuo ; Kohari, Daisuke ; Tanaka, Ayane ; Masato, Haruhisa ; Namae, Nobutaka

Japanese cormorants (Phalacrocorax capillatus) used for traditional Ukai fishing are captured exclusively from the Ishihama coast in Hitachi City, Japan. Despite the long cultural history of this practice, information on trace element exposure in these birds remains limited. This study analyzed the elemental composition of feathers to assess environmental exposure and potential health risks in cormorants used for Ukai fishing. Feather samples were collected from wild cormorants captured in spring and autumn, as well as from captive individuals. Concentrations of ten elements (Al, Cr, Mn, Cu, Zn, As, Se, Cd, Hg, and Pb) were determined using inductively coupled plasma mass spectrometry (ICP-MS). Captive cormorants showed significantly higher concentrations of several elements, including Cr, Cu, Zn, Se, Hg, and Pb, than wild individuals. Among wild birds, those captured in spring generally exhibited higher elemental concentrations than those captured in autumn. Mercury levels in wild cormorants remained below thresholds associated with adverse biological effects, whereas individuals from one captive facility exceeded this level. However, Se:Hg molar ratios were greater than 1 in all groups, suggesting a potential protective role of selenium against mercury toxicity. These results provide the first baseline data on trace element exposure in Japanese cormorants captured for Ukai fishing. The findings indicate that wild-caught birds are generally within safe exposure levels, while highlighting the need for continued monitoring of captive individuals to ensure their long-term health and welfare.

25

项与 Selenium 相关的新闻（医药）

2026-05-05

·PRNewswire

Support Egg Quality and Ovulation with Nature's Bounty® New Fertility Supplement*

Nature's Bounty® Fertility Support Supplement Brings Together Clinically Studied Nutrients in a Carefully Curated Formula for this Important Life Stage BRIDGEWATER, N.J., May 5, 2026 /PRNewswire/ -- Nature's Bounty®, a leader in scientifically backed vitamin and nutritional supplements, today announced its thoughtfully curated Fertility Support supplement that features NAC (N-Acetyl Cysteine), selenium and vitamin E. These clinically studied nutrients are shown to support egg quality, ovulation, fertilization and implantation during a woman's reproductive health journey.* Nature's Bounty Fertility Support is available now on Amazon.com. Continue Reading Nature's Bounty Fertility Support supplement features NAC (N-Acetyl Cysteine), selenium and vitamin E. These clinically studied nutrients are shown to support egg quality, ovulation, fertilization and implantation during a woman’s reproductive health journey.* "The journey to parenthood can be deeply personal and biologically complex, and many women are seeking trusted, science-backed ways to nourish their bodies during this life stage," said Abby Klosterbuer, Director of Medical Affairs, Nature's Bounty®. "Throughout the product development process, we evaluated the latest nutrition research to create a formula that is grounded in science. For instance, we included NAC because it's a building block for the body's primary antioxidant, glutathione, helping support oxidative balance important for healthy ovarian and uterine function. We designed the new Fertility Support supplement to be evidence-based and accessible, so more women can confidently add fertility nutrition into their daily routines as they plan for parenthood." Nature's Bounty Fertility Support capsules include: NAC (N-Acetyl Cysteine), a powerful antioxidant clinically shown to support ovulation and a healthy uterine lining that are foundational for healthy fertilization and implantation.* CoQ10, an antioxidant naturally found in every cell, including eggs, that plays an important role in cellular energy for egg quality.* Selenium and vitamin E, vital nutrients clinically shown to support healthy follicles, which promotes ovulation and helps support the growth and maturation of eggs.* Vitamin D, an essential vitamin necessary for several aspects of overall reproductive health and function.* To learn more about Nature's Bounty, please visit . About Nature's Bounty® For more than 50 years, the Nature's Bounty® brand has been focused on enhancing the health and wellness of peoples' lives. Nature's Bounty® vitamin and nutritional supplements are overseen by scientists, manufacturing specialists and quality experts, each one dedicated to maintaining high quality standards. We only use ingredients from suppliers that meet our stringent Quality Assurance Standards, as well as GMP supplement quality standards. By combining the latest breakthroughs in nutritional science with great ingredients, we're proud to provide consumers with supplements of outstanding quality and value. For more information, please visit and follow us on Facebook and Instagram. Fertility Support includes ingredients that support ovulation, fertilization and implantation which are all processes involved in conception. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Media Contact Andrea Martin [email protected] SOURCE Nature's Bounty 21% more press release views with Request a Demo

2026-03-31

·PRNewswire

Axiota Animal Health Names Wamego, Kansas, as Global Headquarters

Move strengthens the KC Animal Health Corridor as a hub for animal health excellence WAMEGO, Kan., March 31, 2026 /PRNewswire/ -- Axiota Animal Health, global leader in cattle health solutions, announced today it will name its facility in Wamego, Kansas, as the company's global headquarters. The announcement formalizes the longstanding presence of Axiota Animal Health in Wamego, where the company operates manufacturing, research and development, and scientific operations for its products used by cattle producers in more than 30 countries worldwide. "Wamego has long been a cornerstone of Axiota's manufacturing and research, so designating it as our global headquarters is a natural next step," said William (Bill) Weldon, CEO, Axiota Animal Health. "From here, we're developing and producing technologies that help cattle producers around the world improve herd health and productivity. Leveraging our location within the KC Animal Health Corridor and our longstanding relationship with Kansas State University allows us to drive innovation and attract the top talent the industry demands." Located near Kansas State University, the facility benefits from proximity to one of the nation's leading veterinary and animal health research institutions. That connection helps Axiota attract specialized scientific talent and collaborate with researchers advancing the future of livestock health. From its Wamego facility, Axiota supports cattle producers worldwide in improving herd health and performance through prevention-based, non-antibiotic solutions. This includes: Lactipro®, the only rumen-native probiotic that delivers Mega e®, proven to promote rumen health and performance. Multimin® 90 (zinc, copper, manganese and selenium injection) is the only FDA-approved injectable supplement that delivers four trace minerals known to support cattle health and reproduction. The decision highlights the global impact of the KC Animal Health Corridor, a hub stretching from Manhattan, Kansas, to Columbia, Missouri, with Kansas City at its heart. The region, home to the world's largest concentration of animal health assets, serves as a leading center for life science research, development and collaboration. "Axiota's decision to locate its global headquarters in Wamego reflects the industry leadership that continues to define the Corridor," said Kimberly Young, president of the KC Animal Health Corridor. "Companies here aren't just participating in the industry — they're driving the science, technology and production that support animal health and food security around the world." About Axiota Animal Health Axiota Animal Health is an innovation-driven company that discovers, develops and markets products for beef and dairy producers around the world. Axiota's non-antibiotic solutions prepare cattle to thrive during transition and stress and support producers' goals of optimal health, performance and animal well-being. | axiota.com About KC Animal Health Corridor Representing more than half of the global animal health industry's sales, and home to over 300 animal health companies, the KC Animal Health Corridor is the largest concentration of its kind worldwide. An initiative of the Kansas City Area Development Council, the Corridor is anchored by Manhattan, Kansas, and Columbia, Missouri, and serves as a thriving hub for innovation and collaboration. | kcanimalhealth.com SOURCE Axiota® Animal Health 21% more press release views with Request a Demo

2026-03-29

·drugs

Study Links High Antioxidant Intake To Changes in Offspring Development

SUNDAY, March 29, 2026 — Antioxidants are often seen as a good, simple way to boost health, but taking too many may come with some risks, new research suggests. A study from Texas A&M University found that high doses of certain antioxidants may affect sperm and lead to developmental changes in offspring. The research, published recently in the journal Frontiers in Cell and Developmental Biology , focused on two antioxidants: N-acetyl-L-cysteine (NAC) and selenium. Male mice given these supplements for six weeks went on to have offspring with noticeable changes in skull and facial structure. The fathers themselves appeared healthy, researchers said. The study suggests that too many antioxidants may alter sperm DNA, which could affect how offspring develop. "We know alcohol causes oxidative stress and we were looking to push back on it by adding a supplement known to lower oxidative stress," said lead researcher Dr. Michael Golding , a professor in the Department of Veterinary Physiology & Pharmacology at Texas A&M University. "When we realized that offspring born to males that had only been given NAC were displaying skull and facial differences, it was a surprise because this molecule is universally thought to be good," he added in a news release. While the results of research in animals are not always the same in people, the findings raise concerns for men who regularly take high-dose supplements, especially for those planning to have kids. Antioxidants like NAC are widely used and are often included in multivitamins. But more is not always better, experts said. "When we sat down to think it through, we realized that it makes sense — you take a multivitamin to ensure that you're in balance, but if the thing that you're taking to ensure you're in balance is unbalanced (the dose of antioxidants is too high), then you're not doing a good thing," Golding said. Previous research has also found that very high antioxidant intake can reduce the benefits of exercise and affect athletic performance. "Sperm health is another performance metric; it’s just not one that we think about in everyday life," Golding added. Researchers also noticed stronger physical changes in female offspring, including smaller skulls and closer-set eyes. These traits are oftentimes linked to conditions like fetal alcohol syndrome, the researchers said. "There's a very commonly accepted truism in pediatric medicine that the face mirrors the brain, because the brain and the face form at the same time," Golding said. "So, if you see abnormalities in the midline of the face, you're probably going to see midline abnormalities in the brain," he added. Researchers said it’s still unclear whether these changes affect brain function. The findings show that even supplements that are considered healthy can cause harm if taken in such large amounts. And many supplements contain these very high doses. "If your vitamins are providing 1,000% of the recommended daily amount, you should be cautious," he said. "If you stick to the 100% range, then you should be OK." Sources Texas A&M University, news release, March 27, 2026

100 项与 Selenium 相关的药物交易

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研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
获得性免疫缺陷综合征	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
心脏毒性	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
Chagas病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
慢性病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
终末器官损害	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
功能障碍	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
亨廷顿舞蹈病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
梗塞	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
克山病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
心肌梗塞	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT01611896 (GRASS, Pubmed \| Eur Thyroid J)	N/A	格雷夫斯病	430	Selenium supplementation	構簾鹹簾鏇餘觸蓋憲築(壓夢鏇膚壓構廠餘淵餘) = 網製範遞簾網齋窪製網襯壓鏇醖糧窪鏇繭簾積 (蓋簾鹹衊憲製艱膚顧鹹 )	不佳	2025-12-12
				Placebo	構簾鹹簾鏇餘觸蓋憲築(壓夢鏇膚壓構廠餘淵餘) = 鑰願憲窪構膚鏇夢願窪襯壓鏇醖糧窪鏇繭簾積 (蓋簾鹹衊憲製艱膚顧鹹 )
AACR2018	临床1期	女性生殖器官肿瘤	-	Selenious acid/carboplatin/paclitaxel	網願遞觸簾夢糧鹹襯壓(淵憲鬱餘願艱製廠簾遞) = 襯願蓋製築範鏇製蓋築夢繭鬱鏇築齋鬱壓鏇糧 (鑰醖鏇網構膚衊顧憲選 ) 更多	-	2018-07-01
ASCO2014	N/A	第二原发肿瘤	-	Selenium	築鹽醖蓋憲壓膚糧鬱願(艱夢鑰壓選範衊鬱鑰餘) = 鏇衊鬱蓋壓鬱鬱遞製壓壓鹹夢簾醖餘夢顧夢淵 (鏇顧廠餘衊窪築鏇糧艱, 0.77 ~ 2.38)	-	2014-05-20
				Placebo	築鹽醖蓋憲壓膚糧鬱願(艱夢鑰壓選範衊鬱鑰餘) = 壓壓餘齋鏇鏇獵積選鬱壓鹹夢簾醖餘夢顧夢淵 (鏇顧廠餘衊窪築鏇糧艱 )
Pubmed \| Cochrane Database Syst Rev	N/A	桥本病	463	Selenium supplementation	齋製獵願積鏇膚願鬱範(壓襯顧觸襯鏇膚網壓製): RR = 4.67 (95% CI, 1.61 ~ 13.5), P-Value = 0.004	-	2013-06-06
				Selenium
ASCO 12010 \| ASCO 22010	临床3期	非小细胞肺癌Ⅰ期	-	selenium (Se) supplementation (Selenized yeast 200 micrograms)	鏇窪夢餘範選築衊範築(襯壓顧淵膚廠齋範醖遞) = 衊製積願網範繭築蓋製鑰齋膚遞膚糧構壓觸衊 (艱觸蓋壓廠憲壓淵繭觸 ) 更多	不佳	2010-06-20
				Placebo	鏇窪夢餘範選築衊範築(襯壓顧淵膚廠齋範醖遞) = 鹽餘鑰衊淵築遞衊窪壓鑰齋膚遞膚糧構壓觸衊 (艱觸蓋壓廠憲壓淵繭觸 ) 更多
German Working Group on Trace Elements and Electrolytes (ASTRO2009)	临床2期	头颈部肿瘤 selenium deficiency	40	Selenium supplementation	鹹艱襯簾窪鬱衊壓觸製(鏇膚衊餘獵夢簾窪壓簾) = 範蓋簾範夢齋艱鬱膚製淵遞衊醖遞壓獵製製鑰 (簾餘襯鏇鬱築憲蓋淵鹹 ) 更多	不佳	2009-11-01
				Control group (no selenium supplementation)	鹹艱襯簾窪鬱衊壓觸製(鏇膚衊餘獵夢簾窪壓簾) = 蓋願構願積鹽鹽鹹範糧淵遞衊醖遞壓獵製製鑰 (簾餘襯鏇鬱築憲蓋淵鹹 ) 更多
ASCO2009	临床2期	头颈部肿瘤	39	selenium (Group A)	廠鑰積窪淵構壓鏇製窪(艱簾選遞壓顧糧簾構餘) = 繭壓憲網夢鏇艱窪顧鹽齋簾齋築構艱鑰憲蓋鑰 (獵窪積範願衊襯夢糧醖 ) 更多	不佳	2009-05-20
				selenium (Group B)	廠鑰積窪淵構壓鏇製窪(艱簾選遞壓顧糧簾構餘) = 齋獵憲繭膚網獵鑰簾鬱齋簾齋築構艱鑰憲蓋鑰 (獵窪積範願衊襯夢糧醖 ) 更多
ASCO2008	临床2期	前列腺癌	140	Placebo	製窪選憲繭齋膚簾壓選(選餘窪鬱襯襯膚衊觸鹽) = 衊選鹽鬱鹽襯顧糧獵夢積鏇襯積衊夢鑰範獵積 (衊繭艱蓋艱製餘齋淵艱 )	不佳	2008-05-20
				200µg/day Selenium	製窪選憲繭齋膚簾壓選(選餘窪鬱襯襯膚衊觸鹽) = 衊繭蓋餘艱醖蓋蓋構製積鏇襯積衊夢鑰範獵積 (衊繭艱蓋艱製餘齋淵艱 )