Selenium(Selenium) - 药物靶点：survivin_在研适应症：肿瘤_专利_临床

概要

基本信息

药物类型

小分子化药

别名

selenium、Selenase

靶点

survivin

作用方式

抑制剂

作用机制

survivin抑制剂(杆状病毒IAP重复包含蛋白-5抑制剂)

治疗领域

肿瘤

在研适应症

肿瘤

非在研适应症

获得性免疫缺陷综合征脑损伤心脏毒性+ [15]

原研机构-

在研机构

Roswell Park Comprehensive Cancer Center

非在研机构

biosyn Corp.

Fundação Oswaldo Cruz

Boryung Corp.

+ [1]

权益机构-

最高研发阶段临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

关联

195

项与 Selenium 相关的临床试验

TCTR20251027010

/ Not yet recruiting早期临床1期IIT

Effectiveness of integration between Thai traditional herbal sauna and selenium supplement on the bone mineral density and ankle brachial index

开始日期2025-11-03

申办/合作机构

Burapha University

ChiCTR2500110303

/ Not yet recruitingN/AIIT

Clinical efficacy and mechanism study of nano-selenium capsules in patients with thyroiditis triggered by thyroid nodule ablation

开始日期2025-11-01

申办/合作机构

吉林大学中日联谊医院

IRCT20250409065265N1

/ Recruiting临床3期IIT

Investigation of the therapeutic effect of vitamin D with selenium on antioxidant indices and hormonal changes and anti-thyroperoxidase antibody in patients with subclinical Hashimoto's thyroiditis and vitamin-D deficiency

开始日期2025-09-21

申办/合作机构

Isfahan University of Medical Sciences

100 项与 Selenium 相关的临床结果

登录后查看更多信息

100 项与 Selenium 相关的转化医学

登录后查看更多信息

100 项与 Selenium 相关的专利（医药）

登录后查看更多信息

13,484

项与 Selenium 相关的文献（医药）

2026-12-01·MOLECULAR BIOLOGY REPORTS

Selenium alleviates Staphylococcus aureus-induced mastitis by modulating mitochondrial dynamics and inhibiting the ROS/NLRP3/Pyroptosis pathway

Article

作者: Zhang, Junhao ; Hu, Changmin ; Du, Yanting ; Yang, Jinghan ; Hu, Yanjun ; Qi, Xue ; Jiang, Mingxuan

BACKGROUND:

The pathogenesis of bovine mastitis involves inflammation and cell death, with pyroptosis being a key factor in its development. Currently, antibiotics remain the primary therapeutic option for bovine mastitis, however, the increasing prevalence of antibiotic resistance constitutes a major public health threat. Selenium (Se) has been reported to alleviate inflammation primarily through its antioxidant properties, but the mechanism by which Se regulates pyroptosis in bovine mastitis remains unclear.

METHODS AND RESULTS:

In this study, an in vitro mastitis model was established by infecting MAC-T cells with inactivated Staphylococcus aureus (S. aureus) (MOI = 10, 12 h). The results revealed that the mitochondrial membrane potential of the MAC-T cells in the infection group decreased significantly. Moreover, the accumulation of Reactive oxygen species (ROS) was accompanied by the activation of NOD-like receptor family containing pyrin domain 3 (NLRP3), the expression of the pyroptosis-related genes gasdermin D amino terminal fragment (GSDMD-N), and cysteine aspartate specific protease 1 (cleaved-caspase 1). Pretreatment with Se, the NLRP3 inhibitor MCC950 and the antioxidant N-acetylcysteine (NAC) attenuated mitochondrial damage, ROS accumulation, and the inhibition of pyroptosis. An in vivo mastitis model was established in mice fed a high-selenium diet (containing 1.5 mg/kg Se) and intramammarily injected with inactivated S. aureus (1 × 10⁸ CFU/mL). Histological analysis revealed intact alveolar structure and reduced inflammatory cell infiltration in mice fed the high-selenium diet. The expression of the inflammasome NLRP3 downregulated, and the expression of GSDMD-N, a direct executor of pyroptosis, upregulated.

CONCLUSION:

Our in vitro and in vivo results confirmed that Se alleviate mitochondrial damage and pyroptosis by inhibiting the NLRP3 pathway, ultimately alleviating mastitis.

2026-03-01·FOOD MICROBIOLOGY

Enhancing functional metabolites and flavor volatiles of kiwifruit juice fermented with selenium-enriched Limosilactobacillus fermentum Ln-9

作者: Hu, Zeyu ; Wang, Zhouli ; Yue, Tianli ; Wang, Xueer ; Cai, Rui ; Liu, Ling ; Duan, Bowen ; Tan, Weiteng ; Li, Shiqi ; Yuan, Yahong

The application of selenium-enriched lactic acid bacteria (LAB) offers a promising strategy to enhance the nutritional and functional properties of perishable fruits like kiwifruit. This study explored the fermentation of kiwifruit juice using selenium-enriched Limosilactobacillus fermentum Ln-9 (SeLn-9), a mutant strain derived from L. fermentum CICC 21828 (21828), to improve functional metabolites, flavor profiles, and selenium content. The performance was compared with non-selenium strains (Ln-9 and 21828). Results revealed that SeLn-9 outperformed both control strains, achieving higher viable cell counts (>10⁹ CFU/mL) and total phenolic content. Notably, SeLn-9 uniquely synthesized phlorizin and retained significantly elevated vitamin C levels while introducing bioavailable selenium (180 μg/L), meeting daily dietary requirements. Enhanced production of organic acids (lactic acid and acetic acid) and a diverse volatile profile (47 novel aroma compounds) underscored the metabolic advantages of SeLn-9, enriching fruity, floral, and herbal notes. Antioxidant activities of fermented kiwifruit juice correlated strongly with phenolic metabolites and organic acids, maintaining great free radical scavenging capacities. The sensory evaluation demonstrated that SeLn-9-fermented juice exhibited balanced sourness and superior aromatic complexity. These findings emphasize the critical role of selenium enrichment in LAB fermentation, positioning SeLn-9 as a great strain for developing functional kiwifruit beverages with enhanced nutritional value, sensory appeal, and industrial viability.

2026-02-01·Mycotoxin Research

Protective effect of organic selenium and organic chromium dietary supplementation against aflatoxicosis in mice

Article

作者: Shafaei, Negin ; Abdollahzadeh, Roya ; Esmaeili, Fahime ; Mohamadi, Faezeh ; Oskoueian, Faezeh ; Fazeli, Elham ; Oskoueian, Ehsan ; Aminaltojjari, Fatemeh ; Karimi, Ehsan ; Mozafar, Faride Khoshsokhan

Aflatoxins are highly toxic mycotoxins linked to serious health issues, including hepatotoxicity, immunosuppression, and oxidative stress. This study investigated the protective effects of chromium-methionine (Cr-Met) and selenium-methionine (Se-Met) supplementation, both alone and in combination, against aflatoxin-induced toxicity in mice. Five dietary treatments were implemented: a control diet (T1), an aflatoxin-contaminated diet containing 2 mg of aflatoxins per kg of diet (T2), and aflatoxin-contaminated diets supplemented with 0.5 mg of Cr-Met per kg (T3), 0.5 mg of Se-Met per kg (T4), or a combination of both (T5). Exposure to aflatoxins significantly (p < 0.05) impaired growth performance, disrupted liver enzyme profiles, suppressed immune function, and compromised antioxidant defense mechanisms. In contrast, dietary supplementation with T3 and T4 markedly (p < 0.05) enhanced growth performance, increased feed intake, and elevated immunoglobulin levels while reducing oxidative stress markers and liver damage. Gene expression analysis indicated that aflatoxin exposure led to the upregulation of inducible nitric oxide synthase (iNOS) and the downregulation of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx); supplementation effectively reversed these alterations. Notably, the combined supplementation (T5) demonstrated the most significant protective effects, suggesting the role of chromium and selenium in alleviating aflatoxin-induced toxicity (p < 0.05). These findings underscore the potential of using Cr-Met and Se-Met in combination as effective dietary strategies to mitigate aflatoxin toxicity and enhance antioxidant and immune responses.

21

项与 Selenium 相关的新闻（医药）

2025-10-27

·EINPresswire

64K Cellssense Featured in Frontiers in Aging for Pioneering Review on Nanoengineered Mitochondria

Company outlines how nanoengineering approaches may advance studies of mitochondrial function and cellular health. This publication in Frontiers in Aging represents a synthesis of emerging data on mitochondrial nanoengineering, reflecting our commitment to peer-reviewed science and measurable longevity research.” — Thomas Miller, Head of the 64K Cellssense International Research Center LAUSANNE, SWITZERLAND, October 27, 2025 / EINPresswire.com / -- 64K Cellssense announced its Research and Innovation Center published a review article in Frontiers in Aging , a leading Swiss academic journal. The article, titled “Nanoengineered Mitochondria for Mitochondrial Dysfunction and Anti-Aging Interventions,” explores the emerging field of mitochondrial nanoengineering and its implications for maintaining cellular function and energy balance. The review provides a comprehensive overview of recent advances in nanoengineered mitochondria — a rapidly growing focus in life sciences. It details how nanoscale design can support mitochondrial integrity, optimize metabolic efficiency, and enhance resilience under cellular stress. The review offers an international perspective on how nanotechnology is shaping next-generation mitochondrial research, reflecting 64K Cellssense’s contribution to the global dialogue on healthy cellular aging. Within 64K Cellssense’s 12-Dimensional Longevity Framework, mitochondrial performance is studied as a core determinant of cellular function. The review proposes a research framework that integrates nanoengineering strategies to optimize mitochondrial energy systems and mitigate oxidative imbalance at the cellular level. The article also summarizes key natural mitochondrial regulators — including α-ketoglutarate (AKG), ergothioneine (EGT), resveratrol, CoQ10, and selenium — and highlights how nano-delivery approaches may improve their stability and targeted bioavailability in experimental models. Building on these foundational insights, 64K Cellssense continues to develop its proprietary MPNutria ® Nano-Nutrition Delivery Technology, based on metal–phenolic network (MPN) nanostructures — a technology lineage related to the 2025 Nobel Prize -winning research on metal-organic frameworks (MOFs). This technology exemplifies how the brand translates cutting-edge scientific concepts into scalable, experimentally validated applications. While mitochondrial nanoengineering shows considerable potential, the review notes that further research is required to address challenges related to delivery consistency, biological compatibility, and scalable production. The Research and Innovation Center of 64K Cellssense has collaborated on projects with academic and clinical partners in Switzerland, the United States, Australia and China, including, among others, ETH Zurich, Harvard University and Clinique Eden Suisse. Collectively, these efforts reinforce 64K Cellssense’s long-term mission to drive data-driven innovation in cellular health, bridging academic research and practical, scalable applications in life sciences. Anastasia Y. Vitagenix Technology Limited email us here Legal Disclaimer: EIN Presswire provides this news content "as is" without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the author above.

2025-03-14

·drugs

Metal Mixtures During Pregnancy May Lower Midlife Hypertension Risk

FRIDAY, March 14, 2025 -- Optimizing copper, manganese, and vitamin B12 during pregnancy can help lower the risk for high blood pressure and hypertension in midlife, according to a study published online March 6 in Hypertension to coincide with the American Heart Association Epidemiology and Prevention/Lifestyle and Cardiometabolic Health 2025 Scientific Sessions, held from March 6 to 9 in New Orleans. Mingyu Zhang, Ph.D., from Harvard Medical School in Boston, and colleagues measured nonessential and essential metals in red blood cells along with folate and vitamin B12 in plasma during pregnancy (participants enrolled 1999 to 2002) to examine long-term associations with midlife blood pressure and hypertension. Midlife blood pressure was measured from 2017 to 2021. A total of 493 women were followed for a median of 18.1 years. The researchers found that a doubling of copper and manganese was associated with 0.75 and 0.80 times the risk for hypertension, respectively, after adjustment. A slightly increased risk for hypertension was seen in association with higher cesium and selenium, but the 95 percent confidence intervals were wide and crossed the null. A doubling of vitamin B12 was associated with 3.64- and 2.52-mm Hg lower systolic and diastolic blood pressure, respectively. There was a monotonic association for the essential metal mixture with lower blood pressure, while threshold effects were seen for its association with hypertension. "These findings suggest that optimizing essential metal levels during pregnancy, particularly, copper and manganese, along with vitamin B12, may offer protective benefits against high blood pressure and hypertension in midlife," the authors write.

AHA会议临床研究

2025-03-07

·drugs

Select Vitamins, Minerals During Pregnancy Protect Heart Health Later

FRIDAY, March 7, 2025 -- Getting essential vitamins and minerals during pregnancy can help a woman maintain healthy blood pressure into middle age, new research suggests. High levels of the minerals copper and manganese in pregnant women were associated with lower blood pressure decades later, as well as a reduced risk of high blood pressure , researchers reported. Higher levels of vitamin B12 also were associated with lower blood pressure in later life, according to findings published March 6 in the journal Hypertension . “Optimizing these essential metals, minerals and vitamins -- particularly copper, manganese and vitamin B12 -- during pregnancy may offer protective benefits against hypertension in midlife, an especially critical time period for women’s future cardiovascular risk in later life,” lead researcher Mingyu Zhang , an epidemiologist at Beth Israel Deaconess Medical Center in Boston, said in a news release. For the study, his team analyzed data from an ongoing long-term study of nearly 500 pregnant women recruited between 1999 and 2002. The women underwent blood testing during their pregnancy for their levels of healthy essential minerals, such as copper, magnesium, manganese, selenium and zinc, researchers said. They also were tested for levels of folate and vitamin B12. After nearly 20 years of follow up, researchers checked in again with the women, who’d now reached an average age of 51. The women’s blood pressure was tested during this check in, and was considered high if greater than 130/80 or if they’d been prescribed high blood pressure meds. Results showed that if women had doubled levels of copper and manganese in their blood during pregnancy, their risk of midlife high blood pressure was 25% and 20% lower, respectively. Doubled levels of vitamin B12 also contributed to lower blood pressure, but researchers noted that about 95% of participants had B12 levels within the normal range. Copper, manganese, selenium and zinc all lowered blood pressure, and the higher the levels, the more blood pressure benefitted later in life, researchers found. However, the findings should not be interpreted as recommendations, since researchers were unable to tell whether women got these vitamins and minerals from food, dietary supplements or other sources, Zhang said. “More research including clinical trials is needed to determine the optimal dietary intake of these minerals and micronutrients,” Zhang said. Researchers hope to ultimately identify women at high risk for developing high blood pressure later in life and intervene during pregnancy, either with enhanced nutrition or supplements. These results were scheduled for presentation Saturday at an American Heart Association meeting in New Orleans. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

AHA会议临床研究

100 项与 Selenium 相关的药物交易

登录后查看更多信息

研发状态

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
获得性免疫缺陷综合征	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
心脏毒性	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
Chagas病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
慢性病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
终末器官损害	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
功能障碍	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
亨廷顿舞蹈病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
梗塞	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
克山病	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31
心肌梗塞	临床3期	巴西	Fundação Oswaldo Cruz	2008-10-31

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


AACR2018	临床1期	女性生殖器官肿瘤	-	Selenious acid/carboplatin/paclitaxel	製壓廠鹹獵顧觸鏇糧餘(齋襯鑰窪鬱憲餘願獵廠) = 餘膚簾遞廠齋鹽艱鏇構膚廠鹽範選壓選築鹹夢 (鏇製網襯憲鹽餘觸範糧 ) 更多	-	2018-07-01
ASCO2014	N/A	第二原发肿瘤	-	Selenium	蓋艱鑰壓積廠積範壓顧(廠製憲範簾繭鬱蓋糧願) = 網餘淵獵範膚鏇窪憲鹽觸觸構網鏇醖繭餘選範 (糧鏇繭簾醖膚範鏇製獵, 0.77 ~ 2.38)	-	2014-05-20
				Placebo	蓋艱鑰壓積廠積範壓顧(廠製憲範簾繭鬱蓋糧願) = 齋艱觸獵醖憲衊範膚淵觸觸構網鏇醖繭餘選範 (糧鏇繭簾醖膚範鏇製獵 )
Pubmed \| Cochrane Database Syst Rev	N/A	桥本病	463	Selenium supplementation	製壓遞鬱鏇選糧醖夢夢(襯構築簾鑰鑰獵廠願鏇): RR = 4.67 (95% CI, 1.61 ~ 13.5), P-Value = 0.004	-	2013-06-06
				Selenium
ASCO 12010 \| ASCO 22010	临床3期	非小细胞肺癌Ⅰ期	-	selenium (Se) supplementation (Selenized yeast 200 micrograms)	壓壓獵衊鹹範窪遞網獵(積構廠積窪夢觸鑰鏇蓋) = 鬱鏇廠窪鬱艱觸襯鑰鬱願膚鹹鏇夢壓衊繭繭構 (選鏇憲醖願壓範膚夢齋 ) 更多	不佳	2010-06-20
				Placebo	壓壓獵衊鹹範窪遞網獵(積構廠積窪夢觸鑰鏇蓋) = 醖齋膚繭蓋選憲觸選鑰願膚鹹鏇夢壓衊繭繭構 (選鏇憲醖願壓範膚夢齋 ) 更多
German Working Group on Trace Elements and Electrolytes (ASTRO2009)	临床2期	头颈部肿瘤 selenium deficiency	40	Selenium supplementation	鹽簾餘積蓋鬱糧憲構壓(鬱鬱簾衊壓壓膚齋簾蓋) = 鑰製製夢繭艱襯範壓繭選壓蓋積築淵襯廠廠窪 (艱製繭醖鹽淵製簾簾憲 ) 更多	不佳	2009-11-01
				Control group (no selenium supplementation)	鹽簾餘積蓋鬱糧憲構壓(鬱鬱簾衊壓壓膚齋簾蓋) = 鹹顧淵鹹網廠鬱鏇獵構選壓蓋積築淵襯廠廠窪 (艱製繭醖鹽淵製簾簾憲 ) 更多
ASCO2009	临床2期	头颈部肿瘤	39	selenium (Group A)	簾鹹製膚壓顧壓願範選(鹽餘廠築顧選範鑰醖製) = 範餘簾衊鑰範積繭鹹壓積積製範膚艱選壓鑰醖 (窪鹹鬱鬱夢鏇夢鬱繭蓋 ) 更多	不佳	2009-05-20
				selenium (Group B)	簾鹹製膚壓顧壓願範選(鹽餘廠築顧選範鑰醖製) = 廠鏇遞鬱糧選糧餘壓鬱積積製範膚艱選壓鑰醖 (窪鹹鬱鬱夢鏇夢鬱繭蓋 ) 更多
ASCO2008	临床2期	前列腺癌	140	Placebo	襯積餘憲窪襯蓋網艱鏇(築糧願獵願鹹製襯範蓋) = 製築醖憲獵鏇齋遞膚糧艱廠製蓋鹹觸餘觸獵觸 (餘廠艱蓋選膚製簾窪壓 )	不佳	2008-05-20
				200µg/day Selenium	襯積餘憲窪襯蓋網艱鏇(築糧願獵願鹹製襯範蓋) = 蓋簾鹹製衊艱膚蓋繭餘艱廠製蓋鹹觸餘觸獵觸 (餘廠艱蓋選膚製簾窪壓 )