DepYmed to Present Early Data on Its Small Molecule
PTP1B
Inhibitor Program at the 2023 IRSF Rett Syndrome Scientific Meeting

孤儿药
DepYmed to Present Early Data on Its Small Molecule
PTP1B
Inhibitor Program at the 2023 IRSF Rett Syndrome Scientific Meeting
FARMINGDALE, New York, May 31, 2023 (GLOBE NEWSWIRE) -- DepYmed, Inc. (“DepYmed” or the “Company”) is a preclinical stage pharmaceutical company focused on developing transformative treatments for rare diseases and oncology that target the
protein tyrosine phosphatase (PTP)
family of enzymes. Today DepYmed announces it will be presenting two abstracts on its small molecule PTP1B inhibitor
PTP1B
inhibitor program at the 2023 International Rett Syndrome Foundation (IRSF) Rett Syndrome Scientific Meeting. The conference will be held June 5-7, 2023 at the Nashville Marriott at Vanderbilt University in Nashville, Tenn.
“This is a unique opportunity for us to present our mechanism-based approach to treating
Rett Syndrome
and to report progress on our lead clinical candidate at this important scientific forum. We believe our data continue to validate the potential of our compound for this devastating disease,” said Andreas Grill, DepYmed’s President and CEO. “We look forward to sharing these early data at the conference and with the wider scientific community.”
About IRSF
In 1983, a small, dedicated group of parents whose children had
Rett syndrome
formed the first non-profit to focus exclusively on
Rett syndrome
– the International Rett Syndrome Association (IRSA). In 2007, IRSA and Rett Syndrome Research Foundation (RSRF) consolidated resources to better serve families and maximize research investments toward a cure. The International Rett Syndrome Foundation (IRSF) emerged with a mission to accelerate research and empower families that builds upon these foundations’ pioneering work toward care and cure. empower families with information, knowledge, and connectivity. Today, the International
Rett Syndrome
Foundation continues its almost 40-year commitment to creating a world without Rett. It remains focused on accelerating research to treat and cure
Rett syndrome
as it seeks to empower families with information, knowledge, and connectivity.
About DPM-1003
Protein tyrosine phosphatases are major players in the control of cell signaling pathways that are disrupted in many diseases, yet no drug modulators of these enzymes have been successfully developed to date. DepYmed is the first company to develop a new class of orally bioavailable drug candidates that act by inhibiting
PTP1B
, one of the most important PTP drug targets. One of its lead compounds has shown promising efficacy in preclinical models of
Rett syndrome
, and the Company hopes to initiate a Phase 1 clinical trial in 2024. DPM-1003 has been granted Orphan Drug designation by the U.S. Food and Drug Administration and conditionally designated under the FDA’s Rare Pediatric Disease program.
About
Rett Syndrome
Rett syndrome
is a progressive
neurodevelopmental disorder
that almost exclusively affects females. Infants with
Rett syndrome
generally develop normally for 6 to 18 months after birth. At this point, they lose previously acquired skills (developmental regression) such as purposeful hand movements and the ability to communicate. Affected children often develop
autistic-like behaviors
,
breathing irregularities
,
feeding and swallowing difficulties
,
growth retardation
, and
seizures
. Most
Rett syndrome
cases are caused by mutations of the
MECP2
gene on the X chromosome and can present with a wide range of disability ranging from mild to severe. The expression of
PTP1B
, DepYmed’s target in
Rett syndrome
, is regulated by
MECP2
; in turn,
PTP1B
controls important cell functions that are disrupted in the disease.
DepYmed Inc., is a New York based rare disease and
cancer
therapeutic development company that was founded to capitalize on the scientific discoveries of the Tonks lab at Cold Spring Harbor Laboratory in the physiological function of
PTP1B
and ways to modulate its role in various human diseases. DepYmed is currently developing a new class of potent, orally bioavailable small molecule inhibitors of the enzyme
PTP1B
as novel therapeutics for
Rett Syndrome
and different types of
cancer
. In addition, DepYmed has also discovered a novel class of small molecules with copper chelating properties that it is developing as potential therapeutic agents for such diseases as
Wilson disease
and various
cancers
. The company is actively developing a deep pipeline of new compounds with broad therapeutic potential in these emerging drug classes in collaboration with Cold Spring Harbor Laboratory. For more information, please visit the Company’s website at: www.depymed.com.
For Media Inquiries please contact:
Jules Abraham
JQA Partners, Inc.
jabraham@jqapartners.com
917-885-7378
DepYmed:
info@depymedinc.com


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适应症
Rett综合征,神经发育障碍,自闭症
[+6]
靶点
PTP1B,PTPs,MECP2
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