CMIC CMO Co., Ltd.

Orally disintegrating tablet (OD tablet) is a dosage form which can be swallowed without water.Recent progress in formulation and manufacturing technologies enabled 01) tablet with conflicting properties. fast disintegration and sufficient strength (hardness).Examples of such OD tablets processed by two different concepts are introduced.The tablet with amorphous state binder and controlled moisture content, prepared at lower compression pressure followed by heat treatment, exhibited fast disintegrating property due to higher porosity.External lubrication tablet with increased hardness demonstrated fast disintegrating property based on increased hygroscopicity (accelerated water penetration).