排名前五的靶点	数量

NTSR2(neurotensin receptor 2)	4
GPR88(G protein-coupled receptor 88)	3
DAT(多巴胺转运体)	2
κ opioid receptor(κ-阿片受体)	1
CYP2D6 x DAT x NET x adrenergic receptor	1

关联

项与 Research Triangle Institute 相关的药物

Bupropion Hydrochloride

盐酸安非他酮

靶点

CYP2D6 x DAT x NET x adrenergic receptor

作用机制

CYP2D6抑制剂 [+3]

在研机构

Research Triangle Institute [+4]

原研机构

GSK Plc

在研适应症

季节性情感障碍 [+3]

非在研适应症

注意缺陷障碍 [+7]

最高研发阶段批准上市

首次获批国家/地区

美国

首次获批日期1985-12-30

RLX-33

靶点

RXFP3

作用机制

RXFP3拮抗剂

在研机构

Research Triangle Institute

原研机构

Research Triangle Institute

在研适应症-

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

RTI-422

靶点

DAT

作用机制

DAT调节剂

在研机构

Research Triangle Institute

原研机构

Research Triangle Institute

在研适应症-

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

191

项与 Research Triangle Institute 相关的临床试验

NCT05751993 / Not yet recruitingN/AIIT

Piloting a Reinforcement Learning Tool for Individually Tailoring Just-in-time Adaptive Interventions

The purpose of this pilot study is to conduct a 12-week pilot feasibility study testing usability of a reinforcement learning model (AdaptRL) in a weight loss intervention (ADAPT study). Building upon a previous just-in-time adaptive intervention (JITAI), a reinforcement learning model will generate decision rules unique to each individual that are intended to improve the tailoring of brief intervention messages (e.g., what behavior to message about, what behavior change techniques to include), improve achievement of daily behavioral goals, and improve weight loss in a sample of 20 adults.

开始日期2024-12-01

申办/合作机构

UNC Lineberger Comprehensive Cancer Center

[+3]

NCT06572774 / RecruitingN/AIIT

An Integrated Community Clinic Model of Optimized Implementation Strategies to Increase Early Detection of Breast and Cervical Cancers in Kenya

Kenya has a high incidence of breast and cervical cancers, and most women are diagnosed with late-stage disease. The investigators will conduct a study to assess the effectiveness and cost-effectiveness of strategies to increase the uptake of cancer screening and completion of recommended diagnostic and treatment services. The findings can be used to design optimal approaches and plan investments in infrastructure to scale up implementation of breast and cervical cancer screening.

开始日期2024-09-09

申办/合作机构

Research Triangle Institute

[+1]

NCT06480227 / RecruitingN/AIIT

A Randomized Trial of Transurethral Bulking Agent Injection Versus Single-Incision Sling for Stress Urinary Incontinence

This is a multicentered, double-blind, randomized controlled, surgical trial of 358 women with inadequate symptom relief of stress urinary incontinence (SUI) or stress predominant mixed urinary incontinence (MUI) after conservative care.
The Primary Aim is to determine the comparative effectiveness (as defined by "much" or "very much" improved on PGI-I) of transurethral bulking agent (TBA) [for 1 or 2 injections in 12 months] vs. single-incision sling (SIS) 12 months after treatment intervention in women with predominant stress urinary incontinence (SUI).

开始日期2024-08-28

申办/合作机构

Kaiser Permanente, Inc.

[+7]

100 项与 Research Triangle Institute 相关的临床结果

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0 项与 Research Triangle Institute 相关的专利（医药）

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4,775

项与 Research Triangle Institute 相关的文献（医药）

2024-09-01·Journal of Cystic Fibrosis

Adapting the cystic fibrosis care model: Perspectives from people with CF, caregivers, and members of CF care teams

Article

作者: Hempstead, Sarah E ; Flume, Patrick A ; Olmsted, Murrey G ; Brown, Rebekah F ; Flume, Patrick A. ; Brown, A. Whitney ; Brown, Rebekah F. ; Lomas, Paula H ; Lomas, Paula H. ; Brown, A Whitney ; Olmsted, Murrey G. ; Tran, Quynh T. ; Tran, Quynh T ; Aliaj, Enid

BACKGROUND:

Rapidly emerging clinical trends offer the opportunity to amend guidance on issues pertaining to CF care delivery. A national survey was conducted to gather perspectives on CF care including potential adaptations to the care model to best meet the needs of this population.

METHODS:

A survey instrument was developed to capture perspectives on CF care. People with CF (pwCF), including those post lung transplant, caregivers and care teams were surveyed. Descriptive statistics were calculated to characterize respondents and responses.

RESULTS:

In-person, routine visits with the CF care teams were valued by survey respondents. However, reduced in-person visit frequency from the standard three-month interval was supported for individuals in a stable state of health. This was particularly true for pwCF ages two or older and on a modulator. Lung function, pulmonary exacerbation frequency, and transition periods were noted to influence preference for visit frequency. Integrating telehealth with remote monitoring in between visits was broadly supported. For shared care between CF teams and other medical providers (transplant teams and primary care providers (PCP)), good communication, easily accessible health records, and convenient locations were important.

CONCLUSIONS:

Survey findings support adapting CF care based on individual needs and life transitions. Themes identified can inform future areas of study and resource development to support successful modification of the CF care model and shared decision-making between patients and their care providers.

2024-07-02·Health communication

Examining the Longitudinal Relationship Between Perceived and Actual Message Effectiveness: A Randomized Trial

Article

作者: Noar, Seth M. ; Brewer, Noel T. ; Ma, Haijing ; Kieu, Talia ; Hall, Marissa G. ; Gottfredson O'Shea, Nisha ; Rohde, Jacob A.

We sought to examine the relationship between perceived message effectiveness (PME) and actual message effectiveness (AME) in a 3-week randomized trial of vaping prevention advertisements. Participants were US adolescents (n = 1,514) recruited in 2021. We randomly assigned them to view The Real Cost vaping prevention ads or control videos online. Participants viewed three videos at Visit 1, again at Visits 2 and 3, and completed a survey at each visit that assessed AME (susceptibility to vaping) and two types of PME - effects perceptions (potential for behavioral impact) and message perceptions (potential for message processing). At Visit 4, AME was measured. Compared to control, The Real Cost ads led to improved AME (lower susceptibility to vaping at Visit 4, p < .001). This was anticipated by The Real Cost ads eliciting higher PME ratings (higher effects and message perceptions at Visit 1, both p < .001). Furthermore, PME (both effects and message perceptions) at Visit 1 predicted susceptibility to vaping at Visits 1, 2, 3, and 4 (all p < .001). Finally, effects perceptions fully mediated the impact of The Real Cost ads on susceptibility to vaping (β = -.30; p < .001), while message perceptions only partially mediated the effect (β = -.04; p = .001). Our findings indicate a relationship between PME and AME, especially effects perceptions, and suggest that PME may be useful in message pre-testing to select messages with greater behavior change potential.

2024-07-01·Forensic Chemistry

Prevalence of opioid glucuronides in human hair

作者: Hayes, Eugene D. ; Flegel, Ron R. ; Vikingsson, Svante ; Bollinger, Katherine ; Grabenauer, Megan ; Bynum, Nichole D.

Current hair testing methods, which mainly rely on quantification of parent drug analytes, have difficulty distinguishing drug deposited into hair through physiol. processes from drug deposited onto hair via external contamination.Using conjugated phase II metabolites to differentiate between drug use and possible external contamination is advantageous as they are unlikely to be degradation products or synthesis byproducts.In this study, 97 specimens were analyzed for opioid glucuronides and the corresponding parent drugs.Morphine-3-glucuronide and morphine-6-glucuronide were the most prevalent glucuronides and were detected in 82 % of specimens with morphine concentrations ≥ 200 pg/mg (n = 33).Median glucuronide to parent ratios were 0.65 % and 1.12 % for morphine-3-glucuonide and morphine-6-glucuronide resp.Codeine-6-glucuronide was detected in 100 % of specimens with a codeine concentration ≥ 200 pg/mg (n = 8), with a median glucuronide to parent ratio of 2.21 %.Hydromorphone-3-glucuronide was detected in 75 % of specimens with hydromorphone ≥ 200 pg/mg (n = 4) with a median glucuronide to parent ratio of 1.24 %.Oxycodone-3-glucuronide was detected in 37 % of specimens with oxycodone ≥ 200 pg/mg with a median glucuronide to parent ratio of 0.91 %.No hair specimens with a parent concentration less than LOD had a corresponding glucuronide present.This study shows that a 1 pg/mg cutoff for glucuronides provides similar sensitivity as the currently recommended 200 pg/mg cutoff for morphine, codeine, and hydrocodone.

项与 Research Triangle Institute 相关的新闻（医药）

2024-10-21

·PRNewswire

Vietnam Eliminates Trachoma as a Public Health Problem

RTI International congratulates Vietnam in eliminating trachoma – a painful disease impacting the lives of millions of people around the world RESEARCH TRIANGLE PARK, N.C., Oct. 21, 2024 /PRNewswire/ -- RTI International, a nonprofit research institute and leading international development organization, is pleased to join Vietnam, the World Health Organization (WHO) and the United States Agency for International Development (USAID) in celebrating the elimination of trachoma, a painful disease that can lead to blindness, as a public health problem in Vietnam. Globally, Vietnam is the 21st endemic country to achieve validation of elimination of this neglected tropical disease (NTD). More than 8.3 million people in Vietnam are now free from the risk of trachoma infection. The announcement came at the opening of the WHO Regional Committee for the Western Pacific, being held in Manila, Philippines. "We applaud Vietnam for achieving this incredible goal, which has been over half a century in the making," said Tim J. Gabel , president and CEO at RTI International. "Solving this health problem is an important achievement in improving the human condition and we are proud to be among the partners that assisted in this effort." Trachoma, the leading infectious cause of blindness worldwide, causes eyelids to scar and eyelashes to turn inwards eventually resulting in blindness if untreated. Surgery, antibiotics, facial cleanliness practices and environmental improvements (the SAFE strategy) is the WHO endorsed method for eliminating the disease as a public health problem, including the provision of treatment and care for those at risk for the disease. Trachoma control was first initiated in Vietnam in the 1950s; at that time, the prevalence of active trachoma in some communes was as high as 50-90%. In 1999, the Government of Vietnam established a national trachoma program and began mass treatment campaigns with donated azithromycin. USAID began partnering with Vietnam in 2011 to support their efforts to eliminate trachoma. In recent years, USAID's Act to End Neglected Tropical Diseases | East program, through RTI and partner Fred Hollows Foundation, has supported the government to conduct surveys to monitor prevalence of the disease and ensure care has been provided to those impacted by the disease. These efforts and additional technical assistance have supported the Government of Vietnam to formally document their successes to WHO for validation of trachoma elimination as a public health problem. "This achievement would not have been possible without the commitment of the Government of Vietnam to trachoma elimination," says Lisa Rotondo, program director for USAID's Act to End NTDs | East Program at RTI. "The task now will be for Vietnam to continue surveillance for resurgence and to provide care for those already impacted." Additional partners that have contributed to Vietnam's success include the International Trachoma Initiative, the Australian Department of Foreign Affairs and Trade, Tropical Data, and FHI 360, among others. Over the past 18 years, with support from USAID, RTI has partnered with governments and other countries, including Vietnam, Lao People's Democratic Republic, Cambodia and Nepal, to achieve trachoma elimination as a public health problem. Through the USAID Act | East Program, RTI will continue to support countries in Africa, Asia and the Americas in ending NTDs, such as trachoma. Learn more about RTI's work to control and eliminate NTDs around the globe  Media Contact: Kerry Branon 919-541-7300 [email protected] SOURCE RTI International WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

2024-10-08

·PRNewswire

Seattle Children's Recognized as One of the Top 10 Best Children's Hospitals in the U.S.

SEATTLE, Oct. 8, 2024 /PRNewswire/ -- Seattle Children's has been named by U.S. News & World Report to its 2024-2025 Best Children's Hospitals Honor Roll, a distinction awarded to only 10 children's hospitals nationwide. The U.S. News & World Report has been ranking hospitals since 1990, and Seattle Children's is honored to be ranked among the best children's hospitals in the nation for more than 30 years. The rankings help parents and caregivers, along with their physicians, in navigating the challenges of choosing the best possible care for children with serious illnesses or complex medical needs. Continue Reading U.S. News & World Report 2024-2025 Honor Roll Seattle Children's has been named by U.S. News as the No. 1 pediatric hospital in the Pacific region and has ranked in the top 10 nationally in pediatric specialties including Cancer, Diabetes and Endocrine Disorders, Gastroenterology and GI Surgery, Nephrology, Neurology and Neurosurgery and Pulmonology. "As the largest, independent nonprofit children's hospital in our region, we are committed to providing the highest-quality outcomes for the children and families we serve, and it's rewarding to see this acknowledged at a national level," said Seattle Children's CEO, Dr. Jeff Sperring. "Being recognized as one of the top 10 children's hospitals in the nation is a testament to the outstanding care our teams provide and our dedication to our mission of providing hope, care, and cures." U.S. News, together with RTI International, collected and analyzed data from 108 children's hospitals and surveyed thousands of pediatric specialists. Children's hospitals awarded a "Best" designation excelled at factors such as clinical outcomes, level and quality of hospital resources directly related to patient care and expert opinion among pediatric specialists. "For nearly two decades, U.S. News has published Best Children's Hospitals to empower the parents and caregivers of children with complex medical needs," said Ben Harder, chief of health analysis and managing editor at U.S. News. "Children's hospitals appearing on the U.S. News Honor Roll have a track record of delivering unparalleled specialized care." The full rankings for the 2024-2025 Best Children's Hospitals Honor Roll, regional and specialty rankings can be found at USNews.com. MEDIA CONTACT Sabrina Register, Manager, Public Relations [email protected] About Seattle Children's Seattle Children's mission is to provide hope, care and cures to help every child live the healthiest and most fulfilling life possible. Together, Seattle Children's Hospital, Research Institute and Foundation deliver superior patient care, identify new discoveries and treatments through pediatric research, and raise funds to create better futures for patients. Ranked as one of the top children's hospitals in the country by U.S. News & World Report, Seattle Children's serves as the pediatric and adolescent academic medical center for Washington, Alaska, Montana and Idaho – the largest region of any children's hospital in the country. As one of the nation's top five pediatric research centers, Seattle Children's Research Institute is internationally recognized for its work in neurosciences, immunology, cancer, infectious disease, injury prevention and much more. Seattle Children's Foundation, along with Seattle Children's Guild Association – the largest all volunteer fundraising network for any hospital in the country – works with our generous community to raise funds for lifesaving care and research. For more information, visit seattlechildrens.org or follow us on X, Facebook, LinkedIn and Instagram. About U.S. News & World Report U.S. News & World Report is the global leader in quality rankings that empower consumers, business leaders and policy officials to make better, more informed decisions about important issues affecting their lives and communities. A multifaceted digital media company with Education, Health, Money, Travel, Cars, News, Real Estate, Careers and 360 Reviews platforms, U.S. News provides rankings, independent reporting, data journalism, consumer advice and U.S. News Live events. More than 40 million people visit USNews.com each month for research and guidance. Founded in 1933, U.S. News is headquartered in Washington, D.C SOURCE Seattle Children’s WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

临床研究

2024-10-08

·PRNewswire

Children's Hospital Colorado Recognized as a Top Ranked Children's Hospital in the Nation

U.S. News & World Report releases 2024-25 Best Children's Hospitals rankings AURORA, Colo., Oct. 8, 2024 /PRNewswire/ -- Children's Hospital Colorado (Children's Colorado) has been named to the 2024-2025 Best Children's Hospitals Honor Roll by U.S. News & World Report (U.S. News), a distinction awarded to only 10 children's hospitals nationwide. Children's Colorado is proud to continue serving as a pediatric leader right here in our own community, being ranked No. 1 in both the region and the state. In addition to being named as the No. 1 pediatric hospital in Colorado and the Rocky Mountain region, Children's Colorado has been recognized by U.S. News as being exceptional in all ranked specialties, with six of the Children's Colorado specialties ranked among the Top 10, including: Diabetes and endocrinology at No. 5 Pulmonology and lung surgery at No. 6 Cardiology and heart surgery at No. 6 Urology at No. 6 Gastroenterology and GI surgery at No. 7 Cancer at No. 8 For the first time, U.S. News ranked behavioral health programs. Children's Colorado is now recognized among the best in behavioral health, based on a variety of factors around the hospital's quality of behavioral and mental health care for children. "At Children's Hospital Colorado, we like to say that 'here, it's different.' With a U.S. News & World Report Top 10 ranking, we're proving it," said Jena Hausmann, president and CEO of Children's Colorado. "This year's new approach to rankings recognizes a leading group of children's hospitals whose work pushes the child health field to be better, heal more and make new discoveries. We're proud to continue our sustained excellence and earn recognition among these peers. Together, we are improving the health of children through a collaborative spirit, creativity and a tireless, unrelenting dedication to children and innovative research, which is advancing discoveries at an unprecedented rate." For the 2024-25 rankings and ratings, U.S. News ranked the Top 50 centers in each of these 10 pediatric specialties: Cancer, cardiology and heart surgery, diabetes and endocrinology, gastroenterology and gastrointestinal surgery, neonatology, nephrology, neurology and neurosurgery, orthopedics, pulmonology and lung surgery, and urology. These rankings assist parents and caregivers, along with their physicians, in navigating the challenges of choosing the best possible care for children with serious illnesses or complex medical needs. U.S. News, together with RTI International, a North Carolina-based research and consulting firm, collected and analyzed data from 108 children's hospitals and surveyed thousands of pediatric specialists. Children's hospitals awarded a "Best" designation excelled at factors such as clinical outcomes, level and quality of hospital resources directly related to patient care and expert opinion among pediatric specialists. "U.S. News & World Report's annual Best Children's Hospitals evaluation empowers parents and caregivers with a data-driven guide to help them find the best pediatric hospital to treat their child," said Ben Harder, chief of health analysis and managing editor at U.S. News. The full rankings for the 2024-2025 Best Children's Hospitals Honor Roll, regional and specialty rankings can be found at USNews.com. ABOUT CHILDREN'S HOSPITAL COLORADO Children's Hospital Colorado is one of the nation's leading and most expansive nonprofit pediatric healthcare systems with a mission to improve the health of children through patient care, education, research and advocacy. Founded in 1908 and ranked among the best children's hospitals in the nation as recognized by U.S. News & World Report, Children's Colorado has established itself as a pioneer in the discovery of innovative and groundbreaking treatments that are shaping the future of pediatric healthcare worldwide. Children's Colorado offers a full spectrum of family-centered care at its urgent, emergency and specialty care locations throughout Colorado, including an academic medical center on the Anschutz Medical Campus in Aurora, hospitals in Colorado Springs, Highlands Ranch and Broomfield, and outreach clinics across the region. For more information, visit or connect with us on Facebook, Instagram and YouTube. ABOUT U.S. NEWS & WORLD REPORT U.S. News & World Report is the global leader in quality rankings that empower consumers, business leaders and policy officials to make better, more informed decisions about important issues affecting their lives and communities. A multifaceted digital media company with Education, Health, Money, Travel, Cars, News, Real Estate, Careers and 360 Reviews platforms, U.S. News provides rankings, independent reporting, data journalism, consumer advice and U.S. News Live events. More than 40 million people visit USNews.com each month for research and guidance. Founded in 1933, U.S. News is headquartered in Washington, D.C. Media Contacts: Rachael Fowler Children's Colorado Media Line: 303-890-8314 [email protected] SOURCE Children's Hospital Colorado WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

临床研究

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

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药物(靶点)	适应症	全球最高研发状态

Bupropion analogues(Research Triangle Institute) ( MATs x nAChRα3&β4 )	戒烟更多	临床前
NTRC-844 ( NTSR2 )	疼痛更多	临床前
RTOXA-43 ( OX1R x OX2R )	发作性睡病更多	临床前
盐酸安非他酮 ( CYP2D6 x DAT x NET x adrenergic receptor )	戒烟更多	临床前
NTRC-824 ( NTSR2 )	疼痛更多	临床前