Delving into the Latest Updates on Merck Serono SpA with Synapse

一项在垂体抑制且处于绝经前的中国健康女性受试者中评估900 IU促卵泡激素α（果纳芬）+450 IU促黄体激素α（乐芮）联合用药与皮下（SC）注射Pergoveris（含900 IU促卵泡激素α+450 IU促黄体激素α的固定复方制剂）液体和冻干（FD）制剂相比的生物等效性的开放标签、随机、三周期交叉的单中心I期研究。

主要目的：评估Pergoveris冻干制剂（受试制剂1）与其中各个组分（果纳芬和乐芮，参比制剂）联合给药在垂体抑制的中国健康女性受试者中的生物等效性（BE），用药方法为皮下（SC）注射900 IU促卵泡激素α/450 IU促黄体激素α。评估Pergoveris液体制剂（受试制剂2）与其中各个组分（果纳芬和乐芮，参比制剂）联合给药在垂体抑制的中国健康女性受试者中的BE，用药方法为皮下注射900 IU促卵泡激素α/450 IU促黄体激素α。次要目的：评价Pergoveris 冻干制剂和Pergoveris 液体制剂在垂体抑制的中国健康女性受试者中的安全性和耐受性。评估单剂量使用受试制剂和参比制剂后的其他药代动力学（PK）参数

开始日期2021-05-08

申办/合作机构

Merck Europe BV

[+2]

EUCTR2010-020196-23-IT

/ Not yet recruiting临床2期

A phase II, multicentre, open label, prospective, interventional study to evaluate the sperm DNA fragmentation in idiopathic male infertility before and after treatment with Gonal-f PEN 900 IU. - ND

开始日期2011-04-14

申办/合作机构

Merck Serono SpA

EUCTR2009-013333-24-IT

/ Not yet recruitingN/A

Multicenter, open-label, 12 weeks Phase IV study to assess adherence to treatment in relapsing multiple sclerosis (RMS) subjects switching from other injectable DMDs using ReBiSmart to self-inject Rebif New Formulation (RNF) In a multi-dose cartriDGE (BRIDGE) - BRIDGE

开始日期2009-08-03

申办/合作机构

Merck Serono SpA

100 项与 Merck Serono SpA 相关的临床结果

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0 项与 Merck Serono SpA 相关的专利（医药）

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1,041

项与 Merck Serono SpA 相关的文献（医药）

2023-04-25·Neurology

Immune Response Following COVID-19 Vaccination (mRNA or Non-mRNA) in Patients with Relapsing Multiple Sclerosis Treated with the Bruton’s Tyrosine Kinase Inhibitor Evobrutinib: An Update (P2-3.017)

作者: Drouin, Elise E. ; Alexandri, Nektaria ; Tomic, Davorka ; Bar-Or, Amit ; Montalban, Xavier ; Hyvert, Yann ; Seitzinger, Andrea ; Cunningham, Anthony ; Cross, Anne H.

2023-04-25·Neurology

Neurofilament Light Chain Levels and Disease Activity During Long-Term Treatment of Relapsing Multiple Sclerosis with the Bruton’s Tyrosine Kinase Inhibitor Evobrutinib (P1-3.011)

作者: Li, Ying ; Kuhle, Jens ; Tomic, Davorka ; Benkert, Pascal ; Thangavelu, Karthinathan ; Hyvert, Yann ; Montalban, Xavier ; Kappos, Ludwig

2023-04-25·Neurology

The MS-LINK Outcomes Study Cohort: Study design and a descriptive analysis of baseline key PROs, disease, and sociodemographic characteristics (P13-3.010)

作者: Livingston, Terrie ; Pardo, Gabriel ; English, Jeffrey ; Tornatore, Carlo ; Riser, Emily ; Sloane, Jacob ; Caon, Christina ; Piette, Elizabeth ; Freeman, Leorah

100 项与 Merck Serono SpA 相关的药物交易

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100 项与 Merck Serono SpA 相关的转化医学

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