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项与 Kagawa University 相关的药物

BW-1003C87

靶点

Sodium channels

作用机制

钠通道阻滞剂

在研机构-

原研机构

GSK Plc

在研适应症-

非在研适应症

癫痫 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

88

项与 Kagawa University 相关的临床试验

JPRN-UMIN000054047 / RecruitingIIT

Testing the Effectiveness of Attention Bias Modification Training to Divert Attention from Food - Testing the Effectiveness of Attention Bias Modification Training for Food

开始日期2024-04-03

申办/合作机构

Kagawa University

JPRN-UMIN000052433 / SuspendedIIT

A Multicenter Prospective Cohort Study to Establish a Predictive Model for the Treatment-Related Acute Kidney Disease by Noninvasive Tubular Aging Assessment - A Multicenter Prospective Cohort Study to Establish a Predictive Model for the Treatment-Related Acute Kidney Disease by Noninvasive Tubular Aging Assessment

开始日期2023-10-01

申办/合作机构

Kagawa University

JPRN-UMIN000054523 / RecruitingIIT

Investigation of the molecular pathogenesis of cardiac amyloidosis using 18F-flutemetamol and 11C-PiB PET/CT and 99mTc-HMDP scintigraphy. - FMM, PiB, and HMDP accumulation in cardiac amyloidosis

开始日期2023-09-11

申办/合作机构

Kagawa University

100 项与 Kagawa University 相关的临床结果

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0 项与 Kagawa University 相关的专利（医药）

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15,919

项与 Kagawa University 相关的文献（医药）

2024-12-01·Applied Microbiology and Biotechnology

X-ray structure and characterization of a probiotic Lactobacillus rhamnosus Probio-M9 L-rhamnose isomerase

Article

作者: Kurahara, Lin Hai ; Izumori, Ken ; Yamamoto, Naho ; Yoshida, Hiromi ; Yoshihara, Akihide

AbstractA recombinant L-rhamnose isomerase (L-RhI) from probiotic Lactobacillus rhamnosus Probio-M9 (L. rhamnosus Probio-M9) was expressed. L. rhamnosus Probio-M9 was isolated from human colostrum and identified as a probiotic lactic acid bacterium, which can grow using L-rhamnose. L-RhI is one of the enzymes involved in L-rhamnose metabolism and catalyzes the reversible isomerization between L-rhamnose and L-rhamnulose. Some L-RhIs were reported to catalyze isomerization not only between L-rhamnose and L-rhamnulose but also between D-allulose and D-allose, which are known as rare sugars. Those L-RhIs are attractive enzymes for rare sugar production and have the potential to be further improved by enzyme engineering; however, the known crystal structures of L-RhIs recognizing rare sugars are limited. In addition, the optimum pH levels of most reported L-RhIs are basic rather than neutral, and such a basic condition causes non-enzymatic aldose-ketose isomerization, resulting in unexpected by-products. Herein, we report the crystal structures of L. rhamnosus Probio-M9 L-RhI (LrL-RhI) in complexes with L-rhamnose, D-allulose, and D-allose, which show enzyme activity toward L-rhamnose, D-allulose, and D-allose in acidic conditions, though the activity toward D-allose was low. In the complex with L-rhamnose, L-rhamnopyranose was found in the catalytic site, showing favorable recognition for catalysis. In the complex with D-allulose, D-allulofuranose and ring-opened D-allulose were observed in the catalytic site. However, bound D-allose in the pyranose form was found in the catalytic site of the complex with D-allose, which was unfavorable for recognition, like an inhibition mode. The structure of the complex may explain the low activity toward D-allose.Key points• Crystal structures of LrL-RhI in complexes with substrates were determined.• LrL-RhI exhibits enzyme activity toward L-rhamnose, D-allulose, and D-allose.• The LrL-RhI is active in acidic conditions.

2024-12-01·Techniques in Coloproctology

Simple technique of double-layer enterotomy closure using a bidirectional barbed suture material when performing intracorporeal side-to-side anastomosis in robot-assisted right colectomy for colon cancer

Article

作者: Okano, Keiichi ; Kondo, Akihiro ; Feng, Dongping ; Kobara, Hideki ; Kumamoto, Kensuke ; Asano, Eisuke

2024-12-01·Endoscopy

Simple use of Y-connector for proper positioning and contrast aspiration in biliary metal stent placement

Article

作者: Ogi, Tomohiro ; Kamada, Hideki ; Ono, Masafumi ; Masaki, Tsutomu ; Kobara, Hideki ; Kobayashi, Kiyoyuki ; Nomura, Takako

100 项与 Kagawa University 相关的药物交易

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100 项与 Kagawa University 相关的转化医学

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