Sangart, Inc.

Deep Genomics' BigRNA was built out of 1 trillion genomic signals captured from thousands of datasets, and includes 1.8 billion tunable parameters. Deep Genomics is taking two emerging technologies—which in recent years have captured the public’s attention for different reasons—and is finding they can work great together. The company has put forward an artificial-intelligence-powered foundation model designed to explore RNA biology, and how the small pieces of genetic material can contribute to various diseases or provide avenues for new therapies.  AI foundation models, as a category, describe systems trained on massive amounts of information that can then be tailored to produce a variety of different outputs—this family includes the recently popular text and image generators such as ChatGPT and other programs. RNA research, meanwhile, famously demonstrated its potential in the COVID-19 vaccines developed by Pfizer, BioNTech and Moderna, and is currently being explored for a range of diseases. Deep Genomics’ AI, dubbed BigRNA, is a transformer neural network designed to predict the biological mechanisms that regulate RNA expression tissue-by-tissue, to help better understand how specific variants in genes ultimately give rise to different diseases. At the same time, the program can identify potential binding sites for proteins and microRNAs, which could possibly be exploited for the discovery and development of new drug compounds. “Building machine learning models that can predict gene expression from DNA sequence has been a long-standing research goal, and one that has seen significant strides owing to recent advancements in deep learning,” Brendan Frey, Deep Genomics’ founder and chief innovation officer, said in a statement. After being given a DNA or RNA sequence, the AI can examine the effects of non-coding genes, as well as mutations that may or may not alter the ultimate function of a particular protein, and then help design matching RNA-based therapeutics, Frey said. “In a comprehensive study of 14 genes, BigRNA consistently designed highly effective steric blocking oligonucleotides that act in a tissue-specific manner, including for genes involved in Wilson disease and spinal muscular atrophy,” Frey added.  By intervening in how cells process RNA, these oligonucleotides could potentially help reverse the effects of a disease-causing genetic variant, by blocking the overproduction of a troublesome protein or increasing the production of a deficient one. BigRNA was built out of 1 trillion genomic signals captured from thousands of datasets, and includes 1.8 billion tunable parameters, the company said. The details of the model were published on the journal preprint site BioRxiv. The company said it also plans to present its data at future scientific meetings.  The computer model looks to deliver on Deep Genomics’ long promise that AI can help deliver gene-based therapies that can be programmed for different objectives. The Toronto-based company raised $180 million in a 2021 series C venture capital round with a pitch to advance research on at least 10 computer-designed drugs.  Currently, its pipeline lists a handful of undefined preclinical programs in metabolic and central nervous system diseases, though it previously identified Wilson disease as a target—a rare genetic condition where excess copper is stored within the body’s tissues. Earlier this month the company made a change to its leadership. It appointed Brian O’Callaghan to serve as CEO, while Frey transitioned from the position to chief innovation officer. “I’m proud of the team, the progress we have made, and the molecules we are advancing through animal studies, and I look forward to sharing updates on recent achievements in the months ahead,” Frey said in a September 15 release. O’Callaghan most recently held the top spot at ObsEva, the women’s-health biotech that restructured its C-suite earlier this year in a bid to save cash, ahead of its delisting from the Nasdaq in March. He has also served as CEO of Petra Pharma, Acucela, Sangart and BioPartners.

REDWOOD CITY, Calif., Nov. 19, 2021 (GLOBE NEWSWIRE) -- Bolt Biotherapeutics (Nasdaq: BOLT), a clinical-stage biotechnology company pioneering a new class of immuno-oncology agents that combine the targeting precision of antibodies with the power of both the innate and adaptive immune systems, today announced the appointments of Brian O’Callaghan and Frank D. Lee to the Board of Directors. With these additions, longtime Director Peter Moldt, Ph.D. is stepping down from the Board of Directors and current Director Jim Healy, M.D., Ph.D. will be assuming the role of Lead Independent Director. “Brian is a strategic leader with deep biotechnology and pharmaceutical experience across many therapeutics areas, leading new medicines from concept to commercialization. His leadership will prove invaluable as we advance our immuno-oncology pipeline. Frank brings experience shaping treatment paradigms for HER2 breast cancer patients from his time at Genentech and has a proven track record of commercial leadership in building innovative product strategies. We are eager to benefit from his knowledge as we make patient-focused decisions to expand our pipeline,” said Randall Schatzman, Ph.D., CEO of Bolt Biotherapeutics. “Bolt Biotherapeutics has had a transformational year, from our February IPO to our steady progress in the BDC-1001 dose-escalation trial and establishment of collaborations with Genmab, Innovent Biologics, and Bristol Myers Squibb, all while advancing our novel pipeline and demonstrating our leadership in the immuno-oncology space. Dr. Moldt has been a tremendous contributor to Bolt’s successes as a private company over the last several years and on behalf of the whole Board of Directors, I would like to thank him for his hard work and dedication.” Mr. O’Callaghan has 30 years of experience in biotechnology, pharmaceutical and clinical research organizations, holding senior management and board roles at public and private companies in Europe and the U.S. He currently serves as Chief Executive Officer at ObsEva SA (Nasdaq: OBSV), a clinical-stage pharmaceutical company developing novel therapies to improve women’s health. Mr. O’Callaghan also serves on the board of several privately held biotechnology companies, including Indaptus Therapeutics, Aquavit Therapeutics and Biocom Purchasing Group. Earlier, he held chief executive officer positions at Petra Pharma, Acucela, Sangart and NPS BioPartners, as well as senior management positions at Pfizer, Merck Serono, Novartis, Covance and NPS Pharmaceuticals. Mr. O’Callaghan earned an M.B.A. from the Henley Business School at the University of Reading and a diploma from the Marketing Institute of Ireland. “Bolt has formed a robust pipeline of immune-stimulating, myeloid-engaging therapeutics with the goal of offering long-term tumor remissions for patients. The uniqueness of the Boltbody™ Immune-stimulating Antibody Conjugate (ISAC) approach is intriguing, and I look forward to sharing my experience with the Bolt team as they advance pipeline programs through clinical development,” said Mr. O’Callaghan. Mr. Lee has more than 25 years of experience in product development and commercial leadership across a wide range of therapeutic areas within the biotech and pharmaceutical industries. He currently serves as President and Chief Executive Officer of Forma Therapeutics (Nasdaq: FMTX), a clinical-stage biopharmaceutical company focused on rare hematologic diseases and cancers. Prior to joining Forma, Mr. Lee spent 13 years at Genentech, where he was most recently Senior Vice President of global product strategy. Previously, as Vice President of Genentech’s HER2/breast cancer franchise, he was responsible for U.S. P&L for Herceptin®, Perjeta® and Kadcyla®, driving revenues over $4 billion and launching the first HER2 neoadjuvant indication for early HER2 breast cancer patients. Previously, as Vice President of oral oncolytics at Genentech, Mr. Lee held P&L responsibility for Tarceva®, Zelboraf®, Erivedge®, and Xeloda®, advancing personalized medicine for cancer patients with EGFR+ NSCLC and BRAF+ melanoma, and establishing a new treatment option for patients with advanced basal cell carcinoma. Prior to joining Genentech, Mr. Lee spent approximately 13 years at Novartis, Janssen and Eli Lilly. Mr. Lee earned a B.E. in Chemical Engineering from Vanderbilt University and an M.B.A. from the Wharton Graduate School of Business at the University of Pennsylvania. “Bolt is pioneering a new category of immunotherapies based on the Boltbody ISAC platform and is well poised to make a transformative impact on the lives of patients,” said Mr. Lee. “I am excited to help the Bolt Biotherapeutics drive patient-focused decisions that could advance and grow the company’s pipeline of product candidates.” About Bolt Biotherapeutics, Inc. Bolt Biotherapeutics, Inc. is a clinical-stage biotechnology company pioneering a new class of immuno-oncology agents that combine the targeting precision of antibodies with the power of both the innate and adaptive immune systems Bolt’s proprietary Boltbody™ Immune-stimulating Antibody Conjugate (ISAC) approach uses immunostimulants to engage and activate myeloid cells that directly kill tumor cells. This leads to the conversion of immunologically “cold” tumors to “hot” tumors. Bolt’s lead candidate, BDC-1001, is a Boltbody ISAC comprised of a HER2-targeting biosimilar of trastuzumab conjugated to one of Bolt’s proprietary TLR7/8 agonists for the treatment of patients with HER2-expressing solid tumors. Bolt is also advancing additional Boltbody ISAC product candidates targeting CEA and PD-L1. For more information, visit . Forward-Looking Statements This press release contains forward-looking statements about us and our industry that involve substantial risks and uncertainties and are based on our beliefs and assumptions and on information currently available to us. All statements other than statements of historical facts contained in this press release, including statements regarding the success and results of our pipeline programs and product candidates are forward-looking statements. In some cases, you can identify forward-looking statements because they contain words such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” or “would,” or the negative of these words or other similar terms or expressions. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. Forward-looking statements represent our current beliefs, estimates and assumptions only as of the date of this press release and information contained in this press release should not be relied upon as representing our estimates as of any subsequent date. These statements, and related risks, uncertainties, factors and assumptions, include, but are not limited to the potential product candidates that we develop may not progress through clinical development or receive required regulatory approvals within expected timelines or at all; clinical trials may not confirm any safety, potency or other product characteristics described or assumed in this press release; such product candidates may not be beneficial to patients or become commercialized. These risks are not exhaustive. Except as required by law, we assume no obligation to update these forward-looking statements, or to update the reasons actual results could differ materially from those anticipated in the forward-looking statements, even if new information becomes available in the future. Further information on factors that could cause actual results to differ materially from the results anticipated by our forward-looking statements is included in the reports we have filed or will the SEC, including our Quarterly Report on Form 10-Q for the three months ended September 30, 2021. These filings, when available, are available on the investor relations section of our website at investors.boltbio.com and on the SEC’s website at . Investor Relations and Media Contacts: Karen L. Bergman Vice President, Communications and Investor Relations Bolt Biotherapeutics, Inc. 650-665-9295 kbergman@boltbio.com Sarah McCabe Stern Investor Relations, Inc. 212-362-1200 sarah.mccabe@sternir.com Maggie Beller or David Schull Russo Partners, LLC 646-942-5631 maggie.beller@russopartnersllc.com david.schull@russopartnersllc.com

Geneva, Switzerland and Boston, MA – January 4, 2021 – ObsEva SA (NASDAQ: OBSV / SIX: OBSN), a clinical-stage biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health, today announced the appointment of David Renas as Chief Financial Officer (CFO) and member of the company’s Executive Committee, effective today. He will be based in the U.S. “David has demonstrated a track record of leadership and we are delighted to welcome him onto the executive team,” said Brian O’Callaghan, Chief Executive Officer of ObsEva. “I’m confident he will play a key role in further strengthening our relationships with investors and potential partners as we prepare to file a new drug application (NDA) in the U.S. in the first half of 2021 for Yselty, for the treatment of heavy menstrual bleeding and pain associated with uterine fibroids in pre-menopausal women, and further develop Ebopiprant for the treatment of pre-term labor following the recent release of our positive Ph II data.” “I would also like to thank our Chief Administrative Officer (CAO), Fabien de Ladonchamps, for the wonderful job he has done as interim CFO”. David Renas joins ObsEva with more than 30 years of financial and legal experience, including 15 years within the pharmaceutical and life sciences industry. Most recently, he served as CFO at Petra Pharma and CFO and General Counsel at Sangart, where amongst other accomplishments he helped guide the company through 11 clinical trials conducted across 20 countries. David Renas also served as a Partner at Adkins Black LLP. Prior to focusing on the life sciences industry, he was an attorney in private practice with Gray Cary Ware & Freidenrich (now DLA Piper) and Foley & Lardner, and a CPA at Deloitte. David Renas holds a Bachelor of Arts in Economics from Stanford University and a Juris Doctorate from the University of California at Davis. “I am thrilled to be joining as CFO at such an important time in the development of ObsEva which has recently submitted a Marketing Authorization Application (MAA) for its lead product Yselty for uterine fibroids to the European Medicines Agency (EMA) and has an anticipated NDA submission in 1H 2021. I look forward to working with the exceptional team on this exciting journey,” said David Renas. About ObsEva ObsEva is a biopharmaceutical company developing and commercializing novel therapies to improve women’s reproductive health and pregnancy. Through strategic in-licensing and disciplined drug development, ObsEva has established a late-stage clinical pipeline with development programs focused on treating endometriosis, uterine fibroids, preterm labor, and improving embryo transfer outcomes following in vitro fertilization. ObsEva is listed on the Nasdaq Global Select Market and is trading under the ticker symbol "OBSV" and on the SIX Swiss Exchange where it is trading under the ticker symbol “OBSN”. For more information, please visit . Cautionary Note Regarding Forward Looking Statements Any statements contained in this press release that do not describe historical facts may constitute forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as "believe," "expect," "may," "plan," "potential," "will," and similar expressions, and are based on ObsEva’s current beliefs and expectations. These forward-looking statements include expectations regarding the clinical development of ObsEva’s product candidates, and ObsEva’s plan to submit its MAA in Europe and NDA in the United States. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements. Risks and uncertainties that may cause actual results to differ materially include uncertainties inherent in the conduct of clinical trials, clinical development and related interactions with regulators, , ObsEva’s reliance on third parties over which it may not always have full control, the impact of the novel coronavirus outbreak, and other risks and uncertainties that are described in the Risk Factors section of ObsEva’s Annual Report on Form 20-F for the year ended December 31, 2019, the Risk Factors disclosed in ObsEva’s Report on Form 6-K filed with the Securities and Exchange Commission (SEC) on November 5, 2020 and other filings ObsEva makes with the SEC. These documents are available on the Investors page of ObsEva’s website at . Any forward-looking statements speak only as of the date of this press release and are based on information available to ObsEva as of the date of this release, and ObsEva assumes no obligation to, and does not intend to, update any forward-looking statements, whether as a result of new information, future events or otherwise. For further information, please contact: CEO Office contact Shauna Dillon Shauna.dillon@ obseva .ch +41 22 552 1550 Attachment