Halo Pharmaceutical, Inc.

Kane Also Signs Long-Term Manufacturing Agreement With Halo PharmaWINNIPEG, Manitoba, June 27, 2024 (GLOBE NEWSWIRE) -- Kane Biotech Inc. (TSX- V:KNE; OTCQB:KNBIF) (“Kane Biotech” or “Kane”) announces that it has made its first commercial-scale sale of revyve™ Antimicrobial Wound Gel product (“revyve™”) to ProgenaCare Global LLC (“ProgenaCare”). Kane has now completely fulfilled its obligation related to the USD$500,000 initial manufacturing scale up fee received upon signing an exclusive distribution agreement for the US wound care market in May 2023, after receiving U.S. Food and Drug Administration 510(k) clearance for revyve™ Antimicrobial Wound Gel. Kane has subsequently been working with Halo Pharma on the technology transfer and manufacturing scale-up phases of product commercialization. “This is another major milestone for Kane,” said Marc Edwards, President & CEO. “There has been a significant buildup of interest and demand for revyve™ amongst ProgenaCare’s customers as well as Kane’s existing and potential distributor network globally.” “We are delighted to have revyve™ in full scale commercial production,” said Howard Walthall, CEO, ProgenaCare Global. “The feedback from patients and clinicians on the product from our limited initial launch has been excellent. With ample quantities now available, we look forward to being able to help even more patients along their healing journey.” Kane recently presented new in vitro data on the efficacy of revyve™ Antimicrobial Wound Gel at the Symposium on Advanced Wound Care (SAWC), Special Operations Medical Association (SOMA), and Medical Technology Enterprise Consortium (MTEC) conferences. Kane also announces that it has signed a four-year commercial manufacturing services agreement with Halo Pharma for the manufacturing of revyve™. Manufacturing will take place at Halo Pharma’s cGMP compliant pharmaceutical manufacturing and packaging facility located in Mirabel, Quebec. “We worked closely with Halo over the last year during the technology transfer and scale-up phases,” said Mr. Edwards. “We will be placing orders for revyve™ at full-scale manufacturing volumes as we look forward to meeting market demand for this product.” About Kane Biotech Kane Biotech Inc. is a biotechnology company engaged in the research, development and commercialization of technologies and products that prevent and remove microbial biofilms. Kane has a portfolio of biotechnologies, intellectual property (67 patents and patents pending, trade secrets and trademarks) and products developed by Kane's own biofilm research expertise and acquired from leading research institutions. DispersinB®, coactiv+™, coactiv+®, DermaKB™, DermaKB Biofilm™, and revyve™ are trademarks of Kane Biotech Inc. Kane is listed on the TSX Venture Exchange under the symbol "KNE" and on the OTCQB Venture Market under the symbol “KNBIF”. About ProgenaCare ProgenaCare is a purpose-driven medical device company leveraging cutting-edge advances in biomaterials and medical device technologies to provide effective, affordable advanced wound care solutions to patients across the socioeconomic spectrum and around the world. About Halo Pharma Halo Pharma is a leading provider of pharmaceutical services, including contract dosage form development, commercial manufacturing, and analytical services. Halo Pharma’s capabilities in the areas of tech transfer, process and pharmaceutical product development, formulation development, production, scale-up and validation, and analytical method development allow it to partner with clients from development through commercialization or at any point along the way. For more information: Marc EdwardsRay DupuisChief Executive OfficerChief Financial Officer Kane Biotech IncKane Biotech Inc medwards@kanebiotech.comrdupuis@kanebiotech.com Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. Caution Regarding Forward-Looking InformationThis press release contains certain statements regarding Kane Biotech Inc. that constitute forward-looking information under applicable securities law. These statements reflect management’s current beliefs and are based on information currently available to management. Certain material factors or assumptions are applied in making forward-looking statements, and actual results may differ materially from those expressed or implied in such statements. These risks and uncertainties include, but are not limited to, risks relating to Kane’s: (a) financial condition, including lack of significant revenues to date and reliance on equity and other financing; (b) business, including its early stage of development, government regulation, market acceptance for its products, rapid technological change and dependence on key personnel; (c) intellectual property including the ability of Kane to protect its intellectual property and dependence on its strategic partners; and (d) capital structure, including its lack of dividends on its common shares, volatility of the market price of its common shares and public company costs. Further information about these and other risks and uncertainties can be found in the disclosure documents filed by Kane with applicable securities regulatory authorities, available at www.sedarplus.ca. Kane cautions that the foregoing list of factors that may affect future results is not exhaustive.

WINNIPEG, Manitoba, June 27, 2024 (GLOBE NEWSWIRE) -- Kane Biotech Inc. Inc. (TSX- V:KNE; OTCQB:KNBIF) (“Kane Biotech” or “Kane”) announces that it has made its first commercial-scale sale of revyve™ Antimicrobial Wound Gel product (“revyve™”) to ProgenaCare Global LLC (“ProgenaCare”). Kane has now completely fulfilled its obligation related to the USD$500,000 initial manufacturing scale up fee received upon signing an exclusive distribution agreement for the US wound care market in May 2023, after receiving U.S. Food and Drug Administration 510(k) clearance for revyve™ Antimicrobial Wound Gel. Kane has subsequently been working with Halo Pharma on the technology transfer and manufacturing scale-up phases of product commercialization. “This is another major milestone for Kane,” said Marc Edwards, President & CEO. “There has been a significant buildup of interest and demand for revyve™ amongst ProgenaCare’s customers as well as Kane’s existing and potential distributor network globally.” “We are delighted to have revyve™ in full scale commercial production,” said Howard Walthall, CEO, ProgenaCare Global. “The feedback from patients and clinicians on the product from our limited initial launch has been excellent. With ample quantities now available, we look forward to being able to help even more patients along their healing journey.” Kane recently presented new in vitro data on the efficacy of revyve™ Antimicrobial Wound Gel at the Symposium on Advanced Wound Care (SAWC), Special Operations Medical Association (SOMA), and Medical Technology Enterprise Consortium (MTEC) conferences. Kane also announces that it has signed a four-year commercial manufacturing services agreement with Halo Pharma for the manufacturing of revyve™. Manufacturing will take place at Halo Pharma’s cGMP compliant pharmaceutical manufacturing and packaging facility located in Mirabel, Quebec. “We worked closely with Halo over the last year during the technology transfer and scale-up phases,” said Mr. Edwards. “We will be placing orders for revyve™ at full-scale manufacturing volumes as we look forward to meeting market demand for this product.” About Kane Biotech Kane Biotech Inc. is a biotechnology company engaged in the research, development and commercialization of technologies and products that prevent and remove microbial biofilms. Kane has a portfolio of biotechnologies, intellectual property (67 patents and patents pending, trade secrets and trademarks) and products developed by Kane's own biofilm research expertise and acquired from leading research institutions. DispersinB®, coactiv+™, coactiv+®, DermaKB™, DermaKB Biofilm™, and revyve™ are trademarks of Kane Biotech Inc. Kane is listed on the TSX Venture Exchange under the symbol "KNE" and on the OTCQB Venture Market under the symbol “KNBIF”. About ProgenaCare ProgenaCare is a purpose-driven medical device company leveraging cutting-edge advances in biomaterials and medical device technologies to provide effective, affordable advanced wound care solutions to patients across the socioeconomic spectrum and around the world. About Halo Pharma Halo Pharma is a leading provider of pharmaceutical services, including contract dosage form development, commercial manufacturing, and analytical services. Halo Pharma’s capabilities in the areas of tech transfer, process and pharmaceutical product development, formulation development, production, scale-up and validation, and analytical method development allow it to partner with clients from development through commercialization or at any point along the way. For more information: Marc Edwards Ray Dupuis Chief Executive Officer Chief Financial Officer Kane Biotech Inc Kane Biotech Inc medwards@kanebiotech.com rdupuis@kanebiotech.com Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. Caution Regarding Forward-Looking Information This press release contains certain statements regarding Kane Biotech Inc. that constitute forward-looking information under applicable securities law. These statements reflect management’s current beliefs and are based on information currently available to management. Certain material factors or assumptions are applied in making forward-looking statements, and actual results may differ materially from those expressed or implied in such statements. These risks and uncertainties include, but are not limited to, risks relating to Kane’s: (a) financial condition, including lack of significant revenues to date and reliance on equity and other financing; (b) business, including its early stage of development, government regulation, market acceptance for its products, rapid technological change and dependence on key personnel; (c) intellectual property including the ability of Kane to protect its intellectual property and dependence on its strategic partners; and (d) capital structure, including its lack of dividends on its common shares, volatility of the market price of its common shares and public company costs. Further information about these and other risks and uncertainties can be found in the disclosure documents filed by Kane with applicable securities regulatory authorities, available at . Kane cautions that the foregoing list of factors that may affect future results is not exhaustive.

WILMINGTON, Del.--( BUSINESS WIRE )--Noramco, a leading global active pharmaceutical ingredients manufacturer specializing in controlled substances, today announced its launch of the Noramco Group, a newly created comprehensive North American-based supply chain solution including subsidiaries Purisys, Noramco, and the newly acquired drug product CDMO, Halo Pharma. This strategic combination unites the strengths of these entities to provide a robust, North American-based supply chain solution for both clinical and commercial APIs and drug products. In the wake of escalating drug shortages in the United States and quality concerns that are disrupting patient access, Noramco is taking a pivotal step to address these critical issues. The current crisis, primarily driven by lack of reliable foreign supply, limited domestic manufacturing capacity for APIs and drug products, and logistical bottlenecks, has led to unprecedented challenges in ensuring the availability of essential medications. The COVID-19 pandemic underscored the fragility of the existing system, heavily reliant on overseas manufacturing (often from a single foreign source of supply) and exposed the risks of a globalized supply network. 1,2 In response, Noramco is championing a shift towards enhanced supply chain performance and increased domestic production in North America with the formation of the Noramco Group. Lee Karras, CEO of the Noramco Group, emphasized the importance of this alignment in the current market, stating, "The COVID-19 pandemic exposed critical vulnerabilities in our drug supply chain. Government responses, while well-intentioned, proved to be somewhat superficial, leaving the threat of future disruptions unaddressed. The formation of the Noramco Group is our proactive solution to some of these challenges. We are uniquely positioned to provide our customers with a complete, North American-based supply chain solution. By leveraging our advanced manufacturing capabilities, stringent quality control and compliance measures, and timely delivery, we aim to mitigate the risks associated with drug shortages and ensure a stable and reliable supply of vital APIs and drug products. We are committed to supporting patients by ensuring the supply of critical, lifesaving drugs.” Noramco , based in Wilmington, Delaware, supplies commercial APIs globally, supporting various medical treatments such as, pain management and drug abuse treatment. Purisys , located in Athens, Georgia, offers specialized clinical API development and manufacturing services, focusing on controlled substances and pharmaceutical reference standards. Halo Pharma , with operations in Whippany, New Jersey, and Montreal, Quebec, is a contract development and manufacturing organization (CDMO) that provides a wide range of manufacturing services for diverse dosage forms, catering to both brand and generic pharmaceutical clients from development through commercialization. The alignment of these three companies is set to reduce overall complexity in industry processes, minimize logistics costs, and improve regulatory compliance. A notable benefit, especially for pharma and biotech companies working with New Chemical Entities (NCEs), includes the protection of intellectual property with a known domestic source. Additionally, the new Noramco Group structure of combined API and drug product CDMO services in North America could potentially increase opportunities for securing National Institutes of Health (NIH) and other government grants and contracts. This strategic move positions the Noramco Group at the forefront of U.S. pharmaceutical supply chain reliability. To explore how the Noramco Group can support API to drug product supply needs, visit www.noramco.com . To learn about customizing a solutions-oriented approach to clinical trial material delivery and commercial scale delivery of APIs and finished dose forms, please see Noramco Group executives at DCAT Week, March 18-21, 2024, in New York City or contact the Noramco Group online . References: Bowman, R. J. An Urgent Call to Revive the U.S. Pharmaceuticals Supply Chain . SupplyChainBrain. August 7, 2023. Edwards. E. The U.S. Needs to Reimagine Its Pharma Supply Chain . Harvard Business Review. August 12, 2021. About Noramco Headquartered in Wilmington Delaware, Noramco is a global supplier of active ingredients (APIs) - including controlled substances - to the pharmaceutical industry. Noramco’s APIs are used by many of the leading brand and generic pharma companies, as well as small- to mid-scale pharma companies. Noramco’s APIs are used in over 350 products and sold in over 30 counties. Noramco manufactures APIs that are used across a broad set of indications such as ADHD, pain management and abuse treatment and prevention. About Purisys Headquartered in Athens Georgia, Purisys is a leading supplier of API CDMO services and pharmaceutical reference standards. Its 17,000-square-foot manufacturing facility and innovation center is staffed by scientists, engineers, and other professionals who have decades of experience in complex high-barrier custom synthetic chemistry. Purisys’ CDMO services are designed to support the development of custom APIs for a wide range of clinical and niche commercial applications. Purisys has specialized capabilities in controlled substance APIs, possessing 6 DEA registrations encompassing 48 drug codes. Purisys stocks a catalog of more than 250 commercial reference standards that support pharmaceutical drug product development and manufacturing. About Halo Pharma Halo Pharma is a rapidly growing contract development and manufacturing organization (CDMO) that provides scientific and development expertise, as well as a wide spectrum of manufacturing services, from its locations in Whippany, New Jersey, USA and Montreal, Quebec, Canada to its international client base. Halo offers fully integrated capabilities in a variety of dosage forms including tablets, capsules, powders, liquids, creams, sterile and non-sterile ointments and suppositories. The company is registered to work with any of these dosages in the CI-CV DEA designations. Halo Pharma’s capabilities in the areas of tech transfer, process and product development, production, scale-up/validation and analytical method development allow us to partner with clients from development through commercialization or at any point along the way. For more information, please contact services@halopharma.com .