排名前五的靶点	数量

NOX(NADPH氧化酶家族)	8
BRD9(溴结构域蛋白-9)	4
HASPIN(histone H3 associated protein kinase)	4
7BS protein arginine methyltranferases	3
CYBB(细胞色素b-245重链)	2

关联

项与 University of Salerno 相关的药物

18F-AVT-011

靶点

P-gp

作用机制

P-gp抑制剂

在研机构

University of Salerno

原研机构

Avant Imaging & Integrated Media, Inc.

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

NCATS-SM7270

靶点

CYBB

作用机制

CYBB抑制剂

在研机构

Russian Academy of Sciences [+1]

原研机构

University of Salerno

在研适应症

阿尔茨海默症 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Compound 7e(University of Salerno)

靶点

EPHX2 x PGES

作用机制

EPHX2抑制剂 [+1]

在研机构

University of Salerno

原研机构

University of Salerno

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

项与 University of Salerno 相关的临床试验

NCT07273669

/ Active, not recruitingN/A

Advanced Robotic Beds for the Early Rehabilitation of Cardiac Surgery Patients

The goal of this clinical trial is to evaluate whether LOLE.K, a new and specialized robotic bed, is effective in the rehabilitation of patients who have undergone surgery. The primary objectives of the trial are:
* Efficacy of LOLE.K: Does the LOLE.K robotic bed improve early rehabilitation in patients who undergone cardiac surgery?
* Impact on recovery: Does LOLE.K influence wound healing, muscle and neurological recovery, and psychological well-being?
To address these questions, the researchers will compare the use of LOLE.K with standard physical therapy to determine whether the robotic bed results in better outcomes in post-operative rehabilitation.

开始日期2025-09-22

申办/合作机构

University of Salerno

NCT06909682

/ Not yet recruitingN/A

Smart Monitoring and Analysis System Based on Artificial Intelligence for Patients With Chronic Heart Failure Using Advanced Mini-Invasive and Wearable Medical Devices

The goal of this observational, multicenter study is to evaluate whether AI-driven remote monitoring using a mini-invasive wearable device can improve clinical outcomes in adult patients (≥18 years) with chronic heart failure (CHF).
The main questions it aims to answer are:
* Can continuous remote monitoring reduce hospital admissions (emergency visits and hospitalizations) by 20% compared to standard care?
* Does wearable-based remote monitoring improve functional, biochemical, and instrumental parameters in CHF patients? Researchers will compare patients using the wearable device (intervention group) to those receiving standard clinical follow-up (control group) to assess whether AI-driven monitoring leads to fewer hospitalizations, better disease management, and improved quality of life.
Participants will:
* Wear the EmbracePlus (Empatica Inc.) device continuously for six months (intervention group only).
* Have their biometric data (SpO₂, HRV, EDA, respiratory rate, temperature, sleep quality) monitored remotely.
* Receive automated alerts and teleconsultations if abnormal physiological changes are detected.
* Attend scheduled follow-up visits (remote and in-person) for clinical evaluation and treatment adjustments.
The study aims to provide real-world evidence on whether integrating wearable health technology with AI analytics can enhance CHF management and improve patient outcomes.

开始日期2025-08-01

申办/合作机构

University of Salerno

NCT07023536

/ Not yet recruitingN/A

Evaluation of the Effectiveness of a Cardiac Telerehabilitation Program in Chronic Heart Failure

The goal of this observational study is to evaluate whether a home-based cardiac tele-rehabilitation program can improve functional capacity in adults (18 years and older) with chronic heart failure. The main questions it aims to answer are:
Does tele-rehabilitation improve peak oxygen uptake (VO₂ max) compared to standard in-hospital rehabilitation? Does it improve cardiac function, exercise tolerance, biochemical markers, and quality of life? Are functional gains maintained at 24 weeks? Researchers will compare patients who opt for tele-rehabilitation using wearable devices and a remote monitoring platform with those undergoing standard in-person rehabilitation. Participants will follow an 8-week individualized training program and undergo assessments at baseline, 4, 8, 16, and 24 weeks.

开始日期2025-07-01

申办/合作机构

University of Salerno

100 项与 University of Salerno 相关的临床结果

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0 项与 University of Salerno 相关的专利（医药）

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9,479

项与 University of Salerno 相关的文献（医药）

2026-04-01·INTERNATIONAL JOURNAL OF CARDIOLOGY

Baseline clinical profile of patients with obstructive hypertrophic cardiomyopathy in the Italian Mavacamten early access program

Article

作者: Carigi, S ; Ricci, F ; Chimenti, C ; Leuzzi, C ; Graziani, F ; Del Franco, A ; Monte, I ; Limongelli, G ; Losi, M A ; Guaricci, A I ; Perugini, E ; Olivotto, I ; Bonacchi, G ; Di Spigno, F ; Boriani, G ; Murzilli, R ; Negri, F ; Di Marco, M ; Crotti, L ; Ruggieri, R ; Calabrò, P ; Calore, C ; Pontone, G ; Calò, L ; Pasqualucci, D ; Merlo, M ; Lofiego, C ; Patti, G ; Musumeci, M B ; Quarta, G ; Sinagra, G ; Scelsi, L ; Barocelli, F ; Evangelista, A ; Mabritto, B ; Marra, W Grosso ; Spoladore, R ; Cerrato, N ; Agostoni, P ; Galasso, G ; Todiere, G ; Agricola, E ; Guerra, F ; Biagini, E ; Bertero, E ; Piepoli, M F ; De Caterina, R ; Baratta, P ; Carluccio, E ; Marazia, S ; Pieroni, M ; Re, F ; Raineri, C ; Ammirati, E ; Chinaglia, A ; Saletti, E ; Santolamazza, C ; Moretti, M ; Chiriatti, C

BACKGROUND:

Obstructive hypertrophic cardiomyopathy (oHCM) has recently seen the introduction of mavacamten, a disease-specific therapy that alleviates obstruction and symptoms with potential effects on disease expression. Since most patients remain symptomatic with conventional therapies, mavacamten constitutes an efficacious treatment strategy METHODS: The early access program (EAP) for mavacamten treatment ran from September 2023 to September 2024. We collected clinical and echocardiographic data prospectively RESULTS: 337 patients with oHCM (53% male, mean age 61.4 ± 12.3 years) were receiving mavacamten treatment from 54 centers in Italy. The EAP cohort was older and showed a more advanced cardiac phenotype, showing lower left ventricular ejection fraction (LVEF) (66 ± 6% vs 74 ± 6% in EXPLORER-HCM cohort, p < 0.0001) and higher left atrial volume index (51.1 ± 16.4 ml/m² vs 40.5 ± 12.3 ml/m², p < 0.0001. Only 74 (22%) patients in the EAP group were candidates for septal reduction therapy (SRT). Echocardiographic parameters like LVEF, maximal wall thickness and LAVI as well as pharmacologic therapy showed no difference between subgroups, while LVOT obstruction gradient was higher in SRT candidates (40 vs 63 mmHg, p < 0.0001)..

CONCLUSION:

The compassionate use program for mavacamten in Italy demonstrated significant engagement. The Italian oHCM cohort were older and exhibited more advanced disease stages compared to those in the EXPLORER-HCM trial. Only one-quarter of the patients were eligible for SRT, they did not show a more severe biomarker or echocardiographic parameters compared to those without indication. Mavacamten provides an additional option for oHCM patients unresponsive to standard therapy, especially those symptomatic but ineligible for SRT.

2026-03-01·Veterinary and Animal Science

New frontiers in regenerative medicine: Protocol standardization and morphological assessment of leukocyte-platelet rich fibrin in cows, with a longitudinal study on growth factor release dynamics

Article

作者: Valle, Giovanni Della ; Fatone, Gerardo ; De Biase, Davide ; Ferrara, Gianmarco ; Ciaramella, Paolo ; Guccione, Jacopo ; Aragosa, Federica ; Caterino, Chiara ; Alterisio, Maria Chiara

Leukocyte-Platelets Rich Fibrin (L-PRF) is a platelet-derived autologous agent. It is a powerful wound-sealing biological scaffold that promotes the healing process through the release of growth factors (GFs) and matrix proteins. To date, the l-PRF in bovines has not yet been investigated and a standardized production protocol has not yet been described. Therefore, the aim of the study was to standardise the l-PRF production protocol and to evaluate macroscopically and histologically the l-PRF membranes obtained and observe the GFs release over time and lactation phases: at 1 h (T0), 4 h (T1), 24 h (T2), and 168 h (T3) after extraction. Eighty cows were divided into four groups of 20 animals, based on their lactation phase. A whole blood sample of 20 ml was taken and divided for l-PRF clot production and haemato-biochemical investigations. The membranes presented the following overall mean characteristics: a length of 34.4 ± 7.3 cm, a width of 12.5 ± 2.6 cm, and a weight of 4.9 ± 0.17 cm. Histological analysis showed a well-defined histoarchitecture consisting of a first layer of erythrocytes, a layer of leukocytes, erythrocytes, and platelets, a layer of leukocytes, a layer of platelets, and finally a layer of slightly eosinophilic fibrin. The GFs significantly increased with upward trends in all phases of lactation and at each time control, overlapping the behavior of GF in other species. Based on the encouraging findings of this study, further clinical trials for applicative potential of the l-PRF membrane in bovine medicine should be assessed.

2026-03-01·JSES international

Persistent scapular dyskinesis after arthroscopic rotator cuff repair: a prospective study

Article

作者: Familiari, Filippo ; Cofano, Erminia ; Galasso, Olimpio ; Mancuso, Claudia ; Imbrogno, Alessandro ; Paola, Lorena ; Mantovani, Matteo ; Mercurio, Michele ; Gasparini, Giorgio

Background:

The supraspinatus plays a critical role in stabilizing the glenohumeral joint and facilitating arm elevation. The biomechanical disruption caused by supraspinatus tears changes the normal force couple balance between the deltoid and rotator cuff muscles, often resulting in superior migration of the humeral head and altered scapulohumeral rhythm (SHR). This study aims to prospectively compare the shoulder kinematics of patients preoperatively and after arthroscopic rotator cuff repair using magnetic inertial measurement units with a motion analysis system.

Methods:

A prospective study was conducted with data collection on 21 patients who underwent shoulder arthroscopy for rotator cuff tear repair. Preoperatively and at a minimum 12-month follow-up, each patient was evaluated using the range of motion (ROM) assessment and the Constant-Murley Score (CMS). Patients were examined using the ShowMotion 3D kinematic tracking system (NCS Lab, Modena, Italy), which uses wireless wearable noninvasive magnetic and inertial measurement units sensors to assess the three-dimensional kinematics of the shoulder. For each plane of elevation (ie, flexion and abduction), the SHR was described by 3 scapulothoracic rotations (ie, protraction-retraction, mediolateral rotation, and posterior-anterior tilting) as a function of humeral anteflexion or humeral abduction.

Results:

Active flexion and external rotation ROM showed statistically significant improvement (P = .039 and P = .006, respectively). CMS pain, strength, and total showed statistically significant improvement (P = .039 and P = .006, respectively). All the patients showed a nonstatistically significant difference of the SHR along the entire ROM between pre- and postoperative evaluation. The P value in flexion and abduction was >.05; the only statistically significant value was on tilt at 60° in flexion (P = .044).

Conclusion:

A persistent scapular dyskinesis was observed after arthroscopic rotator cuff repair. Despite a statistically significant improvement reported for active flexion, active external rotation, and for the total CMS, scapular dyskinesis is not resolved with surgery and may contribute to worse long-term outcomes. Further biomechanical and clinical research studies are needed to define specific rehabilitation programs, to maximize outcomes, and to prevent possible cause of reinjury of the rotator cuff repaired.

项与 University of Salerno 相关的新闻（医药）

2023-03-20

·Science Daily

Sculpting quantum materials for the electronics of the future

The development of new information and communication technologies poses new challenges to scientists and industry. Designing new quantum materials -- whose exceptional properties stem from quantum physics -- is the most promising way to meet these challenges. An international team has designed a material in which the dynamics of electrons can be controlled by curving the fabric of space in which they evolve. These properties are of interest for next-generation electronic devices, including the optoelectronics of the future. The development of new information and communication technologies poses new challenges to scientists and industry. Designing new quantum materials -- whose exceptional properties stem from quantum physics -- is the most promising way to meet these challenges. An international team led by the University of Geneva (UNIGE) and including researchers from the universities of Salerno, Utrecht and Delft, has designed a material in which the dynamics of electrons can be controlled by curving the fabric of space in which they evolve. These properties are of interest for next-generation electronic devices, including the optoelectronics of the future. These results can be found in the journal Nature Materials. The telecommunications of the future will require new, extremely powerful electronic devices. These must be capable of processing electromagnetic signals at unprecedented speeds, in the picosecond range, i.e. one thousandth of a billionth of a second. This is unthinkable with current semiconductor materials, such as silicon, which is widely used in the electronic components of our telephones, computers and game consoles. To achieve this, scientists and industry are focusing on the design of new quantum materials. Thanks to their unique properties -- especially the collective reactions of the electrons that compose them -- these quantum materials could be used to capture, manipulate and transmit information-carrying signals (for example photons, in the case of quantum telecommunications) within new electronic devices. Moreover, they can operate in electromagnetic frequency ranges that have not yet been explored and would thus open the way to very high-speed communication systems. A warp drive ''One of the most fascinating properties of quantum matter is that electrons can evolve in a curved space. The force fields, due to this distortion of the space inhabited by the electrons, generate dynamics totally absent in conventional materials. This is an outstanding application of the principle of quantum superposition,'' explains Andrea Caviglia, full professor at the Department of Quantum Matter Physics in the Faculty of Science of the UNIGE and last author of the study. After an initial theoretical study, the international team of researchers from the Universities of Geneva, Salerno, Utrecht and Delft designed a material in which the curvature of the space fabric is controllable. ''We have designed an interface hosting an extremely thin layer of free electrons. It is sandwiched between strontium titanate and lanthanum aluminate, which are two insulating oxides,'' says Carmine Ortix, professor at the University of Salerno and coordinator of the theoretical study. This combination allows us to obtain particular electronic geometrical configurations which can be controlled on-demand. One atom at a time To achieve this, the research team used an advanced system for fabricating materials on an atomic scale. Using laser pulses, each layer of atoms was stacked one after another. ''This method allowed us to create special combinations of atoms in space that affect the behavior of the material,'' the researchers detail. While the prospect of technological use is still far off, this new material opens up new avenues in the exploration of very high-speed electromagnetic signal manipulation. These results can also be used to develop new sensors. The next step for the research team will be to further observe how this material reacts to high electromagnetic frequencies to determine more precisely its potential applications.

2023-02-05

·生物探索

百岁老人携带的抗衰老基因可使心脏年龄倒退10岁！

虽然目前长生不老仍然只是镜花水月的传说，但健康长寿却是大部分人看上去可以企及的目标。而过去人口统计的工作发现，有些区域寿命超过100岁的人口比例较高，这些区域被命名为“蓝色地带”（Blue Zone），目前，意大利撒丁岛、日本冲绳、哥斯达黎加尼科亚半岛、希腊伊卡利亚岛和美国加利福尼亚州洛马琳达被确定为蓝色地带。不过，百岁老人之所以长寿的秘密依然尚未揭开。生活方式、基因遗传、环境因素均是可能的答案，但又无法解释全部。比如2011年发表于journal of the american geriatrics society上的一项研究，以近500名95岁或以上的德系犹太人为研究对象，结果发现，这群长寿者存在大量的不良生活习惯。他们中60%的人大量吸烟，一半的人终生肥胖或超重，饮酒的比例更高，而运动习惯甚至不如对照组。英国老年研究权威专家、布莱顿大学生物老年学教授Richard Farager更是表示：“我们需要告诉对长寿感兴趣的人的第一件事，就是不要向百岁老人或超级百岁老人寻求有关生活秘诀的建议。”图1 百岁老人的生活方式无法解释长寿（图源：[1]）2020年另一项关注德系犹太百岁老人的的研究则表明，百岁老人身上携带的可能导致晚年疾病的基因变异和普通人群一样多，有人甚至携带了两种常见的阿尔茨海默病危险基因而仍没有患病。图2 长寿者与普通人群携带的致病基因变异负担相似（图源：[2]）因此，一个合理的解释是，这些长寿者并非缺少不良基因变异，而是携带着有益的“长寿基因”。这些基因能够帮助长寿者降低心血管疾病、阿尔兹海默病和其他疾病的风险。此外，研究还发现，这些超级长寿者在晚年比其他人更加健康。纽约阿尔伯特爱因斯坦医学院衰老研究所所长Nir Barzilai博士在其2020年发表的新书“Age Later: Health Span, Life Span, and the New Science of Longevity”中表示，他所研究的百岁老人，在生命的尽头会迅速地走向死亡，最后的五到八年都没有疾病发生，而疾病最终真的来临时，只会持续几个星期。Barzilai称之为“巨大的长寿红利”。如果能将超级长寿者的长寿因素复刻到普通人身上，将对“健康老龄化”具有重大意义。图3 《Age Later: Health Span, Life Span, and the New Science of Longevity》（图源：[4]）保护心血管健康的长寿相关突变LAV-BPIFB4 此前，意大利萨勒诺大学的研究人员通过一系列研究发现，一种名为LAV-BPIFB4的长寿相关突变较多地存在于意大利南部百岁老人中。BPIFB4是一种分泌蛋白，其在长寿个体的血清中水平升高。该突变可通过改善NO释放和血管生成改善心血管健康。使用LAV-BPIFB4对缺陷小鼠进行全身基因治疗的结果表明能够挽救老年小鼠的内皮和一氧化氮合酶功能障碍，减少小鼠动脉粥样硬化和炎症，证实了该基因有望成为一种对抗心血管疾病的新治疗工具。不仅如此，萨勒诺大学的研究团队还发现LAV-BPIFB4的基因治疗能在亨廷顿舞蹈病小鼠模型中预防疾病进展，在免疫系统衰退的晚期衰老小鼠模型中能够减少免疫衰老细胞的积累、扭转衰老过程中NAD+水平下降的趋势。LAV-BPIFB4的基因治疗还显著延迟了老年小鼠对应激事件的脆弱性的进展。种种迹象都表明LAV-BPIFB4对于长寿确实是一个重要的突变。近日，英国布里斯托大学和意大利MultiMedica Group的研究团队发表的一项最新研究证明，LAV-BPIFB4可以保护从那些需要心脏移植的心力衰竭患者身上所采集得的细胞。该研究以“The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy”为题发表于Cardiovascular Research。图4 研究成果（图源：[5]）研究团队发现，单次施用LAV-BPIFB4可以阻止中年小鼠心脏功能的衰退。更值得注意的是，当将这种基因用于老年小鼠时，其心脏表现出与在老年患者身上观察到的相同变化，该基因使心脏的生物钟年龄倒退了相当于人类十多年的时间。这项为期三年的研究也在针对试管中的人类心脏细胞展开。MultiMedica Group的研究人员对患有严重心脏问题的老年患者的心脏细胞进行基因管理，然后将其功能与健康人进行比较。研究的第一作者、MultiMedica Group 的研究员Monica Cattaneo表示：“老年患者的细胞，尤其是那些被称之为‘周细胞’（pericytes）的心血管构建支持细胞，功能出现受损。通过在试管中添加长寿基因/蛋白质，我们观察到心脏回春的过程：老年心力衰竭患者的心脏细胞恢复了正常功能，可以更高效地构建新血管。”该研究首次表明，长寿基因不仅可以由百岁老人遗传给他们的后代，也可以转移到无关的人身上保护心脏。研究的通讯作者Paolo Madeddu和Annibale Puca教授认为，这项研究有望推动百岁老人遗传学所启发的疗法的进展。Madeddu教授补充道：“我们的发现证实，健康的突变基因可以逆转老年人心脏功能的下降。我们现在感兴趣的是是否能使用蛋白质代替基因起到相同作用。目前基因治疗广泛用于治疗由坏基因引起的疾病，但基于蛋白质的治疗比基因治疗安全度、可行性都更高。”责编|风立宵校对|乔维钧End参考资料：[1]Rajpathak SN, Liu Y, Ben-David O, et al. Lifestyle factors of people with exceptional longevity. J Am Geriatr Soc. 2011 Aug;59(8):1509-12. doi: 10.1111/j.1532-5415.2011.03498.x.[2]Gutman D, Lidzbarsky G, Milman S, et al. Similar burden of pathogenic coding variants in exceptionally long-lived individuals and individuals without exceptional longevity. Aging Cell. 2020 Oct;19(10):e13216. doi: 10.1111/acel.13216.[3]https://theconversation.com/why-its-still-a-scientific-mystery-how-some-can-live-past-100-and-how-to-crack-it-172020[4]https://www.timesofisrael.com/only-as-old-as-your-genes-ashkenazi-super-agers-could-hold-key-to-long-life/[5]Monica Cattaneo, Antonio P Beltrami, Anita C Thomas, et al, The longevity-associated BPIFB4 gene supports cardiac function and vascularization in aging cardiomyopathy, Cardiovascular Research, 2023; cvad008, https://doi.org/10.1093/cvr/cvad008 [6]https://www.bristol.ac.uk/news/2023/january/anti-aginggene.html 本文系生物探索原创，欢迎个人转发分享。其他任何媒体、网站如需转载，须在正文前注明来源生物探索。往期精选围观人为什么活的累？Nature解密“卷王”根源：人类总是选择做加法解决问题热文为什么英美医生给新冠患者开Paxlovid的处方率这么低？热文负面情绪催人老！研究发现：有效管理情绪可预防病理性衰老热文面包还是爱情？饥饿雄性果蝇进食优先于求爱，Nature发现“饱暖思淫欲”根源热文爱的荷尔蒙：把大狮子变成小猫咪，总共分几步？点击“阅读原文”，了解更多~

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