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最高研发阶段临床前 |
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A Scalable, Chromatography-Free Synthesis of the Potent and Highly Selective ERβ Agonist EGX358
作者: Chaudhury, Subhabrata ; Wetzel, Edward A. ; Donaldson, William A. ; Thennakoon, Dulanjali
Abstract4-[trans-4-(Hydroxymethyl)cyclohexyl]phenol (EGX358) is a potent and highly selective estrogen receptor beta (ERβ) agonist which has demonstrated efficacy for moderation of a chemically induced hot flash and for memory consolidation in an ovariectomized mouse model for menopause. An improved synthetic route to EGX358 is reported which proceeds in four steps and which is chromatography-free.
100 项与 ESTRIGENIX THERAPEUTICS, INC. 相关的药物交易
100 项与 ESTRIGENIX THERAPEUTICS, INC. 相关的转化医学