Objective: To establish an inductively coupled plasma mass spectrometry(ICP-MS) method with direct injection technique to detect 11 element impurities(Li, V, Fe, Co, Ni, Cu, As, Cd, Sb, Hg, Pb) in sodium potassium magnesium calcium and glucose injection for children. Methods: ICP-MS was used for determination with He mode. The plasma mode was HMI-8, a halophilic sampling system. The sampling depth was 10.0 mm. The power of radio frequency was 1600 W. The nebulizer gas flow was 0.67 L·min∼(-1). The dilution gas flow was 0.26 L·min∼(-1). The auxiliary gas flow was 0.9 L·min∼(-1) and the plasma gas flow was 15.0 L·min∼(-1). The speed of nebulizer pump was 0.10 rps and the temperature of atomizer chamber was 2.0 °C. Results: Regression coefficients of the standard curve of the 11 elements impurities were all more than 0.999 0. The limit of detection and quantitation were all less than 10% of the limit concentration The recovery rate was within the range of 83.42% - 111.62%. The RSD of repeatability and intermediate precision was less than or equal to 4.46% and 5.19% resp. The contents of 11 element impurities in 3 batches of samples all met the limit requirements. Conclusion: The established method in our study was highly sensitive and had little groundmass interference with direct injection technique, which were suitable for the control of element impurities in sodium potassium magnesium calcium and glucose injection for children.