Research on the Scientific Connotation of Cancer Toxin Pathogenesis Based on the Interaction Between Flora and Tumor-Establishment of Cohort Under the Guidance of the Pathogenesis of Cancer Toxin in Traditional Chinese Medicine

The study aims to investigate the potential mechanisms by which the interaction between the microbiota and tumors leads to the occurrence and development of cancer by collecting clinical information and biological samples from healthy individuals and cancer patients.

开始日期2024-09-22

申办/合作机构

中国中医科学院广安门医院

[+5]

NCT06470477 / Not yet recruitingN/AIIT

Molecular Characteristics of Phlegm-heat Syndrome in Ischemic Stroke: A Cohort Study

The molecular characteristics of ischemic stroke with phlegm-heat syndrome and candidate biomarkers were identified based on multi-omics data. The main purpose of this study is to validate the molecular characteristics and biomarkers of phlegm-heat syndrome in ischemic stroke, and to demonstrate the association of biomarkers with clinical outcomes.

开始日期2024-06-20

申办/合作机构

Dongzhimen Hospital

NCT06089395 / Not yet recruiting早期临床1期IIT

A Randomized and Double-blind Clinical Trial of Jiajian Guishen Granules on the Modulation of Ovarian Function in Patients With Poor Ovarian Response

Relying on the Department of Gynecology of Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine and chaoyang hospital of Capital medical university, this randomized controlled clinical study was carried out to investigate the application of kidney tonifying herbs to patients with poor ovarian response（POR）.
A total of 76 patients with POR were collected and stratified district groups were randomly divided into a test group and a control group, with 38 patients included in each group. The experimental group was intervented with JJGS granules + coenzyme Q10 simulant, and the control group was intervened with coenzyme Q10 + JJGS granules simulant. AMH, serum basal sex hormone, AFC, TCM syndrome score, modified Kupperman scale and pregnancy status were observed before and after treatment to investigate the effects of Jiajian Guishen granules on the ovarian function of POR patients.

开始日期2024-06-01

申办/合作机构

Dongzhimen Hospital

[+1]

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项与 Dongzhimen Hospital 相关的文献（医药）

2024-09-01·Cancer Gene Therapy

Understanding, diagnosing, and treating pancreatic cancer from the perspective of telomeres and telomerase

Review

作者: Pang, Bo ; Yi, Li ; Zhang, Xiyuan ; Liu, Fudong ; Chen, Jiaqin ; Li, Yuanliang ; Jiang, Xiaochen ; Shou, Songting ; Geer, En ; Pu, Zhenqing ; Zhang, Chuanlong ; Zhang, Xing

AbstractTelomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while in precancerous lesions of cancer, telomeres in cells are usually significantly shortened. At this time, telomerase is still in an inactive state, and it is not until before and after the onset of cancer that telomerase is reactivated, causing cancer cells to proliferate. Methylation of the telomerase reverse transcriptase (TERT) promoter and regulation of telomerase by lactate dehydrogenase B (LDHB) is the mechanism of telomerase reactivation in pancreatic cancer. Understanding the role of telomeres and telomerase in pancreatic cancer will help to diagnose and initiate targeted therapy as early as possible. This article reviews the role of telomeres and telomerase as biomarkers in the development of pancreatic cancer and the progress of research on telomeres and telomerase as targets for therapeutic intervention.

2024-09-01·Heliyon

Extracellular vesicles for the treatment of ulcerative colitis: A systematic review and meta-analysis of animal studies

Article

作者: Chen, Meng ; Zhang, Dong-Mei ; Yu, Ze-Yu ; Zhang, Di ; Li, Yu-Jing ; Zhang, Fu-Rong

BackgroundExtracellular vesicles (EVs) are being considered as a potential therapeutic option for ulcerative colitis (UC), and numerous preclinical studies have been conducted on the use of EVs for UC.MethodsA systematic review was conducted to compare the therapeutic effects of mammalian EVs and placebo on UC in animal models, along with a meta-analysis comparing naïve (unmodified) EVs and placebo. The search was performed in four databases (PubMed, Web of Science, Scopus, and EMBASE) up to September 13th, 2023. The primary outcomes included disease activity index (DAI), colonic mucosal damage index (CMDI), and adverse effects (PROSPERO ID: CRD42023458039).ResultsA total of 69 studies were included based on pre-determined criteria, involving 1271 animals. Of these studies, 51 measured DAI scores, with 98 % reporting that EVs could reduce DAI scores. Additionally, 5 studies reported CMDI and all showed that EVs could significantly reduce CMDI. However, only 3 studies assessed adverse effects and none reported any significant adverse effects. The meta-analysis of these studies (40 studies involving 1065 animals) revealed that naïve EVs could significantly decrease the DAI score (SMD = -3.00; 95 % CI: -3.52 to -2.48) and CMDI (SMD = -2.10; 95 % CI: -2.85 to -1.35).ConclusionThe results indicate that mammalian EVs have demonstrated therapeutic benefits in animal models of UC; however, the safety profile of EVs remains inadequate which highlights the need for further research on safety outcomes.

2024-08-13·Sexual Medicine

Association of serum uric acid with male sexual hormones and erectile dysfunction: a bidirectional 2-sample Mendelian randomization analysis

Article

作者: Feng, Jun-Long ; Feng, Wei-Dong ; Gao, Zi-Xiang ; Chen, Hui ; Wang, Bin ; Zhao, Cong

AbstractBackgroundObservational studies indicated that serum uric acid (SUA) was associated with male sexual hormones and erectile dysfunction (ED). However, their relationship was still heterogeneous.AimThis study conducted 2-sample univariate mendelian randomization (UVMR) and multivariate mendelian randomization (MVMR) to explore the causal relationship between SUA and sexual hormones as well as ED.MethodsGenetic variants associated with SUA were derived from the UK Biobank database (N = 437 354). Outcomes from the IEU Open GWAS and summary data sets were sexual hormones (sex hormone–binding globulin [SHBG], testosterone, estradiol [E2], follicle-stimulating hormone, luteinizing hormone) and ED, with 3301 to 625 650 participants. UVMR analysis primarily utilized the inverse variance weighted method, complemented by MVMR analysis. Thorough sensitivity analyses were carried out to ensure the reliability of results. Moreover, mediation analysis was conducted to estimate the mediated effect between SUA and outcomes.OutcomesThe primary outcomes included results of UVMR and MVMR analysis and mediation analysis, along with sensitivity analyses involving the Cochran Q test, the MR Egger intercept test, leave-1-out analysis, and the MR-PRESSO method (mendelian randomization pleiotropy residual sum and outlier).ResultsUVMR analysis revealed that an elevated SUA level could decrease levels of SHBG (β = –0.10, P = 1.70 × 10–7) and testosterone (β = –0.10, P = 5.94 × 10–3) and had a positive causal effect on ED (odds ratio, 1.10; P = .018). According to reverse mendelian randomization results, increased levels of SHBG (β = –0.06, P = 4.82 × 10–4) and E2 (β = –0.04, P = .037) could also reduce SUA levels. As shown by MVMR analysis, SUA had a negative effect on SHBG and testosterone levels (P < .05), while the significant causal relationship between SUA and ED disappeared. Furthermore, SHBG mediated 98.1% of the effect of SUA on testosterone levels. Results of other mendelian randomization analyses were not statistically significant. No pleiotropy was found by sensitivity analysis in this study.Clinical ImplicationsGiven the causal relationship between SUA and sexual hormones, we must focus on SUA and E2 levels in men, especially patients with hypogonadism and ED.Strengths and LimitationsThis study evaluated the causal effect of SUA on male sexual hormones and ED genetically for the first time, clarifying the common biases in observational studies and confirming the negative relationship between SUA and testosterone level. Limitations include a population based on European ancestry, some crossover of the samples, and unobserved confounding factors.ConclusionGenetic studies provide evidence for the causal relationship between SUA and male sexual hormones (SHBG, testosterone, E2), while the relationship between SUA and ED should be further evaluated.

项与 Dongzhimen Hospital 相关的新闻（医药）

2023-06-19

·PRNewswire

An Integration of Traditional Chinese Medicine and Modern Medicine Realized by Dongzhimen Hospital of Beijing University of Chinese Medicine

BEIJING, June 19, 2023 /PRNewswire/ -- A news report by haiwainet.cn: Beijing College of Traditional Chinese Medicine (now Beijing University of Traditional Chinese Medicine) and Dongzhimen Hospital, one of its affiliates, cooperated with The Staudinger Company Group in establishing the TCM-Klinik Bad Kötzting, the first licensed TCM hospital in Germany. In terms of patient diagnosis and treatment, the hospital always gives priority to curative effects, and treats patients under the guidance of TCM theories and concepts, showcasing the features and advantages of TCM with successful practices. When it comes to TCM publicity, the hospital has hosted various activities that attracted people in the local area and from neighboring countries, as well as wide coverage by foreign media. In this way, the hospital contributed to the dissemination of TCM overseas. In 2008, the hospital was bestowed with the the 2008 International Award for Contribution to Chinese Medicine, the highest award in the field of international TCM cooperation, by the World Federation of Chinese Medicine Societies (WFCMS). This honor highlighted the great contribution made by the hospital to TCM publicity and education. Promoting the integration of TCM and Modern Medicine Adhering to the concepts of offering patient-centered therapies and combining prevention and treatment, the hospital is committed to safeguarding the health of patients with "the essence in the two schools of medicine", and conducing to the integration of TCM medicine and modern medicine. With regard to exchanges between TCM and Western medicine, the hospital has carried out in-depth discussions with medical institutions worldwide, and co-founded the China-Europe TCM Cooperation and Development Forum with the WFCMS. All these efforts have injected vitality into TCM in its process to become modern and go global. In terms of scientific research on TCM, the hospital has published a total of 156 articles and monographs, and formulated or compiled many standards and other relevant materials, in order to promote standardization in TCM education and research. This also facilitates the integration of TCM and modern medicine. By unremittingly exploring how to integrate TCM and modern medicine and delving deeply into research on TCM, the hospital has emerged as a pioneer in terms of introducing TCM to the world, a bridge for the communication between Chinese and Western cultures, and a contributor to the implementation of the Belt and Road Initiative. SOURCE haiwainet.cn

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