Tremeau Pharmaceuticals, Inc.

Dr. Corrigan brings over three decades of life sciences leadership experience to Silver Creek. SAN FRANCISCO, Feb. 12, 2024 /PRNewswire/ -- Silver Creek Pharmaceuticals, a clinical-stage biotechnology company focused on the selective targeting of naturally-occurring growth factors to promote cell survival and growth, has appointed Mark Corrigan, MD, as President. Continue Reading (PRNewsfoto/SILVER CREEK PHARMACEUTICALS) "We are pleased to welcome Dr. Corrigan to lead Silver Creek through its next phase of growth," said Tim Throsby, Silver Creek's Chairman of the Board. "We are confident that Mark's deep experience in drug development and life sciences leadership will enable the company to continue to advance scp776 and our Smart Growth Factor™ platform, bringing us one step closer to achieving our mission of changing lives by rescuing cells from injury." "The elegance and innovation behind Silver Creek's Smart Growth Factor™ platform is very compelling, and the pre-clinical data around scp776 is equally impressive. I am excited to join the team at a time when the ARPEGGIO study is gaining momentum, and to help guide the organization through this much-anticipated data read-out," said Dr. Corrigan. Dr. Corrigan is an industry veteran with over three decades of life sciences leadership and drug development experience. Dr. Corrigan most recently served as CEO of Tremeau Pharmaceuticals, a non-opioid pain company that he co-founded. Dr. Corrigan previously served as CEO of Correvio Pharma Corp, leading their acquisition by Advanz Pharma in 2021. Prior to that, he served as Executive Vice President, Research and Development, at Sepracor. Prior to joining Sepracor, Dr. Corrigan spent 10 years with Pharmacia & Upjohn, culminating as Vice President of Global Clinical Research and Experimental Medicine. Dr. Corrigan serves as Chairman of the Board of Elios Therapeutics and as a member of the Board of Wave Life Sciences and Trevena Pharmaceuticals. Dr. Corrigan previously served on the Board of Cubist prior to its acquisition by Merck and on the Board of Avanir prior to its acquisition by Otsuka. Dr. Corrigan holds a B.A. and M.D. from the University of Virginia and received specialty training in psychiatry at Maine Medical Center and Cornell University. About scp776 Scp776 is Silver Creek's lead investigational therapy. Scp776 is a first-in-class, targeted fusion protein that harnesses the cell survival function of insulin-like growth factor 1 (IGF-1). Scp776 is currently being evaluated in ARPEGGIO, a Phase II study for the treatment of acute ischemic stroke (NCT05585606). About ARPEGGIO ARPEGGIO (NCT05585606) is a randomized, placebo-controlled Phase II study evaluating the safety and neuroprotective capacity of scp776 in subjects undergoing endovascular thrombectomy for acute ischemic stroke. ARPEGGIO is actively enrolling subjects at multiple centers across the United States. For more information, please visit . About Silver Creek Pharmaceuticals Silver Creek is a clinical-stage biotechnology company headquartered in San Francisco, CA. Silver Creek's Smart Growth Factor™ technology enables the rapid development of targeted therapeutics with broad scope and applicability. Our lead asset, scp776, is a first-in-class, targeted fusion protein that harnesses the cell survival function of IGF-1. For more information about Silver Creek, please visit . Media Contact: Corey MacGregor VP, New Products Planning Silver Creek Pharmaceuticals [email protected] SOURCE Silver Creek Pharmaceuticals, Inc.

CHESTERBROOK, Pa. , July 20, 2023 (GLOBE NEWSWIRE) -- Trevena, Inc. (Nasdaq: TRVN), a biopharmaceutical company focused on the development and commercialization of novel medicines for patients with central nervous system (CNS) disorders, today announced that Mark Corrigan, M.D. has been appointed to the Company’s Board of Directors, effective July 18 2023. “We are pleased to welcome Mark to Trevena’s Board of Directors,” said Carrie Bourdow, Trevena’s President and CEO. “Mark has over 30 years of experience in the life sciences industry and broad neuroscience expertise. He will be an invaluable member of the Board and guide to the management team as we continue to execute on our corporate strategy and advance our novel S1P receptor modulator, TRV045, for the potential treatment of epilepsy and chronic pain.” “This is a very exciting time for Trevena, a company with the proven ability to take a novel product from initial discovery through development, approval and launch,” said Dr. Corrigan. “Trevena has an innovative pipeline of wholly owned CNS assets, and I am particularly excited about the many near-term milestones, including data readouts from the two proof-of-concept studies for TRV045.” Dr. Corrigan is a highly successful pharmaceutical executive with more than 30 years of industry experience. Dr. Corrigan has served as Chief Executive Officer of Tremeau Pharmaceuticals, a pharmaceutical company that Dr. Corrigan co-founded, since January 2023. Dr. Corrigan has also served on the Board of Directors of Tremeau since April 2017. Prior to his appointment as CEO of Tremeau, Dr. Corrigan served as Chief Executive Officer of Correvio Pharma Corp, a specialty pharmaceutical company, and prior to that as President of Research & Development of Tremeau. Dr. Corrigan serves as Chairman of the Board of Directors of Elios Therapeutics and as a member of the Board of Directors of Nabriva Therapeutics and Wave Life Sciences. In addition, Dr. Corrigan is currently a visiting professor in the Department of Psychiatry at Brigham and Women’s Hospital in Boston, MA. Dr. Corrigan previously served on the Board of Directors of Cubist Pharmaceuticals, a hospital acute care focused company, prior to its approximately $9.5 billion acquisition by Merck. He also served as a member of the Board of Directors and Chair of the Scientific Advisory Committee of Avanir Pharmaceuticals, a CNS focused company, prior to its approximately $3.5 billion acquisition by Otsuka Pharmaceutical. Dr. Corrigan holds a B.A. and M.D. from the University of Virginia and received specialty training in psychiatry at Maine Medical Center and Cornell University. About Trevena Trevena, Inc. is a biopharmaceutical company focused on the development and commercialization of innovative medicines for patients with CNS disorders. The Company has one approved product in the United States, OLINVYK® (oliceridine) injection, indicated in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate. The Company’s novel pipeline is based on Nobel Prize winning research and includes three differentiated investigational drug candidates: TRV045 for diabetic neuropathic pain and epilepsy, TRV250 for the acute treatment of migraine and TRV734 for maintenance treatment of opioid use disorder. For more information, please visit www.Trevena.com About TRV045 TRV045 is a novel, selective sphingosine-1-phosphate subtype 1 (S1P1) receptor modulator being developed as a potential treatment for acute and chronic neuropathic pain secondary to diabetic peripheral neuropathy. Through a collaboration with the National Institutes of Health, Trevena is also exploring TRV045 as a potential treatment for epilepsy. S1P receptors are located throughout the body, including the central nervous system, where they are believed to play a role in modulating neurotransmission and membrane excitability. Trevena's discovery efforts have identified a family of compounds that are highly selective for the S1P1 receptor. TRV045 reversed thermal hyperalgesia, a measure of neuropathic pain, in nonclinical models of diabetic peripheral neuropathy and chemotherapy-induced peripheral neuropathy. TRV045 was not associated with lymphopenia and produced no changes in blood pressure, heart rate, or respiratory function at or above pharmacologically active doses in nonclinical studies. TRV045 is an investigational product and is not yet approved by the FDA. Forward-Looking Statements Any statements in this press release about future expectations, plans and prospects for the Company, including statements about the Company’s strategy, future operations, clinical development and trials of its therapeutic candidates and approved product, plans for potential future product candidates and other statements containing the words “anticipate,” “believe,” “estimate,” “expect,” “intend,” “may,” “plan,” “predict,” “project,” “suggest,” “target,” “potential,” “will,” “would,” “could,” “should,” “continue,” and similar expressions, constitute forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the status, timing, costs, results and interpretation of the Company’s clinical trials or any future trials of any of the Company’s investigational drug candidates; the uncertainties inherent in conducting clinical trials; expectations for regulatory interactions, submissions and approvals, including the Company’s assessment of discussions with FDA; available funding; uncertainties related to the Company’s intellectual property; uncertainties related to the ongoing COVID-19 pandemic, other matters that could affect the availability or commercial potential of the Company’s therapeutic candidates and approved product; and other factors discussed in the Risk Factors set forth in the Company’s Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in other filings the Company makes with the SEC from time to time. In addition, the forward-looking statements included in this press release represent the Company’s views only as of the date hereof. The Company anticipates that subsequent events and developments may cause the Company’s views to change. However, while the Company may elect to update these forward-looking statements at some point in the future, it specifically disclaims any obligation to do so, except as may be required by law. For more information, please contact: Investor Contact: Dan FerryManaging DirectorLifeSci Advisors, LLCdaniel@lifesciadvisors.com(617) 430-7576 Company Contact: Bob YoderSVP and Chief Business OfficerTrevena, Inc.(610) 354-8840

Tremeau is presenting two abstracts, highlighting the following: TRM-201 achieves comparable exposures of rofecoxib at a lower nominal dose (17.5 mg) compared to historical VIOXX 25 mg Rofecoxib’s favorable gastrointestinal tolerability pro chronic off-label use of VIOXX’s acute dose (50 mg), leading to a perception of a unique CV safety risk CONCORD, Mass.--(BUSINESS WIRE)--Tremeau Pharmaceuticals will present two abstracts highlighting a potential path forward for rofecoxib, the active ingredient in VIOXX, as a non-opioid treatment option during the American College of Rheumatology’s (ACR) Convergence Meeting in Philadelphia. The Massachusetts-based pharmaceutical company is focused on developing non-opioid pain treatments for patients with significant unmet needs. “Many people living with pain cannot take traditional non-steroidal anti-inflammatory drugs (NSAIDs) due to their increased risk of bleeding and gastrointestinal ulcers,” said Tremeau Chief Development Officer Judith Boice. “These patients are often left with the inadequate options of living with pain, or resorting to opioids for pain relief.” “Tremeau is developing TRM-201 (rofecoxib), a COX-2 selective NSAID, as a potential treatment option for people living with pain whose needs are not satisfied by traditional NSAIDs,” Dr. Boice added. “These posters highlight the work that Tremeau has done to establish a scientific bridge between TRM-201 and historical VIOXX, and why, at the right dose, rofecoxib carries no unique risk and several unique benefits compared to traditional NSAIDs.” Both Tremeau abstracts include a virtual poster presentation: Virtual Poster Presentations Title: Establishing a Scientific Bridge to Historic VIOXX to Enable a Reintroduction of Rofecoxib: Pharmacokinetic Evaluation of TRM 201 (Rofecoxib) Session: Sunday, Nov. 13, 9-10:30 a.m. Summary of findings: TRM-201 achieves comparable exposure at a lower nominal dose (17.5 mg) compared to the historic data for 25 mg of the previously marketed rofecoxib (VIOXX), with a shorter Tmax. These data suggest that TRM-201 has a higher bioavailability and is more rapidly absorbed than VIOXX. Title: Diagnosing the Cardiovascular Risk of VIOXX: A Place for Rofecoxib in Pain Management Session: Monday, Nov. 14, 1-3 p.m. Summary of findings: A combination of dose, clinical profile, and commercialization choices created a perception of a unique CV safety issue for VIOXX. Given its unique profile, rofecoxib ≤25 mg/day may be a viable treatment option in patient populations for whom traditional NSAIDs are avoided and where opioids are frequently used. Both abstracts were published in an online supplement of Arthritis and Rheumatology. About TRM-201 (Rofecoxib) TRM-201 is an investigational non-opioid pain treatment containing rofecoxib. Previously marketed as VIOXX, rofecoxib was shown to be a highly potent cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug, or NSAID, with a well-established efficacy pro multiple indications. Rofecoxib has been shown to have greater blood-brain barrier penetration than any COX-2 selective NSAID currently available in the U.S. Rofecoxib was shown to have no effect on bleeding time and was the only COX-2 selective NSAID ever approved in the U.S. to demonstrate a reduced risk of gastrointestinal bleeding versus a traditional NSAID in a controlled trial. VIOXX was voluntarily withdrawn from the market in 2004 due to concerns about cardiovascular safety. It has since been demonstrated in multiple, often industry-independent studies that cardiovascular safety is a dose- and duration-dependent risk of all NSAIDs. Tremeau has gained agreement with FDA that it has established a comparable level of rofecoxib exposure for TRM-201 compared with the previously marketed version of VIOXX. About Tremeau Pharmaceuticals Tremeau is a Massachusetts-based pharmaceutical company focused on providing non-opioid pain treatments for patients with significant unmet needs. Tremeau’s unique approach to acute and chronic pain in select conditions is rooted in the mechanism of action, documented efficacy, and clinically differentiated pro COX-2 selective NSAIDs. Tremeau’s lead clinical stage product, TRM-201 (rofecoxib), is a COX-2 selective NSAID and a potent non-opioid analgesic with a well-established benefit-risk profile. VIOXX is a registered trademark of Tremeau Pharmaceuticals, Inc.