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主要目的：确定 SLS-005 0.75 g/kg 治疗成人脊髓小脑性共济失调 3 型 (SCA3) 的疗效次要目的：确定 SLS-005 治疗成人脊髓小脑共济失调 3 型 (SCA3) 的安全性和耐受性探索性目的：评估 0.5 g/kg 的 SLS-005 治疗成人脊髓小脑性共济失调 3 型 (SCA3) 的疗效确定 SLS-005 在 SCA 成人中的 PK 确定 SLS-005 治疗对与 SCA 成人神经轴突损伤相关的血液生物标志物的影响

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申办/合作机构

赛纽仕医药信息咨询（北京）有限公司

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CTR20243672 / Not yet recruitingN/A

静脉补充多种微量元素注射液(III)对全肠外营养（TPN）受试者全血/血清微量元素水平变化的影响：一项多中心、前瞻性、单臂、探索性研究

验证多种微量元素注射液（III）的有效性和安全性

开始日期-

申办/合作机构

Fresenius Kabi Norge AS

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100 项与 Fresenius Kabi Norge AS 相关的临床结果

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0 项与 Fresenius Kabi Norge AS 相关的专利（医药）

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1

项与 Fresenius Kabi Norge AS 相关的文献（医药）

PLOS ONE3区 · 综合性期刊

The high tolerance to aluminium in crucian carp (Carassius carassius) is associated with its ability to avoid hypoxia

3区 · 综合性期刊

ArticleOA

作者: Nilsson, Göran E ; Schjolden, Joachim ; Sørensen, Jørgen ; Poléo, Antonio B S

It is well known that aluminium is the principle toxicant killing fish in acidified freshwater systems, and it has been shown that crucian carp (Carassius carassius) can survive exposures to aqueous aluminium levels toxic to most other freshwater fish species. The crucian carp has a remarkable ability to survive anoxic conditions, and the aim of the present study was to reveal if the tolerance to aluminium can be associated with the ability to survive prolonged anoxia. Crucian carps were exposed to either acidic Al-rich water (pH 5.8; 960 μg Al/l), acidic Al-poor water (pH 5.8; 50 μg Al/l) or untreated control water (pH 6.5; 50 μg Al/l). Blood, muscle and gill samples were collected from exposed fish, and closed respirometry was performed to measure critical O2-tension an normoxic O2-consumption. The results show an increased gill surface area in Al-exposed fish, while the critical O2-tension did not change. The normoxic O2-consumption was lower in Al-exposed fish and might be due to a reduced metabolic rate. The results suggest that crucian carp exposed to aluminium do not become hypoxic, since haematocrit, plasma lactate and blood ethanol did not differ from that of control fish after 14 days of exposure. We also observed an initial loss of plasma chloride and sodium, followed by a stabilisation of these ions at a lower level than in control fish. The decrease in plasma ions caused a transient increase in haematocrit and water content in muscle tissue, returning to control levels when the ion concentrations stabilised, suggesting that the water balance was restored. We conclude that the high tolerance to aluminium in crucian carp is associated with its ability to avoid hypoxia as well as an ability to counteract a continuous loss of plasma ions.

100 项与 Fresenius Kabi Norge AS 相关的药物交易

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100 项与 Fresenius Kabi Norge AS 相关的转化医学

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