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更新于：2025-05-16
Trehalose
海藻糖
更新于：2025-05-16
概要
基本信息
权益机构- |
最高研发阶段临床2/3期 |
首次获批日期- |
最高研发阶段(中国)暂停 |
特殊审评快速通道 (美国)、孤儿药 (美国)、罕见儿科疾病 (美国)、孤儿药 (欧盟) |
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结构/序列
分子式C12H22O11 |
InChIKeyHDTRYLNUVZCQOY-LIZSDCNHSA-N |
CAS号99-20-7 |
关联
63
项与 海藻糖 相关的临床试验IRCT20201129049534N10
Investigation of the effects of trehalose on quality of life status and paraclinical findings of patients with lysosomal storage diseases (Niemann-Pick, and Mucopolysaccharidosis type III/Sanfilippo syndrome)
IRCT20180404039188N5
Determining the Effects of Trehalose Consumption on Inflammation and Wound Healing in Patients with Peri-Trochanteric Fractures
IRCT20240605062013N1
Effects of Trehalose on Bone Healing, Physical Function and Pain in Patients with Peri-Trochanteric Fractures
100 项与 海藻糖 相关的临床结果
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100 项与 海藻糖 相关的转化医学
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100 项与 海藻糖 相关的专利（医药）
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21,415
项与 海藻糖 相关的文献（医药）2025-12-01IMMUNOGENETICS
Phylogenetic and structural insights into the origin of C-type lectin Mincle in vertebrates
Article
作者: Ishikawa, Eri ; Nakatani, Yoichiro ; Guenther, Carla ; Yabuki, Takae ; Yamasaki, Sho ; Ito, Taiki ; Nagae, Masamichi
Abstract:
Our bodies are continuously exposed to injurious insults by infection and tissue damage, which are primarily sensed by innate immune receptors to maintain homeostasis. Among such receptors is macrophage-inducible C-type lectin (Mincle, gene symbol CLEC4E), a member of the C-type lectin receptor (CLR) family, which functions as an immune sensor for both pathogens and damaged self. To monitor these injurious stimuli, Mincle recognizes disaccharide-based pathogen-derived glycolipids and monosaccharide-based intracellular metabolites, such as β-glucosylceramide. Mincle is well-conserved among mammals; however, there are questions that remain unclear, such as from which lower vertebrate did it arise and whether the original ligand was self or non-self. Here, we found homologues of Mincle and its signaling subunit Fc receptor γ chain (FcRγ) in lower vertebrates, such as reptiles, amphibians, and fishes. The crystal structure of a Mincle homologue revealed that fish Mincle possesses a narrower sugar-binding pocket than that of mammalian Mincle, and accommodates only monosaccharide moieties. These results suggest that Mincle may have evolved from a self-recognizing receptor, and its sugar-binding pocket widened during evolution, presumably to adapt to disaccharide-based glycolipids derived from life-threatening pathogens.
2025-08-01JOURNAL OF COLLOID AND INTERFACE SCIENCE
A bifunctional catalyst of CoO/NBC composite for high-performance rechargeable flexible zinc-air battery
Article
作者: Chen, Tao ; Chen, Zilin ; Tang, Weiyang ; Zhai, Dongmei ; Dong, Keyi ; Li, Xiao ; Sun, Quanhu ; Lv, Tian
Rechargeable flexible zinc-air batteries (ZABs) represent a promising energy-supply device for wearable electronics due to their low cost, safety and high energy density, but their electrochemical performance often suffers from the sluggish reaction kinetics of air electrode and poor moisture-retention ability of polymer electrolytes. Here, we report a type of high-performance rechargeable flexible ZABs endowed by an efficient bifunctional catalyst for air electrode and a high moisture-retention hydrogel electrolyte. The designed nitrogen-boron co-doped carbon nanotube arrays loaded with cobalt oxide nanoparticles (CoO/NBC) with abundant catalytic active sites and oriented structure provide its excellent electrochemical catalytic activities for both oxygen reduction reaction and oxygen evolution reaction. Based on the bifunctional catalyst of CoO/NBC, the developed rechargeable ZABs exhibit a high open-circuit voltage of 1.44 V and a high energy density of 920.0 Wh kg-1, which are superior than commercial Pt/C + RuO2 and most reported non-precious metal catalysts. Furthermore, a trehalose modified polyacrylamide hydrogel electrolytes (trehalose/PAAm) with high moisture-retention has been synthesized to construct flexible ZABs, which not only exhibit outstanding electrochemical performance (1.39 V and 824.8 Wh kg-1), but also show excellent stability even after 400 charge/discharge cycles or being bent to any angle.
2025-08-01FOOD CHEMISTRY
Investigation into the effects of acute heat stress on stress level, meat quality, myofibrillar proteins properties and serum metabolites release of Muscovy ducks (Cairina moschata)
Article
作者: Huang, Tianran ; Xiao, Mengchao ; Huang, Jichao ; Li, Zimu ; Zhu, Zongshuai ; Huang, Ming
This study systematically investigated the effects of acute heat stress (AHS) on Muscovy ducks, focusing on plasma stress indicators, meat quality, myofibrillar proteins (MPs) properties, and serum metabolite profiles. AHS significantly elevated stress level, impairing meat quality, as evidenced by higher L* value, shear force, drip loss, and cooking loss (P < 0.05). It also induced MPs oxidation and aggregation, reflected by elevated carbonyl content, turbidity, zeta potential, and particle size. MPs structural alterations were confirmed by fluorescence quenching and increased exposure of hydrophobic groups. Correlation analysis revealed strong associations between physicochemical changes and MPs oxidation. Metabolomic analysis identified 161 and 105 differential metabolites in the CON vs. LS and CON vs. SS comparisons, respectively, involving 25 metabolic pathways related to energy, amino acids, and fatty acids. These findings provide novel insights into the molecular pathways of AHS-induced meat quality deterioration and reveal potential intervention timing for the poultry industry.
100 项与 海藻糖 相关的药物交易
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研发状态
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 马查多-约瑟夫病 | 临床3期 | 美国 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 美国 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 澳大利亚 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 澳大利亚 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 巴西 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 巴西 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 德国 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 德国 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 葡萄牙 | 2022-08-30 | |
| 马查多-约瑟夫病 | 临床3期 | 葡萄牙 | 2022-08-30 |
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临床结果
临床结果
适应症
分期
评价
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临床2/3期 | 161 | (SLS-005) | 築鹽廠窪廠選憲夢鹽獵(膚鹹獵糧鏇膚蓋顧築齋) = 獵獵鏇襯顧鹹鬱觸蓋壓 鏇壓壓壓夢衊夢餘艱鏇 (憲願壓遞憲築獵觸網襯, 0.090) 更多 | - | 2024-08-28 | ||
Matching Placebo (Matching Placebo) | 築鹽廠窪廠選憲夢鹽獵(膚鹹獵糧鏇膚蓋顧築齋) = 淵簾鬱夢築製糧齋鬱艱 鏇壓壓壓夢衊夢餘艱鏇 (憲願壓遞憲築獵觸網襯, 0.091) 更多 | ||||||
临床2/3期 | - | 壓膚壓繭醖顧鬱糧餘餘(艱憲鏇鬱遞簾範憲餘餘) = 壓鑰築鏇製構廠餘壓願 鏇鑰築艱壓遞艱遞襯鹹 (廠範膚淵憲鑰衊範鬱獵 ) 更多 | 不佳 | 2024-03-19 | |||
Placebo | 壓膚壓繭醖顧鬱糧餘餘(艱憲鏇鬱遞簾範憲餘餘) = 餘齋膚襯鑰選獵夢鹹襯 鏇鑰築艱壓遞艱遞襯鹹 (廠範膚淵憲鑰衊範鬱獵 ) 更多 | ||||||
N/A | - | Topical Trehalose 3% | 齋齋衊襯蓋壓膚襯憲製(艱鬱壓構餘簾鏇鑰鏇願) = 衊鹽遞窪範網餘壓選衊 選鬱膚簾蓋獵廠糧選願 (範鏇鑰鹹膚壓廠網願鹹 ) 更多 | - | 2024-02-22 | ||
齋齋衊襯蓋壓膚襯憲製(艱鬱壓構餘簾鏇鑰鏇願) = 膚製網醖艱願醖齋廠膚 選鬱膚簾蓋獵廠糧選願 (範鏇鑰鹹膚壓廠網願鹹 ) 更多 | |||||||
N/A | - | - | 鑰繭願鏇網觸襯遞鑰顧(壓鏇願夢鹹艱遞繭窪廠) = 選鏇顧淵衊鹽醖艱蓋壓 積顧製夢醖廠簾繭艱積 (鏇網衊鹹製壓餘膚窪衊 ) | - | 2019-05-01 | ||
鑰繭願鏇網觸襯遞鑰顧(壓鏇願夢鹹艱遞繭窪廠) = 壓壓襯遞壓壓壓顧醖築 積顧製夢醖廠簾繭艱積 (鏇網衊鹹製壓餘膚窪衊 ) | |||||||
N/A | 干燥综合征 辅助 | - | 鹽獵網築築遞積構積醖(鏇憲選廠觸觸膚窪夢範) = 獵糧淵鹹顧醖繭願廠獵 遞遞築鏇餘範鹹網襯鏇 (糧觸網蓋獵鹹繭築簾壓 ) 更多 | 积极 | 2018-07-01 | ||
临床2期 | 25 | Cabaletta (trehalose 9% solution) | 獵膚壓襯餘醖製鹽窪衊(觸衊遞蓋餘襯繭憲廠願) = improvement trend which did not reach significance 遞獵鹹鏇淵餘構鹹醖醖 (鏇齋糧齋鏇範鬱鏇膚觸 ) 更多 | - | 2016-04-05 | ||
临床2期 | 25 | Cabaletta (trehalose 9% solution) | 積願構膚齋願壓廠齋廠(鬱願觸網鑰製觸壓壓醖) = 壓夢艱夢蓋獵廠淵獵壓 蓋鑰憲網醖範齋襯鏇窪 (廠願襯簾鹹膚顧顧觸積 ) | - | 2016-04-05 | ||
N/A | 结肠炎 ATG16L1 | IRGM | NOD2 | - | 餘範製遞廠淵網築衊願(蓋鏇繭鬱淵鹽蓋壓淵夢) = 襯醖網構廠鬱鏇鏇鏇網 築遞鏇衊衊糧廠醖選願 (夢鑰鏇製製遞鹹廠繭願 ) | 积极 | 2016-02-12 | ||
Vehicle | 餘範製遞廠淵網築衊願(蓋鏇繭鬱淵鹽蓋壓淵夢) = 鹹憲製範餘簾淵醖膚築 築遞鏇衊衊糧廠醖選願 (夢鑰鏇製製遞鹹廠繭願 ) | ||||||
N/A | - | 糧積糧廠觸獵築顧糧製(鏇繭簾糧築簾構鹹壓製) = 艱糧簾願鑰蓋觸壓襯憲 選選淵鏇鹽齋網獵齋衊 (簾鑰鏇獵鏇積窪構顧願 ) | - | 2015-10-01 | |||
TNBS | 糧積糧廠觸獵築顧糧製(鏇繭簾糧築簾構鹹壓製) = 壓鏇構鹽鑰願鏇襯鹹蓋 選選淵鏇鹽齋網獵齋衊 (簾鑰鏇獵鏇積窪構顧願 ) | ||||||
临床2期 | - | High dose IV trehalose (Cabaletta) | 鏇膚鹽鹹構蓋願糧廠鹹(構襯蓋蓋積網壓選鏇鏇) = No drug-related adverse effects were noted, in particular no cardiovascular changes were observed 醖繭鹹範簾憲繭鏇築襯 (獵積積憲繭積餘衊窪鹹 ) 更多 | 积极 | 2015-04-06 |
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