Third molar extraction is a common dental procedure, offently related with pain and swelling. The purpose of this study is to evaluate if Meloxicam has a better effect relieving pain after the extraction than Ibuprofen, one of the most common pain relieving drugs administered after this procedure.

开始日期2024-12-15

申办/合作机构

Universidad Austral de Chile

NCT06792864

/ Enrolling by invitation临床3期IIT

Effectiveness of 3D Printed Polycaprolactone and Tricalcium Phosphate Bone Scaffold for Bone Regeneration in Cranioplasty: Randomized Clinical Trial

The objective of this clinical trial is to evaluate the effectiveness of a 3D bone scaffold in relation to a scaffold formed by PCL + β-TCP (polycaprolactone and beta-tricalcium phosphate), compared to the use of PMMA (polymethyl methacrylate) acrylic cement for bone regeneration in patients undergoing cranioplasty in the city of Valdivia, Chile, between the years 2024-2025.
The main beneficiaries will be patients, users of the public or private health system, who require bone regeneration. The intermediate beneficiaries are the health team: doctors specialized in surgery and orthopedics, dedicated in their professional work to bone reconstruction and regeneration.

开始日期2024-07-01

申办/合作机构

Universidad Austral de Chile

NCT06773923

/ Enrolling by invitation临床3期IIT

Effectiveness of Patient-specific 3D-printed Resorbable Scaffolds of Polycaprolactone, Beta-tricalcium Phosphate, and Metformin Used for Maxillary Bone Regeneration: Randomized Clinical Trial

The objective of this study is to test the bone formation capacity of a 3D printed scaffold with a plastic material called Polycaprolactone (PCL), compared to the use of synthetic bone grafts, for bone formation in the maxilla or mandible of elderly patients in the city of Valdivia between the years 2023-2024.
The main beneficiaries will be patients, users of the public or private health system, who require bone regeneration. The intermediate beneficiaries are the health team: doctors specializing in surgery and orthopedics, dentists, maxillofacial surgeons, dedicated to bone reconstruction and regeneration.
The innovation of this new material is based on the provision of a biocompatible plastic, easy to handle, for domestic 3D printing of bone matrices that can be grafted in areas requiring bone regeneration.

开始日期2024-07-01

申办/合作机构

Universidad Austral de Chile

100 项与 Universidad Austral de Chile 相关的临床结果

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0 项与 Universidad Austral de Chile 相关的专利（医药）

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项与 Universidad Austral de Chile 相关的文献（医药）

2025-12-01·THERIOGENOLOGY

A single injection of a long-acting oxytocin analog (carbetocin) at estrus onset synchronizes ovulations and enhances ovulation rate in ewes

Article

作者: Jp, Bottino ; Jdr, Santos ; Mi, Vazquez ; Mgk, Rodriguez ; M, Ratto ; R, Ungerfeld

Intromission during mating induces oxytocin release, likely shortening behavioral estrus and enhancing luteal function in ewes. Oxytocin's short half-life and limited transfer into the brain, however, restrict its exogenous use. Carbetocin, a long-acting oxytocin analog with peripheral effects, may be a practical pharmacological alternative. The aim was to determine whether systemic administration of Carbetocin could induce changes in sexual receptivity, follicular development, timing of ovulation during the estrous period, and luteal function similar to those observed after multiple matings. Timing of behavioral estrus was synchronized among 20 multiparous Merilin ewes. Upon detection of estrus, ewes were randomly assigned to a control (CON, n = 10) or Carbetocin-treated (CAR, n = 10) group. Ewes in the CAR group were administered a single intravenous dose of Carbetocin (0.2 mg/100 kg) at estrous onset. Follicular and luteal dynamics were monitored by ultrasonography, and sexual receptivity was assessed based on the ewe' immobility when mounted of a ram. Luteal images were analyzed using ImageJ™ software to quantify both total and perfused corpus luteum areas. Carbetocin treatment increased the ovulation rate (1.9 ± 0.2 and 1.4 ± 0.2; P = 0.04) and reduced the dispersion in interval between the end of estrus and time of ovulation (SD: 3.86 and 8.01, respectively, P = 0.04). In conclusion, Carbetocin administration at the onset of estrus enhanced synchrony in time of ovulation among ewes, and increased ovulation rate but compared with ewes where there were multiple matings, did not shorten duration of estrus.

2025-11-01·MARINE POLLUTION BULLETIN

Combined effects of PVC microplastics and thermal rise alter the oxidative stress response in Antarctic fish Harpagifer antarcticus and Sub-Antarctic Harpagifer bispinis

Article

作者: McCormick, Stephen D ; Cheng, Chi-Hing Christina ; Chacoff, Luis Vargas ; Guerreiro, Pedro M ; González-Wevar, Claudio ; Nualart, Daniela P ; Paschke, Kurt

This study evaluated the oxidative stress response in two cold-water fish species, the Antarctic Harpagifer antarcticus and the sub-Antarctic H. bispinis, following exposure to single and combined stressors: polyvinyl chloride (PVC) microplastics and thermal increase. Fish were exposed for 24 h to two temperature regimes (2 °C and 5 °C for H. antarcticus; 8 °C and 12 °C for H. bispinis) and were orally administered a PVC microplastic solution (200 mg/L). Oxidative stress was assessed through transcriptional and enzymatic activity analyses of key antioxidant markers: catalase, glutathione peroxidase, superoxide dismutase, and glutathione reductase. In H. antarcticus, gill antioxidant gene expression decreased in response to both stressors when applied individually, while H. bispinis exhibited transcriptional upregulation under the same conditions. In H. antarcticus, enzymatic activity in gill tissues increased for all four enzymes following exposure to both microplastics and elevated temperature. In contrast, H. bispinis showed a differential enzymatic response: thermal stress induced CAT activity, whereas exposure to microplastics specifically increased GR activity. At the hepatic level, H. antarcticus displayed increased transcription of antioxidant genes following exposure to both stressors. In H. bispinis, transcriptional upregulation was limited to GR and SOD in response to microplastics. However, under the combined exposure of multiple stressors, an inactivation of the antioxidant enzyme response was observed in the gills. This could indicate a functional collapse of the antioxidant system under conditions of exacerbated acute stress. The observed responses raise concerns about the potential vulnerability of polar and subpolar fishes, considering their ecological importance in trophic networks and the increasing pressure from multiple anthropogenic stressors in a rapidly changing climate.

2025-10-01·VETERINARY RESEARCH COMMUNICATIONS

Enterococcus species identified by MALDI-TOF MS in milk from dairy cow mastitis cases and herd surveys

Article

作者: Bronzo, Valerio ; Addis, Maria Filippa ; Monistero, Valentina ; Salgado, Miguel ; Moroni, Paolo ; Penati, Martina ; Ulloa, Fernando

Abstract:

Enterococcus species are increasingly recognized as mastitis pathogens in dairy cows. Reliable species information is required for correctly defining the regional epidemiology of enterococcal mastitis, establishing its relationships with management variables, and understanding its impact on udder health. We investigated the species distribution of enterococci in bovine milk from subclinical mastitis (SCM) and clinical mastitis (CM) cases and full herd surveys (HS) using MALDI-TOF MS as identification method. A total of 21,864 milk samples from 106 dairy herds were routinely collected and analyzed according to the National Mastitis Council (NMC) guidelines over one year. Enterococcus spp. were found in 4.86% of CM, 5.05% of SCM, and 1.37% of HS milk samples. Overall, E. saccharolyticus was the most prevalent species (55.65%), followed by E. faecium (27.25%), and E. cecorum (5.51%), which showed a significant association with SCM (p-value = 0.0128). This study provides novel data on the Enterococcus species distribution in full herds survey and mastitis cases, highlighting the relevance of MALDI-TOF MS in refining enterococcal mastitis epidemiology, as true prevalence and species distribution may have been skewed by conventional biochemical tests.

项与 Universidad Austral de Chile 相关的新闻（医药）

2024-10-24

·梅斯医学

EANM 2024 | 对话智利南方大学Alejandro Rojas-Fernandez教授：小结构大应用，纳米抗体突破性进展

纳米抗体因其结构域小、稳定性好、给药途径灵活、溶解度高、可通过微生物表达等独特优势，逐渐成为新一代治疗性生物医药与临床诊断试剂中的新兴力量。纳米抗体凭借优良的特性，在科研、诊断和治疗治疗领域广泛应用。值得关注的是，从骆驼科动物（如羊驼）血液中提纯的抗体正逐渐成为生物医学领域的重要工具，并且有可能在未来医疗保健方面发挥重要作用。近日，在2024年第37届欧洲核医学协会年会(EANM) 上，梅斯医学有幸采访到了智利南方大学的Alejandro Rojas-Fernandez教授，他不仅在纳米抗体研究上有着深刻见解，同时也是两家公司的企业家。梅斯医学：您能否详细介绍一下您的研究成果吗？ Alejandro Rojas-Fernandez教授：纳米抗体因具有较小的相对分子质量，其独特的分子结构得到了广泛的关注。我们的研究工作聚焦于抗体科学，尤其是在羊驼抗体片段这一独特领域。羊驼抗体的独特之处在于它们仅包含一个重链可变区（VHH），而不含有轻链，这让它们能够识别并结合到传统抗体无法触及的抗原上的微小区域——单一的多肽。这种特殊的结构赋予了羊驼纳米抗体一系列优势，包括更好的组织穿透能力、更高的热稳定性以及在体内更长的半衰期等。基于这些特点，我们专门致力于开发和利用这些纳米抗体来探索其应用潜力，尤其是那些传统治疗方法难以解决的问题，如病毒感染（包括新型冠状病毒）和癌症。例如，在新冠疫情期间，我们的研究团队发现羊驼血液中的一些纳米抗体能够有效地与病毒表面的关键蛋白结合，从而阻止病毒进入宿主细胞，并且激发人体自身的免疫应答。尽管，这些纳米抗体不能完全清除病毒，但其能够显著降低病毒载量，并且通过激活宿主的免疫系统，促进个体产生更多的自身抗体。从长远来看，这种治疗策略有助于增强患者的免疫力，减少病毒造成的伤害，并能加速患者康复。梅斯医学：如何从这些抗体中筛选出高亲和力的抗体的呢？ Alejandro Rojas-Fernandez教授：我们通过给羊驼接种不同的目标病毒或肿瘤生物标志物，以激发免疫系统对特定目标产生反应。这一过程涉及到需要将严格处理的目标物质注射入羊驼体内，刺激其免疫系统产生针对这些抗原的抗体。为了确保实验的安全性和有效性，我们遵循严格的伦理标准和科学流程。在免疫反应发生后，我们会定期采集羊驼的血液样本。这些血液样本富含免疫系统产生的抗体，其中就包括了我们感兴趣的单域抗体（VHH）。随后，在实验室环境中，我们会运用一系列先进的生物技术手段来筛选和鉴定那些对特定目标具有高亲和力的抗体。这些技术包括但不限于噬菌体展示技术、流式细胞术以及表面等离子共振技术（SPR）等。我们的目标是识别那些能够与目标抗原紧密结合的抗体，并进一步开发其作为潜在治疗药物的可行性。尽管整个筛选过程可能耗时长达两年，但得益于羊驼体内产生的丰富抗体多样性，我们已成功从数以百万计的抗体中筛选出十几个具有高亲和力的候选抗体。这些候选抗体将在后续的研究中接受进一步的测试与优化，期望最终能够转化成有效的治疗药物，为患有相应疾病的患者带来福音。梅斯医学：在您的研究过程中，遇到的最大挑战是什么？ Alejandro Rojas-Fernandez教授：开发能够快速中和病毒的抗体不仅要求对病毒的生物学特性有深入的理解，还需要具备快速设计和测试新抗体候选物的能力。病毒的演化速度很快，因此必须确保抗体能够及时应对新的变种。为了实现这一点，我们不仅需要依赖传统的免疫学技术，还结合了最新的计算生物学工具，以加速抗体的设计与优化过程。此外，生产高纯度的符合良好生产规范（GMP）级别的抗体对于推进临床试验和最终实现产品的商业化至关重要。GMP级别的生产涉及复杂的工艺流程，包括细胞培养、抗体表达、纯化以及一系列的质量控制步骤。每一步都需要严格监控，以确保最终产品的安全性和有效性。同时，GMP生产还需要大量的资源投入，包括先进的设施、训练有素的技术人员以及持续的质量管理体系。尽管如此，这些挑战也为我们提供了宝贵的机遇，激励我们在科学研究和技术进步方面不断追求卓越。我们相信，通过不懈的努力和持续的创新，我们能够克服当前的障碍，达到更高的研究和治疗标准，为患者提供更安全、更有效的治疗方案。来源 | 梅斯医学官网编辑 | Swagpp ●一天8杯水？喝太多！最新研究：每日最佳饮水量找到了！能降低全因、疾病死亡率，但不能超过...... ●震撼！坐车9小时去大三甲看病，医生下班了，睡在座椅下，副主任医师心疼加号！医生：不想被道德绑架，渴望有加号、退号和拒绝就诊的权力 ●荒唐！医学生发布大体老师头骨合影至短视频平台，自称“无所畏惧”！网友怒批：轻佻无知、毫无尊重，这样搞我们以后谁还敢去捐献遗体？版权说明：梅斯医学（MedSci）是国内领先的医学科研与学术服务平台，致力于医疗质量的改进，为临床实践提供智慧、精准的决策支持，让医生与患者受益。欢迎个人转发至朋友圈，谢绝媒体或机构未经授权以任何形式转载至其他平台。点击下方「阅读原文」立刻下载梅斯医学APP！

诊断试剂

100 项与 Universidad Austral de Chile 相关的药物交易

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100 项与 Universidad Austral de Chile 相关的转化医学

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