iTeos Therapeutics SA

NEW YORK, July 08, 2024 (GLOBE NEWSWIRE) -- LEXEO Therapeutics Inc. (Nasdaq: LXEO), a clinical stage genetic medicine company, today announced the appointment of Tim Van Hauwermeiren, co-founder and Chief Executive Officer of argenx SE, as an independent, non-executive director to its Board of Directors. Mr. Van Hauwermeiren is a seasoned biotech executive with over two decades of experience in both general management and business development across the life sciences and consumer goods industries. “Tim is a highly accomplished life-sciences entrepreneur who has built one of Europe’s most successful biotech companies, and I am thrilled to welcome him to our Board of Directors,” said R. Nolan Townsend, Chief Executive Officer of Lexeo Therapeutics. “Tim’s deep and relevant experience in company building from clinical to commercial stage will be an invaluable asset to Lexeo as we embark on our next phase of growth and progress our pipeline into later stages of clinical and commercial development.” Mr. Van Hauwermeiren is co-founder, CEO and a Board Member of argenx, a global immunology company valued at almost $25 billion focused on severe autoimmune diseases. During his 15-year tenure, he has overseen the development and launch of the company’s first commercial product, efgartigimod, for the treatment of multiple severe autoimmune diseases, and he has expanded the company’s footprint across Europe, the U.S. and Asia. Additionally during his time at argenx, Mr. Van Hauwermeiren has secured more than $4 billion in funding through equity raises and business development transactions with major pharmaceutical companies. Prior to argenx, Mr. Van Hauwermeiren held roles with increasing levels of responsibility at Ablynx and Procter & Gamble. “I am honored to join Lexeo’s Board at this important stage in the company’s growth,” said Mr. Van Hauwermeiren. “I am impressed by the company’s innovative science, pipeline and bold thinking, and I look forward to sharing my experiences and learnings with the management team as we work to bring life-changing therapies to patients with devastating genetic diseases.” Mr. Van Hauwermeiren also serves on the Board of Directors of iTeos Pharmaceuticals, and previously served on the Board of Directors of RayzeBio prior to the company’s acquisition by Bristol Myers Squibb. He holds a B.Sc. and M.Sc. in bioengineering from Ghent University and an Executive MBA from The Vlerick School of Management. About Lexeo Therapeutics Lexeo Therapeutics is a New York City-based, clinical stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer’s disease programs. Media Response: Janine Bogris (201) 245-6838 janine.bogris@inizioevoke.com

SAN DIEGO, Nov. 01, 2023 (GLOBE NEWSWIRE) -- RayzeBio, Inc. (Nasdaq: RYZB), a targeted radiopharmaceutical company developing an innovative pipeline against validated solid tumor targets, today announced the appointment of Tim Van Hauwermeiren to its board of directors. As co-founder and CEO of argenx, Tim has built a reputation for his strong execution and innovation, leading argenx from early-stage development into a global immunology company. “RayzeBio has the potential to transform the oncology treatment landscape through targeted radiopharmaceuticals. I see a lot of parallels between RayzeBio and argenx and look forward to leveraging my experience to help RayzeBio unlock the full potential of this emerging modality,” said Tim. Tim Van Hauwermeiren co-founded argenx and has served as Chief Executive Officer since 2008. Tim has more than 20 years of general management and business development experience across the life sciences and consumer goods sectors, including at Ablynx and Procter & Gamble. He holds a B.Sc. and M.Sc. in bioengineering from Ghent University and an Executive MBA from The Vlerick School of Management. Tim serves on the Board of Directors of iTeos Pharmaceuticals. “I am thrilled to welcome Tim to our board of directors,” said Ken Song, M.D., President and CEO of RayzeBio. “He has been a major force in scaling argenx from a small private company to a global commercial organization bringing forth innovative medicines to help patients. His perspective as a successful operator can help inform us as we continue to build and maintain our leadership in radiopharmaceuticals.” In connection with Tim joining the board of directors, Aaron Royston, M.D. has resigned as a board member, effective November 1, 2023. Dr. Royston served as a director of the company from August 2020. “RayzeBio has made tremendous progress in a very short timeframe. I look forward to staying engaged as an investor and continuing to see the company flourish,” said Dr. Royston. Dr. Royston indicated that his resignation was not a result of any disagreement with the company on any matter relating to the company's operations, policies or practices. About RayzeBioRayzeBio is building a vertically integrated radiopharmaceutical therapeutics (RPT) company to treat various cancers, with its lead program in a Phase 3 clinical trial. RayzeBio has created a pipeline of multiple drug candidates in therapeutic areas with significant market opportunities. Much like antibody drug conjugates emerged as a new and transformative treatment modality in certain cancers, the company sees an opportunity for innovative radiopharmaceutical therapeutics to follow a similar path. RayzeBio believes its strategic investments in building a robust product pipeline, development capabilities, and manufacturing infrastructure position the company to be an industry-leading pioneer in the broad application of RPT for cancer. Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Statements in this press release that are not statements of historical fact are forward-looking statements. Such forward-looking statements include, without limitation, statements regarding the company's potential to transform the oncology treatment landscape through targeted radiopharmaceuticals, and to build and maintain a leadership position in radiopharmaceuticals. Words such as “believe,” “anticipate,” “plan,” “expect,” “intend,” “will,” “may,” “goal,” “potential” and similar expressions are intended to identify forward-looking statements, though not all forward-looking statements necessarily contain these identifying words. These forward-looking statements are based on the beliefs of the management of the company as well as assumptions made by and information currently available to the company. Such statements reflect the current views of the company with respect to future events and are subject to known and unknown risks and uncertainties, including business, regulatory, economic and competitive risks and uncertainties about the company, including, without limitation, risks inherent in developing drug candidates, future results from the company’s ongoing and planned clinical trials, the company’s ability to obtain adequate financing to fund its planned clinical trials and other expenses, risks that future clinical trial results may not be consistent with interim, initial or preliminary results or results from prior preclinical studies or clinical trials, trends in the industry, the legal and regulatory framework for the industry and future expenditures. In light of these risks and uncertainties, the events or circumstances referred to in the forward-looking statements may not occur. The actual results may vary from the anticipated results and the variations may be material. Other factors that may cause the company’s actual results to differ from current expectations are discussed in the company’s filings with the Securities and Exchange Commission (the “SEC”), including the section titled “Risk Factors” in the company’s Registration Statement on Form S-1 filed with the SEC on September 11, 2023. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date this press release is given. Except as required by law, the company undertakes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise. Contact: Arvind KushEmail: info@rayzebio.com

DUBLIN, Dec. 14, 2022 /PRNewswire/ -- The "Global Anti TIGIT Antibody Clinical Trials & Companies Insight 2023" report has been added to ResearchAndMarkets.com's offering. This report provides an in-depth analysis of the product pipeline and developer companies, highlighting the current treatment practices, emerging drugs, and market share of individual therapies. In addition to other elements, the study includes a detailed assessment of the current market landscape, providing information about the product's mechanism of action, dosage and administration, and other development activities. Report Highlights: Global Anti-TIGIT Antibodies Market Dynamics Insight On Anti TIGIT Antibodies Clinical Trials Insight By Phase, Company, Country, Indication Anti-TIGIT Antibodies In Clinical Trials : > 45 Overview Of Partnerships and Collaborations In The Global Anti-TIGIT Antibodies Market Global Anti-TIGIT Antibodies Market Outlook Competitive Landscape The advancement in the field of genomics has led to the identification of T-cell immunoreceptors with immunoglobulin and ITIM domain (TIGIT) as a promising emerging immune checkpoint target. TIGIT indirectly suppresses T-cell activation and is expressed in multiple types of immune cells, including regulatory T (Treg) cells, activated T cells, and natural killer (NK) cells. TIGIT is upregulated in T cells and NK cells after ligand binding, inhibiting these cells' ability to kill tumor cells. Increased TIGIT expression s also associated with advanced disease and poor survival outcomes. Additionally, increased TIGIT expression after treatment is associated with disease recurrence. Since its identification as a potential immunotherapy target, pharmaceutical companies have developed a robust pipeline of TIGIT inhibitors and are reporting promising preclinical and clinical trial results. Recently, iTeos Therapeutics has announced promising preclinical and clinical analyses supporting the multifaceted mechanism of action of its anti-TIGIT antibody, EOS-448/GSK4428859A, which is being developed in collaboration with GlaxoSmithKline. Various combinations of anti-TIGIT antibody isotopes have been studied in cancer models of mice. Depending on the isotope used, the preclinical analyses of these combinations have demonstrated different anti-tumor activities. Strong anti-tumor activities have been found while using the isotope engaging the Fcandgamma; R, which has been linked to the activation of effector CD8 T cells and the reduction in the number of Treg cells in the tumor microenvironment. EOS-448 has further been shown to induce the depletion of the precursors of exhausted T cells in addition to regulatory T cells, but not of stem-like memory T cells. Recent years have seen an increase in collaborations and partnerships between companies for the faster development of novel drugs. Shanghai Junshi Biosciences and Coherus Bioscience recently announced that the two are taking their immuno-oncology collaboration agreement further by allowing Coherus to initiate its option to license the former's potential anti-TIGIT antibody - JS 006 - in the US and China. Regulatory bodies of the two regions have already approved the drug's Investigational new drug (IND) applications, allowing the companies to develop it further clinically. Apart from this, clinical trials are ongoing which are assessing the drug's safety, pharmacokinetic properties, and tolerability post-dose escalation and expansion, as a monotherapy and in combination with toripalimab, an anti-PD-1 antibody, in patients with advanced solid tumors. Apart from these trends in the market, the pipeline of novel TIGIT inhibitor is highly crowded which suggests a promising future of the market. The key drugs in research and development include including AB 154, Ociperlimab, COM902, EOS448, Tiragolumab, and others. As per our analysis, TIGIT inhibitor is expected to enter the market by 2024, which will transform the overall immunotherapy market during the forecast period. However, the market will mainly be restricted by the long duration of drug development and stringent regulatory guidelines. However, as the healthcare sector of the majority of regions is shifting towards novel therapeutic approaches drug regulatory bodies are providing special provisions and rapid approvals are expected in coming years. As per report findings, the global market is expected to have opportunity of more than US$ 300 Million once the first Anti TIGIT antibody is commercially approved in coming years. The Anti-TIGIT Antibody clinical development and the market opportunity are driven by the rising occurrence of different forms of cancer, technological advancements in the field of immune-oncology for cancer treatment, and rising awareness concerning the benefits of targeted therapies over conventional cancer therapies. Apart from this, rising government initiatives, increasing awareness among the population, and the development of favorable reimbursement policies are also boosting the growth of the market during the forecast period. Key Topics Covered: 1. Introduction to TIGIT Inhibitor 2. Role Of TIGIT Inhibitors By Indications 2.1 TIGIT Inhibitors in Cancer 2.2 TIGIT Inhibitors in HIV 2.3 TIGIT in Autoimmune Disorders 3. Mechanism of Anti TIGIT Antibodies 3.1 Overview 3.2 Clinical Approaches to Target TIGIT 4. Partnerships and Collaborations In The Global Anti TIGIT Antibodies Market 5. Global TIGIT inhibitors Clinical Trials Overview 5.1 By Company 5.2 By Country 5.3 By Indication 5.4 By Patient Segment 6. Global Anti TIGIT Antibody Clinical Pipeline By Company, Indication and Phase 6.1 Research 6.2 Preclinical 6.3 Phase-I 6.4 Phase-I/II 6.5 Phase-II 6.6 Phase-III 7. FDA Orphan Designation for Tiragolumab 8. Global Anti TIGIT Antibody Market Dynamics 8. 1 Market Drivers 8.2 Commercialization Challenges 9. Global TIGIT Inhibitor Market Future Outlook 10. Competitive Landscape 10.1 Arcus Biosciences 10.2 Agenus 10.3 Astellas Pharma 10.4 AstraZeneca 10.5 BeiGene 10.6 Bristol Myers Squibb 10.7 Compugen 10.8 Gilead Sciences 10.9 iTeos Therapeutics 10.10 Merck 10.11 Roche 10.12 Seagen 10.13 Shanghai Henlius Biotech For more information about this report visit Media Contact: Research and Markets Laura Wood, Senior Manager [email protected] For E.S.T Office Hours Call +1-917-300-0470 For U.S./CAN Toll Free Call +1-800-526-8630 For GMT Office Hours Call +353-1-416-8900 U.S. Fax: 646-607-1907 Fax (outside U.S.): +353-1-481-1716 Logo: SOURCE Research and Markets