Recently, the global epidemic of obesity is increasing significantly.Obesity is treated with anti-obesity medications and surgery and complications related to these treatments prompt the search of phytochems. that confer anti-obesity effects.Artemisiae Argyi Folium (Aiye), a Chinese herb used as both food and medicine, exhibits potent anti-obesity effects.Aiye essential oil components are responsible for lipase activity inhibition, intestinal barrier protection, and blood lipid regulation effects.The current research aims to identify the anti-obesity essential oil components of Aiye through the integration of GC-MS, network pharmacol., and mol. docking.In present study, the Aiye essential oil components were identified by GC-MS anal.Network pharmacol. and mol. docking were integrated to predict the anti-obesity mechanisms of Aiye essential oil components.In total, 49 essential oil components were identified, containing 308 anti-obesity targets.The network pharmacol. anal. revealed that the essential oil components may combat obesity through the Wnt signaling pathway, PI3K-Akt signaling pathway, MAPK signaling pathway, prolactin signaling pathway, and cAMP signaling pathway, etc.For mol. docking, there were 99 out of 140 with a binding affinity of less than -5 kcal/mol, indicating a moderate binding between essential oil components and targets.The present study revealed 308 potential anti-obesity targets of 49 essential oil components of Aiye.More than 70% of the binding between components and targets had moderate interaction.More than five anti-obesity signaling pathways of 49 Aiye essential oil components were identified.Therefore, the current research indicated that the essential oil components of Aiye may confer anti-obesity benefits.