Fujinaga Pharm Co. Ltd.

Effect of Glyteer (GL) on edema and epidermal hyperplasia in mouse ear by 12-o-tetradecanoylphorbol-13-acetate (TPA) were investigated by its topical application; and the effects were compared with those of betamethasone 17-valerate (BV), indomethacin (IM) and cyclosporin (CS). GL significantly inhibited the edema in mouse ear at 6 hr after TPA treatment. The inhibitory activity of GL on the edema had the same potency as those of BV, IM and CS. Furthermore, GL inhibited the epidermal weight and its protein amount on the hyperplastic response in mouse ear at 3 days after TPA treatment, and the inhibitory activity of GL was also confirmed by the pathologic findings. The mode of the inhibitory action of GL was the same as those of BV and CS, but not that of IM. From those results, it is suggested that GL possesses a potent therapeutic effect for psoriasis.

Antihistaminic and antifungal constituents in dry-distillation tar of nonfat soybean were examinedFour active principles norharman, harman, benzo[f]-quinoline, and phenanthridine were isolated by a suitable combination of column chromatog.

The delayed-type allergic-dermatitis test in mice and UV-induced erythema and blood vessel-permeability tests in guinea pigs indicated that the anti-inflammatory action of glyteercortisone ointment (containing hydrocortisone acetate  [50-03-3], glyteer (residues of soybean distillate) and diphenhydramine) as not affected by using white petrolatum or polyethylene glycol  [25322-68-3] as base.