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本研究的总体目的是在中度至极重度COPD受试者中，使用格隆铵和富马酸福莫特罗MDI（GFF MDI，14.4/9.6 μg 释出剂量， BID）、富马酸福莫特罗MDI（FF MDI，9.6μg 释出剂量， BID）和格隆铵MDI（ GP MDI，14.4 μg释出剂量， BID）相互比较以及与安慰剂MDI相比，治疗24周的疗效和安全性。

开始日期2016-04-26

申办/合作机构

阿斯利康投资（中国）有限公司

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449

项与 Fisons Ltd. 相关的文献（医药）

2011-05-11·Journal of Pharmacy and Pharmacology

The fate of [14C] lactose administered into the lungs of rats and monkeys

Article

作者: Moss, G F ; Ritchie, Jean T ; Clark, B

After intratracheal administration of 20 mg Intal (a 1:1 disodium cromoglycate-lactose mixture) [15826-37-6] to monkeys, the lactose [63-42-3] was absorbed unchanged by the lungs and excreted in urine.Little metabolism of lactose by rat lung was observed in vivo or in vitro.Lactose is used to improve the flow properties of the aerosol powder of disodium cromoglycate administered in the treatment of asthma.

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

Isolation and identification of the fluorescent degradation product of some β-lactam antibiotics

3区 · 医学

Article

作者: Barbhaiya, R H ; Payling, D W ; Turner, P ; Brown, R C

AbstractA fluorescent degradation product of cephalexin, recently employed in the determination of this antibiotic in aqueous solution and human plasma, has been isolated and identified as 2-hydroxy-3-phenyl-6-methylpyrazine. Spectroscopically and chromatographically the product is indistinguishable from that obtained by the same method from a series of other cephalosporins and penicillins bearing an α-amino group on the side-chain, and from the pyrazine structure produced by synthesis. Two reported methods for the fluorimetric determination of ampicillin have also been found to yield the same degradation product and not the suggested diketopiperazine structure.

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

A simple colorimetric method for the estimation of d(−)-penicillamine in plasma

3区 · 医学

Article

作者: Mann, J ; Mitchell, P D

A simple colorimetric method based on the reaction of 5,5'-dithiobis-2-(nitrobenzoic acid) with D-(-)-penicillamine (I) [52-67-5] was used to measure the plasma concentration of I in rabbits after administration of the drug by various routes.A calibration curve for I in a pooled sample of rabbit plasma was linear to 50 μg I/mL and concentrations down to 2 μg/mL could be detected.The method gave a recovery of 66% of I added to plasma.Plasma from 5 rheumatoid arthritis patients receiving chronic I (125 mg) therapy was also analyzed; 2 h after I therapy plasma I concentration was <2 μg/mL.

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