Delving into the Latest Updates on Central Institute of Medicinal & Aromatic Plants with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

ERβ(雌激素受体β)	1

关联

1

项与 Central Institute of Medicinal & Aromatic Plants 相关的药物

Compound 24b(CIMAP)

靶点

ERβ

作用机制

ERβ调节剂

在研机构

Central Institute of Medicinal & Aromatic Plants [+1]

原研机构

Academy of Scientific & Innovative Research [+1]

在研适应症

肿瘤

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Central Institute of Medicinal & Aromatic Plants 相关的临床结果

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2,815

项与 Central Institute of Medicinal & Aromatic Plants 相关的文献（医药）

2025-06-01·Archives of Microbiology

Formononetin exerts synergistic action with artesunate against multi-drug-resistant P. falciparum arresting ring-to-schizont transition by inducing reactive oxygen species

Article

作者: Kumar, Saurabh ; Mina, Pooja Rani ; Bhakuni, Rajendra Singh ; Kumar, Parmanand ; Shanker, Karuna ; Verma, Ajeet Kumar ; Kapkoti, Deepak Singh ; Pal, Anirban ; Ramdas ; Darokar, Mahendra P

Malaria, caused by Plasmodium falciparum, presents significant challenges for treatment due to the parasite's complex life cycle and increasing multi-drug resistance. Artemisinin-based combination therapies (ACTs) are the current standard treatment, resistance development necessitates the exploration of new therapeutic targets. Recent evidence suggests that targeting oxidative stress to arrest blood stage ring to schizont growth progression in Plasmodium could offer a novel approach to combat drug-resistant malaria. Phytomolecules have been recognized for their potential to modulate oxidative stress with artemisinin derivatives. In the present study, we aimed to evaluate the effectiveness of formononetin (FMT), a natural isoflavonoid, alone and in combination with artesunate (ART) against multidrug-resistant P. falciparum (K1) strain and to decipher the underlying mechanism of action. The study presents compelling evidence demonstrating the anti-plasmodial action of FMT alone (IC₅₀ value 212µM) and synergistic interaction (FICI 0.13) with ART at a 1:1 ratio against the K1 strain of P. falciparum. The combination treatment affected the progression of P. falciparum from the ring stage to the schizont and showed the effect at asexual erythrocytic stages. Moreover, the combination resulted in a notable increase in reactive oxygen species (ROS) levels, both independently and in combination with ART. In combination with ART, FMT effectively modulated the total glutathione (GSH) level. Moreover, FMT and ART demonstrated the ability to induce apoptosis-like death of parasites, as evidenced by the Lipid peroxidation (malondialdehyde-MDA) and DNA fragmentation (TUNEL) levels. These results indicate that FMT could potentially ameliorate the growth of multidrug-resistant malaria parasites, enhance the effects of ART, and be suitable for developing anti-plasmodial agents from a cheap and sustainable source.

2024-12-20·Journal of Plant Development

SHADE-INDUCED PHENOTYPIC PLASTICITY AND ITS IMPACT ON THE ECONOMIC TRAITS OF PATCHOULI, POGOSTEMON CABLIN (BLANCO) BENTH., A HIGH-VALUE AROMATIC CROP

作者: RAVI KUMARA, Rajesh ; ARUL PRAKASH, Thankaswamy ; KEERTHI, Paddambail Ellianna ; YOGENDRA, Naraganahalli Dasappa ; SUNDERASAN, Velusamy

The study was conducted to assess the patchouli crop responses to varying light intensities: full-sunlight (open-condition), 30% shade, and 50% shade. It showed notable variations in growth, development, essential oil yield, and chemical composition between full-sunlight and partial-shade conditions. Plants grown in 50% shade exhibited significant increases in height (113.83 cm), inter-nodal length (8.81 cm), leaf area (59.17 cm2), petiole length (3.78 cm), and width (3.44 mm) compared to open conditions. However, reductions in branches/plant (14.26), fresh weight (152.95 g), dry weight (29.64 g), leaf thickness (117.57 µm), number of trichomes (13.14 no./mm2), number of oil glands (10.14 no./mm2), and oil content (0.98%) were observed in 50% shade plants compared to open conditions. Anatomical modifications like bundle sheath extensions (BSEs) were present in 30% and 50% of shade-grown plants but absent in open-condition-grown plants.

2024-12-01·Genetic Resources and Crop Evolution

In silico characterization of a MYB TF (WsMYB46) from the medicinal plant Withania somnifera L. predicting its probable role in secondary cell wall biosynthesis

作者: Vasudev, Prema G. ; Thakur, Sudipa

In the current study, a MYB (Myeloblastosis) Transcription Factor (TF) gene sequence (WsMYB46) has been retrieved from the transcriptome repertoire of the medicinal plant Withania somnifera and it has been structurally and functionally characterised using different bioinformatics tools.Amino acid sequence comparison of WsMYB46 and MYB TFs from 30 medicinal plants and the model plant Arabidopsis thaliana provided information about the conserved DNA binding domains of WsMYB46.The anal. suggests that WsMYB46 belongs to the R2R3 family of MYB TFs.The in silico prediction of the physicochem. properties of WsMYB46 and the MYB TFs show that they are localized in the nucleus, contain 312-438 amino acid residues, and are hydrophilic and acidic in nature, with a theor. pI between 5.15 and 6.65.A 3-D model of the WsMYB46 protein has been constructed, and the functional annotation indicates that the WsMYB46 gene is involved in mRNA and cellular processing.The high degree of structural similarity of WsMYB46 with AtMYB46/AtMYB83, which are known to have important roles in the regulation of secondary cell wall biosynthesis, indicates the possible functional role of WsMYB46 in the regulation of secondary cell wall biosynthesis.The in silico gene expression anal. showed its low expression during salt stress. 427 miRNA sequences from A. thaliana were selected to identify the possible miRNA targets in WsMYB46.Six miRNAs with target sites in WsMYB46 were identified.This comprehensive in silico study of WsMYB46 and other MYB TFs from medicinal plants would be helpful to gain a deeper understanding of MYB TFs and their roles in medicinal plants.

100 项与 Central Institute of Medicinal & Aromatic Plants 相关的药物交易

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100 项与 Central Institute of Medicinal & Aromatic Plants 相关的转化医学

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