Diabetes Mellitus is a disease that affects nearly 1 in 5 people in United Arab Emirates and is one of leading causes of death and disability. The main reason for this condition is either relative or near complete deficiency of essential hormone made by our pancreas called "insulin", which is required to utilize blood sugar (glucose), and insulin shortage leads to increased blood glucose. The common types of this condition include type 2 Diabetes Mellitus (the most common with almost 90% of all diabetes patients having this condition), which is related to mismatch of body requirements and production of essential hormone called insulin (relative deficiency) and type 1 diabetes, in which body's own defense system causes of destruction of insulin producing cells in the pancreas (near complete deficiency of insulin). However, in younger age group (below the age of 35) there is another type of diabetes which affects nearly 1 out 1000 people and is Maturity onset diabetes of the young (MODY). MODY is a condition passed by parents in 50% of the kids due to an affected single gene and most common forms of MODY do not require any Insulin treatment. However as type 1 Diabetes is generally identified in younger age group, 80% of patient who have MODY cannot be diagnosed and are labelled with other forms of diabetes instead, and may receive unnecessary insulin injections. Although, there has been a lot of research done in the west on prevalence of MODY in white/Caucasian population, the studies in Middle East are minimal. Also, in the white/Caucasian population, a reliable risk calculator has been developed that predicts the risk of having MODY, which if found to be high, is then confirmed by genetic testing for MODY. There is no study available on presence of MODY or on the reliability of the MODY risk calculator among young Emirati population. There is also no data on MODY being misdiagnosed as other forms of diabetes in Emirati population.
This study proposal aims to address this gap of knowledge and assess the reliability of MODY calculator in young Emirati patients with diabetes and to see if any MODY patient exist in Diabetes clinics of Tawam hospital Abu Dhabi, who may have been misdiagnosed as type 1 or type 2.

开始日期2024-03-01

申办/合作机构

United Arab Emirates University

NCT06606275 / Active, not recruitingN/A

The Safety and Effectiveness of Warfarin Vs Apixaban in Patients with Non-Valvular Atrial Fibrillation/ Venous Thromboembolism and End-Stage Kidney Disease on Dialysis

This is a retrospective study of End-Stage Kidney Disease (ESKD) patients on dialysis receiving apixaban or warfarin at Tawam Hospital [a tertiary care hospital in Al Ain, UAE]. The study aims to assess the appropriateness of prescribing apixaban and warfarin in this population and evaluate their safety and effectiveness.

开始日期2024-01-01

申办/合作机构

Abu Dhabi Health Services Co.

[+2]

NCT05733078 / Recruiting临床2期IIT

Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism Requiring High Levothyroxine Dosage; a Randomized Control Trial

Thyroid disease affects almost a quarter of a billion individuals worldwide and more than 50% of them being not aware of this condition. The commonest thyroid disease is iodine deficiency related thyroid dysfunction with nearly 2 billion people around the globe at risk with insufficient iodine intake. Autoimmune thyroid disorders are commonest cause of thyroid dysfunction in iodine sufficient parts of the world. Sub-optimally or untreated hypothyroidism can lead to cognitive decline, dyslipidemia, hypertension, infertility as well as cardiovascular and neuromuscular problems. The prevalence of hypothyroidism can vary in general population with up-to 5.3% people with overt hypothyroidism based on studies from the West, with estimated 10% of the population having subclinical hypothyroidism globally. In the gulf region however, there are no national studies that provide insight into exact prevalence of hypothyroidism, however some cross-sectional screening studies indicate frequency of hypothyroidism to be as high as 5-10%.
Levothyroxine is a synthetic hormone with structure similar to naturally occurring thyroxine, and it is used as replacement monotherapy of hypothyroidism. It is mainly absorbed via small intestine. The optimal daily levothyroxine dosage requirement is 1.6 microgram/kg body weight/day, which can normalize TSH in most patients, however many studies indicate that nearly half the patient on replacement therapy may not attain a normal TSH and require further doses, possibly due to interference or malabsorption. Multiple dose change and repeated diagnostic procedures in these patients can not only increased health costs but increased of ensuing complications secondary to sub-optimally controlled hypothyroidism. Instead of increasing levothyroxine doses and getting variable response, recent study have shown improvement in thyroid function by adding on vitamin C alongside levothyroxine dose, albeit only in a specific subset of patient having gastritis. The effect of Vitamin C on improving levothyroxine also been shown to be effective over a short period in a non-randomized, non-controlled setting. Our study aims to investigate whether addition of vitamin C to levothyroxine can improve the biochemical and clinical thyroid status in a randomized controlled setting.

开始日期2023-11-01

申办/合作机构

United Arab Emirates University

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2025-01-01·FOOD CHEMISTRY

Co-encapsulation of borage seed oil and peppermint oil blends within ultrasound-assisted soy protein isolate/purity gum ultra complex nanoparticles: Fabrication, structural interaction mechanisms, and in vitro digestion studies

Article

作者: Shoaib, Muhammad ; Khalifa, Ibrahim ; Alsulami, Tawfiq ; Iqbal, Muhammad Waheed ; Sun, Yufan ; Zhong, Mingming ; Rehman, Abdur ; Wang, Junxia ; Rasheed, Hafiz Abudul ; Zhao, Yongjun ; Miao, Song ; Ren, Xiaofeng ; Liang, Qiufang

This study aimed at co-encapsulating borage seed oil (BSO)- and peppermint oil (PO) blends in ultrasound-assisted complex nanoparticles stabilized by soy protein isolate (SPI) and purity gum ultra (PGU) in different ratios: SPI/PGU-1:0 (NP₁), 0:1 (NP₂), 1:1 (NP₃), 1:3 (NP₄), and 3:1 (NP₅). The BSO- and PO-loaded SPI/PGU complex nanoparticles (BP-loaded SPNPs) coded as NP₄ (SPI-PGU-1:3) revealed a zeta potential of -33.27 mV, a PDI of 0.14, and the highest encapsulation efficiency (81.38 %). The main interactions observed among SPI, PGU, BSO, PO, and a blend of BSO and PO, as determined by FTIR and molecular docking, involved hydrophobic effects, electrostatic attraction, and H-bonding. These interactions played crucial roles in the production of BP-loaded SPNPs. XRD results validated the alterations in the structure of BP-loaded SPNPs caused by varying proportions of SPI and PGU. The thermal capacity of BP-loaded SPNPs (NP₄), as determined by TGA, exhibited the lowest amount of weight loss compared to other BP-loaded SPNPs. Morphological results revealed that NP₄ and NP₅ exhibited a spherical surface and two distinguishable layers, indicating successful coating of PGU onto the droplet surface. In addition, BP-loaded SPNPs (NP₄) exhibited a higher antioxidant effect due to their improved progressive release and prolonged release of co-encapsulated BSO and PO during in vitro digestion. The comprehensive investigation of the co-encapsulation of BSO and PO in complex nanoparticles, dietary supplements, and double-layered emulsified systems provides valuable insights into the development of functional foods.

2024-12-31·Journal of Natural Fibers

Investigating the Effect of Varied Short Bamboo Fiber Content on the Thermal, Impact, and Flexural Properties of Green Epoxy Composites

作者: Chandrasekar, M. ; Singh, Balbir ; Ismail, Ahmad Safwan ; Hashem, Mohamed ; Senthilkumar, K. ; Khiari, Ramzi ; Jawaid, Mohammad ; Fouad, Hassan

In this study, the thermal and mech. characteristics of bamboo fiber-reinforced greenpoxy matrix composites were evaluated by varying the fiber loading from 30wt.% to 60wt.% during the compression molding process.The thermal behavior using dynamic mech. anal. (DMA) and thermogravimetric anal. (TGA) and their impact and flexural properties of the composites were studied.The results indicate that thermal characterization, the highest peak E′ was observed: B-40 > B-60 > B-30 > B-50, while the peak E′′ was found to be B-40 > B-30 > B-60 > B-50.The order for tan delta was B-30 > B-40 > B-50 > B-60.The TGA results indicated improved thermal stability with increasing fiber loading, as evidenced by higher residue % and lower weight loss %.Regarding the mech. properties the impact strength of the composites increased with increasing fiber loading, with the maximum value of 8435.33 J/m2 at 50wt.%.The composite with a 60wt.% fiber loading showed the highest flexural modulus (4.70GPa), while the flexural strength improved at 40wt.%.The SEM anal. of fractured specimens from flexural tests of composite materials with varying fiber volume fractions revealed that an optimal balance between fiber and matrix resin enhanced mech. properties.

2024-12-31·International Journal of Veterinary Science and Medicine

Seroprevalence and molecular detection of Brucella infection in livestock in the United Arab Emirates

Article

作者: Edo, Bedaso Mammo ; Mohteshamuddin, Khaja ; Alkalbani, Meera Saeed ; Alfaki, Ibrahim Abdalla ; Tibbo, Markos ; Abdelazim, Assem Sobhi ; Kayaf, Kaltham ; Abdelhalim, Mohamed Moustafa ; Al Nuaimat, Mervat Mari ; Willingham, Arve Lee ; Albizreh, Abdallah A. ; Eltahir, Yassir Mohammed ; Koliyan, Rafeek Aroul ; Sori, Teshale ; Bayissa, Berecha ; Hamad, Mohamed Elfatih ; Degefa, Berhanu Adenew ; Alhosani, Naeema ; Ameni, Gobena ; Zewude, Aboma ; Barigye, Robert

项与 United Arab Emirates University 相关的新闻（医药）

2024-05-13

·PRNewswire

Department of Health - Abu Dhabi Unveils 'Declaration of Principles' on Bioconvergence to Enhance Global Healthcare Outcomes

ABU DHABI, UAE, May 13, 2024 /PRNewswire/ -- An an outcome of the Health Leaders Forum (HLF) organised during Abu Dhabi Global Healthcare Week (ADGHW), the Department of Health – Abu Dhabi (DoH), the regulator of the healthcare sector in the Emirate, unveiled a Declaration of Principles on Bioconvergence, to transform healthcare, improve human health and well-being. As a first-of-its-kind initiative, the Declaration outlines global principles covering guidance on transparency, accountability, and bias mitigation, as well as research ethics and ethical decision-making in the field of Bioconvergence. Continue Reading DoH Unveils ‘Declaration of Principles’ on Bioconvergence to Enhance Healthcare Outcomes (PRNewsfoto/The Department of Health - Abu Dhabi) Bioconvergence has been recognised as the latest technological trend of the 21st century for the healthcare sector. It is a transdisciplinary field that merges engineering and life sciences, and is set to revolutionise the health-tech industry. Bioconvergence fuses life sciences with a vast number of technologies from fields such as mathematics, engineering, and physical and computational sciences. The Declaration of Principles will witness leading local and global entities collaborate with DoH including Amazon, Microsoft, UAE University (UAEU), Mohammad Bin Zayed University for AI (MBZUAI), Core 42 and Masdar City. Segmented into six strategic pillars, the principles aim to advance Bioconvergence research and development, encourage investment in the field to address urgent healthcare challenges, establish international cooperation frameworks, prioritise research areas in public health and personalised medicine, and promote the adoption of advanced technologies such as Artificial Intelligence (AI) and nanomedicine. Dr. Asma Ibrahim Al Mannaei, the Executive Director of the Research and Innovation Centre at the Department of Health – Abu Dhabi (DoH): "In the intricacies of Bioconvergence, establishing fundamental principles is not merely a choice, but a collective responsibility. These principles serve as a beacon of transparency, guardians of accountability and shields against any form of bias. With the ever-evolving intersection of health and technology, integrity and diligence remain guiding threads for the Department of Health – Abu Dhabi. Reinforcing Abu Dhabi's position as a leading destination for innovation in healthcare, the unique Declaration serves as a testament to the Department's continued efforts to build a healthier world and shape the future of healthcare for generations to come." Moreover, upholding ethical standards and responsible practices involve raising awareness on the benefits and risks of Bioconvergence technologies, establishing ethical guidelines, and ensuring accessibility and affordability for all. Investment in education and workforce development entails supporting skill development, integrating Bioconvergence into relevant curricula, fostering interdisciplinary collaboration, and promoting diversity in the field. Additionally, fostering collaboration and the exchange of knowledge among stakeholders, advocating for supportive policies and regulations, and engaging the community through awareness campaigns and transparent communication are crucial steps in advancing Bioconvergence research and innovation while maintaining community's trust and support. These key pillars will support accelerating the future of healthcare and life sciences by making quality health a global priority. Held under the patronage of His Highness Sheikh Khaled bin Mohamed bin Zayed Al Nahyan, Crown Prince of Abu Dhabi and Chairman of Abu Dhabi Executive Council, Abu Dhabi Global Healthcare Week is a major government initiative taking place between 13 and 15 May 2024. ADGHW seeks to accelerate collaboration, innovation, and investment, and bring together researchers, policymakers, healthcare specialists, investors, and entrepreneurs across the global healthcare and life science ecosystem. For more information please visit: About Department of Health – Abu Dhabi (DoH): The DoH is the regulatory body of the healthcare sector at the Emirate of Abu Dhabi and ensures excellence in healthcare by monitoring the health status of the population. DoH defines the strategy for the health system, monitors and analyses the health status of the population and performance of the system. In addition, DoH shapes the regulatory framework for the health system, inspects against regulations, enforce standards, and encourages adoption of world-class best practices and performance targets by all healthcare service providers in the Emirate. DoH also drives programmes to increase awareness and adoption of healthy living standards among the residents of the Emirate of Abu Dhabi in addition to regulating scope of services, premiums and reimbursement rates of the health system. For further information on DoH, visit and follow on X, Instagram, Facebook, LinkedIn and YouTube. Photo - SOURCE The Department of Health - Abu Dhabi