Delving into the Latest Updates on Alcon Research LLC with Synapse

概览

疾病领域	数量

神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

ADRA1(肾上腺素能受体α-1家族)	1

关联

1

项与 Alcon Research LLC 相关的药物

Phenylephrine Hydrochloride

盐酸去氧肾上腺素

靶点

ADRA1

作用机制

ADRA1激动剂

在研机构

Hikma Pharmaceuticals USA, Inc. [+7]

原研机构

Kowa Co., Ltd.

在研适应症

麻醉 [+6]

非在研适应症

大便失禁 [+4]

最高研发阶段批准上市

首次获批国家/地区

日本

首次获批日期1954-10-11

3

项与 Alcon Research LLC 相关的临床试验

DRKS00031788 / RecruitingN/A

UV Femtosecond Laser Assisted Lenticule Extraction Sphere Nomogram Study - RFO268-C001

开始日期2023-09-28

申办/合作机构

Alcon Research LLC

DRKS00020134 / CompletedN/A

Clinical Investigation of Patient Outcomes after IOL Implantation with Different IOL Delivery Systems - ILT142-P001

开始日期2020-09-04

申办/合作机构

Alcon Research LLC

DRKS00020388 / CompletedN/A

Postmarket Study of outcomes from WaveLight® EX500 InnovEyes™ treatment in conjunction with the InnovEyes™ Sightmap - RFP911-P001

开始日期2020-07-07

申办/合作机构

Alcon Research LLC

100 项与 Alcon Research LLC 相关的临床结果

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0 项与 Alcon Research LLC 相关的专利（医药）

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21

项与 Alcon Research LLC 相关的文献（医药）

2024-04-01·Contact Lens and Anterior Eye

Evaluating the in vitro wettability and coefficient of friction of a novel and contemporary reusable silicone hydrogel contact lens materials using an in vitro blink model

Article

作者: Drolle, Elizabeth ; Ngo, William ; Phan, Chau-Minh ; Jones, Lyndon ; Shows, Amanda ; Liang, Shuang ; Subbaraman, Lakshman ; Hui, Alex ; Shi, Xinfeng ; Bose, Susmita ; Zheng, Ying ; Wy Chan, Vivian ; Sharma, Vinay ; Wu, James

PURPOSETo evaluate the in vitro wettability and coefficient of friction of a novel amphiphilic polymeric surfactant (APS), poly(oxyethylene)-co-poly(oxybutylene) (PEO-PBO) releasing silicone hydrogel (SiHy) contact lens material (serafilcon A), compared to other reusable SiHy lens materials.METHODSThe release of fluorescently-labelled nitrobenzoxadiazole (NBD)-PEO-PBO was evaluated from serafilcon A over 7 days in a vial. The wettability and coefficient of friction of serafilcon A and three contemporary SiHy contact lens materials (senofilcon A; samfilcon A; comfilcon A) were evaluated using an in vitro blink model over their recommended wearing period; t = 0, 1, 7, 14 days for all lens types and t = 30 days for samfilcon A and comfilcon A (n = 4). Sessile drop contact angles were determined and in vitro non-invasive keratographic break-up time (NIKBUT) measurements were assessed on a blink model via the OCULUS Keratograph 5 M. The coefficient of friction was measured using a nano tribometer.RESULTSThe relative fluorescence of NBD-PEO-PBO decreased in serafilcon A by approximately 18 % after 7 days. The amount of NBD-PEO-PBO released on day 7 was 50 % less than the amount released on day 1 (6.5±1.0 vs 3.4±0.5 µg/lens). The reduction in PEO-PBO in the lens also coincided with an increase in contact angles for serafilcon A after 7 days (p < 0.05), although there were no changes in NIKBUT or coefficient of friction (p > 0.05). The other contact lens materials had stable contact angles and NIKBUT over their recommended wearing period (p > 0.05), with the exception of samfilcon A, which had an increase in contact angle after 14 days as compared to t = 0 (p < 0.05). Senofilcon A and samfilcon A also showed an increase in coefficient of friction at 14 and 30 days, respectively, compared to their blister pack values (p < 0.05).CONCLUSIONThe results indicate that serafilcon A gradually depletes its reserve of PEO-PBO over 1 week, but this decrease did not significantly change the lens performance in vitro during this time frame.

2024-02-01·Ophthalmology and Therapy

Multi-symptom Relief with Propylene Glycol-Hydroxypropyl-Guar Nanoemulsion Lubricant Eye Drops in Subjects with Dry Eye Disease: A Post-Marketing Prospective Study

Article

作者: Tauber, Joseph ; Awisi-Gyau, Deborah ; Miller, Jason R ; Bickle, Katherine

INTRODUCTIONThe study aimed to evaluate multi-symptom relief of dry eye manifestations with the use of propylene glycol-hydroxypropyl-guar (PG-HPG) nanoemulsion lubricant eye drops, among subjects with dry eye disease (DED).METHODSThis was a post-marketing, prospective, single-arm study conducted in the USA. Subjects aged ≥ 18 years, with tear breakup time (TBUT) ≤ 10 s for both eyes, dry eye questionnaire-5 (DEQ-5) "watery eyes" symptom score 1-4, symptoms of burning/stinging, sore and tired eyes as determined by impact of dry eye on everyday living-symptom bother (IDEEL-SB) questionnaire, and IDEEL-SB score 16-65 were included. Subjects were required to complete IDEEL-SB and DEQ-5 at days 0, 14 ± 2, and 28 ± 2, and self-administer one drop of PG-HPG four times daily for 28 ± 2 days. Primary endpoints were change from baseline at day 28 in symptoms of sore, stinging/burning, and tired eyes on IDEEL-SB; and symptom of watery eyes on DEQ-5. Other endpoints evaluated were corneal staining and TBUT at baseline and day 28 ± 2; symptom relief (5-point Likert scale) at day 28 ± 2, and safety.RESULTSOf 119 subjects enrolled, 95 completed the study (mean ± SD age 61.2 ± 13.0 years; female 69.5%). Mean IDEEL-SB scores reduced significantly from baseline at day 28 for symptoms of aching/sore eyes (change from baseline - 1.0 ± 1.1), burning/stinging eyes (change from baseline - 1.1 ± 0.9), and tired eyes (change from baseline - 1.1 ± 1.0) (all p < 0.0001). Mean DEQ-5 score for watery eye symptoms significantly reduced from baseline at day 28 (change from baseline - 0.9 ± 1.0, p < 0.0001). Corneal staining at day 28 was comparable to baseline. TBUT improved from baseline to day 28. On a Likert scale, more than 50% of subjects reported relief from symptoms of sore, stinging, and burning eyes. Three (3.1%) subjects reported treatment-emergent adverse events (non-ocular).CONCLUSIONSPG-HPG nanoemulsion lubricant eye drops significantly improved multiple dry eye symptoms in subjects with DED over 28 days, with no new safety concerns.TRIAL REGISTRATIONClinicalTrials.gov Identifier, NCT05056155.

2023-09-18·ACS applied bio materials

Biomimetic-Engineered Silicone Hydrogel Contact Lens Materials.

Review

作者: Wu, James Yuliang ; Yao, George ; Ishihara, Kazuhiko ; Yamaoka, Tetsuji ; Shi, Xinfeng ; Fukazawa, Kyoko

Contact lenses are one of the most successful applications of biomaterials. The chemical structure of the polymers used in contact lenses plays an important role in determining the function of contact lenses. Different types of contact lenses have been developed based on the chemical structure of polymers. When designing contact lenses, materials scientists consider factors such as mechanical properties, processing properties, optical properties, histocompatibility, and antifouling properties, to ensure long-term wear with minimal discomfort. Advances in contact lens materials have addressed traditional issues such as oxygen permeability and biocompatibility, improving overall comfort, and duration of use. For example, silicone hydrogel contact lenses with high oxygen permeability were developed to extend the duration of use. In addition, controlling the surface properties of contact lenses in direct contact with the cornea tissue through surface polymer modification mimics the surface morphology of corneal tissue while maintaining the essential properties of the contact lens, a significant improvement for long-term use and reuse of contact lenses. This review presents the material science elements required for advanced contact lenses of the future and summarizes the chemical methods for achieving these goals.

100 项与 Alcon Research LLC 相关的药物交易

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100 项与 Alcon Research LLC 相关的转化医学

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