Objective: To select the synthetic route of fenticonazole nitrate. Methods: Thiophenol and p-bromobenzaldehyde were used as starting materials for condensation to obtain 4-(phenylthio)benzaldehyde, followed by sodium borohydride reduction and halogenation to give 4-(phenylthio)benzyl chloride, which was subjected to condensation reaction with 1-(2,4-dichlorophenyl)-2-imidazoleethanol in the presence of sodium hydroxide under phase transfer catalysis to yield fenticonazole nitrate. Results and conclusion: The reagents were cheap and easy to obtain, the synthesis cost was low, the operation was simple, and there is no special requirement for the equipment, which was suitable for large-scale production