Objective To study the effect of Xuesaitong dispersion tablets on brain edema and inflammation caused by chronic cerebral ischemia in the rat model; and determine the influence of Xuesaitong dispersion tablets on PGI2/ TXA2 and EDRF/NO signaling pathways to further investigate the mechanism.Methods Chronic cerebral ischemia rat models caused by permanent bilateral common carotid artery ligation.The SD rats were randomly devided into model group, Sham group, Dengzhan Xixin granule group (1.5 g·kg-1 ) and Xuesaitong high, medium and low dose groups (50, 25, 12.5 mg·kg-1 , resp.), 10 rats in each group, and administrated with correspondent drugs once a day for 10 days.Serum contents of ICAM-1, PGI2, TXA2, NO, EDRF were detected using ELISA; and the fresh weight and dry weight of brain tissue were measured to calculate the water content of brain tissue.Results Compared with Sham group rats, water content of brain tissue and the serum levels of ICAM-1 and TXA2 in model rats were significantly increased (P<0.01), the serum contents of PGI2, NO and EDRF were significantly decreased (P<0.05, P<0.01).Compared with model rats, water content of brain tissue and the serum levels of ICAM-1 and TXA2 were significantly decreased in the high and medium dose Xuesaitong dispersion tablets group rats (P<0.05, P<0.01), and the serum contents of PGI2, NO and EDRF were significantly increased (P<0.05, P<0.01).Conclusion Xuesaitong dispersion tablets has a beneficial effect on chronic cerebral ischemia via regulating PGI2/TXA2 and EDRF/NO signaling pathways.