To construct the platform for exercise counseling for pregnant women, and evaluate the effects of that telecare platform integration model for exercise consultation on exercise behaviors and prenatal health outcomes among pregnant women during pregnancy.

开始日期2023-12-15

申办/合作机构

Mackay Medical College

NCT06220708 / CompletedN/AIIT

Effects Of Dance Movement Therapy On Compassionate Flow In Nursing Students: An Experimental Study

This study aimed to investigate the differences in compassionate flow among nursing students both before and after an educational intervention.

开始日期2023-09-01

申办/合作机构

Mackay Medical College

TCTR20230727001 / Not yet recruiting早期临床1期IIT

Effects of Virtual Reality with Different Motor Priming Strategies on Turning and Postural Stability in Individuals with Chronic Stroke

开始日期2023-09-01

申办/合作机构

Mackay Medical College

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项与 Mackay Medical College 相关的文献（医药）

2024-12-01·Molecular Biology Reports

Syndecan-4 is required for early-stage repair responses during zebrafish heart regeneration

Article

作者: Chen, Yu-Chieh ; Chuang, Yung-Jen ; Yang, Chung-Chi ; Chen, Wei-Chen ; Lai, Zih-Yin ; Chen, Po-Hsun ; Wang, Ko-Ying ; Lu, Guan-Yun ; Lai, Ting-Yu ; Liu, Lawrence Yu-Min ; Liu, Wei-Cen ; Yang, Chiao-Yu

AbstractBackgroundThe healing process after a myocardial infarction (MI) in humans involves complex events that replace damaged tissue with a fibrotic scar. The affected cardiac tissue may lose its function permanently. In contrast, zebrafish display a remarkable capacity for scar-free heart regeneration. Previous studies have revealed that syndecan-4 (SDC4) regulates inflammatory response and fibroblast activity following cardiac injury in higher vertebrates. However, whether and how Sdc4 regulates heart regeneration in highly regenerative zebrafish remains unknown.Methods and ResultsThis study showed that sdc4 expression was differentially regulated during zebrafish heart regeneration by transcriptional analysis. Specifically, sdc4 expression increased rapidly and transiently in the early regeneration phase upon ventricular cryoinjury. Moreover, the knockdown of sdc4 led to a significant reduction in extracellular matrix protein deposition, immune cell accumulation, and cell proliferation at the lesion site. The expression of tgfb1a and col1a1a, as well as the protein expression of Fibronectin, were all down-regulated under sdc4 knockdown. In addition, we verified that sdc4 expression was required for cardiac repair in zebrafish via in vivo electrocardiogram analysis. Loss of sdc4 expression caused an apparent pathological Q wave and ST elevation, which are signs of human MI patients.ConclusionsOur findings support that Sdc4 is required to mediate pleiotropic repair responses in the early stage of zebrafish heart regeneration.

2024-11-01·American Journal of Clinical Dermatology

Predicting the Time to Relapse Following Withdrawal from Different Biologics in Patients with Psoriasis who Responded to Therapy: A 12-Year Multicenter Cohort Study

Article

作者: Hung, Sung Jen ; Tsai, Tsen-Fang ; Huang, Chang-Ming ; Hui, Rosaline Chung-Yee ; Lee, Chaw-Ning ; Huang, Yu-Huei ; Chiu, Hsien-Yi ; Wu, Nan-Lin

BACKGROUNDFor patients with psoriasis, discontinuation of biologics following remission has become more common in daily practice.OBJECTIVEWe aimed to identify predictors and construct a predictive model for time to relapse following withdrawal from biologics.METHODSThis 12-year, multicenter, observational cohort study was performed in six dermatology centers between February 2011 and February 2024. We identified biological treatment episodes in patients with moderate-to-severe psoriasis and included only treatment episodes in which a clinical response (≥ 50% reduction in Psoriasis Area and Severity Index score [PASI 50] from baseline) was achieved and the patient withdrew from biological therapy with a well-controlled status (PASI < 10 and ≥ 50% improvement in PASI from baseline). The primary outcome was time to relapse, which was defined as the period from the last biologic administration to relapse. An extended multivariate Cox proportional hazards analysis (Prentice-Williams-Peterson Gap time model) was used to predict relapse and generate a predictive model.RESULTSThis study screened 1613 biological treatment episodes, and 991 treatment episodes were enrolled. The time to relapse decreased significantly as the number of previous withdrawals from biological treatment increased (p < 0.001). Similarly, the time to relapse decreased significantly as the number of previous biologics used increased (p < 0.001). The maximum PASI improvement during biological treatment decreased and the PASI score at withdrawal of biological treatment increased in parallel as the number of prior withdrawals from biologics increased. The time to relapse following withdrawal was longest for interleukin (IL)-23 inhibitors (IL-23i), followed by the IL-12/23i, IL-17 inhibitors (IL-17i), and tumor necrosis factor-α inhibitors. After adjustment, multivariate Cox regression identified the following significant predictors of relapse following withdrawal: the mechanisms of action of biologics (hazard ratio [HR] for IL-17i vs IL-12/23i, 1.59; HR for IL-23i vs IL-12/23i, 0.60), number of previous withdrawals from biological treatment (HR 1.23; 95% confidence interval [CI] 1.13‒1.33), time to achieve PASI 50 (HR 1.01; 95% CI 1.00‒1.02), maximum PASI improvement on biologics (HR 0.98; 95% CI 0.98‒0.99), and PASI at the end of therapy (HR 1.03; 95% CI 1.01‒1.05). The model had good predictive and discriminative ability.CONCLUSIONSThese results have the potential to help physicians and patients make individualized treatment decisions; information on the risk of relapse of psoriasis at specific timepoints following the withdrawal of biologics is particularly valuable for patients considering discontinuation of biologics or as-needed biologic therapy. However, the benefit and risk of repeated withdrawals of biologics should be carefully weighed, as the treatment efficacy and duration of remission decline as the number of withdrawals increases.

2024-11-01·The American Journal of Surgery

Temporal research trends in parathyroid surgery

Review

作者: Kuo, Chi-Yu ; Cheng, Shih-Ping ; Chi, Shun-Yu

BACKGROUNDProgress has been observed in the pathophysiology of calcium homeostasis, localization studies, and intraoperative adjuncts in parathyroid surgery. The aim of this study is to gain a comprehensive perspective on the research landscape of parathyroid surgery over time.METHODSA search of the Web of Science Core Collection was conducted to identify publications on parathyroid surgery from 1985 to 2024. Keywords were manually curated, and their frequencies were calculated based on the publication year.RESULTSPublications on secondary hyperparathyroidism have decreased in recent years, but those on calcimimetics, tertiary hyperparathyroidism, and parathyroid cancer have increased. Publications related to sestamibi scans have decreased, while research on four-dimensional computed tomography and positron emission tomography has increased. Research on fluorescence and ablation treatment has recently been on the rise. The citation count per publication was positively correlated with the number of contributing institutions.CONCLUSIONWe provide an overview of contemporary research themes and emerging topics related to parathyroid surgery. The endocrine surgery community could benefit from more inter-institutional partnerships to foster scientific progress.

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