A Phase 1b, Randomized, Uncontrolled, Single-masked, Safety, Tolerability, and Pharmacokinetic Study of Multiple Doses of Three Different Concentrations (0.1%, 1.0%, 5.0%) of SAR 1118 Ophthalmic Solution in Human Subjects Undergoing Elective Pars Plana Vitrectomy (PPV)

The purpose of this study is to determine the safety, tolerability, and pharmacokinetics of SAR 1118 within the anterior and posterior chamber of the eye and plasma in subjects undergoing elective vitrectomy when treated with escalating concentrations of the study drug for approximately 1 week.

开始日期2009-08-01

申办/合作机构

The Johns Hopkins University

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项与 SARcode Bioscience, Inc. 相关的文献（医药）

2014-02-01·Ophthalmology1区 · 医学

Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease

1区 · 医学

Article

作者: Kennedy, Kathryn S ; Semba, Charles P ; McLaurin, Eugene B ; Lonsdale, John D ; Eiferman, Richard A ; Torkildsen, Gail L ; Sheppard, John D ; D'Ambrosio, Francis A

PURPOSE:

To assess the efficacy and safety of lifitegrast ophthalmic solution 5.0% compared with placebo in subjects with dry eye disease.

DESIGN:

Prospective, randomized, double-masked, placebo-controlled, parallel arm, multicenter clinical trial.

PARTICIPANTS:

A total of 588 adult subjects with dry eye disease.

METHODS:

Eligible subjects were randomized 1:1 to receive topically administered lifitegrast (5.0%) or placebo (vehicle) twice daily for 84 days after a 14-day open-label placebo run-in period. After enrollment (day 0), subjects were evaluated at days 14, 42, and 84. Key objective (fluorescein and lissamine staining scores [Ora scales]) and subjective (Ocular Surface Disease Index [OSDI], 7-item visual analog scale, and ocular discomfort score [Ora scale]) measures were assessed at all visits.

MAIN OUTCOME MEASURES:

The primary objective efficacy measure (sign) was mean change from baseline inferior corneal staining score (ICSS) at day 84. The co-primary subjective efficacy measure (symptom) was the mean change from baseline in the visual-related function subscale score of the Ocular Surface Disease Index (VR-OSDI). Supportive measures included corneal fluorescein scores (superior, central, total region) and conjunctival lissamine scores (nasal, temporal, total region) and symptom scores at day 84.

RESULTS:

The study met the primary objective efficacy ICSS end point in demonstrating superiority of lifitegrast compared with placebo (P = 0.0007). Lifitegrast significantly reduced corneal fluorescein staining (superior, P = 0.0392; total cornea, P = 0.0148) and conjunctival lissamine staining (nasal, P = 0.0039; total conjunctiva, P = 0.0086) at day 84 versus placebo. Significant (P < 0.05) improvements in nasal and total lissamine scores were observed at day 14 and maintained through day 84. The study did not meet the co-primary subjective VR-OSDI measure (P = 0.7894). However, significant improvements were observed at day 84 in ocular discomfort (P = 0.0273) and eye dryness (P = 0.0291), the most common and severe symptoms reported at baseline in both groups. There were no unanticipated or serious ocular adverse events (AEs). The most frequent reported ocular AEs were transient intermittent instillation site symptoms (irritation, discomfort) primarily on the initial lifitegrast dose at day 0.

CONCLUSIONS:

Lifitegrast ophthalmic solution 5.0% significantly reduced corneal fluorescein and conjunctival lissamine staining and improved symptoms of ocular discomfort and eye dryness compared with placebo when administered twice daily over 84 days.

2013-05-01·Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics4区 · 医学

Corneal Inflammation Is Inhibited by the LFA-1 Antagonist, Lifitegrast (SAR 1118)

4区 · 医学

Article

作者: Zhang, Rui ; Sun, Yan ; Pearlman, Eric ; Gadek, Thomas R. ; O'Neill, Charles A.

PURPOSE:

Sterile corneal infiltrates can cause pain, blurred vision, and ocular discomfort in silicone hydrogel contact-lens users. The current study investigates the potential for the synthetic lymphocyte functional antigen-1 (LFA-1) antagonist lifitegrast (SAR 1118) to block corneal inflammation using a murine model.

METHODS:

The role of LFA-1 (CD11a/CD18) was examined either in CD18(-/-) mice, by intraperitoneal injection of anti-CD11a, or by topical application of lifitegrast. Corneal inflammation was induced by epithelial abrasion and exposure to either tobramycin-killed Pseudomonas aeruginosa or Staphylococcus aureus in the presence of a 2-mm-diameter punch from a silicone hydrogel contact lens. After 24 h, corneal thickness and haze were examined by in vivo confocal microscopy, and neutrophil recruitment to the corneal stroma was detected by immunohistochemistry.

RESULTS:

Neutrophil recruitment to the corneal stroma and development of stromal haze were significantly impaired in CD18(-/-) mice or after injection of anti-CD11a. Topical lifitegrast also inhibited P. aeruginosa- and S. aureus-induced inflammation, with the optimal application being a 1% solution applied either 2 or 3 times prior.

CONCLUSION:

As LFA-1-dependent neutrophil recruitment to the corneal stroma can be blocked by topical lifitegrast, this reagent could be used in combination with antibiotics to prevent leukocyte infiltration to the corneal stroma in association with contact-lens wear.

2012-07-01·Eye (London, England)3区 · 医学

Safety, tolerability, and bioavailability of topical SAR 1118, a novel antagonist of lymphocyte function-associated antigen-1: a phase 1b study

3区 · 医学

Article

作者: P Gehlbach ; Q D Nguyen ; C Semba ; O Shaikh ; W Stark ; S Solomon ; D M Paskowitz ; D V Do ; J T Handa ; T R Gadek

PURPOSE:

A growing body of evidence points to a role for inflammation mediated by lymphocyte function-associated antigen-1 (LFA-1) and its ligand intercellular adhesion molecule-1 in the pathogenesis of diabetic macular oedema. This phase 1b clinical trial assessed the safety, tolerability, and pharmacokinetics of topically administered SAR 1118, a novel LFA-1 antagonist, in human subjects.

METHODS:

In this prospective, randomized, double-masked trial, 13 subjects scheduled for vitrectomy received one of three concentrations of topical SAR 1118 (0.1, 1.0, or 5.0%) twice daily for 1 week before surgery. Undiluted aqueous and vitreous samples were collected at surgery and analysed for the concentration of the medication.

RESULTS:

All subjects completed the entire course of medication. The only adverse events reported were instillation site irritation (4/13, 31%) and dysgeusia (3/13, 23%). These were mild and transient, occurring at the highest dose. Mean concentrations (ng/ml) of SAR 1118 in the aqueous humour were 0.25, 37.2, and 101.1 for the 0.1%, 1.0%, and 5.0% dose groups, respectively. SAR 1118 was below the level of detection (0.5 ng/ml) for all vitreous samples except in a single subject who had a history of prior vitrectomy and a dislocated intraocular lens.

CONCLUSIONS:

Topical SAR 1118 was safe and well tolerated, and dose-dependent levels of drug were detected in aqueous. However, vitreous levels were below the threshold of detection with the concentrations tested. Further investigation of this medication for posterior segment applications would require intravitreal delivery or chemical modification of the drug.

项与 SARcode Bioscience, Inc. 相关的新闻（医药）

2024-10-08

·精准药物

综述｜(2016–2020)上市药物中的分子手性中心构建

Asymmetric Synthesis of US - FDA Approved Drugs over Five Years (2016–2020): A Recapitulation of Chirality” 由 Rekha Tamatam 和 Dongyun Shin 撰写。论文强调了 2016 - 2020 年期间 FDA 批准的手性药物的合成方法，特别关注通过手性诱导、拆分或手性池进行的不对称合成。手性药物具有多种优势，包括：（1）由于更好的药代动力学和药效学性质，手性药物与非手性对应物相比可能具有更高的效力；（2）通过分离特定的对映体，手性药物可以减少不必要的副作用；（3）手性药物可以通过靶向特定的酶或受体来增强药物传递；（4）使用单一异构体可以降低生产成本，从而降低患者的药品价格。一个手性中心的药物的合成方法 1.1. Lifitegrast (2016) ： Lifitegrast 由美国加利福尼亚州布里斯班的 SARcode Bioscience 公司研发，用于治疗干眼症。Lifitegrast 的全合成从市售的手性底物3-溴-L-苯丙氨酸开始，经过10步反应完成，产率为 88%。 1.2. Acalabrutinib (2017)：阿卡拉布替尼由阿塞塔制药公司研发，用于治疗套细胞淋巴瘤（MCL）。从 4-溴苯甲酸（）出发，经过四步反应得到中间体。市售的手性脯氨酸衍生物与通过酰氯进行酰胺化反应，以 86% 的产率生成阿卡拉布替尼。 1.3. Pemafibrate (2017) ：培米贝特由兴和制药公司研发，用于治疗高脂血症。手性片段由对映体纯的（S）-2-羟基丁内酯（）在三甲基硅基碘存在下通过开环反应合成。的氢化还原以及使用2,6-二甲基吡啶进行的三氟甲磺酸酯加成生成。在碳酸钾和乙腈作用下发生构型翻转，以 75%的产率生成培米贝特。 1.4. Letermovir (2017) AiCuris公司开发了莱特莫韦用于治疗巨细胞病毒感染。在尿素环化步骤中，莱特莫韦中引入了一个手性中心。尿素在金鸡纳碱类相转移催化剂存在下，于磷酸钾水溶液和甲苯的双相混合物中发生环化反应，生成喹唑啉酮外消旋体（A12）。 1.5. Netarsudil(2017）艾尔建制药公司开发了奈他舒地尔用于治疗高眼压症。Evans噁唑烷酮（A15）作为手性助剂，随后在过氧化氢存在下被去除。二酯A14进行区域选择性水解，接着通过酰氯形成和酰胺化反应生成酯衍生物A16。用LiHMDS和Boc保护的苯并三唑基甲胺处理Evans噁唑烷酮化合物生成A17，奈他舒地尔的关键立体化学结构通过A17构建。 1.6. Niraparib (2017) 默克公司发现并由泰萨罗公司开发的尼拉帕利，通过酰氯形成和酰胺化反应生成酯衍生物A16。尼拉帕利用于治疗腹膜癌。具有一个手性中心的尼拉帕利从哌啶亚单元获得，由溴苯（A19）合成。亚硫酸氢盐加合物在ATA-302酶催化和吡哆醛-5-磷酸（PLP）共催化下进行转氨酶反应，生成手性哌啶A22。 1.7. Lorlatinib (2018）洛拉替尼由辉瑞公司研发，是一种肿瘤药物。洛拉替尼是一种大环化合物，由手性醇中间体A25构建而成。这个关键步骤涉及使用生物催化剂进行对映选择性还原。 1.8. Elobixibat Hydrate (2018) EA制药公司和持田制药公司开发了依洛昔巴特水合物，用于治疗慢性特发性便秘。在TBTU和甲基（R-2-氨基-2-苯基乙酸A28存在下，通过酸酯偶联生成单一手性碳。 1.9. Tezacaftor (2018) 由Vertex 制药公司发现和开发，特扎卡福是一种广泛作用的囊性纤维化跨膜传导调节因子（CFTR）。它的规模化合成（方案9）从3-氟-4-硝基苯胺A31开始。其区域选择性溴化从3-氟-4-硝基苯胺开始，与N-溴代琥珀酰亚胺（NBS）反应生成中间体A32。市售的（R）-缩水甘油基苄基醚A33通过酸催化开环在苯胺上诱导手性，接着还原硝基得到A34。后续步骤，包括Sonogashira偶联、Larock型环化和酸 - 胺偶联，以84%的产率得到特扎卡福。 1.10. Pyrotinib Maleate (2018) 恒瑞制药研发了马来酸吡咯替尼，它是一种泛ErbB受体酪氨酸激酶抑制剂，用于治疗转移性乳腺癌。马来酸吡咯替尼的千克级合成下图所示。手性片段A37由N-Boc-D-脯氨醇A36经过四步反应合成。 1.11. Encorafenib (2018) 康奈非尼与比美替尼（binimetinib）联合使用，用于治疗转移性黑色素瘤。目前，康奈非尼由辉瑞公司销售。手性的引入方式如下：在碱的存在下，用氯甲酸苄酯和氯甲酸甲酯处理(S)-(−)-1,2-二氨基丙烷二盐酸盐A39，生成氨基甲酸酯衍生物A40。经过氢化后，得到手性亚基A41。 1.12. Duvelisib Monohydrate (2018) Duvelisib一水合物最初由因泰利金（Intellikine）公司开发，后来授权给维瑞斯姆肿瘤公司（Verastem Oncology），用于治疗慢性淋巴细胞白血病和小淋巴细胞淋巴瘤。因泰利金公司公布的Duvelisib一水合物的千克级合成方法在方案12中进行了讨论。用正己基锂处理的韦恩瑞布酰胺（Weinreb amide）A44与苯甲酰胺A43结合，经过四步反应形成手性异喹啉A45。在最后一步中，在甲醇中用D-酒石酸进行盐析，然后用氨水提高A45的对映体纯度。 1.13. Elagolix sodium(2018) 艾拉戈利克斯钠用于治疗子宫内膜异位症女性患者，由艾伯维和神经分泌生物科学公司开发。与度维利塞一水合物类似，在尿嘧啶与甲磺酸酯衍生物进行烷基化的过程中引入手性；后者化合物是由(−)-N-叔丁氧羰基-D-α-苯甘氨醇与甲磺酰氯反应合成。 1.14. Tegoprazan (2018) 泰戈泊扎兰最初由辉瑞公司发现，后由乐化制药和CJ医疗进一步开发，用于治疗胃食管反流病（GERD）。泰戈泊扎兰的可扩展合成方法如方案14所示。在三正丁基膦和1,1′-(偶氮二甲酰)二哌啶（ADDP）存在下，在苯并咪唑环上引入对映纯的苯并二氢吡喃醇侧链A53是合成的关键步骤。然后，3,5-二氟苯酚（A50）与丙炔酸甲酯发生缩合反应，生成E式和Z式（1:1混合物）的烯醇醚（A51）。接着进行氢化，随后进行分子内傅克酰基化反应，并用硼杂噁唑烷催化剂（A52）进行不对称还原，生成苯并二氢吡喃醇（A53）。最后，对后者进行重结晶，得到对映纯的手性亚基A53。 1.15. Alpelisib (2019) 诺华制药开发了阿培利司。它用于治疗转移性乳腺癌。在合成的最后一步中，在三乙胺存在下，通过L-脯氨酸酰胺A56在A55的咪唑环上引入手性中心（方案15）。 1.16. Solriamfetol (2019) 索利氨酯由 SK 生物制药公司开发，用于治疗与阻塞性睡眠呼吸暂停（OSA）和发作性睡病相关的埃勒斯-当洛斯综合征（EDS）。索利氨酯的千克级合成如方案16所示。在酸的存在下，由D-苯丙氨醇（A58）和氰酸钠一步合成索利氨酯，产率为89%。 1.17. Pretomanid (2019) 普瑞玛尼是一种抗分枝杆菌药物，用于治疗结核病（TB）。它是结核病联盟开发的首个抗结核药物。环氧化物A61在二异丙基乙胺存在下与前手性硝基咪唑A60偶联，发挥其作为手性底物的作用，生成A62。 1.18. Zanubrutinib (2019) 百济神州开发了泽布替尼用于治疗套细胞淋巴瘤。与上述的手性库方法不同，泽布替尼是首个通过手性拆分方法生产的药物。泽布替尼通过用L-二苯甲酰酒石酸（LDBTA）处理，以拆分方法获得其纯对映体形式。 1.19. Darolutamide (2019) 达罗他胺用于治疗非转移性去势抵抗性前列腺癌。它由奥立安集团和拜耳医药保健有限公司开发。达罗他胺不对称合成的关键步骤是将手性异丙胺片段插入到的联芳基骨架中，然后通过酸介导脱除片段上的 Boc 保护基，生成中间体A68。 1.20. Cenobamate (2019) SK制药公司开发了西诺巴胺，用于治疗部分性发作癫痫。方案20中展示的酶催化过程概述了其在胶红酵母（一种氧化还原酶）存在下的不对称催化氢化。 1.21. Avapritinib (2020) 通过手性拆分（Chiralresolution）A73。Blueprint医药开发了阿伐替尼（avapritinib），用于治疗转移性胃肠道癌症。通过超临界流体色谱分离中间体A73进行手性拆分，以68%的产率生成对映纯的阿伐替尼。 1.22. Berotralstat (2020) 贝罗司他用于预防遗传性血管性水肿（HAE）发作。与阿伐替尼的合成方法相同，在最后一步通过超临界流体色谱法以纯对映体形式合成贝罗司他。 1.23. Lonafarnib (2020) 洛那法尼用于治疗哈钦森-吉尔福德早衰症综合征（HGPS）。与贝罗司他不同，洛那法尼的手性是通过手性分离获得的。中间体A77经二异丁基氢化铝（DIBAL）还原后进行手性分离，生成具有一个立体中心的手性亚基A78。这些连续的步骤产生洛那法尼。 1.24. Osilodrostat (2020）奥西卓司他用于治疗库欣病，是一种11β-羟化酶抑制剂。手性奥西卓司他的生成方式与贝罗司他类似。中间体A80通过手性高效液相色谱（HPLC）分离直接生成药物。 1.25. Oliceridine (2020) 奥利塞林，一种中枢神经系统（CNS）药物，用于治疗中度至重度急性疼痛。在奥利塞林的全合成中，手性中间体A83通过A82的脱羧反应获得，随后进行超临界流体色谱（SFC）手性分离。 1.26. Remimazolam (2020) Acacia制药公司开发了瑞马唑仑，一种超短效苯二氮䓬类药物。在氯仿中用手性底物A86处理A85，生成了取代产物，该产物经过碱促进的F-moc脱保护和乙酸促进的缩合反应，经过三步生成环化中间体A87。 1.27. Ozanimod (2020) 奥扎尼莫德用于治疗复发型多发性硬化症。手性亚磺酰胺片段A90作为手性辅助基团，通过在A91的茚上插入一个手性中心来发挥作用（方案27）。片段A90与茚衍生物A89作为手性辅助基团，通过在茚上插入一个手性中心来发挥作用。奥扎尼莫德由中间体通过连续步骤合成A91. 两个手性中心的药物的合成方法未完待续！声明：发表/转载本文仅仅是出于传播信息的需要，并不意味着代表本公众号观点或证实其内容的真实性。据此内容作出的任何判断，后果自负。若有侵权，告知必删！长按关注本公众号粉丝群/投稿/授权/广告等请联系公众号助手觉得本文好看，请点这里↓

申请上市上市批准

2023-09-13

·CPHI制药在线

仿制药 | 干眼药物立他司特首仿报产

关注并星标CPHI制药在线 9月11日，成都康弘药业集团股份有限公司3类仿制药「立他司特滴眼液」的上市申请获CDE受理。立他司特（Lifitegrast）是一种新型小分子整合素抑制剂，通过抑制淋巴细胞功能相关抗原1（LFA-1）与细胞间粘附分子1的结合，从而减少由T淋巴细胞介导的炎症水平。 2016年7月，原研立他司特滴眼液被FDA批准用于治疗干眼症症状和体征，商品名为Xiidra。作为首个且唯一一个专门针对干眼症症状和体征的非类固醇滴眼液，Xiidra市场表现不错，2021年、2022年全球销售额分别为4.68亿美元和4.87亿美元。值得一提的是，Xiidra几经易手。该药最初由SARcode Bioscience开发，2013年Shire通过收购SARcode Bioscience将其纳入囊中。2018年武田收购Shire获得Xiidra，2019年武田将Xiidra相关权益卖个诺华。今年7月，诺华（Novartis）又将Xiidra卖给眼部健康专家博士伦（Bausch+Lomb)。据悉，Xiidra化合物专利于2024年11月15日到期，适应症专利于2026年5月17日到期。目前，Xiidra还未在国内获批，但康弘药业、齐鲁制药、贝特制药、辰欣药业四家企业已开始布局Xiidra仿制药市场。其中康弘药业率先递交立他司特滴眼液3类仿制药上市申请，预计有望取得该品种首仿生产批件。除了Xiidra，维眸生物也研发了一款治疗干眼症的LFA-1拮抗剂，即VVN001。该药新一代LFA-1拮抗剂，可高效阻断LFA-1与配体ICAM-1的结合，有效控制眼部炎症反应，缓解干眼症状。在美国开展的2期临床试验结果显示：在完成84天治疗期后，主要疗效终点指标--下方角膜荧光染色较基线的改善表面VVN001具有良好的治疗效果，5%治疗组的改善明显高于对照组。干眼治疗新进展据2020年《中国干眼专家共识定义和分类》，干眼是多因素引起的慢性眼表疾病，是由泪液的质、量及动力学异常导致的泪膜不稳定或眼表微环境失衡，可伴有眼表炎症、组织损伤及神经异常，造成眼部多种不适症状和/或视功能障碍。干眼是全球最常见的眼表疾病。受生活方式改变、电子产品广泛使用等影响，干眼发病率不断攀升，据悉其全球发病率大约5.5%-33.7%，我国干眼发病率约为21%-30%。治疗方面，干眼治疗包括物理治疗、修复治疗、抗炎治疗。物理治疗包括热敷、睑板腺按摩、清洁眼睑等，通过促进睑板腺通畅，减轻眼睛局部炎症，增强泪液稳定性。以人工泪液（玻璃酸钠滴眼液）为代表的修复治疗多用于干眼轻症患者，是目前国内对于干眼最常用的给药方案。抗炎治疗主要针对中重度干眼患者，代表药物如糖皮质激素、免疫抑制剂环孢素、非甾体抗炎药。干眼药物市场规模巨大，据悉2020年全球干眼产品销售额约为52.4亿美元，预测2023-2024年干眼产品销售额将达峰值，约为58.0亿美元。具体品种上，环孢素眼用制剂是销售额最高的一款干眼产品，2020年销售额高达24.2亿美元。鉴于干眼巨大的市场体量，越来越多的药企开始涉足该领域，且取得不错进展。据不完全统计，近年来全球监管机构批准了多款新活性成分干眼药物，如Xiidra、Eysuvis、Tyrvaya（varenicline，伐尼克兰溶液）鼻喷雾剂、Miebo。 Eysuvis（0.25％氯替泼诺混悬型滴眼液）是FDA批准的唯一一款皮质醇类干眼药物，其利用Kala Pharmaceuticals的Ampplify黏液穿透颗粒（MPP）给药技术，以增强皮质类激素在眼表的渗透性，用于短期（长达两周）治疗干眼的体征和症状。 Tyrvaya鼻喷雾剂是一种高选择性胆碱能激动剂，通过激活三叉神经副交感神经通路，从而增加基础泪膜的生成，2021年10月被FDA批准用于治疗干眼症（DED）的症状和体征。 Miebo是一款首创、无水、非甾体、单组分不含防腐剂的滴眼液，活性成分全氟己基辛烷是一种半氟烷烃，可防止泪液过度蒸发并具有恢复泪膜平衡的能力。2023年5月，该药被FDA批准用于治疗干眼的症状，成为FDA批准的首个，且唯一一个直接针对干眼泪液蒸发的药物。此外，目前全球还有多款干眼新药处于后期临床，如Reproxalap、RGN-259、AR-15512、SkQ1、PL-9643、Tivanisiran。其中Reproxalap是一款潜在首创小分子活性醛化物质（RASP）抑制剂，通过降低RASP水平，达到抑制炎症、缓解症状的作用。今年2月，该药治疗干眼的新药申请获FDA受理。 RGN-259是一种新型治疗性肽（胸腺素β4），具有保护组织以及促进修复及再生的特性，拟用于治疗中重度干眼。 AR-15512是一款瞬时受体电位TRPM8激动剂。TRPM8受体是位于角膜神经末梢的冷热感受器离子通道，AR-15512通过激活角膜中的冷热感受器，增加泪液的产生和眨眼速度，恢复泪膜的稳定性，减少眼部不适。 SKQ1是一种小分子心磷脂过氧化抑制剂，通过向线粒体提供抗氧化剂质体醌，靶向活性氧发挥作用。 PL-9643是一款黑素皮质素受体（MCR）激动剂，研究显示其可显著减少角膜上皮损伤，具有与Restasis（环孢菌素滴眼液）相似的效果。 Tivanisiran是一种基于RNA干扰的药物，能够将TRPV1基因沉默，降低TRPV1的表达，从而治疗干眼症。已公布研究结果显示，Tivanisiran能够明显减轻眼部不适及疼痛，改善干眼患者的结膜充血状态，且安全性良好。总结眼科是医药领域药物研发的黄金赛道，干眼作为常见的眼科疾病，更是国内外药企争相布局的热门领域。随着干眼发病率的上升，干眼药物市场需求也不断增加。虽然全球已获批多款干眼新药，但干眼市场仍有待进一步挖掘。希望企业的付出不会白费，更加高效、安全的干眼新药早日获批上市。智药研习社近期课程报名来源：CPHI制药在线声明：本文仅代表作者观点，并不代表制药在线立场。本网站内容仅出于传递更多信息之目的。如需转载，请务必注明文章来源和作者。投稿邮箱：Kelly.Xiao@imsinoexpo.com▼更多制药资讯，请关注CPHI制药在线▼点击阅读原文，进入智药研习社~

并购专利到期临床结果

2023-05-09

·PRNewswire

SARC LAUNCHES NATIONAL VIRTUAL MULTIDISCIPLINARY TUMOR BOARD FOR SARCOMA, REPRESENTING NEARLY 20% OF CHILDHOOD CANCERS AND 1% OF ADULT CANCERS

ANN ARBOR, Mich., May 9, 2023 /PRNewswire/ -- SARC (Sarcoma Alliance for Research Through Collaboration) is proud to announce that it has launched a national, virtual multidisciplinary sarcoma tumor board. As the care of patients with cancer, particularly uncommon cancers such as sarcoma, becomes increasingly complex and therapeutic options become more nuanced, input of multiple expert clinicians is more critical than ever for educated, optimal decision making for the treating physicians and surgeons. Continue Reading Virtual, national tumor board enables physicians & surgeons to get expert guidance on how to treat sarcomas Tweet this The SARC Multidisciplinary Tumor Board (SMTB) brings together sarcoma experts, complementing and expanding the geographic reach of local or regional institutional tumor boards. The SMTB provides a uniquely focused forum for physicians and surgeons to present sarcoma patient cases for in-depth, evidence-based discussion of tumor diagnosis and management of adults and children before or after diagnostic procedures, biopsies, surgery, or at relapse. "We are excited about our SARC Multi-Disciplinary Tumor Board," said Dr. Scott Okuno, SARC's Chief Medical Officer and Professor of Oncology at Mayo Clinic, "as this allows all sarcoma providers, regardless of whether they are practicing in a small, geographically remote center or a major center, to get opinions how to treat and manage all types of bone and soft tissue sarcoma from experts in the sarcoma field." "In 2023 SARC proudly celebrates our twentieth year facilitating and driving team science," said Steven Young, President & CEO of SARC, "and this tumor board extends support to the broader clinical community." For more information, or to submit cases for consideration, clinicians are directed to: . About SARC SARC (Sarcoma Alliance for Research Through Collaboration) is a US-based, non-profit (501(c)(3)) organization dedicated to fostering progress in the prevention and treatment of sarcoma to improve patient outcomes and ultimately find a cure. SARC was formed by the sarcoma research community in 2003 to bring together the best cancer centers in the world supported by centralized infrastructure for the conduct of multi-institutional collaborative sarcoma research. Since founding, SARC has fast-tracked and sponsored twenty-six Phase I, II and III clinical trials along with correlative studies to better understand the biologic bases for what drugs and combinations are most effective in treating sub-groups of patients, young investigator mentorship and grants programs, and the investigation of key biological questions across nearly 90 medical centers with specialized sarcoma programs in the United States and overseas. To learn more about the SARC organization, its impactful programs and innovative investigator-initiated clinical trials, and how to help support its mission, please visit the SARC website at . What Is Sarcoma? Sarcomas are cancers of the bony skeleton (the skull, vertebrae, ribs, and extremities), and the so-called soft tissues, including muscle and fat. Sarcomas are disproportionately common in children and young adults but occur at all ages. There are many different types of sarcomas, leading to diagnostic and therapeutic challenges. SARC and our collaborators are working to advance the science and treatment of sarcomas. SOURCE SARC

临床1期

100 项与 SARcode Bioscience, Inc. 相关的药物交易

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100 项与 SARcode Bioscience, Inc. 相关的转化医学

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