GX15–070MS, a synthetic small molecule induces apoptosis in vitro and in vivo in chronic lymphocytic leukemia
作者: Kitada, S. ; Castro, J. E. ; Kipps, T. J. ; Viallet, J. ; Reed, J. C. ; Contreras, D. ; Prada, C. E.
3167 Chronic lymphocytic leukemia (CLL) B cells express high levels of anti-apoptotic proteins of the Bcl-2 family, such as Mcl-1, Bcl-XL, and Bcl-2. These proteins enhance the resistance of CLL ce...